BR112014010559A2 - citocromo p450 e seu uso para oxidação enzimática de terpenos - Google Patents

citocromo p450 e seu uso para oxidação enzimática de terpenos

Info

Publication number
BR112014010559A2
BR112014010559A2 BR112014010559A BR112014010559A BR112014010559A2 BR 112014010559 A2 BR112014010559 A2 BR 112014010559A2 BR 112014010559 A BR112014010559 A BR 112014010559A BR 112014010559 A BR112014010559 A BR 112014010559A BR 112014010559 A2 BR112014010559 A2 BR 112014010559A2
Authority
BR
Brazil
Prior art keywords
cytochrome
nucleic acid
terpenes
provides
terpene
Prior art date
Application number
BR112014010559A
Other languages
English (en)
Other versions
BR112014010559B1 (pt
Inventor
Deguerry Fabienne
Schalk Michel
Original Assignee
Firmenich & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Firmenich & Cie filed Critical Firmenich & Cie
Publication of BR112014010559A2 publication Critical patent/BR112014010559A2/pt
Publication of BR112014010559B1 publication Critical patent/BR112014010559B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

resumo citocromo p450 e seu uso para oxidação enzimática de terpenos. a presente invenção fornece sequências de ácido nucleico e aminoácidos de um citocromo p450 com a capacidade de oxidar as moléculas de terpeno. ela também fornece um método de oxidação de moléculas de terpenos compreendendo o contato do citocromo p450 da invenção com a molécula de terpeno que deverá ser oxidada. particularmente, tal método pode ser conduzido in vitro ou in vivo para produzir moléculas de terpeno oxidadas, o que pode ser usado em diferentes campos técnicos como, por exemplo: aromas e fragrâncias. a presente invenção também fornece um vetor de expressão contendo ácido nucleico. um organismo hospedeiro não humano ou uma célula transformada com o ácido nucleico também é objetivo da invenção.
BR112014010559-6A 2011-11-01 2012-10-25 Citocromo p450 e seu uso para oxidação enzimática de terpenos BR112014010559B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11187409 2011-11-01
EP111874095 2011-11-01
PCT/EP2012/071096 WO2013064411A1 (en) 2011-11-01 2012-10-25 Cytochrome p450 and use thereof for the enzymatic oxidation of terpenes

Publications (2)

Publication Number Publication Date
BR112014010559A2 true BR112014010559A2 (pt) 2017-04-18
BR112014010559B1 BR112014010559B1 (pt) 2021-11-16

Family

ID=47074728

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014010559-6A BR112014010559B1 (pt) 2011-11-01 2012-10-25 Citocromo p450 e seu uso para oxidação enzimática de terpenos

Country Status (11)

Country Link
US (1) US10000773B2 (pt)
EP (1) EP2773751B1 (pt)
JP (2) JP5993019B2 (pt)
CN (1) CN103906834B (pt)
BR (1) BR112014010559B1 (pt)
ES (1) ES2625861T3 (pt)
HU (1) HUE034344T2 (pt)
MX (1) MX352318B (pt)
PL (1) PL2773751T3 (pt)
RU (1) RU2625224C2 (pt)
WO (1) WO2013064411A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115536485A (zh) * 2022-10-14 2022-12-30 中山大学 利用废旧太阳能电池中EVA和PET制备1,7-二表-α-雪松烯的方法

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2625861T3 (es) * 2011-11-01 2017-07-20 Firmenich Sa Citocromo p450 y su uso para la oxidación enzimática de terpenos
WO2015040197A1 (en) 2013-09-19 2015-03-26 Laurent Daviet Method for producing fragrant alcohols
BR112016025905B1 (pt) 2014-05-06 2024-01-09 Firmenich S.A Drimenol sintases ii
WO2016087179A1 (en) 2014-12-02 2016-06-09 Firmenich Sa Intermediates and process for the preparation of sandalwood oil building blocks
BR112017021401B1 (pt) * 2015-04-09 2024-01-09 Firmenich Sa Produção de compostos fragrantes
GB201601249D0 (en) 2016-01-22 2016-03-09 Firmenich & Cie Production of manool
US20170191086A1 (en) * 2015-12-30 2017-07-06 Natura Cosméticos S.A. Process for the transformation of essential oils comprising linalol
US20210161092A1 (en) * 2016-02-16 2021-06-03 Ajikumar Parayil KUMARAN Secondary metabolite screening system
MX2019006635A (es) 2016-12-22 2019-08-21 Firmenich & Cie Produccion de manool.
CN110691850A (zh) 2017-06-02 2020-01-14 弗门尼舍有限公司 生产折叶苔醇和/或补身醇的方法
CN111527203A (zh) * 2018-01-18 2020-08-11 弗门尼舍有限公司 细胞色素p450单加氧酶催化的倍半萜的氧化
BR112020023411A2 (pt) 2018-05-29 2021-03-09 Firmenich S/A Método para produzir compostos de albicanol
WO2020051488A1 (en) * 2018-09-06 2020-03-12 Manus Bio, Inc. Microbial production of rotundone
AT523014A1 (en) * 2019-10-14 2021-04-15 Pharmgenetix Gmbh FUNCTIONAL CYTOCHROME p450 IN VITRO ASSAY
WO2021130241A1 (en) 2019-12-23 2021-07-01 Firmenich Sa Biochemically produced sandalwood oil
CN114507696B (zh) * 2022-03-15 2024-03-15 浙江工业大学 一种高粱素的制备方法
CN114672425B (zh) * 2022-04-11 2023-09-15 湖北工业大学 产α-古巴烯的重组酿酒酵母及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9825421D0 (en) * 1998-11-19 1999-01-13 Isis Innovation Process for oxidising terpenes
RU2285044C2 (ru) * 1999-07-27 2006-10-10 Басф Акциенгезельшафт Новые цитохром р450-монооксигеназы и их применение для окисления органических соединений
CN1589327A (zh) 2001-09-17 2005-03-02 植物研究国际公司 用于生物转化的植物酶
US20090031455A1 (en) 2004-10-14 2009-01-29 Plant Research International B.V. Terpene hydroxylation
MX2008000200A (es) 2005-07-05 2008-04-07 Univ California Polinucleotidos que codifican enzimas que modifican el isoprenoide y sus metodos de uso.
GB0719620D0 (en) * 2007-10-08 2007-11-14 Isis Innovation Mutant Enzymes
EP2432877B1 (en) 2009-05-20 2017-03-15 Firmenich S.A. Method for producing (+) -zizaene
JP5526381B2 (ja) * 2009-09-07 2014-06-18 学校法人近畿大学 セスキテルペン変換酵素遺伝子及びそれを利用した酸化セスキテルペンの製造方法
US20120227134A1 (en) * 2009-11-17 2012-09-06 Basf Plant Science Company Gmbh Plants with Increased Yield
ES2625861T3 (es) * 2011-11-01 2017-07-20 Firmenich Sa Citocromo p450 y su uso para la oxidación enzimática de terpenos

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115536485A (zh) * 2022-10-14 2022-12-30 中山大学 利用废旧太阳能电池中EVA和PET制备1,7-二表-α-雪松烯的方法

Also Published As

Publication number Publication date
ES2625861T3 (es) 2017-07-20
WO2013064411A1 (en) 2013-05-10
EP2773751A1 (en) 2014-09-10
US20150218588A1 (en) 2015-08-06
MX352318B (es) 2017-11-21
CN103906834B (zh) 2016-11-16
BR112014010559B1 (pt) 2021-11-16
JP2014532418A (ja) 2014-12-08
MX2014004995A (es) 2014-05-22
HUE034344T2 (en) 2018-02-28
JP5993019B2 (ja) 2016-09-14
RU2014122157A (ru) 2015-12-10
EP2773751B1 (en) 2017-03-01
JP6359058B2 (ja) 2018-07-18
CN103906834A (zh) 2014-07-02
RU2625224C2 (ru) 2017-07-12
PL2773751T3 (pl) 2017-08-31
US10000773B2 (en) 2018-06-19
JP2017042161A (ja) 2017-03-02

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/10/2012, OBSERVADAS AS CONDICOES LEGAIS.