BR112014030760A2 - produção biotecnológica de ácido 2-hidróxi-isobutírico - Google Patents

produção biotecnológica de ácido 2-hidróxi-isobutírico

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Publication number
BR112014030760A2
BR112014030760A2 BR112014030760A BR112014030760A BR112014030760A2 BR 112014030760 A2 BR112014030760 A2 BR 112014030760A2 BR 112014030760 A BR112014030760 A BR 112014030760A BR 112014030760 A BR112014030760 A BR 112014030760A BR 112014030760 A2 BR112014030760 A2 BR 112014030760A2
Authority
BR
Brazil
Prior art keywords
isobutyric acid
hydroxy
biotechnological production
acetogenic
bacterium
Prior art date
Application number
BR112014030760A
Other languages
English (en)
Inventor
Przybylski Denise
Harms Hauke
H Müller Roland
Haas Thomas
Rohwerder Thore
Schiemann Yvonne
Original Assignee
Evonik Industries Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Industries Ag filed Critical Evonik Industries Ag
Publication of BR112014030760A2 publication Critical patent/BR112014030760A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

resumo patente de invenção: “produção biotecnológica de ácido 2-hidróxi-isobutírico”. a presente invenção refere-se a uma bactéria knallgas ou bactéria acetogênica que expressa uma coenzima a 2-hidróxi-isobutiril mutase, a um método para a produção de ácido 2-hidróxi-isobutírico, compreendendo o contato em um meio aquoso da bactéria knallgas ou acetogênica com uma mistura gasosa que compreende hidrogênio e dióxido de carbono e ao uso da bactéria knallgas ou bactéria acetogênica para a produção de ácido 2-hidróxi-isobutírico.
BR112014030760A 2012-06-15 2013-06-14 produção biotecnológica de ácido 2-hidróxi-isobutírico BR112014030760A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12172192 2012-06-15
EP20120173010 EP2674489A1 (en) 2012-06-15 2012-06-21 Biotechnological 2-hydroxyisobutyric acid production
PCT/EP2013/062336 WO2013186340A1 (en) 2012-06-15 2013-06-14 Biotechnological 2-hydroxyisobutyric acid production

Publications (1)

Publication Number Publication Date
BR112014030760A2 true BR112014030760A2 (pt) 2017-07-25

Family

ID=46354049

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014030760A BR112014030760A2 (pt) 2012-06-15 2013-06-14 produção biotecnológica de ácido 2-hidróxi-isobutírico

Country Status (9)

Country Link
US (1) US20150267231A1 (pt)
EP (2) EP2674489A1 (pt)
KR (1) KR20150018813A (pt)
CN (1) CN104364373A (pt)
BR (1) BR112014030760A2 (pt)
CA (1) CA2875453A1 (pt)
MX (1) MX2014015285A (pt)
RU (1) RU2015100279A (pt)
WO (1) WO2013186340A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2602328A1 (de) * 2011-12-05 2013-06-12 Evonik Industries AG Verfahren zur Oxidation von Alkanen unter Verwendung einer AlkB Alkan 1-Monooxygenase
EP2631298A1 (en) 2012-02-22 2013-08-28 Evonik Industries AG Biotechnological method for producing butanol and butyric acid
EP2647696A1 (de) 2012-04-02 2013-10-09 Evonik Degussa GmbH Verfahren zur aeroben Herstellung von Alanin oder einer unter Verbrauch von Alanin entstehenden Verbindung
DE102012207921A1 (de) 2012-05-11 2013-11-14 Evonik Industries Ag Mehrstufiges Syntheseverfahren mit Synthesegas
EP2759598A1 (de) 2013-01-24 2014-07-30 Evonik Industries AG Verfahren zur Herstellung von alpha, omega-Alkandiol
EP2944697A1 (en) 2014-05-13 2015-11-18 Evonik Degussa GmbH Method of producing nylon
EP3020819A1 (en) * 2014-11-17 2016-05-18 Evonik Degussa GmbH Fatty acid and derivatives production
CA2937594A1 (en) 2015-02-26 2016-08-26 Evonik Degussa Gmbh Alkene production
CN108473967B (zh) 2015-12-17 2022-03-29 赢创运营有限公司 基因修饰的产乙酸细胞
US10731185B2 (en) 2016-03-22 2020-08-04 University Of Georgia Research Foundation, Inc. Genetically engineered microbes and methods for producing citramalate
CN109790106A (zh) 2016-07-27 2019-05-21 赢创德固赛有限公司 N-乙酰基高丝氨酸
DK3339387T3 (da) 2016-12-22 2020-09-21 Evonik Operations Gmbh Forbindelser på basis af addukter med isocyanater til belægningssammensætninger
CN109868231B (zh) * 2017-12-01 2022-05-06 中国科学院烟台海岸带研究所 一种贪铜菌(Cupriavidus)及其应用
WO2019152753A1 (en) * 2018-02-01 2019-08-08 Invista Textiles (U.K.) Limited Methods and materials for the biosynthesis of beta hydroxy fatty acid anions and/or derivatives thereof and/or compounds related thereto
WO2019191763A1 (en) 2018-03-30 2019-10-03 Invista North America S.A.R.L. Methods for controlling oxygen concentration during aerobic biosynthesis
EP3775242A1 (en) 2018-03-30 2021-02-17 INVISTA Textiles (U.K.) Limited High hydrogen utilization and gas recycle
CN111936623B (zh) 2018-03-30 2023-08-25 英威达纺织（英国）有限公司 用于生物合成制造庚二酸的材料与方法和合成多肽的利用
CN112004934B (zh) 2018-03-30 2024-02-23 英威达纺织（英国）有限公司 用于生物合成制造碳基化学品的材料和方法
US20190352674A1 (en) 2018-05-02 2019-11-21 Invista North America S.A.R.L. Materials and methods for controlling limitation conditions in product biosynthesis for non-phb generating species of the genera ralstonia or cupriavidus and organisms related thereto
EP3788057A1 (en) 2018-05-02 2021-03-10 INVISTA Textiles (U.K.) Limited Materials and methods for controlling regulation in biosynthesis in species of the genera ralstonia or cupriavidus and organisms related thereto
US11788055B2 (en) 2018-05-02 2023-10-17 Inv Nylon Chemicals Americas, Llc Materials and methods for controlling oxidation and reduction in biosynthetic pathways of species of the genera ralstonia and cupriavidus and organisms related thereto
US11053287B2 (en) 2018-05-02 2021-07-06 Inv Nylon Chemicals Americas, Llc Materials and methods for differential biosynthesis in species of the genera Ralstonia and Cupriavidus and organisms related thereto

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1414970A2 (en) 2001-08-06 2004-05-06 Degussa AG Production of l-lysine by genetically modified corynebacterium glutamicum strains
AU2002355462A1 (en) 2001-08-06 2003-02-24 Degussa Ag Coryneform bacteria which produce chemical compounds ii
DE102006017760A1 (de) * 2006-03-24 2007-09-27 Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh Verfahren zur enzymatischen Herstellung von 2-Hydroxy-2-methylcarbonsäuren
US8241877B2 (en) * 2008-05-01 2012-08-14 Genomatica, Inc. Microorganisms for the production of methacrylic acid
DE102008002715A1 (de) 2008-06-27 2009-12-31 Evonik Röhm Gmbh 2-Hydroxyisobuttersäure produzierende rekombinante Zelle
WO2010022763A1 (en) * 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
DE102009046623A1 (de) * 2009-11-11 2011-05-12 Evonik Röhm Gmbh Verwendung eines zu einem MeaB-Protein homologen Proteins zur Erhöhung der enzymatischen Aktivität einer 3-Hydroxycarbonsäure-CoA-Mutase

Also Published As

Publication number Publication date
CA2875453A1 (en) 2013-12-19
KR20150018813A (ko) 2015-02-24
RU2015100279A (ru) 2016-08-10
MX2014015285A (es) 2015-02-20
WO2013186340A1 (en) 2013-12-19
US20150267231A1 (en) 2015-09-24
EP2861730A1 (en) 2015-04-22
EP2674489A1 (en) 2013-12-18
CN104364373A (zh) 2015-02-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]