MX2020005258A - Oxidacion de sesquiterpenos catalizada por monooxigenasa de citocromo p450. - Google Patents
Oxidacion de sesquiterpenos catalizada por monooxigenasa de citocromo p450.Info
- Publication number
- MX2020005258A MX2020005258A MX2020005258A MX2020005258A MX2020005258A MX 2020005258 A MX2020005258 A MX 2020005258A MX 2020005258 A MX2020005258 A MX 2020005258A MX 2020005258 A MX2020005258 A MX 2020005258A MX 2020005258 A MX2020005258 A MX 2020005258A
- Authority
- MX
- Mexico
- Prior art keywords
- cytochrome
- nucleic acid
- sesquiterpenes
- terpene
- provides
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
- C12Y114/15006—Cholesterol monooxygenase (side-chain-cleaving) (1.14.15.6), i.e. cytochrome P450scc
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención proporciona el ácido nucleico y las secuencias de aminoácidos de un citocromo P450 capaz de oxidar moléculas de terpeno. También proporciona los métodos para oxidar las moléculas de terpeno, que comprenden poner en contacto el citocromo P450 con la molécula de terpeno destinada a oxidarse. En particular, el método puede llevarse a cabo in vitro o in vivo para producir moléculas de terpeno oxidadas, que pueden usarse en diferentes campos técnicos tales como, por ejemplo, perfumería y saborizantes. La presente invención también proporciona un vector de expresión que contiene el ácido nucleico. Un organismo hospedero no humano o una célula transformada con el ácido nucleico también es un objeto de la invención.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18152363 | 2018-01-18 | ||
PCT/EP2019/051070 WO2019141739A1 (en) | 2018-01-18 | 2019-01-16 | Cytochrome p450 monooxygenase catalyzed oxidation of sesquiterpenes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020005258A true MX2020005258A (es) | 2020-08-24 |
Family
ID=61187066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020005258A MX2020005258A (es) | 2018-01-18 | 2019-01-16 | Oxidacion de sesquiterpenos catalizada por monooxigenasa de citocromo p450. |
Country Status (7)
Country | Link |
---|---|
US (1) | US20230151393A1 (es) |
EP (1) | EP3697898A1 (es) |
JP (1) | JP7431733B2 (es) |
CN (1) | CN111527203A (es) |
BR (1) | BR112020010924A2 (es) |
MX (1) | MX2020005258A (es) |
WO (1) | WO2019141739A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114621934B (zh) * | 2020-12-10 | 2023-11-24 | 中国科学院大连化学物理研究所 | 一种p450还原酶及其应用 |
CN114639442B (zh) * | 2022-03-30 | 2024-01-30 | 中国农业科学院农业基因组研究所 | 一种基于单核苷酸多态性预测开放阅读框的方法及系统 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130167263A1 (en) * | 2007-10-30 | 2013-06-27 | Monsanto Technology Llc | Nucleic acid molecules and other molecules associated with plants and uses thereof |
DE19931847A1 (de) | 1999-07-09 | 2001-01-11 | Basf Ag | Immobilisierte Lipase |
DE10019380A1 (de) | 2000-04-19 | 2001-10-25 | Basf Ag | Verfahren zur Herstellung von kovalent gebundenen biologisch aktiven Stoffen an Polyurethanschaumstoffen sowie Verwendung der geträgerten Polyurethanschaumstoffe für chirale Synthesen |
DE10019377A1 (de) | 2000-04-19 | 2001-10-25 | Basf Ag | Verfahren zur Immobilisierung von biologisch aktiven Stoffen auf Trägermaterialien und Verwendung der mit biologisch aktiven Stoffen geträgerten Materialien für chirale Synthesen |
EP2311940B1 (en) | 2005-06-17 | 2017-08-09 | Firmenich SA | Novel sesquiterpene synthases and methods of their use |
EP2090662A3 (en) * | 2006-04-05 | 2012-10-31 | Metanomics GmbH | Process for the production of a fine chemical |
US8299318B2 (en) * | 2007-07-05 | 2012-10-30 | Ceres, Inc. | Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics |
EP2432877B1 (en) | 2009-05-20 | 2017-03-15 | Firmenich S.A. | Method for producing (+) -zizaene |
ES2625861T3 (es) * | 2011-11-01 | 2017-07-20 | Firmenich Sa | Citocromo p450 y su uso para la oxidación enzimática de terpenos |
WO2015040197A1 (en) * | 2013-09-19 | 2015-03-26 | Laurent Daviet | Method for producing fragrant alcohols |
EP3183353A2 (en) * | 2014-08-21 | 2017-06-28 | Givaudan S.A. | Process for producing oxygenated products of valencene |
BR112019000892A2 (pt) * | 2016-07-20 | 2019-04-30 | Firmenich & Cie | vetiver |
-
2019
- 2019-01-16 CN CN201980007013.2A patent/CN111527203A/zh active Pending
- 2019-01-16 MX MX2020005258A patent/MX2020005258A/es unknown
- 2019-01-16 US US16/766,225 patent/US20230151393A1/en active Pending
- 2019-01-16 EP EP19700715.6A patent/EP3697898A1/en active Pending
- 2019-01-16 JP JP2020529443A patent/JP7431733B2/ja active Active
- 2019-01-16 WO PCT/EP2019/051070 patent/WO2019141739A1/en unknown
- 2019-01-16 BR BR112020010924-0A patent/BR112020010924A2/pt unknown
Also Published As
Publication number | Publication date |
---|---|
BR112020010924A2 (pt) | 2020-11-17 |
JP7431733B2 (ja) | 2024-02-15 |
WO2019141739A1 (en) | 2019-07-25 |
EP3697898A1 (en) | 2020-08-26 |
CN111527203A (zh) | 2020-08-11 |
JP2021511008A (ja) | 2021-05-06 |
US20230151393A1 (en) | 2023-05-18 |
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