MX2018010529A - Composiciones y metodos para la produccion y administracion de acido ribonucleico. - Google Patents

Composiciones y metodos para la produccion y administracion de acido ribonucleico.

Info

Publication number
MX2018010529A
MX2018010529A MX2018010529A MX2018010529A MX2018010529A MX 2018010529 A MX2018010529 A MX 2018010529A MX 2018010529 A MX2018010529 A MX 2018010529A MX 2018010529 A MX2018010529 A MX 2018010529A MX 2018010529 A MX2018010529 A MX 2018010529A
Authority
MX
Mexico
Prior art keywords
methods
compositions
dsrna
rna
delivery
Prior art date
Application number
MX2018010529A
Other languages
English (en)
Inventor
Haitao Zhang
James A Baum
Allen T Christian
Artem Evdokimov
Farhad Moshiri
Lisa Marie Weaver
Original Assignee
Monsanto Technology Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Technology Llc filed Critical Monsanto Technology Llc
Publication of MX2018010529A publication Critical patent/MX2018010529A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/60—Isolated nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H3/00—Processes for modifying phenotypes, e.g. symbiosis with bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Insects & Arthropods (AREA)

Abstract

La presente invención se refiere a una secuencia de terminador transcripcional, caracterizada porque comprende una secuencia de ácido nucleico seleccionada del grupo que consiste en las SEQ ID NOs: 13, 18 y 21-23; y una construcción de expresión con modificación genética, caracterizada porque comprende: a. un promotor; b. una primera secuencia de ácido nucleico ubicada transcripcionalmente corriente abajo del promotor, en donde la primera secuencia de ácido nucleico codifica un ARN de doble cadena (ARNdc) o una proteína; y c. una segunda secuencia de ácido nucleico, ubicada 3´con respecto a la primera secuencia de terminador transcripcional como se reclama en la reivindicación 1; y d .en donde la primera secuencia de ácido nucleico y la segunda secuencia de ácido nucleico están operativamente unidas al promotor.
MX2018010529A 2013-03-15 2015-09-15 Composiciones y metodos para la produccion y administracion de acido ribonucleico. MX2018010529A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361793506P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
MX2018010529A true MX2018010529A (es) 2022-01-25

Family

ID=50928237

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015013118A MX358744B (es) 2013-03-15 2014-03-13 Composiciones y métodos para la producción y administración de ácido ribonucleico.
MX2018010529A MX2018010529A (es) 2013-03-15 2015-09-15 Composiciones y metodos para la produccion y administracion de acido ribonucleico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015013118A MX358744B (es) 2013-03-15 2014-03-13 Composiciones y métodos para la producción y administración de ácido ribonucleico.

Country Status (14)

Country Link
US (7) US9445603B2 (es)
EP (2) EP2970990B1 (es)
JP (2) JP6522579B2 (es)
KR (3) KR102530901B1 (es)
CN (2) CN105164265B (es)
AR (1) AR095462A1 (es)
AU (1) AU2014233711B2 (es)
BR (1) BR112015023424A2 (es)
CA (1) CA2905961C (es)
ES (2) ES2691803T3 (es)
MX (2) MX358744B (es)
UA (1) UA120349C2 (es)
WO (1) WO2014151581A1 (es)
ZA (1) ZA201506682B (es)

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Also Published As

Publication number Publication date
KR20210116681A (ko) 2021-09-27
EP2970990B1 (en) 2018-07-18
US20190000089A1 (en) 2019-01-03
WO2014151581A9 (en) 2015-12-03
ZA201506682B (en) 2018-11-28
EP3434777A1 (en) 2019-01-30
CN105164265A (zh) 2015-12-16
UA120349C2 (uk) 2019-11-25
AU2014233711A9 (en) 2016-06-16
CN105164265B (zh) 2019-05-10
CA2905961C (en) 2023-04-25
WO2014151581A1 (en) 2014-09-25
EP3434777B1 (en) 2020-09-23
KR102530901B1 (ko) 2023-05-11
KR20230066486A (ko) 2023-05-15
US10757947B2 (en) 2020-09-01
MX358744B (es) 2018-08-31
MX2015013118A (es) 2016-02-09
ES2837575T3 (es) 2021-06-30
JP6522579B2 (ja) 2019-05-29
US20230232838A1 (en) 2023-07-27
AU2014233711B2 (en) 2020-05-28
BR112015023424A2 (pt) 2017-11-28
JP2019150036A (ja) 2019-09-12
CN110229815A (zh) 2019-09-13
CA2905961A1 (en) 2014-09-25
CN110229815B (zh) 2024-02-20
KR20150131310A (ko) 2015-11-24
JP2016517274A (ja) 2016-06-16
EP2970990A1 (en) 2016-01-20
AR095462A1 (es) 2015-10-21
US20170035056A1 (en) 2017-02-09
US10334858B2 (en) 2019-07-02
US20160145630A1 (en) 2016-05-26
JP6935450B2 (ja) 2021-09-15
US10070652B2 (en) 2018-09-11
AU2014233711A1 (en) 2015-10-01
ES2691803T3 (es) 2018-11-28
US9814243B2 (en) 2017-11-14
US20190380348A1 (en) 2019-12-19
US20180092364A1 (en) 2018-04-05
US9445603B2 (en) 2016-09-20
US20140271559A1 (en) 2014-09-18
US11647753B2 (en) 2023-05-16

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