MX2014004995A - Citocromo p450 y su uso para oxidacion enzimatica de terpenos. - Google Patents

Citocromo p450 y su uso para oxidacion enzimatica de terpenos.

Info

Publication number
MX2014004995A
MX2014004995A MX2014004995A MX2014004995A MX2014004995A MX 2014004995 A MX2014004995 A MX 2014004995A MX 2014004995 A MX2014004995 A MX 2014004995A MX 2014004995 A MX2014004995 A MX 2014004995A MX 2014004995 A MX2014004995 A MX 2014004995A
Authority
MX
Mexico
Prior art keywords
cytochrome
nucleic acid
provides
terpene
terpenes
Prior art date
Application number
MX2014004995A
Other languages
English (en)
Other versions
MX352318B (es
Inventor
Michel Schalk
Fabienne Deguerry
Original Assignee
Firmenich & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Firmenich & Cie filed Critical Firmenich & Cie
Publication of MX2014004995A publication Critical patent/MX2014004995A/es
Publication of MX352318B publication Critical patent/MX352318B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona las secuencias del ácido nucleico y el aminoácido de un citocromo P450 capaz de oxidar las moléculas de terpeno. También se provee un método de oxidación de las moléculas de terpeno que comprende poner en contacto el citocromo P450 de la invención con la molécula de terpeno propuesta para que sea oxidada. En particular, el método puede ser llevado a cabo in vitro o in vivo para producir moléculas de terpeno oxidadas, las cuales pueden ser utilizadas en diferentes campos técnicos tales como por ejemplo en perfumería y en saborizantes. La presente invención también provee un vector de expresión que contiene el ácido nucleico. También es un objeto de la invención una célula u organismo hospedero no humano transformado con el ácido nucleico.
MX2014004995A 2011-11-01 2012-10-25 Citocromo p450 y su uso para oxidacion enzimatica de terpenos. MX352318B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11187409 2011-11-01
PCT/EP2012/071096 WO2013064411A1 (en) 2011-11-01 2012-10-25 Cytochrome p450 and use thereof for the enzymatic oxidation of terpenes

Publications (2)

Publication Number Publication Date
MX2014004995A true MX2014004995A (es) 2014-05-22
MX352318B MX352318B (es) 2017-11-21

Family

ID=47074728

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014004995A MX352318B (es) 2011-11-01 2012-10-25 Citocromo p450 y su uso para oxidacion enzimatica de terpenos.

Country Status (11)

Country Link
US (1) US10000773B2 (es)
EP (1) EP2773751B1 (es)
JP (2) JP5993019B2 (es)
CN (1) CN103906834B (es)
BR (1) BR112014010559B1 (es)
ES (1) ES2625861T3 (es)
HU (1) HUE034344T2 (es)
MX (1) MX352318B (es)
PL (1) PL2773751T3 (es)
RU (1) RU2625224C2 (es)
WO (1) WO2013064411A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2625224C2 (ru) * 2011-11-01 2017-07-12 Фирмениш Са Цитохром p450 и его применение для энзиматического окисления терпенов
CN112176000B (zh) 2013-09-19 2024-09-10 弗门尼舍有限公司 用于生产芳香醇的方法
ES2759724T3 (es) 2014-05-06 2020-05-12 Firmenich & Cie Drimenol sintasas y procedimiento de producción de drimenol
US9879203B2 (en) 2014-12-02 2018-01-30 Firmenich Sa Intermediates and process for the preparation of sandalwood oil building blocks
EP3303599A4 (en) * 2015-04-09 2019-05-01 Firmenich SA MANUFACTURE OF ODORANT COMPOUNDS
GB201601249D0 (en) 2016-01-22 2016-03-09 Firmenich & Cie Production of manool
US20170191086A1 (en) * 2015-12-30 2017-07-06 Natura Cosméticos S.A. Process for the transformation of essential oils comprising linalol
WO2017142993A1 (en) * 2016-02-16 2017-08-24 Manus Biosynthesis, Inc. Secondary metabolite screening system
ES2899121T3 (es) 2016-12-22 2022-03-10 Firmenich & Cie Producción de manool
US11293037B2 (en) 2017-06-02 2022-04-05 Firmenich Sa Method for producing albicanol and/or drimenol
EP3697898A1 (en) * 2018-01-18 2020-08-26 Firmenich SA Cytochrome p450 monooxygenase catalyzed oxidation of sesquiterpenes
WO2019229064A2 (en) 2018-05-29 2019-12-05 Firmenich Sa Method for producing albicanol compounds
CN113195726A (zh) * 2018-09-06 2021-07-30 马努斯生物合成股份有限公司 莎草奥酮的微生物生产
AT523014A1 (en) * 2019-10-14 2021-04-15 Pharmgenetix Gmbh FUNCTIONAL CYTOCHROME p450 IN VITRO ASSAY
CN115335514A (zh) * 2019-10-25 2022-11-11 银杏生物制品公司 罗汉果甙的生物合成
MX2022007440A (es) 2019-12-23 2022-06-24 Firmenich & Cie Aceite de sandalo producido bioquimicamente.
CN114507696B (zh) * 2022-03-15 2024-03-15 浙江工业大学 一种高粱素的制备方法
CN114672425B (zh) * 2022-04-11 2023-09-15 湖北工业大学 产α-古巴烯的重组酿酒酵母及其应用
CN115536485B (zh) * 2022-10-14 2024-09-10 中山大学 利用废旧太阳能电池中EVA和PET制备1,7-二表-α-雪松烯的方法
WO2024132991A1 (en) 2022-12-22 2024-06-27 Isobionics B.V. Recombinant production of zizaene and other sesquiterpenesformed by conversion of the bisabolyl cation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9825421D0 (en) * 1998-11-19 1999-01-13 Isis Innovation Process for oxidising terpenes
RU2285044C2 (ru) * 1999-07-27 2006-10-10 Басф Акциенгезельшафт Новые цитохром р450-монооксигеназы и их применение для окисления органических соединений
EP1916307B1 (en) * 2001-09-17 2014-02-26 Dafra Pharma Research & Development BVBA Plant enzymes for bioconversion
US20090031455A1 (en) * 2004-10-14 2009-01-29 Plant Research International B.V. Terpene hydroxylation
ZA200800889B (en) * 2005-07-05 2009-09-30 Univ California Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof
GB0719620D0 (en) * 2007-10-08 2007-11-14 Isis Innovation Mutant Enzymes
CN104017794B (zh) 2009-05-20 2019-04-23 弗门尼舍有限公司 用于生产(+)-客烯的方法
JP5526381B2 (ja) * 2009-09-07 2014-06-18 学校法人近畿大学 セスキテルペン変換酵素遺伝子及びそれを利用した酸化セスキテルペンの製造方法
AU2010320547B2 (en) 2009-11-17 2016-06-09 Basf Plant Science Company Gmbh Plants with increased yield
RU2625224C2 (ru) * 2011-11-01 2017-07-12 Фирмениш Са Цитохром p450 и его применение для энзиматического окисления терпенов

Also Published As

Publication number Publication date
PL2773751T3 (pl) 2017-08-31
JP2017042161A (ja) 2017-03-02
RU2625224C2 (ru) 2017-07-12
WO2013064411A1 (en) 2013-05-10
ES2625861T3 (es) 2017-07-20
HUE034344T2 (en) 2018-02-28
JP6359058B2 (ja) 2018-07-18
EP2773751B1 (en) 2017-03-01
CN103906834B (zh) 2016-11-16
MX352318B (es) 2017-11-21
CN103906834A (zh) 2014-07-02
JP2014532418A (ja) 2014-12-08
JP5993019B2 (ja) 2016-09-14
US10000773B2 (en) 2018-06-19
RU2014122157A (ru) 2015-12-10
BR112014010559A2 (pt) 2017-04-18
US20150218588A1 (en) 2015-08-06
BR112014010559B1 (pt) 2021-11-16
EP2773751A1 (en) 2014-09-10

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