EA201071425A1 - Соли карбоновой кислоты 2-амино-3-карбэтоксиамино-6-(4-фторбензиламино)пиридина - Google Patents

Соли карбоновой кислоты 2-амино-3-карбэтоксиамино-6-(4-фторбензиламино)пиридина

Info

Publication number
EA201071425A1
EA201071425A1 EA201071425A EA201071425A EA201071425A1 EA 201071425 A1 EA201071425 A1 EA 201071425A1 EA 201071425 A EA201071425 A EA 201071425A EA 201071425 A EA201071425 A EA 201071425A EA 201071425 A1 EA201071425 A1 EA 201071425A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ftorbenzylamino
carbetoxyamino
pyridine
amino
carbonic acid
Prior art date
Application number
EA201071425A
Other languages
English (en)
Other versions
EA020545B1 (ru
Inventor
Кристоф Хоок
Асал Кадан
Original Assignee
Авд. Фарма Гмбх Унд Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авд. Фарма Гмбх Унд Ко. Кг filed Critical Авд. Фарма Гмбх Унд Ко. Кг
Publication of EA201071425A1 publication Critical patent/EA201071425A1/ru
Publication of EA020545B1 publication Critical patent/EA020545B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

Описано изготовление карбоксилатной кислотно-аддитивной соли флупиртина формулы (2), в которой R представляет собой водород или C-Салкильную группу, при условии, что RCOOH не представляют собой ни малеиновой, ни глюконовой кислоты.
EA201071425A 2008-06-09 2009-06-09 Соли карбоновой кислоты 2-амино-3-карбэтоксиамино-6-(4-фторбензиламино)пиридина EA020545B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08010472 2008-06-09
PCT/US2009/046775 WO2009152168A2 (en) 2008-06-09 2009-06-09 Carboxylic acid salts of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine

Publications (2)

Publication Number Publication Date
EA201071425A1 true EA201071425A1 (ru) 2011-06-30
EA020545B1 EA020545B1 (ru) 2014-12-30

Family

ID=39939397

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071425A EA020545B1 (ru) 2008-06-09 2009-06-09 Соли карбоновой кислоты 2-амино-3-карбэтоксиамино-6-(4-фторбензиламино)пиридина

Country Status (5)

Country Link
US (1) US8183267B2 (ru)
EP (1) EP2346826A2 (ru)
EA (1) EA020545B1 (ru)
IL (1) IL209836A (ru)
WO (1) WO2009152168A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183267B2 (en) * 2008-06-09 2012-05-22 Awd. Pharma Gmbh & Co. Kg Carboxylic acid salts of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine
US20120028930A1 (en) * 2010-02-26 2012-02-02 Bionevia Pharmaceuticals Inc. Flupirtine salts and polymorphs
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
DE102010063609A1 (de) * 2010-12-20 2012-06-21 Awd.Pharma Gmbh & Co. Kg Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3yl)-carbamidsäureethylester und einer Arylpropionsäure
DE102010063612A1 (de) * 2010-12-20 2012-06-21 Awd.Pharma Gmbh & Co. Kg Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamidsäureethylester und 2-[2-[(2,6-Dichlorphenyl)-amino]-phenyl]-essigsäure

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795858C2 (de) 1968-07-19 1979-01-11 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Benzylaminopyridine
DE3133519A1 (de) 1980-09-13 1982-06-09 Degussa Ag, 6000 Frankfurt "2-amino-3-carbethoxyamino-6-(p-fluor-benzylamino)-pyridin-maleat"
DE3337593A1 (de) 1982-10-27 1984-05-03 Degussa Ag, 6000 Frankfurt 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung
DE3416609A1 (de) 1984-05-05 1985-11-07 Degussa Ag, 6000 Frankfurt 2-amino-3-ethoxycarbonylamino-6-(p-fluor-benzylamino)- pyridin-gluconat und pharmazeutische zubereitungen, die diese substanz enthalten
DE3915184A1 (de) 1988-05-16 1989-11-30 Asta Pharma Ag Substituierte 3-(n-heterocyclyl)-2,6-diaminopyridine und -n-oxide, ihre herstellung und verwendung als arzneimittel
DE4319649A1 (de) 1993-03-18 1994-09-22 Asta Medica Ag Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe
DE19716984A1 (de) 1997-04-23 1998-10-29 Asta Medica Ag Verfahren zur Herstellung von reinem Flupirtin-Maleat und dessen Modifikation A
DE19903275A1 (de) * 1999-01-28 2000-08-03 Merck Patent Gmbh Lyophilisate mit verbesserter Rekonstituierbarkeit
DE10327674A1 (de) * 2003-06-20 2005-01-05 Awd.Pharma Gmbh & Co. Kg Injizierbare Darreichungsform von Flupirtin
DE102005054610B4 (de) 2005-11-08 2010-06-10 Awd.Pharma Gmbh & Co. Kg Flupirtin enthaltende Arzneimittelzubereitung mit kontrollierter Wirkstofffreisetzung
US8183267B2 (en) * 2008-06-09 2012-05-22 Awd. Pharma Gmbh & Co. Kg Carboxylic acid salts of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine

Also Published As

Publication number Publication date
US20090306150A1 (en) 2009-12-10
EP2346826A2 (en) 2011-07-27
US8183267B2 (en) 2012-05-22
WO2009152168A2 (en) 2009-12-17
WO2009152168A3 (en) 2010-03-18
IL209836A (en) 2015-02-26
IL209836A0 (en) 2011-02-28
EA020545B1 (ru) 2014-12-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU