MX2010001733A - Compustos de imidazo[1,2-a]pirazina para tratamiento de infecciones virales tales como hepatitis. - Google Patents

Compustos de imidazo[1,2-a]pirazina para tratamiento de infecciones virales tales como hepatitis.

Info

Publication number
MX2010001733A
MX2010001733A MX2010001733A MX2010001733A MX2010001733A MX 2010001733 A MX2010001733 A MX 2010001733A MX 2010001733 A MX2010001733 A MX 2010001733A MX 2010001733 A MX2010001733 A MX 2010001733A MX 2010001733 A MX2010001733 A MX 2010001733A
Authority
MX
Mexico
Prior art keywords
compounds
imidazopyrazine compounds
formula
imidazopyrazine
cvb
Prior art date
Application number
MX2010001733A
Other languages
English (en)
Spanish (es)
Inventor
Clifford John Harris
Dale Robert Mitchell
Angus Macleod
Nicholas John Palmer
Michael Daniel Goldsmith
Christophe Claude Parsy
Original Assignee
Biofocus Dpi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofocus Dpi Ltd filed Critical Biofocus Dpi Ltd
Publication of MX2010001733A publication Critical patent/MX2010001733A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MX2010001733A 2007-08-21 2008-08-20 Compustos de imidazo[1,2-a]pirazina para tratamiento de infecciones virales tales como hepatitis. MX2010001733A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0716292.8A GB0716292D0 (en) 2007-08-21 2007-08-21 Imidazopyrazine compounds
PCT/EP2008/060896 WO2009024585A2 (en) 2007-08-21 2008-08-20 Imidazo [1,2-a] pyrazine compounds for treatment of viral infections such as hepatitis

Publications (1)

Publication Number Publication Date
MX2010001733A true MX2010001733A (es) 2010-07-06

Family

ID=38566736

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001733A MX2010001733A (es) 2007-08-21 2008-08-20 Compustos de imidazo[1,2-a]pirazina para tratamiento de infecciones virales tales como hepatitis.

Country Status (20)

Country Link
US (1) US8362018B2 (enExample)
EP (2) EP2567960A3 (enExample)
JP (1) JP2010536825A (enExample)
KR (1) KR20100081294A (enExample)
CN (1) CN101835780B (enExample)
AU (1) AU2008290531A1 (enExample)
BR (1) BRPI0815717A2 (enExample)
CA (1) CA2707521A1 (enExample)
CY (1) CY1113872T1 (enExample)
DK (1) DK2193131T3 (enExample)
ES (1) ES2404415T3 (enExample)
GB (1) GB0716292D0 (enExample)
HR (1) HRP20130202T1 (enExample)
MX (1) MX2010001733A (enExample)
NZ (1) NZ584108A (enExample)
PL (1) PL2193131T3 (enExample)
PT (1) PT2193131E (enExample)
SI (1) SI2193131T1 (enExample)
WO (1) WO2009024585A2 (enExample)
ZA (1) ZA201002009B (enExample)

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JP5542214B2 (ja) 2009-10-27 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしての複素環化合物
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WO2012080232A1 (en) * 2010-12-17 2012-06-21 Bayer Pharma Aktiengesellschaft 2-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US9284317B2 (en) * 2010-12-17 2016-03-15 Bayer Intellectual Property Gmbh Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors
US20140187548A1 (en) 2010-12-17 2014-07-03 Bayer Intellectual Property Gmbh 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US8546442B2 (en) 2010-12-23 2013-10-01 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as CCR1 receptor antagonists
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JP6115962B2 (ja) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ．ベー． １−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体
JPWO2013061962A1 (ja) * 2011-10-24 2015-04-02 武田薬品工業株式会社 二環性化合物
WO2014001314A1 (en) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
AU2013289284B2 (en) 2012-07-09 2017-03-30 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
WO2016130501A1 (en) 2015-02-09 2016-08-18 Incyte Corporation Aza-heteroaryl compounds as pi3k-gamma inhibitors
BR112017023038A2 (pt) * 2015-04-29 2018-07-03 Janssen Pharmaceutica Nv imidazopirazinas e pirazolopirimidinas e seu uso como moduladores do receptor ampa
BR122023023802A2 (pt) 2015-04-29 2023-12-26 Janssen Pharmaceutica Nv Compostos azabenzimidazóis, seu uso como moduladores do receptor de ampa e composições farmacêuticas que os compreendem
CN107949563B (zh) * 2015-06-24 2020-06-05 库洛维公司 治疗中有用的吡唑并[1,5-a]三嗪-4-胺衍生物
JP6507976B2 (ja) * 2015-09-30 2019-05-08 東レ株式会社 イミダゾール−２−カルボン酸エステル誘導体又はその塩の製造方法
RS63359B1 (sr) 2015-11-06 2022-07-29 Incyte Corp Heterociklična jedinjenja kao inhibitori pi3k-gama
ES2995198T3 (en) 2016-01-05 2025-02-07 Incyte Corp Pyridine compounds as pi3k-gamma inhibitors
HK1250945A1 (zh) * 2016-03-31 2019-01-18 罗马克实验室有限公司 用於治疗病毒性感染的噻唑化物化合物
TW201803871A (zh) 2016-06-24 2018-02-01 英塞特公司 作為ＰＩ３Ｋ-γ抑制劑之雜環化合物
UY37381A (es) 2016-08-30 2018-03-23 Glaxosmithkline Ip No 2 Ltd Compuestos que inhiben proteasas 3c y 3cl y métodos de uso de los mismos
KR102717072B1 (ko) 2017-10-18 2024-10-15 인사이트 코포레이션 Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체
JP7133023B2 (ja) 2018-01-17 2022-09-07 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Ｐｉ４ｋｉｉｉベータ阻害剤
TWI811428B (zh) 2018-08-21 2023-08-11 日商杏林製藥股份有限公司 雙環雜芳香環衍生物
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
CN109369545B (zh) * 2018-12-14 2020-04-10 东营曜康医药科技有限公司 2-甲基-5-甲酸吡嗪的合成工艺
US20230014730A1 (en) 2019-09-23 2023-01-19 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Phosphodiesterase inhibitors and use
WO2021061803A1 (en) 2019-09-23 2021-04-01 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Phosphodiesterase inhibitors and use
CN115667266A (zh) 2020-06-01 2023-01-31 豪夫迈·罗氏有限公司 新型咪唑并吡嗪衍生物
EP4161930A1 (en) * 2020-06-08 2023-04-12 F. Hoffmann-La Roche AG Novel imidazo-pyrazine derivatives
CN113929633A (zh) * 2021-10-27 2022-01-14 山东大学 一种法匹拉韦的合成方法及其应用
CN113831255B (zh) * 2021-11-25 2022-03-11 山东诚创蓝海医药科技有限公司 一种2-氨基丙二酰胺的制备方法
CN115489188B (zh) * 2022-10-09 2023-08-29 安徽国风新材料股份有限公司 一种家居保护用聚酯薄膜及其制备方法
EP4623911A1 (en) 2024-03-25 2025-10-01 ETH Zurich Pi4kb inhibitors for the treatment of fatty liver disease
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Also Published As

Publication number Publication date
DK2193131T3 (da) 2013-04-22
WO2009024585A2 (en) 2009-02-26
NZ584108A (en) 2012-06-29
EP2193131B1 (en) 2013-01-30
BRPI0815717A2 (pt) 2015-02-10
ES2404415T3 (es) 2013-05-27
EP2567960A3 (en) 2013-06-05
ZA201002009B (en) 2010-12-29
US8362018B2 (en) 2013-01-29
GB0716292D0 (en) 2007-09-26
HRP20130202T1 (hr) 2013-04-30
EP2193131A2 (en) 2010-06-09
HK1143810A1 (en) 2011-01-14
WO2009024585A3 (en) 2009-08-06
KR20100081294A (ko) 2010-07-14
PT2193131E (pt) 2013-04-04
US20110166147A1 (en) 2011-07-07
PL2193131T3 (pl) 2013-07-31
AU2008290531A1 (en) 2009-02-26
CN101835780A (zh) 2010-09-15
CA2707521A1 (en) 2009-02-26
SI2193131T1 (sl) 2013-06-28
EP2567960A2 (en) 2013-03-13
JP2010536825A (ja) 2010-12-02
CY1113872T1 (el) 2016-07-27
CN101835780B (zh) 2013-09-18

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