CN101835780B - 用于治疗病毒感染诸如肝炎的咪唑并[1,2-a]吡嗪化合物 - Google Patents

用于治疗病毒感染诸如肝炎的咪唑并[1,2-a]吡嗪化合物 Download PDF

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Publication number
CN101835780B
CN101835780B CN2008801108961A CN200880110896A CN101835780B CN 101835780 B CN101835780 B CN 101835780B CN 2008801108961 A CN2008801108961 A CN 2008801108961A CN 200880110896 A CN200880110896 A CN 200880110896A CN 101835780 B CN101835780 B CN 101835780B
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China
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alkyl
substituted
halogen
compounds
unsubstituted
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CN2008801108961A
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Chinese (zh)
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CN101835780A (zh
Inventor
A·麦克劳德
D·R·米切尔
N·J·帕尔默
C·C·帕尔西
M·D·戈德史密斯
C·J·哈里斯
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Biofocus DPI Ltd
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Biofocus DPI Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2008801108961A 2007-08-21 2008-08-20 用于治疗病毒感染诸如肝炎的咪唑并[1,2-a]吡嗪化合物 Expired - Fee Related CN101835780B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0716292.8A GB0716292D0 (en) 2007-08-21 2007-08-21 Imidazopyrazine compounds
GB0716292.8 2007-08-21
PCT/EP2008/060896 WO2009024585A2 (en) 2007-08-21 2008-08-20 Imidazo [1,2-a] pyrazine compounds for treatment of viral infections such as hepatitis

Publications (2)

Publication Number Publication Date
CN101835780A CN101835780A (zh) 2010-09-15
CN101835780B true CN101835780B (zh) 2013-09-18

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CN2008801108961A Expired - Fee Related CN101835780B (zh) 2007-08-21 2008-08-20 用于治疗病毒感染诸如肝炎的咪唑并[1,2-a]吡嗪化合物

Country Status (20)

Country Link
US (1) US8362018B2 (enExample)
EP (2) EP2567960A3 (enExample)
JP (1) JP2010536825A (enExample)
KR (1) KR20100081294A (enExample)
CN (1) CN101835780B (enExample)
AU (1) AU2008290531A1 (enExample)
BR (1) BRPI0815717A2 (enExample)
CA (1) CA2707521A1 (enExample)
CY (1) CY1113872T1 (enExample)
DK (1) DK2193131T3 (enExample)
ES (1) ES2404415T3 (enExample)
GB (1) GB0716292D0 (enExample)
HR (1) HRP20130202T1 (enExample)
MX (1) MX2010001733A (enExample)
NZ (1) NZ584108A (enExample)
PL (1) PL2193131T3 (enExample)
PT (1) PT2193131E (enExample)
SI (1) SI2193131T1 (enExample)
WO (1) WO2009024585A2 (enExample)
ZA (1) ZA201002009B (enExample)

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CN109369545B (zh) * 2018-12-14 2020-04-10 东营曜康医药科技有限公司 2-甲基-5-甲酸吡嗪的合成工艺
CN116574099A (zh) 2019-09-23 2023-08-11 南京征祥医药有限公司 磷酸二酯酶抑制剂及用途
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JP7824232B2 (ja) * 2020-06-01 2026-03-04 エフ． ホフマン－ラ ロシュ アーゲー 新規イミダゾピラジン誘導体
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CN113831255B (zh) * 2021-11-25 2022-03-11 山东诚创蓝海医药科技有限公司 一种2-氨基丙二酰胺的制备方法
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Also Published As

Publication number Publication date
BRPI0815717A2 (pt) 2015-02-10
DK2193131T3 (da) 2013-04-22
ES2404415T3 (es) 2013-05-27
CY1113872T1 (el) 2016-07-27
KR20100081294A (ko) 2010-07-14
EP2193131B1 (en) 2013-01-30
HK1143810A1 (en) 2011-01-14
SI2193131T1 (sl) 2013-06-28
CA2707521A1 (en) 2009-02-26
EP2567960A3 (en) 2013-06-05
PL2193131T3 (pl) 2013-07-31
CN101835780A (zh) 2010-09-15
NZ584108A (en) 2012-06-29
MX2010001733A (es) 2010-07-06
WO2009024585A3 (en) 2009-08-06
AU2008290531A1 (en) 2009-02-26
WO2009024585A2 (en) 2009-02-26
US8362018B2 (en) 2013-01-29
EP2567960A2 (en) 2013-03-13
JP2010536825A (ja) 2010-12-02
ZA201002009B (en) 2010-12-29
EP2193131A2 (en) 2010-06-09
PT2193131E (pt) 2013-04-04
GB0716292D0 (en) 2007-09-26
US20110166147A1 (en) 2011-07-07
HRP20130202T1 (hr) 2013-04-30

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