JP2010536825A - 肝炎などのウイルス感染の治療用イミダゾ［１，２−ａ］ピラジン化合物 - Google Patents
肝炎などのウイルス感染の治療用イミダゾ［１，２−ａ］ピラジン化合物 Download PDFInfo
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- JP2010536825A JP2010536825A JP2010521417A JP2010521417A JP2010536825A JP 2010536825 A JP2010536825 A JP 2010536825A JP 2010521417 A JP2010521417 A JP 2010521417A JP 2010521417 A JP2010521417 A JP 2010521417A JP 2010536825 A JP2010536825 A JP 2010536825A
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- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical compound BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 description 1
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 description 1
- 125000005580 triphenylene group Chemical group 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 229950002810 valopicitabine Drugs 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0716292.8A GB0716292D0 (en) | 2007-08-21 | 2007-08-21 | Imidazopyrazine compounds |
| PCT/EP2008/060896 WO2009024585A2 (en) | 2007-08-21 | 2008-08-20 | Imidazo [1,2-a] pyrazine compounds for treatment of viral infections such as hepatitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010536825A true JP2010536825A (ja) | 2010-12-02 |
| JP2010536825A5 JP2010536825A5 (enExample) | 2014-01-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2010521417A Ceased JP2010536825A (ja) | 2007-08-21 | 2008-08-20 | 肝炎などのウイルス感染の治療用イミダゾ［１，２−ａ］ピラジン化合物 |
Country Status (20)
| Country | Link |
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| US (1) | US8362018B2 (enExample) |
| EP (2) | EP2567960A3 (enExample) |
| JP (1) | JP2010536825A (enExample) |
| KR (1) | KR20100081294A (enExample) |
| CN (1) | CN101835780B (enExample) |
| AU (1) | AU2008290531A1 (enExample) |
| BR (1) | BRPI0815717A2 (enExample) |
| CA (1) | CA2707521A1 (enExample) |
| CY (1) | CY1113872T1 (enExample) |
| DK (1) | DK2193131T3 (enExample) |
| ES (1) | ES2404415T3 (enExample) |
| GB (1) | GB0716292D0 (enExample) |
| HR (1) | HRP20130202T1 (enExample) |
| MX (1) | MX2010001733A (enExample) |
| NZ (1) | NZ584108A (enExample) |
| PL (1) | PL2193131T3 (enExample) |
| PT (1) | PT2193131E (enExample) |
| SI (1) | SI2193131T1 (enExample) |
| WO (1) | WO2009024585A2 (enExample) |
| ZA (1) | ZA201002009B (enExample) |
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| JP2013545779A (ja) * | 2010-12-17 | 2013-12-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過剰増殖性障害の治療におけるｍｐｓ−１およびｔｋｋ阻害剤として使用するための６置換イミダゾピラジン |
| JP2014503521A (ja) * | 2010-12-17 | 2014-02-13 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過増殖性障害の処置におけるｍｐｓ−１およびｔｋｋ阻害剤としての使用のための、イミダゾピラジン類 |
| JP2017066077A (ja) * | 2015-09-30 | 2017-04-06 | 東レ株式会社 | イミダゾール−２−カルボン酸エステル誘導体又はその塩の製造方法 |
| JP2018514537A (ja) * | 2015-04-29 | 2018-06-07 | ヤンセン ファーマシューティカ エヌ．ベー． | イミダゾピラジン及びピラゾロピリミジン、並びにａｍｐａ受容体調節物質としてのこれらの使用 |
| JP2018522861A (ja) * | 2015-06-24 | 2018-08-16 | キュロヴィル・アクチボラグ | 療法に有用なピラゾロ［１，５−ａ］トリアジン−４−アミン誘導体 |
| US11312712B2 (en) | 2015-04-29 | 2022-04-26 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as AMPA receptor modulators |
| JP2023527479A (ja) * | 2020-06-01 | 2023-06-28 | エフ． ホフマン－ラ ロシュ アーゲー | 新規イミダゾピラジン誘導体 |
| JP2023529578A (ja) * | 2020-06-08 | 2023-07-11 | エフ． ホフマン－ラ ロシュ アーゲー | 新規イミダゾ－ピラジン誘導体 |
| JP7860905B2 (ja) | 2020-06-08 | 2026-05-18 | エフ． ホフマン－ラ ロシュ アーゲー | 新規イミダゾ－ピラジン誘導体 |
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| GB0716292D0 (en) * | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
| EP2285783B1 (en) | 2008-04-29 | 2014-05-21 | Boehringer Ingelheim International GmbH | Indazole compounds as ccr1 receptor antagonists |
| WO2009137338A1 (en) | 2008-05-06 | 2009-11-12 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as ccr1 antagonists |
| JP5507567B2 (ja) | 2008-09-26 | 2014-05-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体拮抗薬としてのアザインダゾール化合物 |
| TW201107329A (en) | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
| PL2491028T3 (pl) | 2009-10-21 | 2014-05-30 | Boehringer Ingelheim Int | Związki indazolowe i pirazolopirydynowe jako antagoniści receptora CCR1 |
| US8927550B2 (en) | 2009-10-27 | 2015-01-06 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as CCR1 receptor antagonists |
| CA2778949C (en) | 2009-10-30 | 2018-02-27 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors |
| WO2011071730A1 (en) * | 2009-12-08 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
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| ES2551407T3 (es) * | 2010-03-18 | 2015-11-18 | Bayer Intellectual Property Gmbh | Imidazopirazinas |
| JP5793182B2 (ja) | 2010-04-30 | 2015-10-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体アンタゴニストとしてのアザインダゾールアミド化合物 |
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| CA2853221A1 (en) | 2011-10-24 | 2013-05-02 | Tohru Yamashita | Bicyclic compound |
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| US20230014730A1 (en) | 2019-09-23 | 2023-01-19 | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. | Phosphodiesterase inhibitors and use |
| CN113929633A (zh) * | 2021-10-27 | 2022-01-14 | 山东大学 | 一种法匹拉韦的合成方法及其应用 |
| CN113831255B (zh) * | 2021-11-25 | 2022-03-11 | 山东诚创蓝海医药科技有限公司 | 一种2-氨基丙二酰胺的制备方法 |
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| EP4623911A1 (en) | 2024-03-25 | 2025-10-01 | ETH Zurich | Pi4kb inhibitors for the treatment of fatty liver disease |
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- 2008-08-20 US US12/674,525 patent/US8362018B2/en not_active Expired - Fee Related
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- 2008-08-20 AU AU2008290531A patent/AU2008290531A1/en not_active Abandoned
- 2008-08-20 PT PT87873469T patent/PT2193131E/pt unknown
- 2008-08-20 CN CN2008801108961A patent/CN101835780B/zh not_active Expired - Fee Related
- 2008-08-20 CA CA2707521A patent/CA2707521A1/en not_active Abandoned
- 2008-08-20 DK DK08787346.9T patent/DK2193131T3/da active
- 2008-08-20 BR BRPI0815717-0A2A patent/BRPI0815717A2/pt not_active IP Right Cessation
- 2008-08-20 PL PL08787346T patent/PL2193131T3/pl unknown
- 2008-08-20 HR HRP20130202AT patent/HRP20130202T1/hr unknown
- 2008-08-20 EP EP12188861.4A patent/EP2567960A3/en not_active Withdrawn
- 2008-08-20 ES ES08787346T patent/ES2404415T3/es active Active
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| JP2013545779A (ja) * | 2010-12-17 | 2013-12-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過剰増殖性障害の治療におけるｍｐｓ−１およびｔｋｋ阻害剤として使用するための６置換イミダゾピラジン |
| JP2014503521A (ja) * | 2010-12-17 | 2014-02-13 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過増殖性障害の処置におけるｍｐｓ−１およびｔｋｋ阻害剤としての使用のための、イミダゾピラジン類 |
| US12145934B2 (en) | 2015-04-29 | 2024-11-19 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as AMPA receptor modulators |
| JP2018514537A (ja) * | 2015-04-29 | 2018-06-07 | ヤンセン ファーマシューティカ エヌ．ベー． | イミダゾピラジン及びピラゾロピリミジン、並びにａｍｐａ受容体調節物質としてのこれらの使用 |
| US11312712B2 (en) | 2015-04-29 | 2022-04-26 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as AMPA receptor modulators |
| US12139485B2 (en) | 2015-04-29 | 2024-11-12 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as AMPA receptor modulators |
| US12304908B2 (en) | 2015-04-29 | 2025-05-20 | Rapport Therapeutics, Inc. | Azabenzimidazoles and their use as AMPA receptor modulators |
| JP2018522861A (ja) * | 2015-06-24 | 2018-08-16 | キュロヴィル・アクチボラグ | 療法に有用なピラゾロ［１，５−ａ］トリアジン−４−アミン誘導体 |
| JP2017066077A (ja) * | 2015-09-30 | 2017-04-06 | 東レ株式会社 | イミダゾール−２−カルボン酸エステル誘導体又はその塩の製造方法 |
| JP2023527479A (ja) * | 2020-06-01 | 2023-06-28 | エフ． ホフマン－ラ ロシュ アーゲー | 新規イミダゾピラジン誘導体 |
| JP7824232B2 (ja) | 2020-06-01 | 2026-03-04 | エフ． ホフマン－ラ ロシュ アーゲー | 新規イミダゾピラジン誘導体 |
| JP2023529578A (ja) * | 2020-06-08 | 2023-07-11 | エフ． ホフマン－ラ ロシュ アーゲー | 新規イミダゾ－ピラジン誘導体 |
| JP7860905B2 (ja) | 2020-06-08 | 2026-05-18 | エフ． ホフマン－ラ ロシュ アーゲー | 新規イミダゾ－ピラジン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0815717A2 (pt) | 2015-02-10 |
| DK2193131T3 (da) | 2013-04-22 |
| ES2404415T3 (es) | 2013-05-27 |
| CY1113872T1 (el) | 2016-07-27 |
| KR20100081294A (ko) | 2010-07-14 |
| EP2193131B1 (en) | 2013-01-30 |
| HK1143810A1 (en) | 2011-01-14 |
| SI2193131T1 (sl) | 2013-06-28 |
| CA2707521A1 (en) | 2009-02-26 |
| EP2567960A3 (en) | 2013-06-05 |
| PL2193131T3 (pl) | 2013-07-31 |
| CN101835780A (zh) | 2010-09-15 |
| NZ584108A (en) | 2012-06-29 |
| MX2010001733A (es) | 2010-07-06 |
| WO2009024585A3 (en) | 2009-08-06 |
| AU2008290531A1 (en) | 2009-02-26 |
| WO2009024585A2 (en) | 2009-02-26 |
| US8362018B2 (en) | 2013-01-29 |
| EP2567960A2 (en) | 2013-03-13 |
| CN101835780B (zh) | 2013-09-18 |
| ZA201002009B (en) | 2010-12-29 |
| EP2193131A2 (en) | 2010-06-09 |
| PT2193131E (pt) | 2013-04-04 |
| GB0716292D0 (en) | 2007-09-26 |
| US20110166147A1 (en) | 2011-07-07 |
| HRP20130202T1 (hr) | 2013-04-30 |
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