PL2193131T3 - Związki imidazo[1,2-a]pirazyny w leczeniu infekcji wirusowych takich jak zapalenia wątroby - Google Patents

Związki imidazo[1,2-a]pirazyny w leczeniu infekcji wirusowych takich jak zapalenia wątroby

Info

Publication number
PL2193131T3
PL2193131T3 PL08787346T PL08787346T PL2193131T3 PL 2193131 T3 PL2193131 T3 PL 2193131T3 PL 08787346 T PL08787346 T PL 08787346T PL 08787346 T PL08787346 T PL 08787346T PL 2193131 T3 PL2193131 T3 PL 2193131T3
Authority
PL
Poland
Prior art keywords
imidazo
hepatitis
treatment
viral infections
pyrazine compounds
Prior art date
Application number
PL08787346T
Other languages
English (en)
Inventor
Angus Macleod
Dale Robert Mitchell
Nicholas John Palmer
Christophe Claude Parsy
Michael Daniel Goldsmith
Clifford John Harris
Original Assignee
Biofocus Dpi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofocus Dpi Ltd filed Critical Biofocus Dpi Ltd
Publication of PL2193131T3 publication Critical patent/PL2193131T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL08787346T 2007-08-21 2008-08-20 Związki imidazo[1,2-a]pirazyny w leczeniu infekcji wirusowych takich jak zapalenia wątroby PL2193131T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0716292.8A GB0716292D0 (en) 2007-08-21 2007-08-21 Imidazopyrazine compounds
PCT/EP2008/060896 WO2009024585A2 (en) 2007-08-21 2008-08-20 Imidazo [1,2-a] pyrazine compounds for treatment of viral infections such as hepatitis
EP08787346A EP2193131B1 (en) 2007-08-21 2008-08-20 Imidazo[1,2-a]pyrazine compounds for treatment of viral infections such as hepatitis

Publications (1)

Publication Number Publication Date
PL2193131T3 true PL2193131T3 (pl) 2013-07-31

Family

ID=38566736

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08787346T PL2193131T3 (pl) 2007-08-21 2008-08-20 Związki imidazo[1,2-a]pirazyny w leczeniu infekcji wirusowych takich jak zapalenia wątroby

Country Status (21)

Country Link
US (1) US8362018B2 (pl)
EP (2) EP2567960A3 (pl)
JP (1) JP2010536825A (pl)
KR (1) KR20100081294A (pl)
CN (1) CN101835780B (pl)
AU (1) AU2008290531A1 (pl)
BR (1) BRPI0815717A2 (pl)
CA (1) CA2707521A1 (pl)
CY (1) CY1113872T1 (pl)
DK (1) DK2193131T3 (pl)
ES (1) ES2404415T3 (pl)
GB (1) GB0716292D0 (pl)
HK (1) HK1143810A1 (pl)
HR (1) HRP20130202T1 (pl)
MX (1) MX2010001733A (pl)
NZ (1) NZ584108A (pl)
PL (1) PL2193131T3 (pl)
PT (1) PT2193131E (pl)
SI (1) SI2193131T1 (pl)
WO (1) WO2009024585A2 (pl)
ZA (1) ZA201002009B (pl)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0716292D0 (en) * 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
CA2722923C (en) 2008-04-29 2016-08-02 Boehringer Ingelheim International Gmbh Indazole compounds as ccr1 receptor antagonists
CA2722811C (en) 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
PE20110854A1 (es) 2008-09-26 2011-12-23 Boehringer Ingelheim Int DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
EA021015B1 (ru) 2009-10-21 2015-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Индазолы и пиразолопиридины в качестве антагонистов рецептора ccr1
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
WO2011051342A1 (en) 2009-10-30 2011-05-05 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
EP2509952A1 (en) * 2009-12-08 2012-10-17 Boehringer Ingelheim International GmbH Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
EP2547680B1 (en) * 2010-03-18 2015-08-05 Bayer Intellectual Property GmbH Imidazopyrazines
WO2011137109A1 (en) 2010-04-30 2011-11-03 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as ccr1 receptor antagonists
JP5824040B2 (ja) 2010-06-01 2015-11-25 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 置換イミダゾピラジン
CN103403006B (zh) * 2010-12-17 2015-11-25 拜耳知识产权有限责任公司 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的6-硫代-取代的咪唑并吡嗪
CN103370322B (zh) * 2010-12-17 2016-02-10 拜耳知识产权有限责任公司 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的2-取代的咪唑并吡嗪
US20140187548A1 (en) 2010-12-17 2014-07-03 Bayer Intellectual Property Gmbh 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
CA2821819A1 (en) * 2010-12-17 2012-06-21 Marcus Koppitz 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
JP2014503521A (ja) * 2010-12-17 2014-02-13 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過増殖性障害の処置におけるｍｐｓ−１およびｔｋｋ阻害剤としての使用のための、イミダゾピラジン類
CN103443100B (zh) * 2010-12-17 2016-03-23 拜耳知识产权有限责任公司 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的取代的6-咪唑并吡嗪
WO2012087782A1 (en) 2010-12-23 2012-06-28 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as ccr1 receptor antagonists
GB201109763D0 (en) * 2011-06-10 2011-07-27 Ucl Business Plc Compounds
BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
WO2013061962A1 (ja) * 2011-10-24 2013-05-02 武田薬品工業株式会社 二環性化合物
AU2013283426B2 (en) 2012-06-26 2018-02-22 Janssen Pharmaceutica Nv Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological or metabolic disorders
CN104411314B (zh) 2012-07-09 2017-10-20 詹森药业有限公司 磷酸二酯酶10的抑制剂
WO2016130501A1 (en) 2015-02-09 2016-08-18 Incyte Corporation Aza-heteroaryl compounds as pi3k-gamma inhibitors
KR20170141768A (ko) * 2015-04-29 2017-12-26 얀센 파마슈티카 엔.브이. 이미다조피라진 및 피라졸로피리미딘 및 ampa 수용체 조절제로서의 이의 용도
LT3288940T (lt) 2015-04-29 2021-05-10 Janssen Pharmaceutica Nv Azabenzimidazolai ir jų panaudojimas kaip ampa receptoriaus moduliatorių
CA2989722C (en) * 2015-06-24 2023-09-19 Jacob Westman Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy
JP6507976B2 (ja) * 2015-09-30 2019-05-08 東レ株式会社 イミダゾール−２−カルボン酸エステル誘導体又はその塩の製造方法
MA43169B1 (fr) 2015-11-06 2022-05-31 Incyte Corp Composés héterocycliques en tant qu' inhibiteurs pi3k-gamma
ES2833955T3 (es) 2016-01-05 2021-06-16 Incyte Corp Piridinas sustituidas con pirazol/imidazol como inhibidores de PI3K-Gamma
EA202091849A1 (ru) * 2016-03-31 2020-12-11 Ромарк Лабораториз Л.С. Тиазолидные соединения для лечения вирусных инфекций
TW201803871A (zh) * 2016-06-24 2018-02-01 英塞特公司 作為ＰＩ３Ｋ-γ抑制劑之雜環化合物
UY37381A (es) 2016-08-30 2018-03-23 Glaxosmithkline Ip No 2 Ltd Compuestos que inhiben proteasas 3c y 3cl y métodos de uso de los mismos
JOP20200086A1 (ar) 2017-10-18 2020-04-30 Incyte Corp مشتقات إيميدازول مكثفة بها استبدال بمجموعات هيدروكسي ثلاثية كمثبطات لـ pi3k-جاما
BR112020014431A2 (pt) 2018-01-17 2020-12-01 Glaxosmithkline Intellectual Property Development Limited inibidores de pl4kiiibeta
TWI811428B (zh) 2018-08-21 2023-08-11 日商杏林製藥股份有限公司 雙環雜芳香環衍生物
PE20211815A1 (es) 2018-09-05 2021-09-14 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3-quinasa (pi3k)
CN109369545B (zh) * 2018-12-14 2020-04-10 东营曜康医药科技有限公司 2-甲基-5-甲酸吡嗪的合成工艺
US20230014730A1 (en) 2019-09-23 2023-01-19 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Phosphodiesterase inhibitors and use
WO2021249893A1 (en) * 2020-06-08 2021-12-16 F. Hoffmann-La Roche Ag Novel imidazo-pyrazine derivatives
CN113929633A (zh) * 2021-10-27 2022-01-14 山东大学 一种法匹拉韦的合成方法及其应用
CN113831255B (zh) * 2021-11-25 2022-03-11 山东诚创蓝海医药科技有限公司 一种2-氨基丙二酰胺的制备方法
CN115489188B (zh) * 2022-10-09 2023-08-29 安徽国风新材料股份有限公司 一种家居保护用聚酯薄膜及其制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607813B1 (fr) * 1986-12-05 1989-03-31 Montpellier I Universite Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique
DE19915178A1 (de) 1999-04-03 2000-10-05 Univ Mainz Johannes Gutenberg Hepatitis C Virus Zellkultursystem
ATE525384T1 (de) 2000-05-23 2011-10-15 Univ Washington Varianten des hepatitisvirus
AU2002225895A1 (en) 2000-11-07 2002-05-21 Anadys Pharmaceuticals, Inc. Hepatitis c virus constructs characterized by high efficiency replication
ES2287074T3 (es) 2000-12-22 2007-12-16 Boehringer Ingelheim (Canada) Ltd. Molecula de rna autorreplicante del virus de la hepatitis c.
EP2050822B1 (en) 2001-01-23 2013-07-31 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hepatitis C virus replicons and replicon enhanced cells
EP1363702A4 (en) * 2001-01-30 2007-08-22 Cytopia Pty Ltd PROCESS FOR INHIBITING KINASES
AU2007200401A1 (en) * 2002-09-23 2007-02-22 Schering Corporation Imidazopyrazines as cyclin dependent kinase inhibitors
US7576085B2 (en) * 2002-09-23 2009-08-18 Schering Corporation Imidazopyrazines as cyclin dependent kinase inhibitors
KR20050057520A (ko) 2002-09-23 2005-06-16 쉐링 코포레이션 사이클린 의존성 키나제 억제제로서의 이미다조피라진
DE602004024658D1 (de) 2003-02-13 2010-01-28 Merck & Co Inc Verfahren zur vermittlung von zellkulturreplikationsaktivität an unterschiedliche hepatitis-c-virus-isolate
AR043002A1 (es) 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
US7186832B2 (en) 2003-02-20 2007-03-06 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
US7157460B2 (en) 2003-02-20 2007-01-02 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
WO2007056468A1 (en) 2005-11-10 2007-05-18 Schering Corporation Methods for inhibiting protein kinases
CA2628455A1 (en) * 2005-11-10 2007-05-24 Schering Corporation Imidazopyrazines as protein kinase inhibitors
JP5600004B2 (ja) * 2006-09-05 2014-10-01 エモリー ユニバーシティー 感染の予防または治療のためのチロシンキナーゼ阻害剤
WO2008030795A2 (en) * 2006-09-05 2008-03-13 Boards Of Regents, The University Of Texas System Compositions and methods for inhibition of tyrosine kinases
CA2669465A1 (en) 2006-11-08 2008-05-15 Schering Corporation Imidazopyrazines as protein kinase inhibitors
WO2008059373A1 (en) 2006-11-17 2008-05-22 Raqualia Pharma Inc. Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists
US8243049B2 (en) 2006-12-20 2012-08-14 3M Innovative Properties Company Untethered stylus employing low current power converter
GB0716292D0 (en) * 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds

Also Published As

Publication number Publication date
US20110166147A1 (en) 2011-07-07
GB0716292D0 (en) 2007-09-26
CN101835780B (zh) 2013-09-18
HK1143810A1 (en) 2011-01-14
NZ584108A (en) 2012-06-29
SI2193131T1 (sl) 2013-06-28
KR20100081294A (ko) 2010-07-14
MX2010001733A (es) 2010-07-06
CN101835780A (zh) 2010-09-15
WO2009024585A2 (en) 2009-02-26
EP2193131A2 (en) 2010-06-09
JP2010536825A (ja) 2010-12-02
CY1113872T1 (el) 2016-07-27
WO2009024585A3 (en) 2009-08-06
BRPI0815717A2 (pt) 2015-02-10
CA2707521A1 (en) 2009-02-26
US8362018B2 (en) 2013-01-29
DK2193131T3 (da) 2013-04-22
EP2567960A3 (en) 2013-06-05
ZA201002009B (en) 2010-12-29
ES2404415T3 (es) 2013-05-27
EP2567960A2 (en) 2013-03-13
PT2193131E (pt) 2013-04-04
HRP20130202T1 (hr) 2013-04-30
AU2008290531A1 (en) 2009-02-26
EP2193131B1 (en) 2013-01-30

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