WO2011150190A3 - Hcv inhibitor compounds and methods of use thereof - Google Patents

Hcv inhibitor compounds and methods of use thereof Download PDF

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Publication number
WO2011150190A3
WO2011150190A3 PCT/US2011/038110 US2011038110W WO2011150190A3 WO 2011150190 A3 WO2011150190 A3 WO 2011150190A3 US 2011038110 W US2011038110 W US 2011038110W WO 2011150190 A3 WO2011150190 A3 WO 2011150190A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
inhibitor compounds
hcv inhibitor
hcv
compounds
Prior art date
Application number
PCT/US2011/038110
Other languages
French (fr)
Other versions
WO2011150190A2 (en
Inventor
Maosheng Duan
Wieslaw Mieczyslaw Kazmierski
Jingjing Ji
Original Assignee
Anacor Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anacor Pharmaceuticals, Inc. filed Critical Anacor Pharmaceuticals, Inc.
Publication of WO2011150190A2 publication Critical patent/WO2011150190A2/en
Publication of WO2011150190A3 publication Critical patent/WO2011150190A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention features compounds of Formula (I), (II) and (III), pharmaceutical compositions and use in the treatment of viral disease:
PCT/US2011/038110 2010-05-26 2011-05-26 Hcv inhibitor compounds and methods of use thereof WO2011150190A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34849310P 2010-05-26 2010-05-26
US61/348,493 2010-05-26

Publications (2)

Publication Number Publication Date
WO2011150190A2 WO2011150190A2 (en) 2011-12-01
WO2011150190A3 true WO2011150190A3 (en) 2012-03-08

Family

ID=45004812

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/038110 WO2011150190A2 (en) 2010-05-26 2011-05-26 Hcv inhibitor compounds and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2011150190A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EA025560B1 (en) 2012-10-19 2017-01-30 Бристол-Майерс Сквибб Компани Hepatitis c virus inhibitors
WO2014071007A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
PE20151299A1 (en) 2013-01-30 2015-09-18 Dow Agrosciences Llc USE OF BENZOXABOROLS AS VOLATILE ANTIMICROBIAL AGENTS IN MEAT, PLANTS, OR PLANT PARTS
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
WO2014137869A1 (en) * 2013-03-07 2014-09-12 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
TW201735792A (en) 2016-03-07 2017-10-16 農業保鮮股份有限公司 Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608027B1 (en) * 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
US20070249637A1 (en) * 2004-10-21 2007-10-25 Collins Michael R Inhibitors Of Hepatitis C Virus Protease, And Compositions And Treatments Using The Same
US7438920B1 (en) * 1997-08-14 2008-10-21 Vertex Pharmaceuticals Incorporated Crystals of hepatitis C virus helicase or fragments thereof comprising a helicase binding pocket
WO2010088394A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Llc Compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7438920B1 (en) * 1997-08-14 2008-10-21 Vertex Pharmaceuticals Incorporated Crystals of hepatitis C virus helicase or fragments thereof comprising a helicase binding pocket
US6608027B1 (en) * 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
US20070249637A1 (en) * 2004-10-21 2007-10-25 Collins Michael R Inhibitors Of Hepatitis C Virus Protease, And Compositions And Treatments Using The Same
WO2010088394A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Llc Compounds

Also Published As

Publication number Publication date
WO2011150190A2 (en) 2011-12-01

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