MX170919B - Composicion farmaceutica util en la introduccion de formacion de huesos - Google Patents

Composicion farmaceutica util en la introduccion de formacion de huesos

Info

Publication number
MX170919B
MX170919B MX007140A MX714087A MX170919B MX 170919 B MX170919 B MX 170919B MX 007140 A MX007140 A MX 007140A MX 714087 A MX714087 A MX 714087A MX 170919 B MX170919 B MX 170919B
Authority
MX
Mexico
Prior art keywords
introduction
pharmaceutical composition
bone formation
composition useful
bone
Prior art date
Application number
MX007140A
Other languages
English (en)
Spanish (es)
Inventor
Elizabeth A Wang
John M Wozney
Vicki A Rosen
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/031,346 external-priority patent/US4877864A/en
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of MX170919B publication Critical patent/MX170919B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MX007140A 1986-07-01 1987-06-30 Composicion farmaceutica util en la introduccion de formacion de huesos MX170919B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88077686A 1986-07-01 1986-07-01
US94333286A 1986-12-17 1986-12-17
US2828587A 1987-03-20 1987-03-20
US07/031,346 US4877864A (en) 1987-03-26 1987-03-26 Osteoinductive factors

Publications (1)

Publication Number Publication Date
MX170919B true MX170919B (es) 1993-09-22

Family

ID=27487661

Family Applications (1)

Application Number Title Priority Date Filing Date
MX007140A MX170919B (es) 1986-07-01 1987-06-30 Composicion farmaceutica util en la introduccion de formacion de huesos

Country Status (18)

Country Link
EP (3) EP0688869B1 (enExample)
JP (3) JP2713715B2 (enExample)
AT (3) ATE419349T1 (enExample)
AU (1) AU613314B2 (enExample)
CA (1) CA1341212C (enExample)
DE (4) DE10399007I2 (enExample)
DK (2) DK172275B1 (enExample)
ES (1) ES2007625A6 (enExample)
GR (1) GR871028B (enExample)
IE (1) IE75881B1 (enExample)
IL (1) IL83003A (enExample)
LU (1) LU91005I2 (enExample)
MX (1) MX170919B (enExample)
MY (1) MY102505A (enExample)
NL (1) NL300116I2 (enExample)
NZ (1) NZ220894A (enExample)
PT (1) PT85225B (enExample)
WO (1) WO1988000205A1 (enExample)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US6020313A (en) * 1987-10-09 2000-02-01 University Of Kansas Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2
US5035901A (en) * 1987-10-09 1991-07-30 University Of Kansas Bone inducing agent from a human osteosarcoma cell line
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5344654A (en) * 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
ATE142644T1 (de) * 1988-04-08 1996-09-15 Stryker Corp Biosynthetische osteogene proteine und sie enthaltende osteogene vorrichtungen
EP0408649A4 (en) * 1988-04-08 1991-11-27 Genetics Institute, Inc. Bone and cartilage inductive compositions
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US4915301A (en) * 1988-11-15 1990-04-10 International Flavors & Fragrances, Inc. Container with sorbent member and microporous membrane for dispensing vapor from volatile liquid
DK0429570T3 (da) * 1989-03-28 1998-04-27 Genetics Inst Osteoinducerende præparater
JP3504259B2 (ja) 1989-03-28 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 骨誘導組成物
JPH03151877A (ja) * 1989-06-02 1991-06-28 Chiron Corp 骨カルシウム沈着因子
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
CA2064878A1 (en) * 1989-08-21 1991-02-22 Hanne Bentz Bone-specific protein
ATE140965T1 (de) * 1989-09-06 1996-08-15 Takeda Chemical Industries Ltd Protein, dna und ihre verwendung
EP0448704B1 (en) * 1989-10-17 1998-06-17 Stryker Corporation Osteogenic devices
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
ATE253589T1 (de) * 1990-09-26 2003-11-15 Inst Genetics Llc Bmp-5-derivate
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US6399569B1 (en) 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
CA2104678C (en) 1991-03-11 2002-05-14 Charles M. Cohen Protein-induced morphogenesis
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
AU662155B2 (en) 1991-05-10 1995-08-24 Celtrix Pharmaceuticals, Inc. Targeted delivery of bone growth factors
JP3351525B2 (ja) * 1991-06-21 2002-11-25 ジェネティックス・インスティテュート・インコーポレイテッド 骨形成性蛋白医薬処方物
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
AU674500B2 (en) 1991-11-04 1997-01-02 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
DK0625989T3 (da) * 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
IL106278A0 (en) * 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
DE69325913T2 (de) * 1992-09-15 2001-05-17 Creative Biomolecules, Inc. Durch morphogen induzierte periodontolgeweberegeneration
WO1994006399A1 (en) * 1992-09-15 1994-03-31 Creative Biomolecules, Inc. Morphogen-induced periodontal tissue regeneration
KR100227406B1 (ko) * 1993-05-12 1999-12-01 브루스 엠. 에이센 Bmp-11 조성물
US6333168B1 (en) * 1993-05-20 2001-12-25 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of dorsalin-1
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
DE69434651T2 (de) 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
PT831884E (pt) * 1995-06-05 2003-11-28 New York Society Uso de proteinas morfogeneticas do caso para cicatrizacao e reparacao da ligacao do tecido conjuntivo
AU6764396A (en) 1995-08-08 1997-03-05 Thomas Jefferson University Recombinant c-proteinase and processes, methods and uses thereof
US5807981A (en) * 1995-12-13 1998-09-15 Fibrogen Inc. Peptides which are cleaved by C-proteinase
EP0904093A4 (en) 1996-03-22 2004-11-17 Gen Hospital Corp THE ADMINISTRATION OF GROWTH FACTOR POLYPEPTIDES AFTER AN ISCHEMICAL OF THE CENTRAL NERVOUS SYSTEM OR A TRAUMA
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
BR9713130A (pt) * 1996-11-22 2000-02-08 Akzo Nobel Nv Região promotora de bmp-4 e seus fragmentos, vetor compreendendo uma região promotora de bmp-4 ou seus fragmentos, célula hospedeira, processo para a identificação de agentes terapêuticos para a prevenção e/ou tratamento da osteoporose, e, uso de ici 164384.
US6281195B1 (en) * 1997-02-07 2001-08-28 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
DK0980252T3 (da) 1997-05-05 2005-01-31 Curis Inc Terapier til akut nyresvigt
WO1998054572A1 (en) 1997-05-30 1998-12-03 Creative Biomolecules, Inc. Methods for evaluating tissue morphogenesis and activity
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
DK1064382T3 (da) 1998-03-17 2008-12-08 Genentech Inc Homologe polypeptider til VEGF og BMP1
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
EP1094829B8 (en) 1998-07-13 2004-09-22 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US6916783B2 (en) 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
EP1117422B1 (en) 1998-10-06 2005-09-28 Stryker Corporation Use of op-1 for the preparation of a pharmaceutical composition for repairing a defect locus in a non articular cartilage tissue of a mammal
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
JP3786533B2 (ja) 1998-11-12 2006-06-14 善彦 西村 ペプチド及び骨形成促進剤
EP1148897B1 (en) * 1999-02-01 2003-12-10 Genetics Institute, LLC Methods and compositions for healing and repair of articular cartilage
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
WO2001016323A2 (en) * 1999-09-01 2001-03-08 Subsidiary N0.3, Inc. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
EP1238072A2 (en) * 1999-09-01 2002-09-11 Subsidiary N0. 3, INC. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
AU6865100A (en) * 1999-09-02 2001-04-10 Mitsubishi Pharma Corporation Osteogenesis promoting agents
ATE271886T1 (de) 1999-10-15 2004-08-15 Inst Genetics Llc Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
EP1354890B1 (en) 2000-12-28 2007-08-08 Shionogi & Co., Ltd. Chordin-like polypeptides and dna thereof
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
CA2449008A1 (en) 2001-06-01 2002-12-12 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7160725B2 (en) 2001-11-13 2007-01-09 Curis, Inc. Hedgehog signaling promotes the formation of three dimensional cartilage matrices
ES2247423T5 (es) 2001-11-19 2015-12-30 Scil Technology Gmbh Método de producción de un dispositivo recubierto homogéneamente que tiene propiedades osteoinductoras y osteoconductoras
US7160994B2 (en) 2002-03-28 2007-01-09 Trustees Of The University Of Pennsylvania Osteoclast-specific genes and proteins and uses thereof
US8067557B2 (en) 2002-03-28 2011-11-29 The Trustees Of The University Of Pennsylvania OCL-2A3 compositions and uses thereof
PT1539261E (pt) 2002-09-10 2006-08-31 Scil Technology Gmbh Implante metalico revestido sob concentracao reduzida de oxigenio com proteina osteoindutiva
BRPI0413720A (pt) 2003-09-12 2006-10-17 Wyeth Corp bastões e pastas sólidas de fosfato de cálcio injetável para liberação de proteìnas osteogênicas
WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
EP1571159A1 (en) * 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
ATE478008T1 (de) 2004-03-10 2010-09-15 Scil Technology Gmbh Überzogene implantate, ihre herstellung und verwendung davon
EP2298335B1 (en) 2004-05-25 2014-09-03 Stryker Corporation Use of OP-1 for treating cartilage defects
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
AU2006308534B2 (en) 2005-11-01 2013-02-07 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
EP2035030A2 (en) 2006-05-17 2009-03-18 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
EP2078040B1 (en) 2006-11-02 2017-06-28 Daniel J. Capon Methods of producing hybrid polypeptides with moving parts
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
EP2120859B1 (en) 2006-12-21 2013-11-20 Stryker Corporation Sustained-release formulations comprising bmp-7 crystals
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
WO2008157495A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Bone matrix compositions and methods
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
US8058237B2 (en) 2007-08-07 2011-11-15 Advanced Technologies & Regenerative Medicine, LLC Stable composition of GDF-5 and method of storage
CA2718592A1 (en) 2008-02-13 2009-08-20 Keith Hruska Method of treating vascular sclerosis
WO2009129101A1 (en) 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered gdf-5 formulations
US20100204123A1 (en) 2009-02-12 2010-08-12 Mary Elizabeth Pecquet Goad Peripheral Administration of Proteins Including TGF-beta Superfamily Members for Treatment of Systemic Disorders and Disease
EP2396026A2 (en) 2009-02-12 2011-12-21 Stryker Corporation Compositions and methods for minimally-invasive systemic delivery of proteins including tgf- superfamily members
WO2010093959A2 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
CN102369212B (zh) * 2009-03-12 2015-12-16 哈瑟投资公司 具有降低的bmp拮抗剂敏感性的骨形成蛋白2(bmp2)变体
US20120148539A1 (en) 2009-03-24 2012-06-14 Moulay Hicham Alaoui-Ismaili Methods and Compositions for Tissue Engineering
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
US20120107413A1 (en) * 2009-07-23 2012-05-03 Singapore Health Services Pte Ltd Pre-natal mesenchymal stem cells
US20110224138A1 (en) 2009-09-09 2011-09-15 Julie Krop Methods for treating pain induced by injuries and diseases of an articular joint
US20110224410A1 (en) 2009-09-17 2011-09-15 Hile David Buffers for Controlling the pH of Bone Morphogenetic Proteins
CN102822197A (zh) 2009-12-22 2012-12-12 史赛克公司 具有降低的免疫原性的bmp-7变体
JP2020504748A (ja) 2016-12-30 2020-02-13 バイオジェンド セラピューティクス カンパニー リミテッド 組換えポリペプチド、それらの組成物及び方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4588684A (en) 1983-04-26 1986-05-13 Chiron Corporation a-Factor and its processing signals
CA1229789A (en) * 1983-06-06 1987-12-01 David Baylink Polypeptides exhibiting skeletal growth factor activity
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
NZ210699A (en) * 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
DK518384A (da) 1984-01-31 1985-07-01 Idaho Res Found Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
IE60819B1 (en) 1984-07-06 1994-08-10 Sandoz Ltd Lymphokine production and purification
DE3588058T3 (de) 1984-07-16 2005-04-07 Celtrix Pharmaceuticals, Inc., Palo Alto Knorpel-induzierende Polypeptid-Faktoren aus Knochen
ATE78515T1 (de) 1984-10-05 1992-08-15 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors

Also Published As

Publication number Publication date
EP1254956B1 (en) 2008-12-31
IL83003A (en) 1995-07-31
PT85225A (en) 1987-08-01
EP1254956A3 (en) 2002-11-13
EP0313578A4 (en) 1990-10-03
DK172275B1 (da) 1998-02-16
IE75881B1 (en) 1997-09-24
NZ220894A (en) 1990-05-28
ATE234921T1 (de) 2003-04-15
IE970378L (en) 1988-01-01
DE10399007I2 (de) 2006-03-16
DK172503B1 (da) 1998-10-26
EP0313578B1 (en) 1996-08-28
DK53497A (da) 1997-05-09
ATE419349T1 (de) 2009-01-15
WO1988000205A1 (en) 1988-01-14
MY102505A (en) 1992-07-31
GR871028B (enExample) 1988-01-11
JP3093682B2 (ja) 2000-10-03
AU613314B2 (en) 1991-08-01
DK106288D0 (da) 1988-02-29
JPH1070989A (ja) 1998-03-17
DE3752393D1 (de) 2009-02-12
EP0688869B1 (en) 2003-03-19
JP2713715B2 (ja) 1998-02-16
JPH02500241A (ja) 1990-02-01
JPH06298800A (ja) 1994-10-25
DE3751887D1 (de) 1996-10-02
DK106288A (da) 1988-04-28
DE3752364T2 (de) 2004-03-04
ES2007625A6 (es) 1989-07-01
PT85225B (pt) 1990-03-30
IE871739L (en) 1988-01-01
DE3752364D1 (de) 2003-04-24
JP2729222B2 (ja) 1998-03-18
NL300116I2 (nl) 2003-06-02
NL300116I1 (nl) 2003-05-01
EP0688869A1 (en) 1995-12-27
AU7783587A (en) 1988-01-29
EP1254956A2 (en) 2002-11-06
DE10399007I1 (de) 2003-07-31
EP0313578A1 (en) 1989-05-03
ATE141928T1 (de) 1996-09-15
DE3751887T2 (de) 1997-03-06
CA1341212C (en) 2001-04-10
LU91005I2 (en) 2003-03-31
IL83003A0 (en) 1987-12-20

Similar Documents

Publication Publication Date Title
MX170919B (es) Composicion farmaceutica util en la introduccion de formacion de huesos
EP0484401A4 (en) Production of vascular endothelial cell growth factor
ATE358176T1 (de) Menschliche dnase
DE3586159D1 (de) Zusammensetzung und verfahren zur differenzierung von weissen blutzellen.
IL96549A0 (en) Production of a biologically active protein
ATE126433T1 (de) Verwendung von gamma-hydroxy-buttersäuresalzen zur herstellung von pharmazeutischen zusammensetzungen zur verwendung bei der behandlung von alkoholismus und die hergestellten zusammensetzungen.
SE8501050D0 (sv) Biologically active fragments of human antihemophilic factor and method for preparation thereof
ATE78399T1 (de) Verwendung von buspiron zur verbesserung des kurzzeitgedaechtnisses.
IT1224000B (it) Composizione e procedimento per il trattamento e la cura dei capelli
DE68916197D1 (de) Zusammensetzung zur in-vivo bzw. in-vitro steigerung des melaningehaltes der melanocyten und deren in-vitro verwendung.
IT8767494A0 (it) Composizione liquida per il trattamento preventivo e curativo di malattie crittogamiche di tipo oidio e procedimento per la messa in opera di tale composizione
DE3852733D1 (de) Verfahren zur Herstellung von Copolymeren in Perlform und deren Verwendung.
ATE95234T1 (de) Verfahren zur herstellung von proteinen mit fviii aktivitaet und/oder fviii derivate.
NO900616L (no) Fremgangsmaate for fraksjonering av avlinger i industrieltraamateriale.
FI883157A7 (fi) Menetelmä polyklorofosfatseenien ja niistä johdettujen polyorgaanofosfatseenien molekyylimassan säätämiseksi ja tässä menetelmässä käytetyt säätöaineet