ES2007625A6 - Un procedimiento para la produccion de una proteina para huesos y cartilagos. - Google Patents
Un procedimiento para la produccion de una proteina para huesos y cartilagos.Info
- Publication number
- ES2007625A6 ES2007625A6 ES8701909A ES8701909A ES2007625A6 ES 2007625 A6 ES2007625 A6 ES 2007625A6 ES 8701909 A ES8701909 A ES 8701909A ES 8701909 A ES8701909 A ES 8701909A ES 2007625 A6 ES2007625 A6 ES 2007625A6
- Authority
- ES
- Spain
- Prior art keywords
- osteoinductive compositions
- novel osteoinductive
- novel
- compositions
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title 1
- 230000002138 osteoinductive effect Effects 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003239 periodontal effect Effects 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88077686A | 1986-07-01 | 1986-07-01 | |
| US94333286A | 1986-12-17 | 1986-12-17 | |
| US2828587A | 1987-03-20 | 1987-03-20 | |
| US07/031,346 US4877864A (en) | 1987-03-26 | 1987-03-26 | Osteoinductive factors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2007625A6 true ES2007625A6 (es) | 1989-07-01 |
Family
ID=27487661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8701909A Expired ES2007625A6 (es) | 1986-07-01 | 1987-06-30 | Un procedimiento para la produccion de una proteina para huesos y cartilagos. |
Country Status (18)
| Country | Link |
|---|---|
| EP (3) | EP1254956B1 (enExample) |
| JP (3) | JP2713715B2 (enExample) |
| AT (3) | ATE419349T1 (enExample) |
| AU (1) | AU613314B2 (enExample) |
| CA (1) | CA1341212C (enExample) |
| DE (4) | DE3751887T2 (enExample) |
| DK (2) | DK172275B1 (enExample) |
| ES (1) | ES2007625A6 (enExample) |
| GR (1) | GR871028B (enExample) |
| IE (1) | IE75881B1 (enExample) |
| IL (1) | IL83003A (enExample) |
| LU (1) | LU91005I2 (enExample) |
| MX (1) | MX170919B (enExample) |
| MY (1) | MY102505A (enExample) |
| NL (1) | NL300116I2 (enExample) |
| NZ (1) | NZ220894A (enExample) |
| PT (1) | PT85225B (enExample) |
| WO (1) | WO1988000205A1 (enExample) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106748A (en) * | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| IL83003A (en) * | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US6020313A (en) * | 1987-10-09 | 2000-02-01 | University Of Kansas | Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2 |
| US5035901A (en) * | 1987-10-09 | 1991-07-30 | University Of Kansas | Bone inducing agent from a human osteosarcoma cell line |
| US5344654A (en) * | 1988-04-08 | 1994-09-06 | Stryker Corporation | Prosthetic devices having enhanced osteogenic properties |
| EP1225225A3 (en) * | 1988-04-08 | 2003-01-08 | Stryker Corporation | Osteogenic devices |
| US4975526A (en) * | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
| US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
| US5354557A (en) * | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
| US6919308B2 (en) | 1988-04-08 | 2005-07-19 | Stryker Corporation | Osteogenic devices |
| US5670336A (en) * | 1988-04-08 | 1997-09-23 | Stryker Corporation | Method for recombinant production of osteogenic protein |
| US5250302A (en) * | 1988-04-08 | 1993-10-05 | Stryker Corporation | Osteogenic devices |
| US5258494A (en) * | 1988-04-08 | 1993-11-02 | Stryker Corporation | Osteogenic proteins |
| US5162114A (en) * | 1989-02-23 | 1992-11-10 | Stryker Corporation | Bone collagen matrix for xenogenic implants |
| US5266683A (en) * | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5324819A (en) * | 1988-04-08 | 1994-06-28 | Stryker Corporation | Osteogenic proteins |
| US5108753A (en) * | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
| US4968590A (en) * | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
| KR900700617A (ko) * | 1988-04-08 | 1990-08-16 | 브루스 엠. 에이센 | 뼈 및 연골 유도 조성물 |
| US5106626A (en) * | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
| US5284756A (en) * | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
| US4915301A (en) * | 1988-11-15 | 1990-04-10 | International Flavors & Fragrances, Inc. | Container with sorbent member and microporous membrane for dispensing vapor from volatile liquid |
| JP3504259B2 (ja) | 1989-03-28 | 2004-03-08 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | 骨誘導組成物 |
| EP0429570B1 (en) * | 1989-03-28 | 1998-01-14 | Genetics Institute, Inc. | Osteoinductive compositions |
| JPH03151877A (ja) * | 1989-06-02 | 1991-06-28 | Chiron Corp | 骨カルシウム沈着因子 |
| CA2020729A1 (en) * | 1989-07-19 | 1991-01-20 | Michael C. Kiefer | Bone morphogenetic protein |
| AU632160B2 (en) * | 1989-08-21 | 1992-12-17 | Celtrix Pharmaceuticals, Inc. | Bone-specific protein |
| CA2024629C (en) * | 1989-09-06 | 2001-07-24 | Taiheiyo Cement Corporation | Xenopus laevis bone morphogenic protein, dna encoding same and use thereof |
| DK0448704T3 (da) * | 1989-10-17 | 1999-04-06 | Stryker Corp | Osteogene anordninger |
| US5168050A (en) * | 1990-05-24 | 1992-12-01 | Genentech, Inc. | Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion |
| US5645591A (en) | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
| US5364839A (en) * | 1990-06-18 | 1994-11-15 | Genetics Institute, Inc. | Osteoinductive pharmaceutical formulations |
| WO1992005199A1 (en) * | 1990-09-26 | 1992-04-02 | Genetics Institute, Inc. | Bmp-5 derivatives |
| US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
| US5652337A (en) * | 1991-03-11 | 1997-07-29 | Creative Biomolecules, Inc. | OP-3-induced morphogenesis |
| US5739107A (en) * | 1991-03-11 | 1998-04-14 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
| CA2104678C (en) | 1991-03-11 | 2002-05-14 | Charles M. Cohen | Protein-induced morphogenesis |
| US6495513B1 (en) | 1991-03-11 | 2002-12-17 | Curis, Inc. | Morphogen-enhanced survival and repair of neural cells |
| US5656593A (en) * | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
| US5674844A (en) * | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US6090776A (en) * | 1991-03-11 | 2000-07-18 | Creative Bio Molecules, Inc. | Morphogen treatment of organ implants |
| US5849686A (en) * | 1991-03-11 | 1998-12-15 | Creative Biomolecules, Inc. | Morphogen-induced liver regeneration |
| US6800603B2 (en) | 1991-03-11 | 2004-10-05 | Curis, Inc. | Morphogen-induced neural cell adhesion |
| US5652118A (en) * | 1991-03-11 | 1997-07-29 | Creative Biomolecules, Inc. | Nucleic acid encoding a novel morphogenic protein, OP-3 |
| US5972884A (en) * | 1991-03-11 | 1999-10-26 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
| US7056882B2 (en) | 1991-03-11 | 2006-06-06 | Curis, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| US5318898A (en) * | 1991-04-02 | 1994-06-07 | Genetics Institute, Inc. | Production of recombinant bone-inducing proteins |
| US5118667A (en) * | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
| CA2102808A1 (en) | 1991-05-10 | 1992-11-11 | Hanne Bentz | Targeted delivery of bone growth factors |
| EP0591392B1 (en) * | 1991-06-21 | 1996-09-11 | Genetics Institute, Inc. | Pharmaceutical formulations of osteogenic proteins |
| US6022853A (en) * | 1991-08-30 | 2000-02-08 | Creative Biomolecules, Inc. | Morphogen-enriched dietary composition |
| US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
| WO1993009229A1 (en) | 1991-11-04 | 1993-05-13 | Genetics Institute, Inc. | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| UA48105C2 (uk) * | 1992-02-12 | 2002-08-15 | Біофарм Гезельшафт Цур Біотехнологішен Ентвіклунг Вон Фармака Мбх | ФРАГМЕНТ ДНК, ЯКИЙ КОДУЄ БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), РЕКОМБІНАНТНА МОЛЕКУЛА ДНК (ВАРІАНТИ), КЛІТИНА-ХАЗЯЇН (ВАРІАНТИ), СПОСІБ ОДЕРЖАННЯ БІЛКУ РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ (ВАРІАНТИ), АНТИТІЛО АБО ФРАГМЕНТ АНТИТІЛА (ВАРІАНТИ), МОЛЕКУЛА КДНК (ВАРІАНТИ) |
| IL106278A0 (en) * | 1992-07-13 | 1993-11-15 | Sumitomo Metal Ind | Bone formation-inducing protein |
| AU670334B2 (en) * | 1992-09-15 | 1996-07-11 | Creative Biomolecules, Inc. | Morphogen-induced periodontal tissue regeneration |
| WO1994006399A1 (en) * | 1992-09-15 | 1994-03-31 | Creative Biomolecules, Inc. | Morphogen-induced periodontal tissue regeneration |
| PT698094E (pt) * | 1993-05-12 | 2004-05-31 | Inst Genetics Llc | Composicoes de bmp-11 |
| US6333168B1 (en) | 1993-05-20 | 2001-12-25 | The Trustees Of Columbia University In The City Of New York | Cloning, expression and uses of dorsalin-1 |
| US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| ES2255059T3 (es) | 1993-12-07 | 2006-06-16 | Genetics Institute, Llc | Bmp-12, bmp-13 y composiciones suyas inductoras de tendon. |
| US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
| EP1364656B1 (en) * | 1995-06-05 | 2013-11-20 | Genetics Institute, LLC | Use of bone morphogenetic proteins for healing and repair of connective tissue attachment |
| KR19990036272A (ko) | 1995-08-08 | 1999-05-25 | 사우코넨 주시 제이 | 재조합 c-프로테나제와 이의 공정, 제조방법 및 이의 용도 |
| US5807981A (en) * | 1995-12-13 | 1998-09-15 | Fibrogen Inc. | Peptides which are cleaved by C-proteinase |
| KR20000064752A (ko) | 1996-03-22 | 2000-11-06 | 더 제네랄 호스피탈 코포레이션 | 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법 |
| US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| JP2001509010A (ja) * | 1996-11-22 | 2001-07-10 | アクゾ・ノベル・エヌ・ベー | Bmp―4プロモーターならびに骨粗鬆症の予防および/または治療用の治療剤のスクリーニングにおけるその用途 |
| AU6267798A (en) | 1997-02-07 | 1998-08-26 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods of use thereof |
| US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
| US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
| ES2226125T3 (es) | 1997-05-05 | 2005-03-16 | Curis, Inc. | Terapias para insuficiencia renal aguda. |
| AU742663B2 (en) | 1997-05-30 | 2002-01-10 | Stryker Corporation | Methods for evaluating tissue morphogenesis and activity |
| US6391311B1 (en) | 1998-03-17 | 2002-05-21 | Genentech, Inc. | Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1 |
| DK2016951T3 (da) | 1998-03-17 | 2012-09-24 | Genentech Inc | VEGF- og BMP1-homologe polypeptider |
| US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
| WO2000002905A2 (en) | 1998-07-13 | 2000-01-20 | University Of Southern California | Methods for accelerating bone and cartilage growth and repair |
| US6916783B2 (en) | 1998-07-13 | 2005-07-12 | University Of Southern California | Methods for accelerating bone and cartilage growth and repair |
| US7572440B2 (en) | 1999-07-30 | 2009-08-11 | Stryker Corporation | Method for repairing a defect in an intervertebral disc |
| US6958149B2 (en) | 1998-10-06 | 2005-10-25 | Stryker Corporation | Repair of larynx, trachea, and other fibrocartilaginous tissues |
| ES2478257T3 (es) | 1998-10-06 | 2014-07-21 | Stryker Corporation | Composición que comprende una proteína osteogénica seleccionada del grupo que consiste en OP-2, OP-3, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11 , BMP-15, BMP-3B, DPP, Vg-1, Vgr-1, proteína 60A, GDF-1, GDF-2, GDF-3, GDF-6, GDF-7, GDF-8, GDF-9, GDF-10, y GDF-11 para su uso en la reparación de defectos del cartílago no articular |
| JP3786533B2 (ja) | 1998-11-12 | 2006-06-14 | 善彦 西村 | ペプチド及び骨形成促進剤 |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| BR0007892A (pt) * | 1999-02-01 | 2001-10-30 | Genetics Inst | Processos e composições para cicatrização ereparo de cartilagem articular |
| DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
| WO2001016323A2 (en) * | 1999-09-01 | 2001-03-08 | Subsidiary N0.3, Inc. | Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes |
| CA2382030A1 (en) * | 1999-09-01 | 2001-03-08 | Subsidiary No. 3, Inc. | Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes |
| WO2001017562A1 (fr) * | 1999-09-02 | 2001-03-15 | Yamanouchi Pharmaceutical Co., Ltd. | Agents promoteurs de l'osteogenese |
| JP4703926B2 (ja) | 1999-10-15 | 2011-06-15 | ジェネティクス インスティテュート,エルエルシー | 骨形成蛋白をデリバリーするためのヒアルロン酸の処方 |
| DE60129848T2 (de) | 2000-12-28 | 2008-04-24 | Shionogi & Co., Ltd. | Chordin-ähnliche polypeptide und deren dns |
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| ES2305246T3 (es) | 2001-06-01 | 2008-11-01 | Wyeth | Composiciones para la administracion sistemica de secuencias que codifican proteinas oseas morfogeneticas. |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| US7160725B2 (en) | 2001-11-13 | 2007-01-09 | Curis, Inc. | Hedgehog signaling promotes the formation of three dimensional cartilage matrices |
| PT1448246E (pt) | 2001-11-19 | 2005-11-30 | Scil Technology Gmbh | Aparelho com revestimento homogeneo com propriedades osteoindutoras e osteocondutoras |
| US7160994B2 (en) | 2002-03-28 | 2007-01-09 | Trustees Of The University Of Pennsylvania | Osteoclast-specific genes and proteins and uses thereof |
| US8067557B2 (en) | 2002-03-28 | 2011-11-29 | The Trustees Of The University Of Pennsylvania | OCL-2A3 compositions and uses thereof |
| US7763270B2 (en) | 2002-09-10 | 2010-07-27 | Scil Technology Gmbh | Metal implant coated under reduced oxygen concentration with osteoinductive protein |
| BRPI0413720A (pt) | 2003-09-12 | 2006-10-17 | Wyeth Corp | bastões e pastas sólidas de fosfato de cálcio injetável para liberação de proteìnas osteogênicas |
| WO2005065396A2 (en) | 2003-12-31 | 2005-07-21 | Osteotech, Inc. | Improved bone matrix compositions and methods |
| EP1571159A1 (en) * | 2004-03-04 | 2005-09-07 | Bayerische Julius-Maximilians-Universität Würzburg | Mutein of a bone morphogenetic protein and use thereof |
| CA2558395C (en) | 2004-03-10 | 2011-11-29 | Scil Technology Gmbh | Coated implants, their manufacturing and use thereof |
| WO2005115438A1 (en) | 2004-05-25 | 2005-12-08 | Stryker Corporation | Use of morphogenic proteins for treating cartilage defects |
| US8506646B2 (en) | 2005-04-29 | 2013-08-13 | Warsaw Orthopedic, Inc. | Multi-purpose medical implant devices |
| AU2006308534B2 (en) | 2005-11-01 | 2013-02-07 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
| US20090298761A1 (en) | 2006-05-17 | 2009-12-03 | Donald Engelman | Methods of treating cartilage defects using a soluble morphogenic protein complex |
| NZ576445A (en) | 2006-11-02 | 2012-03-30 | Daniel J Capon | Hybrid immunoglobulins with moving parts |
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| CA2671925A1 (en) | 2006-12-21 | 2008-07-10 | Stryker Corporation | Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents |
| WO2008157492A2 (en) | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Osteoinductive demineralized cancellous bone |
| US9554920B2 (en) | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
| EP3207948B1 (en) | 2007-06-15 | 2020-02-26 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| WO2009009688A1 (en) | 2007-07-10 | 2009-01-15 | Osteotech, Inc. | Delivery system |
| CN101801405A (zh) | 2007-08-07 | 2010-08-11 | 先进科技及再生医学有限责任公司 | 包含于酸性水溶液中的gdf-5的蛋白质配方 |
| AU2009214629A1 (en) | 2008-02-13 | 2009-08-20 | Eric T. Choi | BMP-7 for use in treating vascular sclerosis |
| AU2009236459B2 (en) | 2008-04-14 | 2013-07-25 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered GDF-5 formulations |
| CN102369016A (zh) | 2009-02-12 | 2012-03-07 | 史赛克公司 | 用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用 |
| SG173634A1 (en) | 2009-02-12 | 2011-09-29 | Stryker Corp | COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-ß SUPERFAMILY MEMBERS |
| WO2010093950A1 (en) | 2009-02-12 | 2010-08-19 | Osteotech, Inc. | Delivery system cartridge |
| EP2406281B1 (en) * | 2009-03-12 | 2016-02-17 | Haase Investments UG | Bone morphogenetic protein 2 (bmp2) variants with reduced bmp antagonist sensitivity |
| US20120148539A1 (en) | 2009-03-24 | 2012-06-14 | Moulay Hicham Alaoui-Ismaili | Methods and Compositions for Tissue Engineering |
| US20110002897A1 (en) | 2009-06-11 | 2011-01-06 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| WO2011010966A1 (en) * | 2009-07-23 | 2011-01-27 | Agency For Science, Technology And Research (A*Star) | Pre-natal mesenchymal stem cells |
| US20110224138A1 (en) | 2009-09-09 | 2011-09-15 | Julie Krop | Methods for treating pain induced by injuries and diseases of an articular joint |
| EP2352750B1 (en) | 2009-09-17 | 2012-06-13 | Stryker Corporation | Buffers for controlling the ph of bone morphogenetic proteins |
| WO2011087768A1 (en) | 2009-12-22 | 2011-07-21 | Stryker Corporation | Bmp-7 variants with reduced immunogenicity |
| NZ754942A (en) | 2016-12-30 | 2023-02-24 | Biogend Therapeutics Co Ltd | Recombinant polypeptides, compositions, and methods thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4455256A (en) * | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
| US4619989A (en) * | 1981-05-05 | 1986-10-28 | The Regents Of The University Of Cal. | Bone morphogenetic protein composition |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| US4434094A (en) * | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
| US4588684A (en) | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
| EP0128041A3 (en) * | 1983-06-06 | 1986-12-03 | David Jeston Baylink | Polypeptides exhibiting skeletal growth factor activity |
| US4795804A (en) * | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
| NZ210699A (en) * | 1984-01-04 | 1989-06-28 | Int Genetic Eng | Isolation of an osteogenic protein of the p3 immunologically related family |
| ZA848495B (en) | 1984-01-31 | 1985-09-25 | Idaho Res Found | Production of polypeptides in insect cells |
| US4608199A (en) * | 1984-03-20 | 1986-08-26 | Arnold Caplan | Bone protein purification process |
| JP2540509B2 (ja) | 1984-07-06 | 1996-10-02 | サンド・アクチエンゲゼルシヤフト | リンホカインの生産および精製 |
| EP0169016B2 (en) | 1984-07-16 | 2004-04-28 | Celtrix Pharmaceuticals, Inc. | Polypeptide cartilage-inducing factors found in bone |
| EP0177343B1 (en) | 1984-10-05 | 1992-07-22 | Genentech, Inc. | Dna, cell cultures and methods for the secretion of heterologous proteins and periplasmic protein recovery |
| US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
| IL83003A (en) * | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
-
1987
- 1987-06-26 IL IL8300387A patent/IL83003A/en not_active IP Right Cessation
- 1987-06-29 IE IE173987A patent/IE75881B1/en not_active IP Right Cessation
- 1987-06-30 EP EP02014841A patent/EP1254956B1/en not_active Expired - Lifetime
- 1987-06-30 CA CA000540928A patent/CA1341212C/en not_active Expired - Fee Related
- 1987-06-30 WO PCT/US1987/001537 patent/WO1988000205A1/en not_active Ceased
- 1987-06-30 ES ES8701909A patent/ES2007625A6/es not_active Expired
- 1987-06-30 GR GR871028A patent/GR871028B/el unknown
- 1987-06-30 AT AT02014841T patent/ATE419349T1/de not_active IP Right Cessation
- 1987-06-30 DE DE3751887T patent/DE3751887T2/de not_active Expired - Lifetime
- 1987-06-30 MX MX007140A patent/MX170919B/es unknown
- 1987-06-30 DE DE3752364T patent/DE3752364T2/de not_active Expired - Lifetime
- 1987-06-30 AT AT95111771T patent/ATE234921T1/de not_active IP Right Cessation
- 1987-06-30 JP JP62504617A patent/JP2713715B2/ja not_active Expired - Lifetime
- 1987-06-30 NZ NZ220894A patent/NZ220894A/xx unknown
- 1987-06-30 EP EP87905023A patent/EP0313578B1/en not_active Expired - Lifetime
- 1987-06-30 DE DE3752393T patent/DE3752393D1/de not_active Expired - Lifetime
- 1987-06-30 MY MYPI87000921A patent/MY102505A/en unknown
- 1987-06-30 DE DE2003199007 patent/DE10399007I2/de active Active
- 1987-06-30 AU AU77835/87A patent/AU613314B2/en not_active Expired
- 1987-06-30 EP EP95111771A patent/EP0688869B1/en not_active Expired - Lifetime
- 1987-06-30 AT AT87905023T patent/ATE141928T1/de active
- 1987-07-01 PT PT85225A patent/PT85225B/pt unknown
-
1988
- 1988-02-29 DK DK106288A patent/DK172275B1/da not_active IP Right Cessation
-
1993
- 1993-06-01 JP JP5130389A patent/JP2729222B2/ja not_active Expired - Lifetime
-
1997
- 1997-05-09 DK DK199700534A patent/DK172503B1/da not_active IP Right Cessation
- 1997-06-27 JP JP09171615A patent/JP3093682B2/ja not_active Expired - Lifetime
-
2003
- 2003-01-29 LU LU91005C patent/LU91005I2/fr unknown
- 2003-02-24 NL NL300116C patent/NL300116I2/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2007625A6 (es) | Un procedimiento para la produccion de una proteina para huesos y cartilagos. | |
| EP0484401A4 (en) | Production of vascular endothelial cell growth factor | |
| DE3265898D1 (en) | Process for the industrial preparation of collagenous materials from human placental tissues; human collagenous materials obtained and their use in biomaterials | |
| AU4607885A (en) | An implant article for treatment in reconstructive surgery ofdamage caused to bony material | |
| ES8602768A1 (es) | Un procedimiento para la preparacion de nuevas n-(heterociclil biciclo)-4-piperidinaminas. | |
| PL320484A1 (en) | Method of treating diabetes using kgf | |
| GB2211192B (en) | Composition and process for the treatment and care of the hair | |
| EP0249094A3 (en) | Method and plant for the treatment of laminated glass | |
| ZA879403B (en) | Primary biliary cirrhosis autoantigen | |
| NZ224348A (en) | Tanning composition with al and ti | |
| HUT44073A (en) | Process for producing purified human angiogene factor and pharmaceutical compositions containing them | |
| EP0154296A3 (en) | Hair growth stimulating agents and their use | |
| NZ333652A (en) | Inhibition of human rotavirus infection using kappa-casein | |
| HUT50279A (en) | Skin treating cosmetic comprising apple pectine and process for preparation thereof | |
| ZA875413B (en) | Novel compositions rich in oligoelements and processes for their manufacture | |
| HU904603D0 (en) | Process and composition for the decreasig of lead content in living organisms |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SPCF | Request for supplementary protection certificate filed |
Free format text: DIBOTERMIN ALFA (INDUCTOS) Spc suppl protection certif: C200300009 Filing date: 20030225 |
|
| SPCG | Supplementary protection certificate granted |
Free format text: DIBOTERMIN ALFA (INDUCTOS) Spc suppl protection certif: C200300009 Filing date: 20030225 Expiry date: 20120630 Effective date: 20040121 |
|
| FD1A | Patent lapsed |
Effective date: 20100528 |