US6150328A
(en)
*
|
1986-07-01 |
2000-11-21 |
Genetics Institute, Inc. |
BMP products
|
IL83003A
(en)
*
|
1986-07-01 |
1995-07-31 |
Genetics Inst |
Factors that soak bone formation
|
US5106748A
(en)
*
|
1986-07-01 |
1992-04-21 |
Genetics Institute, Inc. |
Dna sequences encoding 5 proteins
|
US6020313A
(en)
*
|
1987-10-09 |
2000-02-01 |
University Of Kansas |
Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2
|
US5035901A
(en)
*
|
1987-10-09 |
1991-07-30 |
University Of Kansas |
Bone inducing agent from a human osteosarcoma cell line
|
US5324819A
(en)
*
|
1988-04-08 |
1994-06-28 |
Stryker Corporation |
Osteogenic proteins
|
US6586388B2
(en)
|
1988-04-08 |
2003-07-01 |
Stryker Corporation |
Method of using recombinant osteogenic protein to repair bone or cartilage defects
|
US4968590A
(en)
*
|
1988-04-08 |
1990-11-06 |
Stryker Corporation |
Osteogenic proteins and polypeptides
|
US5162114A
(en)
*
|
1989-02-23 |
1992-11-10 |
Stryker Corporation |
Bone collagen matrix for xenogenic implants
|
US5670336A
(en)
*
|
1988-04-08 |
1997-09-23 |
Stryker Corporation |
Method for recombinant production of osteogenic protein
|
US5258494A
(en)
|
1988-04-08 |
1993-11-02 |
Stryker Corporation |
Osteogenic proteins
|
US5354557A
(en)
*
|
1988-04-08 |
1994-10-11 |
Stryker Corporation |
Osteogenic devices
|
WO1989009787A2
(fr)
*
|
1988-04-08 |
1989-10-19 |
Creative Biomolecules, Inc. |
Dispositifs osteogeniques
|
US5108753A
(en)
*
|
1988-04-08 |
1992-04-28 |
Creative Biomolecules |
Osteogenic devices
|
US5344654A
(en)
*
|
1988-04-08 |
1994-09-06 |
Stryker Corporation |
Prosthetic devices having enhanced osteogenic properties
|
US4975526A
(en)
*
|
1989-02-23 |
1990-12-04 |
Creative Biomolecules, Inc. |
Bone collagen matrix for zenogenic implants
|
JPH03503649A
(ja)
*
|
1988-04-08 |
1991-08-15 |
ジェネティックス・インスティテュート・インコーポレイテッド |
硬骨および軟骨誘導組成物
|
US5266683A
(en)
*
|
1988-04-08 |
1993-11-30 |
Stryker Corporation |
Osteogenic proteins
|
US5250302A
(en)
*
|
1988-04-08 |
1993-10-05 |
Stryker Corporation |
Osteogenic devices
|
US6919308B2
(en)
|
1988-04-08 |
2005-07-19 |
Stryker Corporation |
Osteogenic devices
|
US5106626A
(en)
*
|
1988-10-11 |
1992-04-21 |
International Genetic Engineering, Inc. |
Osteogenic factors
|
US5284756A
(en)
*
|
1988-10-11 |
1994-02-08 |
Lynn Grinna |
Heterodimeric osteogenic factor
|
US4915301A
(en)
*
|
1988-11-15 |
1990-04-10 |
International Flavors & Fragrances, Inc. |
Container with sorbent member and microporous membrane for dispensing vapor from volatile liquid
|
ATE162223T1
(de)
*
|
1989-03-28 |
1998-01-15 |
Genetics Inst |
Osteoinduktive zusammensetzungen
|
PT94241A
(pt)
*
|
1989-06-02 |
1991-02-08 |
Chiron Corp |
Processo para a preparacao de factor calcificacao ossea e de composicoes farmaceuticas que os contem
|
CA2020729A1
(fr)
*
|
1989-07-19 |
1991-01-20 |
Michael C. Kiefer |
Proteine morphogenetique des os
|
CA2064878A1
(fr)
*
|
1989-08-21 |
1991-02-22 |
Hanne Bentz |
Proteine specifique des os
|
DE69027961T2
(de)
*
|
1989-09-06 |
1997-01-09 |
Takeda Chemical Industries Ltd |
Protein, DNA und ihre Verwendung
|
CA2042577A1
(fr)
*
|
1989-10-17 |
1991-04-18 |
Hermann Oppermann |
Dispositifs osteogeniques
|
US5168050A
(en)
*
|
1990-05-24 |
1992-12-01 |
Genentech, Inc. |
Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
|
US5645591A
(en)
*
|
1990-05-29 |
1997-07-08 |
Stryker Corporation |
Synthetic bone matrix
|
US5364839A
(en)
*
|
1990-06-18 |
1994-11-15 |
Genetics Institute, Inc. |
Osteoinductive pharmaceutical formulations
|
WO1992005199A1
(fr)
*
|
1990-09-26 |
1992-04-02 |
Genetics Institute, Inc. |
Derives bmp-5
|
US5206023A
(en)
*
|
1991-01-31 |
1993-04-27 |
Robert F. Shaw |
Method and compositions for the treatment and repair of defects or lesions in cartilage
|
CA2363965C
(fr)
|
1991-03-11 |
2010-05-18 |
Curis, Inc. |
Morphogenese induite par des proteines
|
US7056882B2
(en)
|
1991-03-11 |
2006-06-06 |
Curis, Inc. |
Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
|
US5652337A
(en)
*
|
1991-03-11 |
1997-07-29 |
Creative Biomolecules, Inc. |
OP-3-induced morphogenesis
|
US6077823A
(en)
*
|
1991-03-11 |
2000-06-20 |
Creative Biomolecules, Inc. |
Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
|
US6090776A
(en)
*
|
1991-03-11 |
2000-07-18 |
Creative Bio Molecules, Inc. |
Morphogen treatment of organ implants
|
US6495513B1
(en)
|
1991-03-11 |
2002-12-17 |
Curis, Inc. |
Morphogen-enhanced survival and repair of neural cells
|
US5739107A
(en)
|
1991-03-11 |
1998-04-14 |
Creative Biomolecules, Inc. |
Morphogen treatment of gastrointestinal ulcers
|
US6800603B2
(en)
|
1991-03-11 |
2004-10-05 |
Curis, Inc. |
Morphogen-induced neural cell adhesion
|
US5656593A
(en)
*
|
1991-03-11 |
1997-08-12 |
Creative Biomolecules, Inc. |
Morphogen induced periodontal tissue regeneration
|
US5972884A
(en)
*
|
1991-03-11 |
1999-10-26 |
Creative Biomolecules, Inc. |
Morphogen treatment of gastrointestinal ulcers
|
US5849686A
(en)
*
|
1991-03-11 |
1998-12-15 |
Creative Biomolecules, Inc. |
Morphogen-induced liver regeneration
|
US5674844A
(en)
*
|
1991-03-11 |
1997-10-07 |
Creative Biomolecules, Inc. |
Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
|
US5652118A
(en)
*
|
1991-03-11 |
1997-07-29 |
Creative Biomolecules, Inc. |
Nucleic acid encoding a novel morphogenic protein, OP-3
|
US5318898A
(en)
*
|
1991-04-02 |
1994-06-07 |
Genetics Institute, Inc. |
Production of recombinant bone-inducing proteins
|
US5118667A
(en)
*
|
1991-05-03 |
1992-06-02 |
Celtrix Pharmaceuticals, Inc. |
Bone growth factors and inhibitors of bone resorption for promoting bone formation
|
AU662155B2
(en)
|
1991-05-10 |
1995-08-24 |
Celtrix Pharmaceuticals, Inc. |
Targeted delivery of bone growth factors
|
DE69213739T2
(de)
*
|
1991-06-21 |
1997-02-20 |
Genetics Inst |
Osteogene proteine enthaltende arzneimittel
|
US6022853A
(en)
*
|
1991-08-30 |
2000-02-08 |
Creative Biomolecules, Inc. |
Morphogen-enriched dietary composition
|
US5270300A
(en)
*
|
1991-09-06 |
1993-12-14 |
Robert Francis Shaw |
Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
|
WO1993009229A1
(fr)
|
1991-11-04 |
1993-05-13 |
Genetics Institute, Inc. |
Proteines heterodimeres morphogenetiques d'os de recombinaison, compositions et procedes d'utilisation
|
CZ287715B6
(en)
*
|
1992-02-12 |
2001-01-17 |
Bioph Biotech Entw Pharm Gmbh |
DNA sequence, recombinant DNA molecule containing thereof, process for preparing protein from the group of TGF-beta substances, pharmaceutical preparation containing such protein, antibody or fragment thereof and its use
|
IL106278A0
(en)
*
|
1992-07-13 |
1993-11-15 |
Sumitomo Metal Ind |
Bone formation-inducing protein
|
EP0665739B1
(fr)
*
|
1992-09-15 |
1999-08-04 |
Creative Biomolecules, Inc. |
Regeneration tissulaire periodontique induite par des morphogenes
|
ATE182778T1
(de)
*
|
1992-09-15 |
1999-08-15 |
Creative Biomolecules Inc |
Durch morphogen induzierte periodontolgeweberegeneration
|
ATE258984T1
(de)
*
|
1993-05-12 |
2004-02-15 |
Inst Genetics Llc |
Bmp-11 zusammensetzungen
|
US6333168B1
(en)
|
1993-05-20 |
2001-12-25 |
The Trustees Of Columbia University In The City Of New York |
Cloning, expression and uses of dorsalin-1
|
US5385887A
(en)
*
|
1993-09-10 |
1995-01-31 |
Genetics Institute, Inc. |
Formulations for delivery of osteogenic proteins
|
US6291206B1
(en)
|
1993-09-17 |
2001-09-18 |
Genetics Institute, Inc. |
BMP receptor proteins
|
US5906827A
(en)
*
|
1994-06-03 |
1999-05-25 |
Creative Biomolecules, Inc. |
Matrix for the manufacture of autogenous replacement body parts
|
KR100440645B1
(ko)
*
|
1995-06-05 |
2004-09-18 |
뉴욕 쏘사이어티 포 더 릴리프 어브 더 럽쳐드 앤드 크리플드 메인테이닝 더 하스피틀 포 스페셜 설져리 |
결합조직부착의치료및치유를위한방법및조성물
|
KR19990036272A
(ko)
*
|
1995-08-08 |
1999-05-25 |
사우코넨 주시 제이 |
재조합 c-프로테나제와 이의 공정, 제조방법 및 이의 용도
|
US5807981A
(en)
*
|
1995-12-13 |
1998-09-15 |
Fibrogen Inc. |
Peptides which are cleaved by C-proteinase
|
EP0894004B2
(fr)
|
1996-03-22 |
2007-02-21 |
Curis, Inc. |
Procede pour favoriser la recuperation fonctionnelle de la coordination motrice, de la parole ou de la perception sensorielle a la suite d'une ischemie ou d'un traumatisme du systeme nerveux central
|
US6498142B1
(en)
|
1996-05-06 |
2002-12-24 |
Curis, Inc. |
Morphogen treatment for chronic renal failure
|
BR9713130A
(pt)
*
|
1996-11-22 |
2000-02-08 |
Akzo Nobel Nv |
Região promotora de bmp-4 e seus fragmentos, vetor compreendendo uma região promotora de bmp-4 ou seus fragmentos, célula hospedeira, processo para a identificação de agentes terapêuticos para a prevenção e/ou tratamento da osteoporose, e, uso de ici 164384.
|
EP1350525A3
(fr)
*
|
1997-02-07 |
2003-12-10 |
Stryker Corporation |
Dispositif ostéogenique sans matrice, implants et méthodes d'utilisation associées
|
US7041641B2
(en)
|
1997-03-20 |
2006-05-09 |
Stryker Corporation |
Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
|
US20010016646A1
(en)
|
1998-03-20 |
2001-08-23 |
David C. Rueger |
Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
|
CA2289123A1
(fr)
|
1997-05-05 |
1998-11-12 |
Creative Biomolecules, Inc. |
Therapies contre l'insuffisance renale aigue
|
WO1998054572A1
(fr)
|
1997-05-30 |
1998-12-03 |
Creative Biomolecules, Inc. |
Procedes pour evaluer la morphogenese des tissus et leur activite
|
US6391311B1
(en)
|
1998-03-17 |
2002-05-21 |
Genentech, Inc. |
Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
|
DK2016951T3
(da)
|
1998-03-17 |
2012-09-24 |
Genentech Inc |
VEGF- og BMP1-homologe polypeptider
|
US7147839B2
(en)
|
1998-05-29 |
2006-12-12 |
Curis, Inc. |
Methods for evaluating tissue morphogenesis and activity
|
EP1094829B8
(fr)
|
1998-07-13 |
2004-09-22 |
University Of Southern California |
Procedes permettant d'accelerer la reparation et la croissance des os et des cartilages
|
US6916783B2
(en)
|
1998-07-13 |
2005-07-12 |
University Of Southern California |
Methods for accelerating bone and cartilage growth and repair
|
US6958149B2
(en)
|
1998-10-06 |
2005-10-25 |
Stryker Corporation |
Repair of larynx, trachea, and other fibrocartilaginous tissues
|
US7572440B2
(en)
|
1999-07-30 |
2009-08-11 |
Stryker Corporation |
Method for repairing a defect in an intervertebral disc
|
WO2000020559A1
(fr)
|
1998-10-06 |
2000-04-13 |
Rush-Presbyterian-St. Luke's Medical Center |
Procede de traitement par chimionucleolyse
|
JP3786533B2
(ja)
|
1998-11-12 |
2006-06-14 |
善彦 西村 |
ペプチド及び骨形成促進剤
|
JP2002535378A
(ja)
*
|
1999-02-01 |
2002-10-22 |
ジェネティックス・インスチチュート・インコーポレーテッド |
関節軟骨の治癒および修復のための方法および組成物
|
DE19906096A1
(de)
|
1999-02-13 |
2000-08-17 |
Walter Sebald |
Protein mit einem Heparin-bindenden Epitop
|
WO2001016323A2
(fr)
*
|
1999-09-01 |
2001-03-08 |
Subsidiary N0.3, Inc. |
Compositions et procedes d'inhibition de l'infection due au virus de l'immunodeficience humaine a l'aide de genes cellulaires humains a regulation negative
|
AU771546B2
(en)
*
|
1999-09-01 |
2004-03-25 |
Ppd Development, Lp |
Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
|
AU6865100A
(en)
*
|
1999-09-02 |
2001-04-10 |
Mitsubishi Pharma Corporation |
Osteogenesis promoting agents
|
JP3910536B2
(ja)
*
|
2000-12-28 |
2007-04-25 |
塩野義製薬株式会社 |
新規ポリペプチドおよびそのdna
|
TWI329129B
(en)
|
2001-02-08 |
2010-08-21 |
Wyeth Corp |
Modified and stabilized gdf propeptides and uses thereof
|
US7160725B2
(en)
|
2001-11-13 |
2007-01-09 |
Curis, Inc. |
Hedgehog signaling promotes the formation of three dimensional cartilage matrices
|
WO2003043673A1
(fr)
|
2001-11-19 |
2003-05-30 |
Scil Technology Gmbh |
Dispositif dote de proprietes osteoinductives et osteoconductrices
|
US8067557B2
(en)
|
2002-03-28 |
2011-11-29 |
The Trustees Of The University Of Pennsylvania |
OCL-2A3 compositions and uses thereof
|
US7160994B2
(en)
|
2002-03-28 |
2007-01-09 |
Trustees Of The University Of Pennsylvania |
Osteoclast-specific genes and proteins and uses thereof
|
ES2260685T3
(es)
|
2002-09-10 |
2006-11-01 |
Scil Technology Gmbh |
Implante metalico recubierto, a una concentracion de oxigeno reducida, con proteina osteoinductora.
|
CA2537735C
(fr)
|
2003-09-12 |
2018-07-24 |
Wyeth |
Barres solides et pates de phosphate de calcium injectables pour la delivrance de proteines osteogeniques
|
EP1701729B1
(fr)
|
2003-12-31 |
2018-05-02 |
Warsaw Orthopedic, Inc. |
Compositions de matrice osseuse ameliorees et methodes associees
|
US8734525B2
(en)
|
2003-12-31 |
2014-05-27 |
Warsaw Orthopedic, Inc. |
Osteoinductive demineralized cancellous bone
|
EP1571159A1
(fr)
*
|
2004-03-04 |
2005-09-07 |
Bayerische Julius-Maximilians-Universität Würzburg |
Mutéine d' une protéine morphogénétique osseuse et son utilisation
|
ATE478008T1
(de)
|
2004-03-10 |
2010-09-15 |
Scil Technology Gmbh |
Überzogene implantate, ihre herstellung und verwendung davon
|
JP5201987B2
(ja)
|
2004-05-25 |
2013-06-05 |
ストライカー コーポレイション |
軟骨欠損を処置するための、形態形成タンパク質の使用
|
US8506646B2
(en)
|
2005-04-29 |
2013-08-13 |
Warsaw Orthopedic, Inc. |
Multi-purpose medical implant devices
|
WO2007053850A2
(fr)
|
2005-11-01 |
2007-05-10 |
Osteotech, Inc. |
Compositions de matrice d’os et méthodes correspondantes
|
US20090298761A1
(en)
|
2006-05-17 |
2009-12-03 |
Donald Engelman |
Methods of treating cartilage defects using a soluble morphogenic protein complex
|
BRPI0716680A2
(pt)
|
2006-11-02 |
2013-09-24 |
Daniel J Capon |
"composto, multÍmero, composiÇço, mÉtodo de afetar a atividade de um alvo, complexo, processo de produÇço do composto, mÉtodo de produÇço de um extensço de aminoÁcidos consecutivos, processo de produÇço de uma extensço de aminoacidos consecutivos , processo para a produÇço de um composto , mÉtodo de produÇço de uma proteina e polipeptÍdeo"
|
AU2007234612B2
(en)
|
2006-12-14 |
2013-06-27 |
Johnson & Johnson Regenerative Therapeutics, Llc |
Protein stabilization formulations
|
US20100184659A1
(en)
|
2006-12-21 |
2010-07-22 |
Warren Jaworowicz |
Sustained-Release Formulations Comprising Crystals, Macromolecular Gels, and Particulate Suspensions of Biologic Agents
|
EP2167147B1
(fr)
|
2007-06-15 |
2017-03-29 |
Warsaw Orthopedic, Inc. |
Compositions de matrice osseuse et méthodes
|
US9554920B2
(en)
|
2007-06-15 |
2017-01-31 |
Warsaw Orthopedic, Inc. |
Bone matrix compositions having nanoscale textured surfaces
|
US7678764B2
(en)
|
2007-06-29 |
2010-03-16 |
Johnson & Johnson Regenerative Therapeutics, Llc |
Protein formulations for use at elevated temperatures
|
US9492278B2
(en)
|
2007-07-10 |
2016-11-15 |
Warsaw Orthopedic, Inc. |
Delivery system
|
JP5323832B2
(ja)
|
2007-08-07 |
2013-10-23 |
アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー |
酸性水溶液中にgdf−5を含むタンパク質製剤
|
CA2718592A1
(fr)
|
2008-02-13 |
2009-08-20 |
Keith Hruska |
Procede de traitement de la sclerose vasculaire
|
JP5599778B2
(ja)
|
2008-04-14 |
2014-10-01 |
デピュイ・シンセス・プロダクツ・エルエルシー |
液体緩衝gdf−5製剤
|
US9011537B2
(en)
|
2009-02-12 |
2015-04-21 |
Warsaw Orthopedic, Inc. |
Delivery system cartridge
|
US20100204123A1
(en)
|
2009-02-12 |
2010-08-12 |
Mary Elizabeth Pecquet Goad |
Peripheral Administration of Proteins Including TGF-beta Superfamily Members for Treatment of Systemic Disorders and Disease
|
JP5819734B2
(ja)
|
2009-02-12 |
2015-11-24 |
ストライカー コーポレイションStryker Corporation |
TGF−βスーパーファミリーメンバー含有タンパク質の最小に侵襲性の全身送達のための組成物および方法
|
EP2406281B1
(fr)
*
|
2009-03-12 |
2016-02-17 |
Haase Investments UG |
Variants de la protéine morphogénétique osseuse 2 (bmp2) avec une sensibilité réduite aux antagonistes des bmp
|
WO2010110974A1
(fr)
|
2009-03-24 |
2010-09-30 |
Stryker Corporation |
Procédés et compositions pour l'ingénierie tissulaire
|
US20110002897A1
(en)
|
2009-06-11 |
2011-01-06 |
Burnham Institute For Medical Research |
Directed differentiation of stem cells
|
SG177467A1
(en)
*
|
2009-07-23 |
2012-02-28 |
Agency Science Tech & Res |
Pre-natal mesenchymal stem cells
|
WO2011031856A1
(fr)
|
2009-09-09 |
2011-03-17 |
Stryker Corporation |
Bmp-7 à utiliser dans le traitement de la douleur induite par les lésions et les maladies d'articulation
|
EP2352750B1
(fr)
|
2009-09-17 |
2012-06-13 |
Stryker Corporation |
Tampons utilisés pour la régulation du ph des protéines morphogénétiques osseuses
|
WO2011087768A1
(fr)
|
2009-12-22 |
2011-07-21 |
Stryker Corporation |
Variants de la bmp-7 dotés d'une immunogénicité réduite
|
NZ746109A
(en)
|
2016-12-30 |
2022-12-23 |
Biogend Therapeutics Co Ltd |
Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof
|