ATE322916T1 - Unter verringerter sauerstoffkonzentration mit einem osteoinduktiven protein beschichtetes metallimplantat - Google Patents

Unter verringerter sauerstoffkonzentration mit einem osteoinduktiven protein beschichtetes metallimplantat

Info

Publication number
ATE322916T1
ATE322916T1 AT03794834T AT03794834T ATE322916T1 AT E322916 T1 ATE322916 T1 AT E322916T1 AT 03794834 T AT03794834 T AT 03794834T AT 03794834 T AT03794834 T AT 03794834T AT E322916 T1 ATE322916 T1 AT E322916T1
Authority
AT
Austria
Prior art keywords
present
under reduced
oxygen concentration
protein under
reduced oxygen
Prior art date
Application number
AT03794834T
Other languages
English (en)
Inventor
Klaus Hellerbrand
Nicola Beaucamp
Ulrich Kohnert
Original Assignee
Scil Technology Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scil Technology Gmbh filed Critical Scil Technology Gmbh
Application granted granted Critical
Publication of ATE322916T1 publication Critical patent/ATE322916T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A61F2/3804—Joints for elbows or knees for elbows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/42—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • A61F2/4202—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes for ankles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/42—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • A61F2/4241—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes for hands, e.g. fingers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31678—Of metal
AT03794834T 2002-09-10 2003-07-09 Unter verringerter sauerstoffkonzentration mit einem osteoinduktiven protein beschichtetes metallimplantat ATE322916T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02020403 2002-09-10

Publications (1)

Publication Number Publication Date
ATE322916T1 true ATE322916T1 (de) 2006-04-15

Family

ID=31985027

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03794834T ATE322916T1 (de) 2002-09-10 2003-07-09 Unter verringerter sauerstoffkonzentration mit einem osteoinduktiven protein beschichtetes metallimplantat

Country Status (13)

Country Link
US (2) US7763270B2 (de)
EP (1) EP1539261B1 (de)
JP (1) JP4358741B2 (de)
CN (1) CN100522241C (de)
AT (1) ATE322916T1 (de)
AU (1) AU2003253049A1 (de)
CA (1) CA2498512C (de)
DE (1) DE60304584T2 (de)
DK (1) DK1539261T3 (de)
ES (1) ES2260685T3 (de)
PL (1) PL207552B1 (de)
PT (1) PT1539261E (de)
WO (1) WO2004024199A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT501408B1 (de) * 2004-12-07 2011-03-15 Physikalisches Buero Steinmueller Gmbh Biologische oberflächen
CN100368026C (zh) * 2005-07-01 2008-02-13 复旦大学附属华山医院 一种丝素蛋白涂层钛网及其制备方法和应用
CN101732762B (zh) * 2010-01-01 2013-04-03 东南大学 能缓释微量元素硒的生物活性人工关节
JP6092091B2 (ja) 2010-03-16 2017-03-08 デピュイ・シンセス・プロダクツ・インコーポレイテッド Ｂｍｐ−２に対し親和性をもつペプチド
US9169308B2 (en) 2013-01-25 2015-10-27 Warsaw Orthopedic, Inc. Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies
US8945872B2 (en) 2013-01-25 2015-02-03 Warsaw Orthopedic, Inc. Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
US9359417B2 (en) 2013-01-25 2016-06-07 Warsaw Orthopedic, Inc. Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
US8956829B2 (en) 2013-01-25 2015-02-17 Warsaw Orthopedic, Inc. Human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9051389B2 (en) 2013-01-25 2015-06-09 Warsaw Orthopedic, Inc. Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5)
CN103550822B (zh) * 2013-11-15 2015-03-04 温州医科大学附属口腔医院 一种装载神经生长因子的钛种植体的制备方法
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US10792129B2 (en) * 2015-02-03 2020-10-06 University Of Maine System Board Of Trustees Soft tissue in-growth of porous, three-dimensionally printed, transcutaneous implants of varying material and pore geometry
DE102018113809A1 (de) * 2018-06-11 2019-12-12 Christoph Karl Gelenkimplantat zur Gewebeneubildung am Gelenk

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329128A1 (de) 1983-08-11 1985-02-28 Bayer Ag, 5090 Leverkusen 3-cycloalkyl-1-(1,3-dioxan-5-yl)-2-(1,2,4-triazol-1-yl)-propan-1-one und -propan-1-ole
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US4877864A (en) 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US5366875A (en) 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US5631142A (en) * 1986-07-01 1997-05-20 Genetics Institute, Inc. Compositions comprising bone morphogenetic protein-2 (BMP-2)
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5459047A (en) 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US6432919B1 (en) * 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5939388A (en) 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US6586388B2 (en) * 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5162114A (en) 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5670336A (en) 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US4975526A (en) 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
EP1225225A3 (de) 1988-04-08 2003-01-08 Stryker Corporation Osteogene Vorrichtungen
US5344654A (en) 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5108436A (en) * 1988-09-29 1992-04-28 Collagen Corporation Implant fixation
US5207710A (en) * 1988-09-29 1993-05-04 Collagen Corporation Method for improving implant fixation
US5258029A (en) * 1988-09-29 1993-11-02 Collagen Corporation Method for improving implant fixation
ATE162223T1 (de) 1989-03-28 1998-01-15 Genetics Inst Osteoinduktive zusammensetzungen
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5158934A (en) * 1989-09-01 1992-10-27 Genentech, Inc. Method of inducing bone growth using TGF-β
ES2118723T3 (es) 1989-10-17 1998-10-01 Stryker Corp Dispositivos osteogenicos.
DK27390D0 (da) 1990-02-02 1990-02-02 Troels Torp Andreassen Fremgangsmaade og apparat til administration af biologisk aktive stoffer
ES2120964T3 (es) 1990-10-18 1998-11-16 Stryker Corp Peptidos osteogenicos.
US6194376B1 (en) 1991-03-11 2001-02-27 Creative Biomolecules, Inc. Method for modulating inflammatory response comprising administering morphogen
US5674844A (en) 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6723698B2 (en) * 1991-03-11 2004-04-20 Curis, Inc. Methods and compositions for the treatment of motor neuron injury and neuropathy
US5707810A (en) * 1991-03-11 1998-01-13 Creative Biomolecules, Inc. Method of diagnosing renal tissue damage or disease
US6800603B2 (en) * 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5650276A (en) * 1991-03-11 1997-07-22 Creative Biomolecules, Inc. Morphogenic protein screening method
US6395883B1 (en) * 1991-03-11 2002-05-28 Curis, Inc. Soluble morphogenic protein complex compositions of matter
US5656593A (en) 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5652337A (en) 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US5739107A (en) * 1991-03-11 1998-04-14 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5849686A (en) 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
CA2363965C (en) * 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6506729B1 (en) * 1991-03-11 2003-01-14 Curis, Inc. Methods and compositions for the treatment and prevention of Parkinson's disease
US6211146B1 (en) * 1991-03-11 2001-04-03 Curis, Inc. 60A protein-induced morphogenesis
EP0575555B1 (de) 1991-03-11 2001-07-18 Curis, Inc. Protein-induzierende morphogenese
US5972884A (en) 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5290763A (en) 1991-04-22 1994-03-01 Intermedics Orthopedics/Denver, Inc. Osteoinductive protein mixtures and purification processes
US5563124A (en) 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5177406A (en) * 1991-04-29 1993-01-05 General Motors Corporation Active matrix vacuum fluorescent display with compensation for variable phosphor efficiency
DE4121043A1 (de) 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
EP0523926A3 (en) 1991-07-15 1993-12-01 Smith & Nephew Richards Inc Prosthetic implants with bioabsorbable coating
DE69233559T2 (de) 1991-08-30 2006-08-31 Curis, Inc., Cambridge Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
JP3693338B2 (ja) 1991-08-30 2005-09-07 キュリス インコーポレイテッド 組織形成因子誘導による炎症反応の調節
SE469653B (sv) 1992-01-13 1993-08-16 Lucocer Ab Poroest implantat
CA2129820C (en) 1992-02-12 2003-06-17 Helge Neidhardt Dna sequences encoding novel growth/differentiation factors
US6120760A (en) * 1992-02-12 2000-09-19 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Growth/differentiation factors of the TGF-β family
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
WO1993015694A1 (en) 1992-02-14 1993-08-19 Board Of Regents, The University Of Texas System Multi-phase bioerodible implant/carrier and method of manufacturing and using same
US5610021A (en) * 1992-02-21 1997-03-11 Creative Biomolecules, Inc. Compositions and methods for identification and use of soluble complex forms of osteogenic proteins
US6071695A (en) * 1992-02-21 2000-06-06 Creative Biomolecules, Inc. Methods and products for identification of modulators of osteogenic protein-1 gene expression
US5397235A (en) * 1993-07-02 1995-03-14 Dental Marketing Specialists, Inc. Method for installation of dental implant
US5560936A (en) * 1992-10-26 1996-10-01 The United States Of America As Represented By The Department Of Health And Human Services Intrinsic inhibitors of aldose reductase
EP0690871A4 (de) 1993-01-12 1999-10-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-5
WO1994015653A1 (en) 1993-01-12 1994-07-21 Genentech, Inc. Tgf-beta formulation for inducing bone growth
US5314368A (en) * 1993-02-03 1994-05-24 Cheng Peter S C Flying ball apparatus
CN1052632C (zh) * 1993-04-16 2000-05-24 成都科技大学 对胶原组织人工瓣膜材料缓钙化的方法
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
ES2255059T3 (es) 1993-12-07 2006-06-16 Genetics Institute, Llc Bmp-12, bmp-13 y composiciones suyas inductoras de tendon.
US6027919A (en) * 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
US6013517A (en) * 1994-05-09 2000-01-11 Chiron Corporation Crossless retroviral vectors
US7431655B2 (en) * 1994-09-29 2008-10-07 Clawson Custom Cues, Inc. Billiard cue
US5681746A (en) 1994-12-30 1997-10-28 Chiron Viagene, Inc. Retroviral delivery of full length factor VIII
ATE197250T1 (de) 1995-03-01 2000-11-15 Stryker Corp Morphogeninduzierte regenerierung der dentin
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
US6027742A (en) * 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US6117456A (en) 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US6287341B1 (en) 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US5676976A (en) 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6541037B1 (en) * 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
US8333996B2 (en) * 1995-05-19 2012-12-18 Etex Corporation Calcium phosphate delivery vehicle and adjuvant
AU699918B2 (en) * 1995-06-05 1998-12-17 Genetics Institute, Llc Methods and compositions for healing and repair of connective tissue attachment
US6043948A (en) * 1995-11-08 2000-03-28 Sony Corporation Information recording and reproducing apparatus
ES2196252T3 (es) 1996-05-10 2003-12-16 Chienna Bv Dispositivo para la incorporacion y administracion de agentes biologicos activos.
US6143948A (en) * 1996-05-10 2000-11-07 Isotis B.V. Device for incorporation and release of biologically active agents
EP0806211B1 (de) 1996-05-10 2002-10-23 IsoTis N.V. Implantatwerkstoff und Verfahren zu seiner Herstellung
EP0806212B1 (de) 1996-05-10 2003-04-02 IsoTis N.V. Vorrichtung zur Aufnahme und Freigabe von biologisch aktiven Substanzen
US6953594B2 (en) * 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
JP4781494B2 (ja) 1996-10-16 2011-09-28 エテックス コーポレイション 不完全結晶性カルシウムホスフェートの製造法及びその使用法
DE19647853A1 (de) 1996-11-19 1998-05-20 Bioph Biotech Entw Pharm Gmbh Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität
US20020082224A1 (en) * 1997-01-14 2002-06-27 Douglas J. Jolly Non-immunogenic prodrugs and selectable markers for use in gene therapy
DK0972520T3 (da) 1997-01-30 2005-12-19 Bioph Biotech Entw Pharm Gmbh Frysetörret sammensætning af humant, knoglemorfogenetisk protein MP52
CA2280931C (en) 1997-02-07 2009-05-05 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US20020098222A1 (en) 1997-03-13 2002-07-25 John F. Wironen Bone paste
GB9709298D0 (en) * 1997-05-09 1997-06-25 Campbell Duncan F Oral anchorage
US20030032586A1 (en) * 1997-05-15 2003-02-13 David C. Rueger Compositions for morphogen-induced osteogenesis
US6129928A (en) 1997-09-05 2000-10-10 Icet, Inc. Biomimetic calcium phosphate implant coatings and methods for making the same
ES2245042T3 (es) * 1997-09-24 2005-12-16 The Regents Of The University Of California Vectores de lentivirus de no primates y sistemas de empaquetamiento.
US20020048805A1 (en) * 1998-01-16 2002-04-25 Julie C. Johnston Feline immunodeficiency virus gene therapy vectors
CA2318575A1 (en) * 1998-01-16 1999-07-22 Chiron Corporation Feline immunodeficiency virus gene therapy vectors
WO1999058701A1 (en) * 1998-05-13 1999-11-18 Genetix Pharmaceuticals, Inc. Novel lentiviral packaging cells
US6261322B1 (en) * 1998-05-14 2001-07-17 Hayes Medical, Inc. Implant with composite coating
KR100298178B1 (ko) 1998-06-29 2001-08-07 박종섭 이미지센서의포토다이오드
US6328765B1 (en) 1998-12-03 2001-12-11 Gore Enterprise Holdings, Inc. Methods and articles for regenerating living tissue
US6423544B1 (en) * 1998-12-31 2002-07-23 Chiron Corporation Compositions and methods for producing recombinant virions
CA2362046A1 (en) 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Osteogenic paste compositions and uses thereof
WO2000045871A1 (en) 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Highly-mineralized osteogenic sponge compositions, and uses thereof
US6730297B1 (en) * 1999-05-28 2004-05-04 Chiron Corporation Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders
SE514323C2 (sv) 1999-05-31 2001-02-12 Nobel Biocare Ab Implantat samt förfarande och användning vid implantat
SE515695C2 (sv) 1999-05-31 2001-09-24 Nobel Biocare Ab Implantat med beläggning av bentillväxtstimulerande substans för applicering i ben och förfarande vid sådant implantat
SE514202C2 (sv) 1999-05-31 2001-01-22 Nobel Biocare Ab På implantat till ben- eller vävnadsstruktur anordnat skikt samt sådant implantat och förfarande för applicering av skiktet
US6399599B1 (en) * 1999-10-13 2002-06-04 Novartis Ag Substituted 2-oxo-1,4-diazacycloalkanes
EP1223990B1 (de) 1999-10-15 2004-07-28 Genetics Institute, LLC Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
WO2001028603A1 (en) 1999-10-15 2001-04-26 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
DE19950386A1 (de) * 1999-10-19 2001-05-10 Miladin Lazarov Biokompatibler Gegenstand
US20020037281A1 (en) * 2000-05-26 2002-03-28 Davidson Beverly L. Methods of transducing neural cells using lentivirus vectors
US6533821B1 (en) * 2000-06-22 2003-03-18 Thomas Lally Bio-adhesive composition, method for adhering objects to bone
US7419829B2 (en) * 2000-10-06 2008-09-02 Oxford Biomedica (Uk) Limited Vector system
WO2002040073A1 (en) 2000-11-20 2002-05-23 Université De Genève Endosseous implant
US20030003565A1 (en) * 2000-11-27 2003-01-02 Dubensky Thomas W. Functional lentiviral vector from an MLV-based backbone
ES2223965T3 (es) * 2000-12-06 2005-03-01 Astra Tech Ab Protesis e implantes medicos revestidos con hidruros metalicos y biomoleculas que tienen biocompatibilidad mejorada.
US20020082679A1 (en) * 2000-12-22 2002-06-27 Avantec Vascular Corporation Delivery or therapeutic capable agents
WO2002054088A2 (en) 2001-01-05 2002-07-11 Duke University Contrast enhancement agent for magnetic resonance imaging
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US20030049328A1 (en) * 2001-03-02 2003-03-13 Dalal Paresh S. Porous beta-tricalcium phosphate granules and methods for producing same
WO2002083188A2 (en) 2001-04-16 2002-10-24 Cassidy James J Dense/porous structures for use as bone substitutes
EP1389978B1 (de) * 2001-05-01 2009-01-07 Amedica Corporation Röntgendurchlässiges knochentransplantat
WO2002087341A1 (en) * 2001-05-01 2002-11-07 Genetix Pharmaceuticals, Inc. Novel self-inactivating (sin) lentiviral vectors
SE519564C2 (sv) 2001-07-04 2003-03-11 Nobel Biocare Ab Implantat, t ex dentalt implantat, belagt med bentillväxtstimulerande medel
SE519566C2 (sv) 2001-07-04 2003-03-11 Nobel Biocare Ab Förfarande för behandling av implantat genom beläggning med kalciumfosfat och bentillväxtstimulerande medel
US6876452B2 (en) * 2001-12-13 2005-04-05 Zygo Corporation Apparatus and methods for high accuracy metrology and positioning of a body
CH695985A5 (de) 2002-01-21 2006-11-15 Straumann Holding Ag Oberflächenmodifizierte Implantate.
WO2006012326A1 (en) * 2004-06-25 2006-02-02 E.I. Dupont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids

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US8257728B2 (en) 2012-09-04
CN100522241C (zh) 2009-08-05
US20110020658A1 (en) 2011-01-27
PT1539261E (pt) 2006-08-31
PL375794A1 (en) 2005-12-12
ES2260685T3 (es) 2006-11-01
CA2498512A1 (en) 2004-03-25
EP1539261A1 (de) 2005-06-15
JP2006503611A (ja) 2006-02-02
US7763270B2 (en) 2010-07-27
US20060240062A1 (en) 2006-10-26
WO2004024199A1 (en) 2004-03-25
EP1539261B1 (de) 2006-04-12
JP4358741B2 (ja) 2009-11-04
CN1681540A (zh) 2005-10-12
DE60304584D1 (de) 2006-05-24
DK1539261T3 (da) 2006-08-07
DE60304584T2 (de) 2007-04-26
AU2003253049A1 (en) 2004-04-30

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