MEP24008A - Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds - Google Patents

Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds

Info

Publication number
MEP24008A
MEP24008A MEP-240/08A MEP24008A MEP24008A ME P24008 A MEP24008 A ME P24008A ME P24008 A MEP24008 A ME P24008A ME P24008 A MEP24008 A ME P24008A
Authority
ME
Montenegro
Prior art keywords
carnitine
alkanoyl
esters
active compounds
pharmacologically active
Prior art date
Application number
MEP-240/08A
Other languages
Bosnian (bs)
English (en)
Inventor
Claudio Pisano
Maria Ornella Tinti
Mose Santaniello
Luciana Critelli
Giovanni Salvatori
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of MEP24008A publication Critical patent/MEP24008A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
MEP-240/08A 1999-04-13 2000-04-11 Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds MEP24008A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999RM000220A IT1306129B1 (it) 1999-04-13 1999-04-13 Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
YUP-702/01A RS50911B (sr) 1999-04-13 2000-04-11 Estri l-karnitina ili alkanoil l-karnitina korisni kao katjonski lipidi za unutarćelijsko oslobađanje farmakološki aktivnih jedinjenja
PCT/IT2000/000137 WO2000061543A2 (en) 1999-04-13 2000-04-11 Esters of l-carnitine or alkanoyl l-carnitines

Publications (1)

Publication Number Publication Date
MEP24008A true MEP24008A (en) 2010-06-10

Family

ID=11406659

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-240/08A MEP24008A (en) 1999-04-13 2000-04-11 Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds
MEP-2008-240A ME00113B (me) 1999-04-13 2000-04-11 Estri l-karnitina ili alkanoil l-karnitina korisni kao katjonski lipidi za unutarćelijsko oslobađanje farmakološki aktivnih jedinjenja

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-2008-240A ME00113B (me) 1999-04-13 2000-04-11 Estri l-karnitina ili alkanoil l-karnitina korisni kao katjonski lipidi za unutarćelijsko oslobađanje farmakološki aktivnih jedinjenja

Country Status (34)

Country Link
US (4) US6797281B1 (es)
EP (3) EP1435232A1 (es)
JP (2) JP4703855B2 (es)
KR (2) KR100684378B1 (es)
CN (2) CN1263730C (es)
AT (2) ATE286873T1 (es)
AU (2) AU776301B2 (es)
BG (3) BG65501B1 (es)
BR (2) BRPI0017460B1 (es)
CA (2) CA2370143C (es)
CZ (1) CZ302628B6 (es)
DE (2) DE60025961T2 (es)
DK (2) DK1426044T3 (es)
EA (2) EA006021B1 (es)
EE (2) EE05719B1 (es)
ES (2) ES2258688T3 (es)
HK (1) HK1045145B (es)
HR (1) HRP20010740B1 (es)
HU (1) HU229366B1 (es)
IL (4) IL145765A0 (es)
IS (2) IS2476B (es)
IT (1) IT1306129B1 (es)
ME (2) MEP24008A (es)
MX (1) MXPA01010359A (es)
NO (2) NO327742B1 (es)
NZ (2) NZ528874A (es)
PL (2) PL204418B1 (es)
PT (2) PT1183228E (es)
RS (3) RS50911B (es)
SI (2) SI1426044T1 (es)
SK (2) SK287253B6 (es)
TR (2) TR200202358T2 (es)
WO (1) WO2000061543A2 (es)
ZA (1) ZA200109291B (es)

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JP4879433B2 (ja) * 2000-01-13 2012-02-22 エミスフェアー・テクノロジーズ・インク 活性剤を送達するための化合物および組成物
DE10113446A1 (de) † 2001-03-19 2002-09-26 Schwarzkopf Gmbh Hans Haarbehandlungsmittel mit Betainen
AU2003280505B2 (en) 2002-06-26 2009-01-15 Syncore Biotechnology Co., Ltd Method of producing a cationic liposomal preparation comprising a lipophilic compound
HUE031505T2 (en) * 2002-06-26 2017-07-28 Syncore Biotechnology Co Ltd A method of producing a cationic liposomal composition comprising a lipophilic compound
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos
WO2006094203A1 (en) * 2005-03-02 2006-09-08 Northeastern University Mitochondriotropic phospholipid vesicles
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
EP1915134A2 (en) * 2005-08-10 2008-04-30 Novartis AG Formulations for 7-(t-butoxy)iminomethyl camptothecin
CA2618084A1 (en) * 2005-08-10 2007-02-15 Novartis Ag Microparticle compositions of the topoisomerase i inhibitor 7-tert-butoxyiminomethylcamptothecin
WO2008024389A2 (en) * 2006-08-23 2008-02-28 Biodelivery Sciences International, Inc. Amphiphilic nucleotide cochleate compositions and methods of using the same
WO2008094959A1 (en) * 2007-02-01 2008-08-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical composition comprising a campothecin derivative
WO2008101173A2 (en) * 2007-02-16 2008-08-21 Cornell University Biodegradable compositions and materials
WO2008144881A1 (en) * 2007-05-28 2008-12-04 Genesis Group Inc. Biodegradable elastomers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol
ES2601856T3 (es) 2007-06-08 2017-02-16 Mannkind Corporation Inhibidores de la IRE-1A
CA2718276A1 (en) * 2008-03-13 2009-09-17 Perkinelmer Las, Inc. Enzymatic substrates for multiple detection systems
EP2532649B1 (en) * 2011-06-07 2015-04-08 Incella GmbH Amino lipids, their synthesis and uses thereof
WO2013032643A2 (en) * 2011-08-31 2013-03-07 Dicerna Pharmaceuticals, Inc. Lipids capable of conformational change and their use in formulations to deliver therapeutic agents to cells
CN113004351A (zh) 2013-03-15 2021-06-22 珀金埃尔默健康科学股份有限公司 与溶酶体贮积症的测试相关的化合物和方法
KR20180114946A (ko) 2016-03-02 2018-10-19 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 면역요법을 위한 sting 활성화 나노백신
WO2018226854A2 (en) 2017-06-06 2018-12-13 Wayne State University Antifouling polymer coatings and reverse coating method
CN115177608B (zh) * 2022-07-26 2023-12-05 南方医科大学南方医院 长链酰基肉碱类化合物在制备预防和/或治疗肝癌的药物中的应用

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Also Published As

Publication number Publication date
DK1183228T3 (da) 2005-05-17
EP1183228A2 (en) 2002-03-06
PT1426044E (pt) 2006-06-30
TR200202358T2 (tr) 2002-12-23
JP5420507B2 (ja) 2014-02-19
EP1426044B1 (en) 2006-02-08
EP1183228B1 (en) 2005-01-12
CN1359370A (zh) 2002-07-17
HK1045145B (en) 2006-01-27
ATE317257T1 (de) 2006-02-15
AU4312300A (en) 2000-11-14
ES2234591T3 (es) 2005-07-01
ATE286873T1 (de) 2005-01-15
EA200300745A1 (ru) 2003-12-25
HRP20010740A2 (en) 2002-10-31
CA2650202C (en) 2012-12-11
HU229366B1 (en) 2013-11-28
IT1306129B1 (it) 2001-05-30
BG65312B1 (bg) 2008-01-31
NZ515270A (en) 2004-02-27
PL351112A1 (en) 2003-03-24
DE60017388T2 (de) 2006-03-30
TR200102941T2 (tr) 2002-05-21
EE05719B1 (et) 2014-08-15
EE201100028A (et) 2011-08-15
BR0009765B1 (pt) 2013-11-05
US20050079209A1 (en) 2005-04-14
NO20014985L (no) 2001-10-12
KR20060113799A (ko) 2006-11-02
RS50911B (sr) 2010-08-31
SI1426044T1 (sl) 2006-04-30
CA2650202A1 (en) 2000-10-19
RS20090448A (sr) 2010-06-30
DE60017388D1 (de) 2005-02-17
EE200100518A (et) 2002-12-16
NZ528874A (en) 2005-09-30
YU70201A (sh) 2004-07-15
BR0009765A (pt) 2002-01-02
BRPI0017460B1 (pt) 2016-04-19
ITRM990220A1 (it) 2000-10-13
AU2004224958A1 (en) 2004-11-25
SK288246B6 (sk) 2015-03-03
ME00113B (me) 2010-10-10
ZA200109291B (en) 2002-08-16
IL145765A (en) 2007-07-04
IS2539B (is) 2009-09-15
PL204418B1 (pl) 2010-01-29
IL175366A (en) 2010-12-30
CN100402017C (zh) 2008-07-16
AU776301B2 (en) 2004-09-02
BG65501B1 (bg) 2008-10-31
NO20085413L (no) 2001-10-12
US7629003B2 (en) 2009-12-08
US20070190128A1 (en) 2007-08-16
BG105971A (en) 2002-08-30
JP2011042657A (ja) 2011-03-03
US6797281B1 (en) 2004-09-28
KR20010113794A (ko) 2001-12-28
WO2000061543A3 (en) 2001-01-11
EA004459B1 (ru) 2004-04-29
DE60025961T2 (de) 2006-08-17
KR100684378B1 (ko) 2007-02-20
PT1183228E (pt) 2005-04-29
CZ302628B6 (cs) 2011-08-10
SK287253B6 (sk) 2010-04-07
NO336949B1 (no) 2015-11-30
KR100798499B1 (ko) 2008-01-28
IL175366A0 (en) 2006-09-05
US7585519B2 (en) 2009-09-08
JP4703855B2 (ja) 2011-06-15
SK14312001A3 (sk) 2002-02-05
IS2476B (is) 2008-12-15
IL185486A0 (en) 2008-01-06
MXPA01010359A (es) 2002-05-06
US20040186175A1 (en) 2004-09-23
RS52682B (sr) 2013-08-30
WO2000061543A2 (en) 2000-10-19
CN1263730C (zh) 2006-07-12
DE60025961D1 (de) 2006-04-20
CA2370143A1 (en) 2000-10-19
IL145765A0 (en) 2002-07-25
JP2002541238A (ja) 2002-12-03
EA200101076A1 (ru) 2002-04-25
NO20014985D0 (no) 2001-10-12
NO327742B1 (no) 2009-09-14
EE05514B1 (et) 2012-02-15
IS8719A (is) 2008-03-07
PL211710B1 (pl) 2012-06-29
HK1045145A1 (en) 2002-11-15
ES2258688T3 (es) 2006-09-01
DK1426044T3 (da) 2006-06-12
HUP0201446A3 (en) 2002-11-28
EP1426044A1 (en) 2004-06-09
AU2004224958B2 (en) 2007-11-22
CZ20013617A3 (cs) 2002-02-13
HUP0201446A2 (en) 2002-08-28
EA006021B1 (ru) 2005-08-25
HK1092732A1 (en) 2007-02-16
IS6095A (is) 2001-09-28
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