MEP17108A - New heterocyclic compounds, their preparations and their use as medicaments, in particular as anti-bacterial agents - Google Patents

New heterocyclic compounds, their preparations and their use as medicaments, in particular as anti-bacterial agents

Info

Publication number
MEP17108A
MEP17108A MEP-171/08A MEP17108A MEP17108A ME P17108 A MEP17108 A ME P17108A ME P17108 A MEP17108 A ME P17108A ME P17108 A MEP17108 A ME P17108A
Authority
ME
Montenegro
Prior art keywords
medicaments
heterocyclic compounds
preparations
bacterial agents
new heterocyclic
Prior art date
Application number
MEP-171/08A
Other languages
Bosnian (bs)
English (en)
Inventor
Maxime Lampilas
Jozsef Aszodi
David Alan Rowlands
Claude Fromentin
Original Assignee
Novexel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8853181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP17108(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novexel filed Critical Novexel
Publication of MEP17108A publication Critical patent/MEP17108A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MEP-171/08A 2000-08-01 2001-07-24 New heterocyclic compounds, their preparations and their use as medicaments, in particular as anti-bacterial agents MEP17108A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0010121A FR2812635B1 (fr) 2000-08-01 2000-08-01 Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
YU6303A RS50214B (sr) 2000-08-01 2001-07-24 Nova heterociklična jedinjenja, njihovo dobijanje i njihova upotreba kao medikamenata, a naročito kao anti-bakterijskih agenasa
PCT/FR2001/002418 WO2002010172A1 (fr) 2000-08-01 2001-07-24 Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens

Publications (1)

Publication Number Publication Date
MEP17108A true MEP17108A (en) 2010-06-10

Family

ID=8853181

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-2008-171A ME00060B (me) 2000-08-01 2001-07-24 Nova heterociklična jedinjenja, njihovo dobijanje i njihova upotreba kao medikamenata, a naročito kao anti-bakterijskih agenasa
MEP-171/08A MEP17108A (en) 2000-08-01 2001-07-24 New heterocyclic compounds, their preparations and their use as medicaments, in particular as anti-bacterial agents

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MEP-2008-171A ME00060B (me) 2000-08-01 2001-07-24 Nova heterociklična jedinjenja, njihovo dobijanje i njihova upotreba kao medikamenata, a naročito kao anti-bakterijskih agenasa

Country Status (42)

Country Link
US (5) US7112592B2 (me)
EP (1) EP1307457B1 (me)
JP (2) JP4515704B2 (me)
KR (1) KR100632906B1 (me)
CN (1) CN1289500C (me)
AP (1) AP1614A (me)
AR (1) AR031716A1 (me)
AT (1) ATE263768T1 (me)
AU (2) AU2001279905B2 (me)
BG (1) BG66094B1 (me)
BR (1) BRPI0112986B8 (me)
CA (1) CA2417475C (me)
CR (1) CR6895A (me)
CZ (1) CZ294956B6 (me)
DE (1) DE60102702T2 (me)
DK (1) DK1307457T3 (me)
DZ (1) DZ3397A1 (me)
EA (1) EA004920B1 (me)
EC (1) ECSP034460A (me)
EE (1) EE05183B1 (me)
ES (1) ES2220793T3 (me)
FR (1) FR2812635B1 (me)
HK (1) HK1060356A1 (me)
HR (1) HRP20030034B1 (me)
HU (1) HU226889B1 (me)
IL (2) IL154187A0 (me)
MA (1) MA26938A1 (me)
ME (2) ME00060B (me)
MX (1) MXPA03000881A (me)
NO (1) NO324940B1 (me)
NZ (1) NZ523707A (me)
OA (1) OA12347A (me)
PL (2) PL216028B1 (me)
PT (1) PT1307457E (me)
RS (1) RS50214B (me)
SI (1) SI1307457T1 (me)
SK (1) SK287597B6 (me)
TR (1) TR200400859T4 (me)
TW (1) TWI292401B (me)
UA (1) UA73791C2 (me)
WO (1) WO2002010172A1 (me)
ZA (1) ZA200300676B (me)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
PL1965798T3 (pl) 2005-12-07 2012-02-29 Basilea Pharmaceutica Ag Użyteczne antybiotyki monobaktamowe
US7906619B2 (en) 2006-07-13 2011-03-15 Achillion Pharmaceuticals, Inc. 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
WO2008008398A2 (en) * 2006-07-14 2008-01-17 Shionogi & Co., Ltd. Oxime compounds and the use thereof
AU2007300531A1 (en) * 2006-09-27 2008-04-03 Merck Sharp & Dohme Corp. Novel inhibitors of beta-lactamase
AU2007309195A1 (en) * 2006-10-23 2008-05-02 Irm Llc Cathepsin proteases inhibitors
WO2008093737A1 (ja) 2007-01-31 2008-08-07 Dainippon Sumitomo Pharma Co., Ltd. アミド誘導体
FR2914923B1 (fr) * 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
WO2008150470A1 (en) 2007-05-31 2008-12-11 Shionogi & Co., Ltd. Oxyimino compounds and the use thereof
FR2921060B1 (fr) * 2007-09-14 2012-06-15 Novexel Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires
CA2712783C (en) 2008-01-18 2013-03-19 Timothy A. Blizzard Beta-lactamase inhibitors
WO2009151152A1 (en) 2008-06-11 2009-12-17 Shionogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof
EP2921559A1 (en) 2008-06-19 2015-09-23 Astra Zeneca Holding France Use of (1r,2s,5r) 1,6-diazabicyclo [3.2.1]octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, monosodium salt as a diagnostic reagent for detecting serine beta-lactamases
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
US20120053350A1 (en) * 2009-04-30 2012-03-01 Ian Mangion Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
US8658639B2 (en) 2009-06-24 2014-02-25 Dainippon Sumitomo Pharma Co., Ltd N-substituted-cyclic amino derivative
FR2951171A1 (fr) 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
DK2657234T3 (da) * 2010-12-22 2017-02-20 Meiji Seika Pharma Co Ltd Optisk aktivt diazabicyclooctanderivat og fremgangsmåde til fremstilling heraf
EP2721005B1 (en) * 2011-06-17 2015-11-25 AstraZeneca AB Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
CN103619843B (zh) * 2011-08-27 2017-01-11 沃克哈特有限公司 1，6‑二氮杂双环[3，2，1]辛‑7‑酮衍生物及其在治疗细菌感染中的用途
AU2012303693B2 (en) * 2011-08-30 2014-07-03 Wockhardt Limited 1,6- diazabicyclo [3,2,1] octan- 7 - one derivatives and their use in the treatment of bacterial infections
US8969567B2 (en) 2011-09-13 2015-03-03 Wockhardt Ltd. Nitrogen containing compounds and their use
AU2012310136B2 (en) 2011-09-13 2016-07-07 Wockhardt Limited Nitrogen containing compounds and their use
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
US9505761B2 (en) 2011-12-02 2016-11-29 Fedora Pharmaceuticals Inc. Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors
US8969570B2 (en) 2012-03-30 2015-03-03 Cubist Pharmaceuticals, Inc. Beta-lactamase inhibitors
US8916709B2 (en) 2012-03-30 2014-12-23 Cubist Pharmaceuticals, Inc. 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors
TW201343645A (zh) 2012-03-30 2013-11-01 Cubist Pharm Inc １，３，４－□二唑及１，３，４－噻二唑β－內醯胺酶抑制劑
EP2831069B1 (en) 2012-03-30 2017-07-12 Merck Sharp & Dohme Corp. Isoxazole beta-lactamase inhibitors
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
AR091222A1 (es) 2012-05-30 2015-01-21 Meiji Seika Pharma Co Ltd INHIBIDOR DE b-LACTAMASA Y PROCESO PARA PREPARARLO
KR101946107B1 (ko) * 2012-08-25 2019-02-08 욱크하르트 리미티드 １,６-디아자비시클로〔３,２,１〕옥탄-７-온 유도체 및 세균 감염의 치료에서의 이의 용도
JPWO2014069351A1 (ja) 2012-11-01 2016-09-08 株式会社カネカ 光学活性二環式ウレア化合物の製造方法
UA111925C2 (uk) 2012-12-11 2016-06-24 Федора Фармасьютікалз Інк. БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ
IN2015DN02381A (me) 2013-02-19 2015-09-04 Api Corp
JP6285968B2 (ja) * 2013-03-08 2018-02-28 ウォックハート リミテッド （２ｓ，５ｒ）−６−ベンジルオキシ−７−オキソ−１，６−ジアザ−ビシクロ［３．２．１］オクタン−２−カルボン酸のナトリウム塩およびその調製
AU2013380573B2 (en) * 2013-03-08 2016-07-07 Wockhardt Limited A process for sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane
US9120795B2 (en) 2013-03-14 2015-09-01 Cubist Pharmaceuticals, Inc. Crystalline form of a β-lactamase inhibitor
JP6427173B2 (ja) * 2013-06-10 2018-11-21 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ｔｅｒｔ−ブチル ４−（（１Ｒ，２Ｓ，５Ｒ）−６−（ベンジルオキシ）−７−オキソ−１，６−ジアザビシクロ［３．２．１］オクタン−２−カルボキサミド）ピペリジン−１−カルボキシレートの調製
JP6453222B2 (ja) 2013-09-24 2019-01-16 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ジアザビシクロオクタン誘導体の製造法とその中間体
US9120796B2 (en) 2013-10-02 2015-09-01 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
NZ757220A (en) * 2013-10-08 2021-12-24 Meiji Seika Pharma Co Ltd Crystalline forms of diazabicyclooctane derivative and production process thereof
MX2016004509A (es) 2013-10-11 2016-10-28 Wockhardt Ltd Compuestos que contienen nitrogeno y su uso.
EP3096754B1 (en) 2014-01-22 2018-08-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
WO2015171474A1 (en) 2014-05-09 2015-11-12 Merck Sharp & Dohme Corp. Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
CN107108624B (zh) 2014-11-17 2020-01-07 恩塔西斯治疗有限公司 用于治疗耐药性细菌感染的组合疗法
EP3227306B1 (en) 2014-12-02 2020-07-15 Merck Sharp & Dohme Corp. Process for the preparation of tert-butyl 4-((2s,5r)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate and analogs thereof
MX2017007191A (es) 2014-12-05 2017-08-28 Meiji Seika Pharma Co Ltd Procedimiento de produccion de cristales de derivado de diazabiciclooctano y preparacion liofilizada estable.
US10667737B2 (en) 2015-03-23 2020-06-02 International Business Machines Corporation Monitoring a person for indications of a brain injury
CN107580595B (zh) * 2015-05-07 2020-09-18 拜欧蒂姆公司 杂环化合物及它们在预防或治疗细菌感染中的应用
EP3091018A1 (en) * 2015-05-07 2016-11-09 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
WO2016206101A1 (en) 2015-06-26 2016-12-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
WO2017002087A1 (en) 2015-07-02 2017-01-05 Wockhardtlimited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002089A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002083A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002086A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
CN107922411B (zh) 2015-08-10 2021-07-02 桑多斯股份公司 阿维巴坦钠的晶型c
WO2017037607A1 (en) 2015-09-01 2017-03-09 Wockhardt Limited (aminomethylidene)amino-substituted (2s,5r)-6-(sulfonyl)-7-oxo-1,6-diazabicyclo[3.2.1 ]octane-2-carboxamide derivatives with antibacterial activity
JP2018515481A (ja) 2015-09-16 2018-06-14 シュアンチュー ファーマ カンパニー，リミティド β−ラクタマーゼ阻害剤とその利用
CA3000087A1 (en) 2015-10-02 2017-04-06 Legochem Biosciences, Inc. Compositions and methods for inhibiting beta-lactamase
WO2017057730A1 (ja) 2015-10-02 2017-04-06 株式会社エーピーアイ コーポレーション ヒドロキシ－ｌ－ピペコリン酸の製造方法
WO2017081615A1 (en) 2015-11-09 2017-05-18 Wockhardt Limited 7-oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections
CN106749242B (zh) * 2015-11-23 2021-04-02 上海医药工业研究院 阿维巴坦中间体的制备方法
EP3411359B1 (en) 2016-02-04 2021-10-13 Merck Sharp & Dohme Corp. Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents
CN105753867B (zh) * 2016-03-24 2018-03-27 齐鲁制药有限公司 一种改进的阿维巴坦钠中间体化合物的制备方法
EP3156400B1 (en) 2016-05-27 2019-05-15 Valoralia I Más D, SL Dihydrooxadiazine compounds for treating infections and cancer
CN106279163A (zh) * 2016-08-12 2017-01-04 上海龙翔生物医药开发有限公司 一种合成阿维巴坦及其中间体光学异构体的方法
JP7183147B2 (ja) * 2016-08-26 2022-12-05 サンド アクツィエンゲゼルシャフト アビバクタム遊離酸
LT3512851T (lt) 2016-09-16 2022-10-25 Entasis Therapeutics Limited Beta-laktamazės inhibitorių junginiai
JOP20190061A1 (ar) 2016-09-28 2019-03-26 Novartis Ag مثبطات بيتا-لاكتاماز
EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
CN106699756B (zh) * 2016-12-30 2019-10-29 淄博鑫泉医药技术服务有限公司 β内酰胺酶抑制剂阿维巴坦的合成方法
MX2019009362A (es) * 2017-02-06 2019-10-22 Mutabilis Compuestos heterociclicos novedosos y sus usos en la prevencion o el tratamiento de infecciones bacterianas.
ES2907858T3 (es) 2017-05-08 2022-04-26 Entasis Therapeutics Inc Compuestos y métodos para el tratamiento de infecciones bacterianas
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
WO2018234962A1 (en) 2017-06-20 2018-12-27 Wockhardt Limited PROCESS FOR O-SULFONATION OF 1,6-DIAZABICYCLO [3.2.1] OCTANE COMPOUNDS
EP3654968B1 (en) 2017-07-17 2023-08-16 Merck Sharp & Dohme LLC Metallo-beta-lactamase inhibitors and methods of use thereof
BR112020006594A2 (pt) 2017-10-02 2020-12-15 Arixa Pharmaceuticals, Inc. Derivados de aztreonam e usos dos mesmos
CN109678856B (zh) * 2017-10-18 2020-09-25 新发药业有限公司 一种阿维巴坦中间体的制备方法
JP7289836B2 (ja) 2017-11-23 2023-06-12 エフ． ホフマン－ラ ロシュ アーゲー プロリンヒドロキシラーゼ、ならびにそれに伴う使用、方法および生成物
CN109956941B (zh) * 2017-12-25 2020-08-04 新发药业有限公司 一种阿维巴坦的简便制备方法
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
US11180500B2 (en) 2018-10-01 2021-11-23 Arixa Pharmaceuticals, Inc. Derivatives of relebactam and uses thereof
CN111072660B (zh) * 2018-10-22 2021-05-18 新发药业有限公司 一种瑞来巴坦的简便制备方法
MX2021011026A (es) 2019-03-12 2021-10-13 Arixa Pharmaceuticals Inc Forma cristalina de un derivado de avibactam.
WO2020219258A1 (en) 2019-04-25 2020-10-29 Arixa Pharmaceuticals, Inc. Methods of synthesizing aztreonam derivatives
CN110078728B (zh) * 2019-05-23 2020-10-23 江西富祥药业股份有限公司 一种阿维巴坦中间体、制备方法及其应用
WO2021106864A1 (en) * 2019-11-25 2021-06-03 Eisai R&D Management Co., Ltd. Process for the preparation of producing pyrazolo[1,5-a] pyrimidine derivatives
US11814385B2 (en) 2021-06-25 2023-11-14 University Of South Florida Small molecule inhibitors targeting Clostridioides difficile sporulation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4939678B1 (me) * 1968-05-06 1974-10-28
US4024147A (en) * 1972-06-30 1977-05-17 John Wyeth & Brother Limited Heterocyclic compounds
US4049821A (en) * 1976-05-12 1977-09-20 A. H. Robins Company, Inc. Method of treating allergy
JPS63119471A (ja) * 1986-09-02 1988-05-24 ザ・ユニバーシテイ・オブ・メルボルン ２−オキソ−４−カルボキシ−ピリミジン
EP0260057A3 (en) * 1986-09-02 1989-02-01 The University Of Melbourne 2-oxo-4-carboxy-pyrimidines
PL179435B1 (pl) * 1993-12-29 2000-09-29 Pfizer Diazabicykliczni antagonisci neurokininy PL
TW358097B (en) * 1996-05-24 1999-05-11 Hoffmann La Roche Beta-lactams and their process and pharmaceutical compositions
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
UA64740C2 (uk) * 1997-02-10 2004-03-15 Пфайзер Продактс Інк. Похідні 2-амінопіридинів, фармацевтична композиція на їх основі (варіанти), спосіб лікування (варіанти), спосіб інгібування nos у ссавця та проміжні сполуки (варіанти)
US6060585A (en) * 1997-03-04 2000-05-09 Wisconsin Alumni Research Foundation β-polypeptide foldamers of well-defined secondary structure
KR100207096B1 (ko) * 1997-07-08 1999-07-15 이명환 시사프라이드의 제조 방법
JP2001508811A (ja) * 1998-04-20 2001-07-03 藤沢薬品工業株式会社 ｃＧＭＰ−ホスホジエステラーゼ阻害剤としてのアントラニル酸誘導体
GB9817029D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
FR2784682B1 (fr) * 1998-10-15 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments
ES2226485T3 (es) * 1998-12-23 2005-03-16 Eli Lilly And Company Amidas aromaticas.
KR20010101355A (ko) * 1999-01-02 2001-11-14 로버트 흐라이탁, 미쉘 베스트 신규한 말론산 유도체, 이의 제조 방법, 이의 용도 및이를 함유하는 약제학적 조성물(인자 ｘａ 활성 억제)
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

Also Published As

Publication number Publication date
YU6303A (sh) 2006-03-03
FR2812635A1 (fr) 2002-02-08
ZA200300676B (en) 2004-05-10
BR0112986B1 (pt) 2014-04-01
KR100632906B1 (ko) 2006-10-13
US20060046995A1 (en) 2006-03-02
PL216028B1 (pl) 2014-02-28
IL154187A (en) 2009-02-11
HRP20030034B1 (en) 2011-03-31
AU2001279905B2 (en) 2005-12-08
EP1307457B1 (fr) 2004-04-07
CA2417475C (en) 2010-04-20
US7638529B2 (en) 2009-12-29
EP1307457A1 (fr) 2003-05-07
RS50214B (sr) 2009-07-15
CA2417475A1 (fr) 2002-02-07
EE200300046A (et) 2004-10-15
US20030199541A1 (en) 2003-10-23
NZ523707A (en) 2005-02-25
BG107497A (bg) 2003-09-30
UA73791C2 (uk) 2005-09-15
US20110213147A1 (en) 2011-09-01
HRP20030034A2 (en) 2004-02-29
US20110021772A1 (en) 2011-01-27
PL234468B1 (pl) 2020-02-28
PT1307457E (pt) 2004-08-31
AP2003002726A0 (en) 2003-06-30
TWI292401B (en) 2008-01-11
AR031716A1 (es) 2003-10-01
DZ3397A1 (fr) 2002-02-07
BG66094B1 (bg) 2011-04-29
ATE263768T1 (de) 2004-04-15
MA26938A1 (fr) 2004-12-20
EA004920B1 (ru) 2004-10-28
TR200400859T4 (tr) 2004-06-21
BR0112986A (pt) 2003-07-08
JP2010138206A (ja) 2010-06-24
DK1307457T3 (da) 2004-08-09
HK1060356A1 (en) 2004-08-06
ECSP034460A (es) 2003-03-10
HUP0302943A2 (hu) 2003-12-29
NO20030494D0 (no) 2003-01-31
PL401469A1 (pl) 2013-02-04
SI1307457T1 (en) 2004-08-31
KR20030019642A (ko) 2003-03-06
HU226889B1 (en) 2010-01-28
CN1289500C (zh) 2006-12-13
CZ294956B6 (cs) 2005-04-13
SK1052003A3 (en) 2003-11-04
CR6895A (es) 2007-07-12
CZ2003223A3 (cs) 2003-08-13
US20060189652A1 (en) 2006-08-24
ES2220793T3 (es) 2004-12-16
SK287597B6 (sk) 2011-03-04
DE60102702T2 (de) 2005-04-07
JP4515704B2 (ja) 2010-08-04
EA200300211A1 (ru) 2003-06-26
JP2004505088A (ja) 2004-02-19
AU7990501A (en) 2002-02-13
CN1468242A (zh) 2004-01-14
ME00060B (me) 2010-06-10
BRPI0112986B8 (pt) 2021-05-25
OA12347A (fr) 2006-05-15
AP1614A (en) 2006-05-21
NO20030494L (no) 2003-03-28
US7112592B2 (en) 2006-09-26
FR2812635B1 (fr) 2002-10-11
US7732610B2 (en) 2010-06-08
HUP0302943A3 (en) 2007-08-28
WO2002010172A1 (fr) 2002-02-07
IL154187A0 (en) 2003-07-31
PL365162A1 (en) 2004-12-27
DE60102702D1 (de) 2004-05-13
NO324940B1 (no) 2008-01-07
MXPA03000881A (es) 2003-06-06
US8178554B2 (en) 2012-05-15
EE05183B1 (et) 2009-06-15

Similar Documents

Publication Publication Date Title
MEP17108A (en) New heterocyclic compounds, their preparations and their use as medicaments, in particular as anti-bacterial agents
MEP7808A (en) Process for preparing 4-trifluoromethylsulphinylpyrazole derivative
YU49195A (sh) 5-člani heteroaril-oksazolidinoni, njihova upotreba za dobijanje lekova kao i lekovi koji ih sadrže
MEP9309A (en) Novel oligosaccharides, preparation method and pharmaceutical compositions containing the same
BRPI0109200B8 (pt) compostos e composições farmacêuticas
MX9604020A (es) Arilalquildiazinonas.
MEP39908A (en) Novel anticholinergic agents that can be used as medicaments and method for the production thereof
NO20074657L (no) Nitrogenholdige aromatiske ringforbindelser
EE03869B1 (et) Sulfiinhappe derivaadid, nende valmistamine ja kasutamine
MEP10408A (en) Platinum derivative pharmaceutical formulations
ME00155B (me) 5-SUPSTITUISANI HINOLIN I IZOHINOLIN DERIVATI, POSTUPAK NJIHOVE PROIZVODNJE l NJIHOVA UPOTREBA KAO ANTI-INFLAMATORNIH SREDSTAVA
MXPA02011370A (es) Iminoazinas substituidas.
YU56302A (sh) Derivati 8,8a-dihidro-indeno/1,2-d/taizola, koji su supstituisani u 8a-položaju,postupak za njihovu proizvodnju i njihova primena kod leka npr.kao anorektičnog sredstva
YU21701A (sh) Farmaceutska sredstva za lečenje parkinsonove bolesti, poremećaja nekontrolisane hiperaktivnosti (adhd) i mikroadenoma
ME00467B (me) 13-točlani azalidi i njihova primena kao antibiotičkih sredstava
MXPA02012910A (es) Amidas de acidobifenilcarboxilico, su preparacion y su uso como medicinas.
YU44301A (sh) 5ht1 antagonisti za antidepresantnu terapiju
BR0015333A (pt) Derivados de isoxazol como inibidores de fosfodiesterase vii
MXPA04001773A (es) Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos.
YU37597A (en) New pyranosid derivatives
HRP20040662B1 (hr) Sulfonamidi koji sadrže heterociklički supstituirani fenil kao inhibitori hiv proteaze širokog spektra
YU238990A (sh) Imidazo (4,5-c) piridini kao antiostereoporozna sredstva
YU74401A (sh) Postupak za dobijanje 2s-3-amino-3-arilpropionske kiseline i njenih derivata
SE0004099D0 (sv) Novel compounds
BR9913601A (pt) Composto, uso do mesmo, composição farmacêutica, e, processo para a preparação de compostos