YU238990A - Imidazo (4,5-c) piridini kao antiostereoporozna sredstva - Google Patents

Imidazo (4,5-c) piridini kao antiostereoporozna sredstva

Info

Publication number
YU238990A
YU238990A YU238990A YU238990A YU238990A YU 238990 A YU238990 A YU 238990A YU 238990 A YU238990 A YU 238990A YU 238990 A YU238990 A YU 238990A YU 238990 A YU238990 A YU 238990A
Authority
YU
Yugoslavia
Prior art keywords
formula
compound
pyridines
imidazo
antiostereoporous
Prior art date
Application number
YU238990A
Other languages
English (en)
Inventor
A.A. Santilli
A.C. Scotese
D.P. Strike
Original Assignee
American Home Products Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Co. filed Critical American Home Products Co.
Publication of YU238990A publication Critical patent/YU238990A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

IMIDAZO (4,5-C) PIRIDINI KAO ANTIOSTEREOPOROZNA SREDSTVA, pronalazak se odnosi na nove imidazo (4,5-c)piridine formule (I): u kojoj R1, R2, R3, R4 i R5 predstavljaju vodonik, alkil, hidroksi, alkiloksi, halogen, trifluorometil, trifluorometoksi, nitro, cijano, fenoksi, benziloksi, aminoacetil, -S(O)p-CH3, ili dve susedne grupe formiraju metilendioksi, m=O-2; n=1-3; p=O-2, i njihove farmaceutski prihvatljive soli, kao i na postupak za dobijanje ovih jedinjenja koji obuhvata reakciju jedinjenja formule (A) sa jedinjenjem formule (B) u kojoj R1-R5 i n imaju gornja značenja, a X je halogen ili tozil, tako da se dobija sulfidno jedinjenje formule (I): u kojoj su R1-R5 i n definisani kao gore i m=O, pa se ovaj sulfid po potrebi oskiduje i dobija jedinjenje formule (I) gde je m=1 i 2.
YU238990A 1989-12-21 1990-12-19 Imidazo (4,5-c) piridini kao antiostereoporozna sredstva YU238990A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45455689A 1989-12-21 1989-12-21
US07/557,247 US5081253A (en) 1989-12-21 1990-07-24 Imidazo(4,5-c)pyridines as antiosteoporotic agents

Publications (1)

Publication Number Publication Date
YU238990A true YU238990A (sh) 1993-10-20

Family

ID=27037512

Family Applications (1)

Application Number Title Priority Date Filing Date
YU238990A YU238990A (sh) 1989-12-21 1990-12-19 Imidazo (4,5-c) piridini kao antiostereoporozna sredstva

Country Status (17)

Country Link
US (1) US5081253A (sh)
EP (1) EP0434405A1 (sh)
JP (1) JPH0551382A (sh)
KR (1) KR910011853A (sh)
CN (1) CN1058594A (sh)
AU (1) AU630531B2 (sh)
BR (1) BR9006502A (sh)
CA (1) CA2032445A1 (sh)
FI (1) FI906270A (sh)
GB (1) GB2239240B (sh)
HU (1) HUT56843A (sh)
IE (1) IE904622A1 (sh)
IL (1) IL96589A0 (sh)
NZ (1) NZ236564A (sh)
PH (1) PH27491A (sh)
PT (1) PT96251A (sh)
YU (1) YU238990A (sh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018035A1 (en) * 1992-03-04 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
US5288871A (en) * 1993-08-02 1994-02-22 American Home Products Corporation Antiosteoporotic imidazo[4,5-c]pyridines
US5635514A (en) * 1994-10-25 1997-06-03 G. D. Searle & Company Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as 5-lipoxgenase inhibitors
US5571819A (en) * 1994-11-22 1996-11-05 Sabb; Annmarie L. Imidazopyridines as muscarinic agents
US5723468A (en) * 1995-10-03 1998-03-03 American Home Products Corporation 6-membered ring fused imidazoles as muscarinic agents
TWI322807B (en) * 2002-01-07 2010-04-01 Eisai R&D Man Co Ltd Novel deazapurines and uses thereof
DK1474425T3 (da) 2002-01-07 2006-09-25 Eisai Co Ltd Deazapuriner og anvendelser deraf
EP3658138B1 (en) * 2017-07-27 2023-04-19 Stingray Therapeutics, Inc. Substituted-3h-imidazo(4,5-c)pyridine and 1h-pyrrolo(2,3-c)pyridine series of novel ectonucleotide pyrophsphatase/phosphodiestrase-1 (enpp1) and stimulator for interferon genes (sting) modulator as cancer immunotherapeutics
CN112996496A (zh) 2018-08-01 2021-06-18 斯汀格瑞治疗股份有限公司 作为癌症免疫疗法的新型外核苷酸焦磷酸酶/磷酸二酯酶-1(ENPP1)和干扰素基因刺激物(STING)调节剂的经取代的-3H-咪唑并[4,5-c]吡啶和1H-吡咯并[2,3-c]吡啶系列

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187977B1 (en) * 1984-12-18 1990-08-29 Otsuka Pharmaceutical Co., Ltd. Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same
KR950001015B1 (ko) * 1986-01-10 1995-02-07 닛뽕 케미화 가부시끼가이샤 술폭시드 유도체의 제조방법
JP2566220B2 (ja) * 1986-01-27 1996-12-25 キヤノン株式会社 情報処理装置
WO1989003830A1 (en) * 1987-10-30 1989-05-05 Aktiebolaget Hässle 2-pyridinylmethyl (sulfinyl or thio)benzimidazoles for treatment of diseases related to bone loss
SE8704248D0 (sv) * 1987-10-30 1987-10-30 Haessle Ab Medical use
EP0322149A2 (en) * 1987-12-22 1989-06-28 Eli Lilly And Company Hydrates of an inotropic agent

Also Published As

Publication number Publication date
FI906270A (fi) 1991-06-22
CA2032445A1 (en) 1991-06-22
US5081253A (en) 1992-01-14
HUT56843A (en) 1991-10-28
GB2239240B (en) 1993-08-18
JPH0551382A (ja) 1993-03-02
BR9006502A (pt) 1991-10-01
AU6831790A (en) 1991-06-27
PH27491A (en) 1993-07-23
PT96251A (pt) 1991-09-30
CN1058594A (zh) 1992-02-12
GB2239240A (en) 1991-06-26
FI906270A0 (fi) 1990-12-19
GB9027494D0 (en) 1991-02-06
IL96589A0 (en) 1991-09-16
EP0434405A1 (en) 1991-06-26
AU630531B2 (en) 1992-10-29
KR910011853A (ko) 1991-08-07
HU908400D0 (en) 1991-07-29
NZ236564A (en) 1992-11-25
IE904622A1 (en) 1991-07-17

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