ME03043B - Irnk sastavi komponente komplementa c5 i metode za njihovu upotrebu - Google Patents

Irnk sastavi komponente komplementa c5 i metode za njihovu upotrebu

Info

Publication number
ME03043B
ME03043B MEP-2017-268A MEP2017268A ME03043B ME 03043 B ME03043 B ME 03043B ME P2017268 A MEP2017268 A ME P2017268A ME 03043 B ME03043 B ME 03043B
Authority
ME
Montenegro
Prior art keywords
irnk
assembles
methods
complement components
complement
Prior art date
Application number
MEP-2017-268A
Other languages
German (de)
English (en)
French (fr)
Unknown language (me)
Inventor
Kevin Fitzgerald
James Butler
Brian Bettencourt
Anna Borodovsky
Satyanarayana Kuchimanchi
Klaus Charisse
Muthiah Manoharan
Martin Maier
Kallanthottathil G Rajeev
Donald Foster
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of ME03043B publication Critical patent/ME03043B/me

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
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    • A61K31/713Double-stranded nucleic acids or oligonucleotides
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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MEP-2017-268A 2013-03-14 2014-03-13 Irnk sastavi komponente komplementa c5 i metode za njihovu upotrebu ME03043B (me)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361782531P 2013-03-14 2013-03-14
US201361837399P 2013-06-20 2013-06-20
US201361904579P 2013-11-15 2013-11-15
US201361912777P 2013-12-06 2013-12-06
US201461942367P 2014-02-20 2014-02-20
PCT/US2014/025882 WO2014160129A2 (en) 2013-03-14 2014-03-13 Complement component c5 irna compositions and methods of use thereof
EP14722018.0A EP2970974B1 (en) 2013-03-14 2014-03-13 Complement component c5 irna compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
ME03043B true ME03043B (me) 2018-10-20

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Application Number Title Priority Date Filing Date
MEP-2017-268A ME03043B (me) 2013-03-14 2014-03-13 Irnk sastavi komponente komplementa c5 i metode za njihovu upotrebu

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US (7) US9249415B2 (OSRAM)
EP (3) EP4649950A2 (OSRAM)
JP (5) JP6524060B2 (OSRAM)
KR (3) KR102605775B1 (OSRAM)
CN (3) CN120574828A (OSRAM)
AU (4) AU2014244116B9 (OSRAM)
BR (1) BR112015022876B1 (OSRAM)
CA (2) CA3216595A1 (OSRAM)
CL (4) CL2015002710A1 (OSRAM)
CR (1) CR20150493A (OSRAM)
CY (1) CY1120289T1 (OSRAM)
DK (1) DK2970974T3 (OSRAM)
DO (1) DOP2015000234A (OSRAM)
EA (1) EA201591707A1 (OSRAM)
ES (1) ES2649490T3 (OSRAM)
GT (1) GT201500293A (OSRAM)
HK (1) HK1252501A1 (OSRAM)
HR (1) HRP20171813T1 (OSRAM)
HU (1) HUE034987T2 (OSRAM)
IL (3) IL288931B2 (OSRAM)
LT (1) LT2970974T (OSRAM)
ME (1) ME03043B (OSRAM)
MX (2) MX418589B (OSRAM)
MY (1) MY201504A (OSRAM)
NZ (1) NZ712336A (OSRAM)
PE (2) PE20160046A1 (OSRAM)
PL (1) PL2970974T3 (OSRAM)
PT (1) PT2970974T (OSRAM)
RS (1) RS56663B1 (OSRAM)
SG (3) SG11201507400SA (OSRAM)
SI (1) SI2970974T1 (OSRAM)
SM (1) SMT201700552T1 (OSRAM)
TW (5) TWI660731B (OSRAM)
UY (2) UY40039A (OSRAM)
WO (1) WO2014160129A2 (OSRAM)

Families Citing this family (70)

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US9228186B2 (en) 2002-11-14 2016-01-05 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
US9879266B2 (en) 2002-11-14 2018-01-30 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
FI3366775T4 (fi) 2011-11-18 2025-11-14 Alnylam Pharmaceuticals Inc Modifioituja rnai-agensseja
KR102605775B1 (ko) 2013-03-14 2023-11-29 알닐람 파마슈티칼스 인코포레이티드 보체 성분 C5 iRNA 조성물 및 그 이용 방법
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CA2904654A1 (en) 2014-10-02
AU2023200132B2 (en) 2025-07-24
SI2970974T1 (sl) 2017-12-29
KR102342916B1 (ko) 2021-12-24
WO2014160129A2 (en) 2014-10-02
JP2025160304A (ja) 2025-10-22
US20160244763A1 (en) 2016-08-25
EP4649950A2 (en) 2025-11-19
IL265594B (en) 2022-01-01
JP2016518331A (ja) 2016-06-23
JP6524060B2 (ja) 2019-06-05
CN105324485B (zh) 2021-11-23
AU2020204161B2 (en) 2022-10-13
KR20210034124A (ko) 2021-03-29
AU2014244116B2 (en) 2020-03-26
WO2014160129A3 (en) 2014-12-04
US20240271136A1 (en) 2024-08-15
HK1221484A1 (zh) 2017-06-02
US20220090068A1 (en) 2022-03-24
US20170268005A1 (en) 2017-09-21
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CN120574828A (zh) 2025-09-02
JP7717783B2 (ja) 2025-08-04
DK2970974T3 (en) 2017-12-04
SG10201700239UA (en) 2017-02-27
DOP2015000234A (es) 2015-12-31
LT2970974T (lt) 2017-12-11
CL2019000107A1 (es) 2020-04-03
CL2017002014A1 (es) 2018-04-27
IL288931B1 (en) 2025-01-01
EA201591707A1 (ru) 2016-03-31
EP2970974A2 (en) 2016-01-20
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HK1252501A1 (en) 2019-05-31
HRP20171813T1 (hr) 2017-12-29
NZ712336A (en) 2020-03-27
HUE034987T2 (en) 2018-05-02
PE20211393A1 (es) 2021-07-27
AU2014244116B9 (en) 2020-08-13
KR102234620B1 (ko) 2021-04-05
US20200032259A1 (en) 2020-01-30
CA3216595A1 (en) 2014-10-02
PT2970974T (pt) 2017-11-29
CN114015692B (zh) 2024-12-31
TW202118875A (zh) 2021-05-16
EP2970974B1 (en) 2017-08-23
EP3312281A2 (en) 2018-04-25
EP3312281A3 (en) 2018-06-27
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CL2015002710A1 (es) 2016-04-22

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