DOP2015000234A - COMPOSICIONES DE ARNi CONTRA EL COMPONENTE C5 DEL COMPLEMENTO Y METODOS PARA SU USO. - Google Patents

COMPOSICIONES DE ARNi CONTRA EL COMPONENTE C5 DEL COMPLEMENTO Y METODOS PARA SU USO.

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Publication number
DOP2015000234A
DOP2015000234A DO2015000234A DO2015000234A DOP2015000234A DO P2015000234 A DOP2015000234 A DO P2015000234A DO 2015000234 A DO2015000234 A DO 2015000234A DO 2015000234 A DO2015000234 A DO 2015000234A DO P2015000234 A DOP2015000234 A DO P2015000234A
Authority
DO
Dominican Republic
Prior art keywords
arni
complement
methods
component
compositions against
Prior art date
Application number
DO2015000234A
Other languages
English (en)
Inventor
Satyanarayana Kuchimanchi
Muthiah Manoharan
Kevin Fitzgerald
James Butler
Brian Bettencourt
Anna Borodovsky
Klaus Charisse
Martin Maier
Kallanthottathil Rajeev
Donald Foster
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of DOP2015000234A publication Critical patent/DOP2015000234A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract

LA INVENCIÓN SE RELACIONA CON ARNI, POR EJEMPLO, COMPOSICIONES DE ÁCIDO RIBONUCLEICO DE HEBRA DOBLE (ARNHD), DIRIGIDAS AL GEN DEL COMPONENTE C5 DEL COMPLEMENTO, Y MÉTODOS PARA USAR DICHO ARNI, POR EJEMPLO, ARNHD, COMPOSICIONES PARA INHIBIR LA EXPRESIÓN DE C5 Y PARA TRATAR SUJETOS QUE TIENEN UNA ENFERMEDAD ASOCIADA CON EL COMPONENTE C5 DEL COMPLEMENTO, POR EJEMPLO, HEMOGLOBINURIA PAROXÍSTICA NOCTURNA. C12N 15/113
DO2015000234A 2013-03-14 2015-09-14 COMPOSICIONES DE ARNi CONTRA EL COMPONENTE C5 DEL COMPLEMENTO Y METODOS PARA SU USO. DOP2015000234A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361782531P 2013-03-14 2013-03-14
US201361837399P 2013-06-20 2013-06-20
US201361904579P 2013-11-15 2013-11-15
US201361912777P 2013-12-06 2013-12-06
US201461942367P 2014-02-20 2014-02-20

Publications (1)

Publication Number Publication Date
DOP2015000234A true DOP2015000234A (es) 2015-12-31

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DO2015000234A DOP2015000234A (es) 2013-03-14 2015-09-14 COMPOSICIONES DE ARNi CONTRA EL COMPONENTE C5 DEL COMPLEMENTO Y METODOS PARA SU USO.

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US (6) US9249415B2 (es)
EP (2) EP2970974B1 (es)
JP (4) JP6524060B2 (es)
KR (4) KR20230162998A (es)
CN (2) CN114015692A (es)
AU (3) AU2014244116B9 (es)
BR (1) BR112015022876B1 (es)
CA (2) CA3216595A1 (es)
CL (4) CL2015002710A1 (es)
CR (1) CR20150493A (es)
CY (1) CY1120289T1 (es)
DK (1) DK2970974T3 (es)
DO (1) DOP2015000234A (es)
EA (1) EA201591707A1 (es)
ES (1) ES2649490T3 (es)
GT (1) GT201500293A (es)
HK (2) HK1221484A1 (es)
HR (1) HRP20171813T1 (es)
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PE (2) PE20211393A1 (es)
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RS (1) RS56663B1 (es)
SG (3) SG10201912286TA (es)
SI (1) SI2970974T1 (es)
TW (4) TWI808369B (es)
UY (2) UY40039A (es)
WO (1) WO2014160129A2 (es)

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US9879266B2 (en) 2002-11-14 2018-01-30 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
HRP20220908T8 (hr) 2011-11-18 2023-02-03 Alnylam Pharmaceuticals, Inc. MODIFICIRANA RNAi SREDSTVA
KR20230162998A (ko) 2013-03-14 2023-11-29 알닐람 파마슈티칼스 인코포레이티드 보체 성분 Ｃ5 ｉＲＮＡ 조성물 및 그 이용 방법
EP3473272A1 (en) 2013-03-29 2019-04-24 Alexion Pharmaceuticals, Inc. Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5
PE20170010A1 (es) * 2014-05-01 2017-03-04 Ionis Pharmaceuticals Inc Composiciones y metodos para modular la expresion del factor b del complemento
EP3812462A1 (en) 2014-08-20 2021-04-28 Alnylam Pharmaceuticals, Inc. Modified double-stranded rna agents
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