ME01267B - 4-fenilaminokinazolin-6-ilamidi - Google Patents
4-fenilaminokinazolin-6-ilamidiInfo
- Publication number
- ME01267B ME01267B MEP-2012-2A MEP212A ME01267B ME 01267 B ME01267 B ME 01267B ME P212 A MEP212 A ME P212A ME 01267 B ME01267 B ME 01267B
- Authority
- ME
- Montenegro
- Prior art keywords
- fluorophenylamino
- chloro
- amide
- enoic acid
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 230000002159 abnormal effect Effects 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 3
- LVXJQMNHJWSHET-UHFFFAOYSA-N N-[4-(3-chloro-4-fluoroanilino)-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 LVXJQMNHJWSHET-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 2
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- IJADXWBHNRTJAH-UHFFFAOYSA-N 4-N-(3-chloro-4-fluorophenyl)-7-methylsulfanylquinazoline-4,6-diamine Chemical compound C=12C=C(N)C(SC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 IJADXWBHNRTJAH-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- QSDKHHKJCWNTCW-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(2,2,2-trifluoroethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C1=C(Cl)C(F)=CC=C1NC(C1=C2)=NC=NC1=CC(OCC(F)(F)F)=C2NC(=O)C=CCN1CCCCC1 QSDKHHKJCWNTCW-UHFFFAOYSA-N 0.000 claims 1
- ICDUDMAKDBBZOT-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(2,2-difluoroethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCC(F)F)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 ICDUDMAKDBBZOT-UHFFFAOYSA-N 0.000 claims 1
- GFMMDHSSOIPFTF-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(2-fluoroethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCCF)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 GFMMDHSSOIPFTF-UHFFFAOYSA-N 0.000 claims 1
- YIRMJUMHPHHBCF-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(2-fluoroethylsulfanyl)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(SCCF)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 YIRMJUMHPHHBCF-UHFFFAOYSA-N 0.000 claims 1
- JGGXWPNXZZHJAI-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(fluoromethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCF)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 JGGXWPNXZZHJAI-UHFFFAOYSA-N 0.000 claims 1
- QMDUDTAUUIGRAT-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(methylamino)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(NC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 QMDUDTAUUIGRAT-UHFFFAOYSA-N 0.000 claims 1
- CRKXEIAEAGVNNS-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(trifluoromethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C1=C(Cl)C(F)=CC=C1NC(C1=C2)=NC=NC1=CC(OC(F)(F)F)=C2NC(=O)C=CCN1CCCCC1 CRKXEIAEAGVNNS-UHFFFAOYSA-N 0.000 claims 1
- XDXLWHQJFSMJFZ-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XDXLWHQJFSMJFZ-UHFFFAOYSA-N 0.000 claims 1
- XYUWLBQNUJRXRJ-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-(2-fluoropiperidin-1-yl)but-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3C(CCCC3)F)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XYUWLBQNUJRXRJ-UHFFFAOYSA-N 0.000 claims 1
- XFXOYVZSTQCSQN-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-(3-fluoropiperidin-1-yl)but-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CC(F)CCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XFXOYVZSTQCSQN-UHFFFAOYSA-N 0.000 claims 1
- YMQSEEOAYCTNQU-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-(4-fluoropiperidin-1-yl)but-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCC(F)CC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 YMQSEEOAYCTNQU-UHFFFAOYSA-N 0.000 claims 1
- CVPYBKFJICOOOM-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-propan-2-yloxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OC(C)C)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 CVPYBKFJICOOOM-UHFFFAOYSA-N 0.000 claims 1
- RYNJCJGKEYFFCT-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-propoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCCC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 RYNJCJGKEYFFCT-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 208000014081 polyp of colon Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56887204P | 2004-05-06 | 2004-05-06 | |
| PCT/IB2005/001139 WO2005107758A1 (en) | 2004-05-06 | 2005-04-25 | 4-phenylamino-quinazolin-6-yl-amides |
| EP05732761A EP1746999B1 (en) | 2004-05-06 | 2005-04-25 | 4-phenylamino-quinazolin-6-yl-amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01267B true ME01267B (me) | 2013-06-20 |
Family
ID=34965519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2012-2A ME01267B (me) | 2004-05-06 | 2005-04-25 | 4-fenilaminokinazolin-6-ilamidi |
Country Status (47)
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1746999B1 (en) | 2004-05-06 | 2011-11-16 | Warner-Lambert Company LLC | 4-phenylamino-quinazolin-6-yl-amides |
| KR100735639B1 (ko) | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
| KR100929146B1 (ko) | 2006-06-28 | 2009-12-01 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 |
| JP5793428B2 (ja) | 2009-03-11 | 2015-10-14 | オークランド ユニサーヴィスィズ リミテッド | プロドラッグ形態のキナーゼインヒビターおよび治療におけるそれらの使用 |
| CN102146059A (zh) * | 2010-02-08 | 2011-08-10 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、制备方法及其应用 |
| CN102382065B (zh) * | 2010-08-30 | 2014-05-28 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| CN102382106A (zh) | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
| CN102452989B (zh) * | 2010-10-19 | 2014-10-22 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| CN103748080B (zh) | 2011-05-26 | 2016-09-28 | 山东轩竹医药科技有限公司 | 喹唑啉衍生物类酪氨酸激酶抑制剂及其制备方法与应用 |
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