BRPI0409233A - processos para a preparação de derivados de n-((((piridinilóxi)-fenilaminoquinazolinil)-alil) acetamida e compostos relacionados, bem como intermediários de tais processos e processos para a preparação de tais intermediários - Google Patents

processos para a preparação de derivados de n-((((piridinilóxi)-fenilaminoquinazolinil)-alil) acetamida e compostos relacionados, bem como intermediários de tais processos e processos para a preparação de tais intermediários

Info

Publication number
BRPI0409233A
BRPI0409233A BRPI0409233-3A BRPI0409233A BRPI0409233A BR PI0409233 A BRPI0409233 A BR PI0409233A BR PI0409233 A BRPI0409233 A BR PI0409233A BR PI0409233 A BRPI0409233 A BR PI0409233A
Authority
BR
Brazil
Prior art keywords
processes
intermediates
preparation
well
related compounds
Prior art date
Application number
BRPI0409233-3A
Other languages
English (en)
Inventor
David Harold Brown Ripin
Michael Girard Vetelino
Lulin Wei
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0409233A publication Critical patent/BRPI0409233A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/66—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"PROCESSOS PARA A PREPARAçãO DE DERIVADOS DE N-((((PIRIDINILóXI)-FENILAMINO)QUINAZOLINIL)-ALIL) ACETAMIDA E COMPOSTOS RELACIONADOS, BEM COMO INTERMEDIáRIOS DE TAIS PROCESSOS E PROCESSOS PARA A PREPARAçãO DE TAIS INTERMEDIáRIOS". A presente invenção refere-se a processos para preparar compostos da fórmula 1 e a seus sais, pró-drogas e solvatos farmaceuticamente aceitáveis, em que R¬ 1¬, R¬ 3¬, R¬ 4¬, R¬ 6¬, R¬ 11¬, R¬ 13¬, R¬ 14¬, R¬ 15¬, R¬ 16¬, R¬ 17¬, k, I, e m são como aqui definidos. A presente invenção também se refere a intermediários representados pela fórmula (3a) em que R¬ 4¬ e R¬ 5¬ são selecionados independentemente a partir de hidrogênio e alquila(C~ 1~-C~ 6~); cada R¬ 13¬, R¬ 14¬, R¬ 15¬ e R¬ 16¬ é independentemente selecionado a partir de hidrogênio, alquila(C~ 1~-C~ 6~) e CH~ 2~OH, R¬ 17¬ e R¬ 18¬ São independentemente alquila(C~ 1~-C~ 6~), e k e I são independentemente um número inteiro de 1 a 3, bem como a um processo para preparar esses intermediários.
BRPI0409233-3A 2003-04-09 2004-03-29 processos para a preparação de derivados de n-((((piridinilóxi)-fenilaminoquinazolinil)-alil) acetamida e compostos relacionados, bem como intermediários de tais processos e processos para a preparação de tais intermediários BRPI0409233A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46163203P 2003-04-09 2003-04-09
US51686003P 2003-11-03 2003-11-03
PCT/IB2004/001069 WO2004089934A1 (en) 2003-04-09 2004-03-29 Processes for the preparation of n-((((pyridinyloxy) -phenylamino) quinazolinyl)- allyl) acetamide derivatives and related compounds as well as intermediates of such processes and processes for the preparation of such intermediates

Publications (1)

Publication Number Publication Date
BRPI0409233A true BRPI0409233A (pt) 2006-03-28

Family

ID=33162255

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409233-3A BRPI0409233A (pt) 2003-04-09 2004-03-29 processos para a preparação de derivados de n-((((piridinilóxi)-fenilaminoquinazolinil)-alil) acetamida e compostos relacionados, bem como intermediários de tais processos e processos para a preparação de tais intermediários

Country Status (14)

Country Link
US (1) US20050026940A1 (pt)
EP (1) EP1615910A1 (pt)
JP (1) JP2006525305A (pt)
KR (1) KR20050118726A (pt)
AR (1) AR044213A1 (pt)
AU (1) AU2004228460A1 (pt)
BR (1) BRPI0409233A (pt)
CA (1) CA2521348A1 (pt)
CL (1) CL2004000744A1 (pt)
MX (1) MXPA05008810A (pt)
RS (1) RS20050652A (pt)
RU (1) RU2005125607A (pt)
TW (1) TW200426141A (pt)
WO (1) WO2004089934A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1746999E (pt) * 2004-05-06 2012-01-11 Warner Lambert Co 4-fenilamino-quinazolin-6-il-amidas
EP1896451A2 (en) * 2005-06-03 2008-03-12 Pfizer Products Incorporated Bicyclic derivatives for the treatment of abnormal cell growth

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225318B1 (en) * 1996-10-17 2001-05-01 Pfizer Inc 4-aminoquinazolone derivatives
AP2001002192A0 (en) * 2000-06-22 2002-12-21 Pfizer Prod Inc Substituted bicyclic derivatives for the treatment of abnormal cell growth.
ATE377009T1 (de) * 2001-11-30 2007-11-15 Osi Pharm Inc Verfahren für die herstellung substituierter bicyclischer derivate zur behandlung von anomalem zellwachstum

Also Published As

Publication number Publication date
KR20050118726A (ko) 2005-12-19
RS20050652A (en) 2007-11-15
AR044213A1 (es) 2005-09-07
CA2521348A1 (en) 2004-10-21
MXPA05008810A (es) 2005-10-18
EP1615910A1 (en) 2006-01-18
WO2004089934A1 (en) 2004-10-21
TW200426141A (en) 2004-12-01
US20050026940A1 (en) 2005-02-03
RU2005125607A (ru) 2006-03-27
CL2004000744A1 (es) 2005-02-11
AU2004228460A1 (en) 2004-10-21
JP2006525305A (ja) 2006-11-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A, 5A, 6A, 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 4A, 5A, 6A, 7A E 8A ANUIDADES.