JO3098B1 - مركبات داي فينيل- بيرازول بيريدين وطريقة تحضيرها واستخدامها كمعدلات المستقبل النووي not - Google Patents

مركبات داي فينيل- بيرازول بيريدين وطريقة تحضيرها واستخدامها كمعدلات المستقبل النووي not

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Publication number
JO3098B1
JO3098B1 JOP/2010/0430A JOP20100430A JO3098B1 JO 3098 B1 JO3098 B1 JO 3098B1 JO P20100430 A JOP20100430 A JO P20100430A JO 3098 B1 JO3098 B1 JO 3098B1
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JO
Jordan
Prior art keywords
alkyl
group
hydrogen
diphenyl
preparation
Prior art date
Application number
JOP/2010/0430A
Other languages
English (en)
Inventor
Luc Even
Florian Auger
Original Assignee
Sanofi Aventis
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Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of JO3098B1 publication Critical patent/JO3098B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

يتمثل موضوع الاختراع الحالي في مركبات الصيغة (I): (I) التي فيها R تمثل ذرة هيدروجين أو ذرة هالوجين أو مجموعة الكيل (C1-6)؛ X تمثل واحد أو أكثر من المستبدلات التي يتم اختيارها من ذرة هيدروجين أو ذرة هالوجين أو مجموعة الكيل (C1-6)، هالو الكيل (C1-6)، الكوكسي (C1-6)، هالو الكوكسي (C1-6)، سيانو، هيدروكسي أو هيدروكسي الكيل (C1-6)؛ Y تمثل ذرة هيدروجين أو ذرة هالوجين أو مجموعة الكيل (C1-6)؛ R1 تمثل مجموعة NR2R3 أو OR4؛ R2 و R3 تمثل، كل على حدة من الأخرى، ذرة هيدروجين أو مجموعة الكيل (C1-6)؛ هيدروكسي الكيل (C1-6) أو أوكسو الكيل (C1-6)، أو بديلا عن ذلك R2 و R3 تشكلان، مع ذرة النيتروجين المرتبطة بهما، حلقي مخلط مستبدلة اختياريا بمجموعة الكيل (C1-6)، هيدروكسي أو أوكسو، R4 تمثل مجموعة الكيل (C1-6)، هيدروكسي الكيل (C1-6) أو أوكسو الكيل (C1-6)، في صورة قاعدة أو ملح إضافة لحمض. استخدامها العلاجي وطرق تخلقيها.
JOP/2010/0430A 2009-12-04 2010-12-02 مركبات داي فينيل- بيرازول بيريدين وطريقة تحضيرها واستخدامها كمعدلات المستقبل النووي not JO3098B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0958651A FR2953520B1 (fr) 2009-12-04 2009-12-04 Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique

Publications (1)

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JO3098B1 true JO3098B1 (ar) 2017-03-15

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Country Status (24)

Country Link
US (1) US8680096B2 (ar)
EP (1) EP2507238B1 (ar)
JP (1) JP5738310B2 (ar)
KR (1) KR101696959B1 (ar)
CN (1) CN102762559B (ar)
AR (1) AR079250A1 (ar)
AU (1) AU2010326429B2 (ar)
BR (1) BR112012013511A2 (ar)
CA (1) CA2782704C (ar)
CL (1) CL2012001461A1 (ar)
CO (1) CO6551713A2 (ar)
EA (1) EA020652B1 (ar)
FR (1) FR2953520B1 (ar)
IL (1) IL220060A (ar)
JO (1) JO3098B1 (ar)
MA (1) MA33893B1 (ar)
MX (1) MX2012006421A (ar)
MY (1) MY157676A (ar)
NZ (1) NZ600368A (ar)
PH (1) PH12012501075A1 (ar)
SG (1) SG181138A1 (ar)
TW (1) TWI481606B (ar)
UY (1) UY33079A (ar)
WO (1) WO2011067544A1 (ar)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2950344B1 (fr) * 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.
FR2950345B1 (fr) * 2009-09-18 2011-09-23 Sanofi Aventis Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique
BR112019010880A2 (pt) 2016-11-28 2019-10-01 Praxis Precision Medicines, Inc. compostos e seus métodos de uso
US11261188B2 (en) 2016-11-28 2022-03-01 Praxis Precision Medicines, Inc. Fused heteroaryl compounds, and methods thereof for treating diseases, disorders, and conditions relating to aberrant function of a sodium channel
WO2018098500A1 (en) * 2016-11-28 2018-05-31 Praxis Precision Medicines, Inc. Compounds and their methods of use
KR20190091323A (ko) * 2016-12-08 2019-08-05 바이엘 크롭사이언스 악티엔게젤샤프트 페닐히드라진 중간체를 단리하거나 정제하지 않고 5-(1-페닐-1h-피라졸-4-일)-니코틴아미드 유도체 및 유사한 화합물을 생성하는 방법
WO2018148745A1 (en) 2017-02-13 2018-08-16 Praxis Precision Medicines , Inc. Compounds and their methods of use
US11731966B2 (en) 2017-04-04 2023-08-22 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11278535B2 (en) 2017-08-15 2022-03-22 Praxis Precision Medicines, Inc. Compounds and their methods of use
CN117756800A (zh) 2018-05-30 2024-03-26 普拉克西斯精密药物股份有限公司 离子通道调节剂
EA202092908A1 (ru) 2018-09-28 2021-05-14 Праксис Пресижн Медсинз, Инк. Модуляторы ионных каналов
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11505554B2 (en) 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators
US11279700B2 (en) 2019-05-31 2022-03-22 Praxis Precision Medicines, Inc. Ion channel modulators
US11767325B2 (en) 2019-11-26 2023-09-26 Praxis Precision Medicines, Inc. Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators
AU2020392128A1 (en) 2019-11-27 2022-06-09 Praxis Precision Medicines, Inc. Formulations of ion channel modulators and methods of preparation and use of ion channel modulators
CN111138325B (zh) * 2019-12-20 2021-11-30 台州学院 一种(Z)-β-磺酰基烯胺类化合物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001139575A (ja) * 1999-11-15 2001-05-22 Fujisawa Pharmaceut Co Ltd 新規ピラゾロピリジン誘導体
FR2906250B1 (fr) * 2006-09-22 2008-10-31 Sanofi Aventis Sa Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
MX2009006704A (es) * 2006-12-22 2009-06-30 Astex Therapeutics Ltd Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa.
FR2928921B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2928924B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
US8198449B2 (en) * 2008-09-11 2012-06-12 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
FR2950344B1 (fr) * 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.

Also Published As

Publication number Publication date
KR20120103672A (ko) 2012-09-19
CO6551713A2 (es) 2012-10-31
MA33893B1 (ar) 2013-01-02
PH12012501075A1 (en) 2019-07-10
IL220060A (en) 2015-05-31
BR112012013511A2 (pt) 2016-06-07
TW201129564A (en) 2011-09-01
CN102762559B (zh) 2014-11-05
FR2953520B1 (fr) 2011-11-25
AU2010326429A1 (en) 2012-06-21
UY33079A (es) 2011-06-01
SG181138A1 (en) 2012-07-30
US20120245164A1 (en) 2012-09-27
EA020652B1 (ru) 2014-12-30
TWI481606B (zh) 2015-04-21
MX2012006421A (es) 2012-10-09
MY157676A (en) 2016-07-15
CA2782704A1 (fr) 2011-06-09
CL2012001461A1 (es) 2012-10-12
HK1169984A1 (en) 2013-02-15
JP2013512884A (ja) 2013-04-18
AR079250A1 (es) 2012-01-04
EA201290520A1 (ru) 2013-01-30
US8680096B2 (en) 2014-03-25
KR101696959B1 (ko) 2017-01-16
FR2953520A1 (fr) 2011-06-10
AU2010326429B2 (en) 2016-07-14
CN102762559A (zh) 2012-10-31
WO2011067544A1 (fr) 2011-06-09
EP2507238B1 (fr) 2013-07-31
JP5738310B2 (ja) 2015-06-24
EP2507238A1 (fr) 2012-10-10
NZ600368A (en) 2013-12-20
CA2782704C (fr) 2018-01-02

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