BRPI0514667A - processos para a preparação de derivados de isotiazol - Google Patents

processos para a preparação de derivados de isotiazol

Info

Publication number
BRPI0514667A
BRPI0514667A BRPI0514667-4A BRPI0514667A BRPI0514667A BR PI0514667 A BRPI0514667 A BR PI0514667A BR PI0514667 A BRPI0514667 A BR PI0514667A BR PI0514667 A BRPI0514667 A BR PI0514667A
Authority
BR
Brazil
Prior art keywords
processes
preparation
isothiazole derivatives
derivatives
isothiazole
Prior art date
Application number
BRPI0514667-4A
Other languages
English (en)
Inventor
David B Damon
Original Assignee
Pfizer Prod Inc
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Osi Pharm Inc filed Critical Pfizer Prod Inc
Publication of BRPI0514667A publication Critical patent/BRPI0514667A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCESSOS PARA A PREPARAçãO DE DERIVADOS DE ISOTIAZOL A presente invenção refere-se a processos e intermediários para a preparação de compostos da Fórmula (1), e seus sais, pró-fármacos, solvatos e hidratos farmaceuticamente aceitáveis, onde R¬ ¬, R¬ ¬ e R¬ ¬ têm as definições fornecidas no relatório descritivo.
BRPI0514667-4A 2004-08-26 2005-08-02 processos para a preparação de derivados de isotiazol BRPI0514667A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60454204P 2004-08-26 2004-08-26
PCT/US2005/027398 WO2006026034A2 (en) 2004-08-26 2005-08-02 Processes for the preparation of isothiazole derivatives

Publications (1)

Publication Number Publication Date
BRPI0514667A true BRPI0514667A (pt) 2008-06-17

Family

ID=36000502

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514667-4A BRPI0514667A (pt) 2004-08-26 2005-08-02 processos para a preparação de derivados de isotiazol

Country Status (22)

Country Link
US (2) US8884025B2 (pt)
EP (1) EP1784183B1 (pt)
JP (2) JP5100390B2 (pt)
KR (1) KR100893977B1 (pt)
CN (1) CN101043888B (pt)
AR (1) AR050613A1 (pt)
AT (1) ATE542533T1 (pt)
AU (1) AU2005280451B2 (pt)
BR (1) BRPI0514667A (pt)
CA (1) CA2578023C (pt)
DK (1) DK1784183T3 (pt)
ES (1) ES2378994T3 (pt)
HK (1) HK1111359A1 (pt)
IL (1) IL181063A0 (pt)
MX (1) MX2007002246A (pt)
NO (1) NO20071319L (pt)
PL (1) PL1784183T3 (pt)
PT (1) PT1784183E (pt)
RU (1) RU2349588C2 (pt)
TW (1) TWI361688B (pt)
WO (1) WO2006026034A2 (pt)
ZA (1) ZA200701016B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2349588C2 (ru) 2004-08-26 2009-03-20 Пфайзер Продактс Инк. Способы получения производных изотиазола
EP2797916B1 (en) 2011-12-28 2017-02-15 Allergan, Inc. 3-phenyl-5-ureidoisothiazole-4-carboximide and 3-amino-5-phenylisothiazole derivatives as kinase inhibitors
CN103833665B (zh) * 2014-02-24 2015-09-23 杰达维（上海）医药科技发展有限公司 一种新的合成异噻唑的方法
US9353093B2 (en) 2014-10-07 2016-05-31 Allergan, Inc. Indole-1-carboxamides as kinase inhibitors
US9403803B2 (en) 2014-10-08 2016-08-02 Allergan, Inc. Indole-3-carboxamides as kinase inhibitors
US9371314B2 (en) 2014-10-09 2016-06-21 Allergan, Inc. Pyridyl benzothiophenes as kinase inhibitors
US9359336B2 (en) 2014-10-09 2016-06-07 Allergan, Inc. Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2408234A1 (de) * 1974-02-21 1975-09-04 Celamerck Gmbh & Co Kg Isothiazolylharnstoffe
US4059433A (en) * 1976-06-18 1977-11-22 Fmc Corporation 3-Alkoxyisothiazole derivatives as herbicides
IL72093A0 (en) * 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-alkyl-5-isothiazolyl)urea derivatives
UA60365C2 (uk) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
HN2000000051A (es) * 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
BR0312798A (pt) * 2002-07-25 2005-05-03 Pfizer Prod Inc Derivados de isotiazol úteis como agentes anticancerìgenos
US20060035954A1 (en) * 2004-08-11 2006-02-16 Sharma Padam N Ammonolysis process for the preparation of intermediates for DPP IV inhibitors
RU2349588C2 (ru) 2004-08-26 2009-03-20 Пфайзер Продактс Инк. Способы получения производных изотиазола

Also Published As

Publication number Publication date
JP2012153705A (ja) 2012-08-16
PL1784183T3 (pl) 2012-07-31
EP1784183A2 (en) 2007-05-16
US9371298B2 (en) 2016-06-21
DK1784183T3 (da) 2012-04-02
ATE542533T1 (de) 2012-02-15
KR20070070158A (ko) 2007-07-03
HK1111359A1 (en) 2008-08-08
AU2005280451A1 (en) 2006-03-09
EP1784183B1 (en) 2012-01-25
NO20071319L (no) 2007-05-29
JP5100390B2 (ja) 2012-12-19
TW200621241A (en) 2006-07-01
IL181063A0 (en) 2007-07-04
US20150065726A1 (en) 2015-03-05
CN101043888B (zh) 2010-08-11
CA2578023A1 (en) 2006-03-09
US8884025B2 (en) 2014-11-11
WO2006026034A3 (en) 2006-06-29
AU2005280451B2 (en) 2009-02-05
JP2008510841A (ja) 2008-04-10
AR050613A1 (es) 2006-11-08
RU2007106847A (ru) 2008-08-27
WO2006026034A2 (en) 2006-03-09
ZA200701016B (en) 2008-05-28
EP1784183A4 (en) 2009-12-09
TWI361688B (en) 2012-04-11
CN101043888A (zh) 2007-09-26
ES2378994T3 (es) 2012-04-19
US20090023924A1 (en) 2009-01-22
MX2007002246A (es) 2007-04-20
CA2578023C (en) 2012-05-15
PT1784183E (pt) 2012-03-09
JP5498524B2 (ja) 2014-05-21
KR100893977B1 (ko) 2009-04-20
RU2349588C2 (ru) 2009-03-20

Similar Documents

Publication Publication Date Title
BRPI0514667A (pt) processos para a preparação de derivados de isotiazol
UA90786C2 (uk) Похідні бензамідів і гетероаренів
BRPI0520870B8 (pt) compostos intermediários para a preparação de alfa-mercaptoacetanilidas de s-triazolila
CR10968A (es) Nuevos derivados de 3-amino-pirrolo[3,4-c]pirazol -5(1h, 4h, 6h) carbaldehido
CR20110370A (es) Derivados de sulfonamida
ATE512961T1 (de) Amorphes nebivolol hydrochlorid und seine herstellung
MY153971A (en) Sulfonamides as trpm8 modulators
WO2006023515A3 (en) Novel thiazole inhibitors of fructose 1,6-bisphosphatase
CR11241A (es) Compuestos de pirazol y su uso como inhibidores de raf
NO20054135L (no) Kipolinon/benzoksazin derivater og anvendelser derav
UY31468A1 (es) Derivados bis-(sulfonilamino) en terapia 065
UY29893A1 (es) Derivados de pirazina
BRPI0715579A2 (pt) "composto, composição farmacêutica e uso de um composto"
IL183237A0 (en) Polymorphs of memantine hydrochloride
EA201000413A1 (ru) Способ получения производных лактамида, новые производные лактамида и препараты, содержащие производные лактамида
BRPI0507903A (pt) derivados de quinazolina e composição farmacêutica compreendendo os mesmos
MY151986A (en) Adamantyl diamide derivatives and uses of same
MX2009011579A (es) Pirimidinonas como moduladores de caseina cinasa ii (ck2).
TW201129564A (en) Diphenylpyrazolopyridine derivatives, preparation thereof and therapeutic use thereof
RS51661B (en) NEW DIOSMETHINE DERIVATIVES, THE PROCEDURE FOR THEIR MAKING AND THE PHARMACEUTICAL MIXTURES CONTAINING THEM
WO2007147771A3 (en) Tetralin and indane derivatives and uses thereof
CR10206A (es) Acidos4-fenil-tiazol-5-carboxilicos amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1
NO20092690L (no) Aminderivater og deres anvendelse i beta-2-adrenoreseptormedierte sykdommer
MX2009006334A (es) Derivados de heteroaril-pirrolidinil- y -piperidinil-cetona.
TW200942529A (en) Pyrrolidinyl derivatives and uses thereof

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: OSI PHARMACEUTICALS, INC. (US) , PFIZER INC. (US)

Free format text: TRANSFERIDO DE: PFIZER PRODUCTS INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B11T Dismissal of application maintained [chapter 11.20 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]