BR9506936A - Derivados de quinazolina substituídos com 4-heterociclila processos para sua preparaçao e seu uso como agentes anticancerosos - Google Patents
Derivados de quinazolina substituídos com 4-heterociclila processos para sua preparaçao e seu uso como agentes anticancerososInfo
- Publication number
- BR9506936A BR9506936A BR9506936A BR9506936A BR9506936A BR 9506936 A BR9506936 A BR 9506936A BR 9506936 A BR9506936 A BR 9506936A BR 9506936 A BR9506936 A BR 9506936A BR 9506936 A BR9506936 A BR 9506936A
- Authority
- BR
- Brazil
- Prior art keywords
- heterocyclyl
- processes
- preparation
- cancer agents
- quinazoline derivatives
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20025994A | 1994-02-23 | 1994-02-23 | |
| PCT/IB1995/000061 WO1995023141A1 (en) | 1994-02-23 | 1995-01-27 | 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9506936A true BR9506936A (pt) | 1997-09-09 |
Family
ID=22740969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9506936A BR9506936A (pt) | 1994-02-23 | 1995-01-27 | Derivados de quinazolina substituídos com 4-heterociclila processos para sua preparaçao e seu uso como agentes anticancerosos |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5736534A (pt) |
| EP (1) | EP0746554A1 (pt) |
| JP (1) | JP2890267B2 (pt) |
| KR (1) | KR100225721B1 (pt) |
| CN (1) | CN1141633A (pt) |
| AU (1) | AU686843B2 (pt) |
| BR (1) | BR9506936A (pt) |
| CA (1) | CA2183655C (pt) |
| CO (1) | CO4340688A1 (pt) |
| CZ (1) | CZ288955B6 (pt) |
| FI (1) | FI963283A (pt) |
| HU (1) | HUT76291A (pt) |
| IL (1) | IL112673A0 (pt) |
| MX (1) | MX9603593A (pt) |
| NO (1) | NO963506L (pt) |
| NZ (1) | NZ278135A (pt) |
| PE (1) | PE4896A1 (pt) |
| PL (1) | PL315941A1 (pt) |
| RU (1) | RU2137762C1 (pt) |
| TW (1) | TW404946B (pt) |
| WO (1) | WO1995023141A1 (pt) |
| ZA (1) | ZA951458B (pt) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE37650E1 (en) | 1991-05-10 | 2002-04-09 | Aventis Pharmacetical Products, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
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| TW321649B (pt) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
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| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
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| GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
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| US5760041A (en) * | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| KR19990082463A (ko) | 1996-02-13 | 1999-11-25 | 돈 리사 로얄 | 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체 |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
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| AU2193797A (en) * | 1996-03-01 | 1997-09-16 | Chiron Corporation | Delivery of therapeutic agents to the prostate |
| CN1116286C (zh) | 1996-03-05 | 2003-07-30 | 曾尼卡有限公司 | 4－苯胺基喹唑啉衍生物 |
| IL126351A0 (en) | 1996-04-12 | 1999-05-09 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| GB9607729D0 (en) * | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
| GB9707800D0 (en) * | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| EP0837063A1 (en) * | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| US6225318B1 (en) | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| WO1998023613A1 (en) * | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Fused bicyclic pyrimidine derivatives |
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US5929080A (en) * | 1997-05-06 | 1999-07-27 | American Cyanamid Company | Method of treating polycystic kidney disease |
| ZA986729B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| US6251912B1 (en) | 1997-08-01 | 2001-06-26 | American Cyanamid Company | Substituted quinazoline derivatives |
| WO1999010349A1 (en) * | 1997-08-22 | 1999-03-04 | Zeneca Limited | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
| US6323209B1 (en) | 1997-11-06 | 2001-11-27 | American Cyanamid Company | Method of treating or inhibiting colonic polyps |
| JPH11236333A (ja) * | 1997-12-30 | 1999-08-31 | Pfizer Prod Inc | 抗ガン剤として有用なイミダゾリン−４−オン誘導体 |
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| CN108245521B (zh) * | 2018-01-24 | 2020-01-03 | 浙江工业大学 | 二丙氨基乙酰氨基苯并氮杂*基喹唑啉类化合物在制备治疗白血病药物中的应用 |
| CN108014114B (zh) * | 2018-01-24 | 2020-08-21 | 浙江工业大学 | 氯乙酰氨基喹唑啉类化合物在制备治疗肺癌药物中的应用 |
| CN108125959B (zh) * | 2018-01-24 | 2019-12-31 | 浙江工业大学 | 二甲氧基苯氨基乙酰氨基喹唑啉类化合物在制备治疗白血病药物中的应用 |
| WO2024086296A1 (en) * | 2022-10-20 | 2024-04-25 | Mekanistic Therapeutics Llc | Compounds useful in modulating egfr and pi3k |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4012513A (en) * | 1971-11-03 | 1977-03-15 | Imperial Chemical Industries Limited | Indole derivatives for providing analgesic and anti-inflammatory effects |
| BE790679A (fr) * | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
| WO1992020642A1 (en) * | 1991-05-10 | 1992-11-26 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
| NZ243082A (en) * | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9323290D0 (en) * | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| GB9314893D0 (en) * | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
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1995
- 1995-01-27 CZ CZ19962413A patent/CZ288955B6/cs not_active IP Right Cessation
- 1995-01-27 RU RU96119255A patent/RU2137762C1/ru active
- 1995-01-27 CN CN95191723A patent/CN1141633A/zh active Pending
- 1995-01-27 WO PCT/IB1995/000061 patent/WO1995023141A1/en active IP Right Grant
- 1995-01-27 MX MX9603593A patent/MX9603593A/es not_active IP Right Cessation
- 1995-01-27 JP JP7522227A patent/JP2890267B2/ja not_active Expired - Lifetime
- 1995-01-27 EP EP95905737A patent/EP0746554A1/en not_active Withdrawn
- 1995-01-27 CA CA002183655A patent/CA2183655C/en not_active Expired - Fee Related
- 1995-01-27 BR BR9506936A patent/BR9506936A/pt not_active Application Discontinuation
- 1995-01-27 KR KR1019960704612A patent/KR100225721B1/ko not_active IP Right Cessation
- 1995-01-27 AU AU29727/95A patent/AU686843B2/en not_active Ceased
- 1995-01-27 US US08/682,565 patent/US5736534A/en not_active Expired - Fee Related
- 1995-01-27 PL PL95315941A patent/PL315941A1/xx unknown
- 1995-01-27 HU HU9602305A patent/HUT76291A/hu unknown
- 1995-02-06 TW TW084100928A patent/TW404946B/zh not_active IP Right Cessation
- 1995-02-16 IL IL11267395A patent/IL112673A0/xx unknown
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- 1995-02-22 CO CO95006643A patent/CO4340688A1/es unknown
- 1995-02-22 ZA ZA951458A patent/ZA951458B/xx unknown
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1996
- 1996-08-19 NZ NZ278135A patent/NZ278135A/en unknown
- 1996-08-22 FI FI963283A patent/FI963283A/fi unknown
- 1996-08-22 NO NO963506A patent/NO963506L/no not_active Application Discontinuation
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|---|---|
| AU2972795A (en) | 1995-09-11 |
| KR970701183A (ko) | 1997-03-17 |
| AU686843B2 (en) | 1998-02-12 |
| MX9603593A (es) | 1997-03-29 |
| RU2137762C1 (ru) | 1999-09-20 |
| HUT76291A (en) | 1997-07-28 |
| JP2890267B2 (ja) | 1999-05-10 |
| CO4340688A1 (es) | 1996-07-30 |
| CA2183655A1 (en) | 1995-08-31 |
| NZ278135A (en) | 1998-03-25 |
| CZ241396A3 (en) | 1997-07-16 |
| PL315941A1 (en) | 1996-12-09 |
| TW404946B (en) | 2000-09-11 |
| HU9602305D0 (en) | 1996-10-28 |
| IL112673A0 (en) | 1995-05-26 |
| JPH09501953A (ja) | 1997-02-25 |
| NO963506L (no) | 1996-10-22 |
| WO1995023141A1 (en) | 1995-08-31 |
| EP0746554A1 (en) | 1996-12-11 |
| ZA951458B (en) | 1996-08-22 |
| FI963283A0 (fi) | 1996-08-22 |
| FI963283A (fi) | 1996-08-22 |
| CA2183655C (en) | 2001-03-06 |
| CN1141633A (zh) | 1997-01-29 |
| US5736534A (en) | 1998-04-07 |
| CZ288955B6 (cs) | 2001-10-17 |
| NO963506D0 (no) | 1996-08-22 |
| PE4896A1 (es) | 1996-03-09 |
| KR100225721B1 (ko) | 1999-10-15 |
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