BR9611709A - Intermediários e seu uso para preparação de bis-indolil maleimidas com ponte-n.n. - Google Patents
Intermediários e seu uso para preparação de bis-indolil maleimidas com ponte-n.n.Info
- Publication number
- BR9611709A BR9611709A BR9611709A BR9611709A BR9611709A BR 9611709 A BR9611709 A BR 9611709A BR 9611709 A BR9611709 A BR 9611709A BR 9611709 A BR9611709 A BR 9611709A BR 9611709 A BR9611709 A BR 9611709A
- Authority
- BR
- Brazil
- Prior art keywords
- intermediates
- bis
- bridge
- preparation
- maleimides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US734595P | 1995-11-20 | 1995-11-20 | |
PCT/US1996/018518 WO1997019080A1 (en) | 1995-11-20 | 1996-11-18 | Novel intermediates and their use to prepare n,n'-bridged bisindolylmaleimides |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9611709A true BR9611709A (pt) | 1999-02-23 |
Family
ID=21725638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9611709A BR9611709A (pt) | 1995-11-20 | 1996-11-18 | Intermediários e seu uso para preparação de bis-indolil maleimidas com ponte-n.n. |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP0776899B1 (pt) |
JP (2) | JP4100708B2 (pt) |
KR (1) | KR100342142B1 (pt) |
CN (1) | CN1066734C (pt) |
AR (2) | AR004718A1 (pt) |
AT (1) | ATE191219T1 (pt) |
AU (1) | AU701659B2 (pt) |
BR (1) | BR9611709A (pt) |
CA (1) | CA2237401C (pt) |
CO (1) | CO4750824A1 (pt) |
CZ (1) | CZ150398A3 (pt) |
DE (1) | DE69607443T2 (pt) |
DK (1) | DK0776899T3 (pt) |
EA (1) | EA000639B1 (pt) |
ES (1) | ES2145978T3 (pt) |
GR (1) | GR3033729T3 (pt) |
HU (1) | HU225716B1 (pt) |
IL (1) | IL124415A (pt) |
MX (1) | MX9803791A (pt) |
MY (1) | MY118946A (pt) |
NO (1) | NO310195B1 (pt) |
NZ (1) | NZ323282A (pt) |
PE (1) | PE17998A1 (pt) |
PL (1) | PL184728B1 (pt) |
PT (1) | PT776899E (pt) |
TR (1) | TR199800876T2 (pt) |
TW (1) | TW371661B (pt) |
UA (1) | UA56145C2 (pt) |
WO (1) | WO1997019080A1 (pt) |
YU (1) | YU49316B (pt) |
ZA (1) | ZA969645B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2245029A1 (en) | 1998-03-13 | 1999-09-13 | University Of British Columbia | Granulatimide compounds as g2 checkpoint inhibitors |
EP1070068B2 (en) * | 1998-03-13 | 2007-01-17 | The University Of British Columbia | Granulatimide derivatives for use in cancer treatment |
US6127401A (en) | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
US6300106B1 (en) | 2000-11-22 | 2001-10-09 | Ppg Industries Ohio, Inc. | Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate |
EP2181999A1 (en) | 2008-11-03 | 2010-05-05 | Zentiva, A.S. | Method of manufacturing ruboxistarin |
WO2023192984A1 (en) * | 2022-03-31 | 2023-10-05 | 4M Therapeutics Inc. | N-desmethyl ruboxistaurin as kinase inhibitor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
HU219709B (hu) * | 1993-12-07 | 2001-06-28 | Eli Lilly And Co. | Proteinkináz C gátló hatású kondenzált indolszármazékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények |
US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
-
1996
- 1996-11-18 TW TW085114104A patent/TW371661B/zh active
- 1996-11-18 CN CN96199575A patent/CN1066734C/zh not_active Expired - Fee Related
- 1996-11-18 ZA ZA9609645A patent/ZA969645B/xx unknown
- 1996-11-18 PT PT96308317T patent/PT776899E/pt unknown
- 1996-11-18 AU AU77388/96A patent/AU701659B2/en not_active Ceased
- 1996-11-18 BR BR9611709A patent/BR9611709A/pt not_active IP Right Cessation
- 1996-11-18 EA EA199800368A patent/EA000639B1/ru not_active IP Right Cessation
- 1996-11-18 DK DK96308317T patent/DK0776899T3/da active
- 1996-11-18 CA CA002237401A patent/CA2237401C/en not_active Expired - Fee Related
- 1996-11-18 EP EP96308317A patent/EP0776899B1/en not_active Expired - Lifetime
- 1996-11-18 CZ CZ981503A patent/CZ150398A3/cs unknown
- 1996-11-18 DE DE69607443T patent/DE69607443T2/de not_active Expired - Fee Related
- 1996-11-18 WO PCT/US1996/018518 patent/WO1997019080A1/en not_active Application Discontinuation
- 1996-11-18 UA UA98052516A patent/UA56145C2/uk unknown
- 1996-11-18 KR KR1019980703626A patent/KR100342142B1/ko not_active IP Right Cessation
- 1996-11-18 HU HU9901975A patent/HU225716B1/hu not_active IP Right Cessation
- 1996-11-18 AT AT96308317T patent/ATE191219T1/de not_active IP Right Cessation
- 1996-11-18 PL PL96326753A patent/PL184728B1/pl not_active IP Right Cessation
- 1996-11-18 TR TR1998/00876T patent/TR199800876T2/xx unknown
- 1996-11-18 IL IL12441596A patent/IL124415A/xx not_active IP Right Cessation
- 1996-11-18 NZ NZ323282A patent/NZ323282A/xx unknown
- 1996-11-18 ES ES96308317T patent/ES2145978T3/es not_active Expired - Lifetime
- 1996-11-18 PE PE1996000828A patent/PE17998A1/es not_active Application Discontinuation
- 1996-11-18 JP JP51983897A patent/JP4100708B2/ja not_active Expired - Fee Related
- 1996-11-18 YU YU61096A patent/YU49316B/sh unknown
- 1996-11-19 MY MYPI96004798A patent/MY118946A/en unknown
- 1996-11-19 CO CO96060836A patent/CO4750824A1/es unknown
- 1996-11-20 AR ARP960105256A patent/AR004718A1/es unknown
- 1996-11-20 AR ARP960105257A patent/AR004719A1/es unknown
-
1998
- 1998-05-08 NO NO19982105A patent/NO310195B1/no not_active IP Right Cessation
- 1998-05-13 MX MX9803791A patent/MX9803791A/es unknown
-
2000
- 2000-06-20 GR GR20000401423T patent/GR3033729T3/el not_active IP Right Cessation
-
2007
- 2007-12-28 JP JP2007338808A patent/JP2008138006A/ja not_active Ceased
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
B24C | Patent annual fee: request for for restoration |
Free format text: REFERENTE 13A., E 14A. ANUIDADE(S). |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE AS 15A, 16A, 17A, 18A E 19A ANUIDADES. PAGAR RESTAURACAO. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2342 DE 24-11-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |