BR9707808A - Composto composição farmacêutica e uso do composto - Google Patents
Composto composição farmacêutica e uso do compostoInfo
- Publication number
- BR9707808A BR9707808A BR9707808A BR9707808A BR9707808A BR 9707808 A BR9707808 A BR 9707808A BR 9707808 A BR9707808 A BR 9707808A BR 9707808 A BR9707808 A BR 9707808A BR 9707808 A BR9707808 A BR 9707808A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical composition
- compound pharmaceutical
- composition
- pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96200543 | 1996-03-01 | ||
| PCT/EP1997/000938 WO1997031937A1 (en) | 1996-03-01 | 1997-02-26 | Serine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9707808A true BR9707808A (pt) | 1999-07-27 |
Family
ID=8223736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9707808A BR9707808A (pt) | 1996-03-01 | 1997-02-26 | Composto composição farmacêutica e uso do composto |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6410684B1 (pt) |
| EP (1) | EP0886647B1 (pt) |
| JP (1) | JP2000506837A (pt) |
| KR (1) | KR19990087415A (pt) |
| CN (1) | CN1212704A (pt) |
| AR (1) | AR006310A1 (pt) |
| AT (1) | ATE221080T1 (pt) |
| AU (1) | AU709330B2 (pt) |
| BR (1) | BR9707808A (pt) |
| CA (1) | CA2246246A1 (pt) |
| CZ (1) | CZ277898A3 (pt) |
| DE (1) | DE69714222T2 (pt) |
| DK (1) | DK0886647T3 (pt) |
| ES (1) | ES2180933T3 (pt) |
| HK (1) | HK1021541A1 (pt) |
| HU (1) | HUP9900390A3 (pt) |
| IL (1) | IL120310A (pt) |
| NO (1) | NO983991L (pt) |
| NZ (1) | NZ331484A (pt) |
| PL (1) | PL328875A1 (pt) |
| PT (1) | PT886647E (pt) |
| RU (1) | RU2178419C2 (pt) |
| TR (1) | TR199801704T2 (pt) |
| TW (1) | TW442452B (pt) |
| WO (1) | WO1997031937A1 (pt) |
| ZA (1) | ZA971667B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6034067A (en) * | 1996-02-13 | 2000-03-07 | Akzo Nobel, N.V. | Serine protease inhibitors |
| WO1998051684A1 (en) | 1997-05-15 | 1998-11-19 | Eli Lilly And Company | Antithrombotic compound |
| ES2205760T3 (es) | 1998-04-30 | 2004-05-01 | Agouron Pharmaceuticals, Inc. | Compuestos antipicornavirales, su preparacion y su utilizacion. |
| AU9031598A (en) * | 1998-08-17 | 2000-03-06 | Cortech, Inc. | Serine protease inhibitors comprising alpha-keto heterocycles |
| AU3511500A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| WO2000051624A2 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Methods and compositions useful in inhibiting apoptosis |
| US6849605B1 (en) | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| MXPA02001179A (es) | 1999-08-04 | 2002-07-30 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis. |
| BR0111727A (pt) | 2000-06-14 | 2003-05-27 | Agouron Pharma | Compostos e composições antipicornavirais, seus usos farmacêuticos, e materiais para a sua sìntese |
| MXPA03000626A (es) * | 2000-07-21 | 2004-07-30 | Schering Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de la hepatitis c. |
| DE60141608D1 (de) | 2000-07-21 | 2010-04-29 | Dendreon Corp | Peptide als inhibitoren der ns3-serinprotease des hepatitis c virus |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| CA2436774A1 (en) | 2001-01-30 | 2002-08-08 | R. Michael Lawrence | Sulfonamide lactam inhibitors of factor xa |
| US7405210B2 (en) * | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
| ES2353309T3 (es) | 2004-03-08 | 2011-03-01 | Prosidion Ltd. | Hidrazidas del ácido pirrolopiridin-2-carboxílico como inhibidores de glucógeno fosforilasa. |
| US20090099176A1 (en) | 2004-12-02 | 2009-04-16 | Thomas Martin Krulle | Pyrrolopyridine-2-carboxylic acid amides |
| JP5740308B2 (ja) * | 2008-10-15 | 2015-06-24 | ダニスコ・ユーエス・インク | 修飾変異ボウマンブリックプロテアーゼインヒビター |
| CA3025253A1 (en) | 2016-06-21 | 2017-12-28 | Orion Ophthalmology LLC | Heterocyclic prolinamide derivatives |
| JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556655A (en) * | 1984-09-24 | 1985-12-03 | Schering Corporation | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
| ZW11290A1 (en) | 1989-07-14 | 1990-10-31 | Smithkline Beecham Corp | Hemoregulatory peptides |
| ATE227581T1 (de) | 1993-04-30 | 2002-11-15 | Merck & Co Inc | Thrombin-inhibitoren |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| ZA951618B (en) | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
| ZA951617B (en) | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
| WO1995035311A1 (en) | 1994-06-17 | 1995-12-28 | Corvas International, Inc. | 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors |
| JPH0820597A (ja) * | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
| JPH11508535A (ja) * | 1994-12-22 | 1999-07-27 | バイオケム ファーマ インコーポレイテッド | 低分子量２環式トロンビン阻害剤 |
-
1997
- 1997-02-25 IL IL12031097A patent/IL120310A/en not_active IP Right Cessation
- 1997-02-25 TW TW086102261A patent/TW442452B/zh not_active IP Right Cessation
- 1997-02-26 PT PT97905099T patent/PT886647E/pt unknown
- 1997-02-26 BR BR9707808A patent/BR9707808A/pt not_active Application Discontinuation
- 1997-02-26 DK DK97905099T patent/DK0886647T3/da active
- 1997-02-26 ZA ZA9701667A patent/ZA971667B/xx unknown
- 1997-02-26 CZ CZ982778A patent/CZ277898A3/cs unknown
- 1997-02-26 WO PCT/EP1997/000938 patent/WO1997031937A1/en not_active Application Discontinuation
- 1997-02-26 JP JP9530600A patent/JP2000506837A/ja not_active Ceased
- 1997-02-26 DE DE69714222T patent/DE69714222T2/de not_active Expired - Fee Related
- 1997-02-26 EP EP97905099A patent/EP0886647B1/en not_active Expired - Lifetime
- 1997-02-26 AU AU18775/97A patent/AU709330B2/en not_active Ceased
- 1997-02-26 HU HU9900390A patent/HUP9900390A3/hu unknown
- 1997-02-26 CA CA002246246A patent/CA2246246A1/en not_active Abandoned
- 1997-02-26 AT AT97905099T patent/ATE221080T1/de not_active IP Right Cessation
- 1997-02-26 RU RU98117949/04A patent/RU2178419C2/ru active
- 1997-02-26 PL PL97328875A patent/PL328875A1/xx unknown
- 1997-02-26 US US09/142,110 patent/US6410684B1/en not_active Expired - Fee Related
- 1997-02-26 TR TR1998/01704T patent/TR199801704T2/xx unknown
- 1997-02-26 ES ES97905099T patent/ES2180933T3/es not_active Expired - Lifetime
- 1997-02-26 NZ NZ331484A patent/NZ331484A/xx unknown
- 1997-02-26 KR KR1019980706833A patent/KR19990087415A/ko not_active Application Discontinuation
- 1997-02-26 CN CN97192682A patent/CN1212704A/zh active Pending
- 1997-03-03 AR ARP970100833A patent/AR006310A1/es unknown
-
1998
- 1998-08-31 NO NO983991A patent/NO983991L/no not_active Application Discontinuation
-
1999
- 1999-06-22 HK HK99102658A patent/HK1021541A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9900390A3 (en) | 2000-11-28 |
| CZ277898A3 (cs) | 1999-06-16 |
| CA2246246A1 (en) | 1997-09-04 |
| DK0886647T3 (da) | 2002-11-04 |
| WO1997031937A1 (en) | 1997-09-04 |
| DE69714222D1 (de) | 2002-08-29 |
| NO983991D0 (no) | 1998-08-31 |
| IL120310A (en) | 2002-02-10 |
| PL328875A1 (en) | 1999-03-01 |
| AU1877597A (en) | 1997-09-16 |
| HK1021541A1 (en) | 2000-06-16 |
| ES2180933T3 (es) | 2003-02-16 |
| ZA971667B (en) | 1997-09-10 |
| US6410684B1 (en) | 2002-06-25 |
| EP0886647A1 (en) | 1998-12-30 |
| TR199801704T2 (xx) | 1998-12-21 |
| NZ331484A (en) | 2000-01-28 |
| TW442452B (en) | 2001-06-23 |
| RU2178419C2 (ru) | 2002-01-20 |
| CN1212704A (zh) | 1999-03-31 |
| JP2000506837A (ja) | 2000-06-06 |
| EP0886647B1 (en) | 2002-07-24 |
| AR006310A1 (es) | 1999-08-25 |
| NO983991L (no) | 1998-10-30 |
| IL120310A0 (en) | 1997-06-10 |
| HUP9900390A2 (hu) | 1999-06-28 |
| DE69714222T2 (de) | 2003-02-20 |
| PT886647E (pt) | 2002-12-31 |
| KR19990087415A (ko) | 1999-12-27 |
| AU709330B2 (en) | 1999-08-26 |
| ATE221080T1 (de) | 2002-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |