BR9711191A - Composto e uso do mesmo - Google Patents

Composto e uso do mesmo

Info

Publication number
BR9711191A
BR9711191A BR9711191A BR9711191A BR9711191A BR 9711191 A BR9711191 A BR 9711191A BR 9711191 A BR9711191 A BR 9711191A BR 9711191 A BR9711191 A BR 9711191A BR 9711191 A BR9711191 A BR 9711191A
Authority
BR
Brazil
Prior art keywords
compound
Prior art date
Application number
BR9711191A
Other languages
English (en)
Inventor
Dorit Baucke
Udo Lange
Helmut Mack
Werner Seitz
Thomas Zierke
Hans Wolfgang Hoffken
Wilfried Hornberger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR9711191A publication Critical patent/BR9711191A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
BR9711191A 1996-08-14 1997-07-29 Composto e uso do mesmo BR9711191A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19632773A DE19632773A1 (de) 1996-08-14 1996-08-14 Neue Thrombininhibitoren
PCT/EP1997/004104 WO1998006741A1 (de) 1996-08-14 1997-07-29 Thrombininhibitoren

Publications (1)

Publication Number Publication Date
BR9711191A true BR9711191A (pt) 1999-08-17

Family

ID=7802624

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9711191A BR9711191A (pt) 1996-08-14 1997-07-29 Composto e uso do mesmo

Country Status (30)

Country Link
US (1) US6114358A (pt)
EP (1) EP0956294B1 (pt)
JP (1) JP4089981B2 (pt)
KR (1) KR20000030002A (pt)
CN (1) CN1228783A (pt)
AR (1) AR009070A1 (pt)
AT (1) ATE268781T1 (pt)
AU (1) AU735364B2 (pt)
BG (1) BG103096A (pt)
BR (1) BR9711191A (pt)
CA (1) CA2263220A1 (pt)
CO (1) CO4900030A1 (pt)
CZ (1) CZ299634B6 (pt)
DE (2) DE19632773A1 (pt)
DK (1) DK0956294T3 (pt)
ES (1) ES2221062T3 (pt)
HR (1) HRP970441B1 (pt)
HU (1) HUP0001826A3 (pt)
ID (1) ID17873A (pt)
IL (1) IL127751A0 (pt)
MY (1) MY132820A (pt)
NO (1) NO990662D0 (pt)
NZ (1) NZ333679A (pt)
PL (1) PL188411B1 (pt)
PT (1) PT956294E (pt)
RU (1) RU2175328C2 (pt)
SK (1) SK284915B6 (pt)
TR (1) TR199900310T2 (pt)
WO (1) WO1998006741A1 (pt)
ZA (1) ZA977239B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
EP1049673A1 (de) * 1998-01-26 2000-11-08 Basf Aktiengesellschaft Heterocyclische amidine als kallikrein protease inhibitoren
WO1999037668A1 (de) * 1998-01-26 1999-07-29 Basf Aktiengesellschaft Thrombininhibitoren
DE69902754T2 (de) * 1998-02-09 2003-08-07 Dimensional Pharm Inc Heteroaryl-amidinen,-methylamidinen und -guanidinen als protease inhibitoren, insbesondere als urokinase inhibitoren
PL351767A1 (en) * 1999-02-09 2003-06-16 Dimensional Pharmaceuticals 3 Heteroaryl amidines, methylamidines and guanidines as protease inhibitors
EP1169315A2 (de) * 1999-04-09 2002-01-09 Basf Aktiengesellschaft Verfahren zur herstellung von thiophenyl-amidinen
HUP0202401A3 (en) 1999-04-09 2003-11-28 Abbott Gmbh & Co Kg Five-membered heterocyclic amidinec as prodrugs of thrombin inhibitors, pharmaceutical compositions comprising thereof and their use
TR200102913T2 (tr) 1999-04-09 2002-01-21 Basf Aktiengesellschaft Tam proteazların düşük moleküler ağırlıklı inhibitörleri.
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
KR20010002891A (ko) * 1999-06-18 2001-01-15 성재갑 아릴 또는 헤테로아릴 그룹을 갖는 트롬빈 억제제 및 그 제조 방법
DE19933861A1 (de) 1999-07-23 2001-01-25 Basf Ag Verfahren zur Herstellung von 2-Aminomethyl-4-cyano-thiazol
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
FI122575B (fi) 2006-12-04 2012-03-30 Dieffenbacher Panelboard Oy Laitteisto kuitujen, kuten lastujen sirottelemiseksi
EP2560966B1 (en) 2010-03-30 2021-01-06 Verseon International Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
CN110101700A (zh) * 2013-03-15 2019-08-09 维颂公司 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途
AU2014238478B2 (en) 2013-03-15 2018-07-19 Verseon Corporation Halogenopyrazoles as inhibitors of thrombin
CN103520160B (zh) * 2013-10-17 2015-04-22 广东药学院 三棱中肽类化合物的应用
CN106687445A (zh) 2014-09-17 2017-05-17 维颂公司 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物
BR112017018092A2 (pt) 2015-02-27 2018-04-10 Verseon Corp composto, composição farmacêutica, e, método para tratar e/ou prevenir uma doença ou distúrbio.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) * 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
NZ302649A (en) * 1995-02-17 2000-01-28 Basf Ag Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
DE19632772A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine

Also Published As

Publication number Publication date
PL331540A1 (en) 1999-07-19
HRP970441B1 (en) 2005-04-30
AU735364B2 (en) 2001-07-05
NZ333679A (en) 1999-09-29
CZ48699A3 (cs) 1999-05-12
CZ299634B6 (cs) 2008-10-01
US6114358A (en) 2000-09-05
WO1998006741A1 (de) 1998-02-19
NO990662L (no) 1999-02-12
IL127751A0 (en) 1999-10-28
HRP970441A2 (en) 1998-06-30
HUP0001826A2 (hu) 2000-09-28
EP0956294A1 (de) 1999-11-17
DE59711714D1 (de) 2004-07-15
PL188411B1 (pl) 2005-01-31
DE19632773A1 (de) 1998-02-19
ZA977239B (en) 1999-02-15
CA2263220A1 (en) 1998-02-19
SK899A3 (en) 1999-06-11
ATE268781T1 (de) 2004-06-15
TR199900310T2 (xx) 1999-04-21
MY132820A (en) 2007-10-31
SK284915B6 (sk) 2006-02-02
RU2175328C2 (ru) 2001-10-27
AR009070A1 (es) 2000-03-08
PT956294E (pt) 2004-10-29
DK0956294T3 (da) 2004-10-11
AU3941797A (en) 1998-03-06
JP2000516598A (ja) 2000-12-12
EP0956294B1 (de) 2004-06-09
NO990662D0 (no) 1999-02-12
CN1228783A (zh) 1999-09-15
KR20000030002A (ko) 2000-05-25
JP4089981B2 (ja) 2008-05-28
CO4900030A1 (es) 2000-03-27
HUP0001826A3 (en) 2002-01-28
ID17873A (id) 1998-02-05
ES2221062T3 (es) 2004-12-16
BG103096A (en) 1999-09-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: ABBOTT GMBH AND CO. KG (DE)

Free format text: TRANSFERIDO DE: BASF AKTIENGESELLSCHAFT

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 6A E 7A ANUIDADES.