PT956294E - Inibidores da trombina - Google Patents

Inibidores da trombina

Info

Publication number
PT956294E
PT956294E PT97936672T PT97936672T PT956294E PT 956294 E PT956294 E PT 956294E PT 97936672 T PT97936672 T PT 97936672T PT 97936672 T PT97936672 T PT 97936672T PT 956294 E PT956294 E PT 956294E
Authority
PT
Portugal
Prior art keywords
trombin
inhibitors
trombin inhibitors
Prior art date
Application number
PT97936672T
Other languages
English (en)
Inventor
Dorit Baucke
Udo Lange
Helmut Mack
Thomas Zierke
Wilfried Hornberger
Werner Seitz
Hans Wolfgang Hoffken
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of PT956294E publication Critical patent/PT956294E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
PT97936672T 1996-08-14 1997-07-29 Inibidores da trombina PT956294E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19632773A DE19632773A1 (de) 1996-08-14 1996-08-14 Neue Thrombininhibitoren

Publications (1)

Publication Number Publication Date
PT956294E true PT956294E (pt) 2004-10-29

Family

ID=7802624

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97936672T PT956294E (pt) 1996-08-14 1997-07-29 Inibidores da trombina

Country Status (30)

Country Link
US (1) US6114358A (pt)
EP (1) EP0956294B1 (pt)
JP (1) JP4089981B2 (pt)
KR (1) KR20000030002A (pt)
CN (1) CN1228783A (pt)
AR (1) AR009070A1 (pt)
AT (1) ATE268781T1 (pt)
AU (1) AU735364B2 (pt)
BG (1) BG103096A (pt)
BR (1) BR9711191A (pt)
CA (1) CA2263220A1 (pt)
CO (1) CO4900030A1 (pt)
CZ (1) CZ299634B6 (pt)
DE (2) DE19632773A1 (pt)
DK (1) DK0956294T3 (pt)
ES (1) ES2221062T3 (pt)
HR (1) HRP970441B1 (pt)
HU (1) HUP0001826A3 (pt)
ID (1) ID17873A (pt)
IL (1) IL127751A0 (pt)
MY (1) MY132820A (pt)
NO (1) NO990662L (pt)
NZ (1) NZ333679A (pt)
PL (1) PL188411B1 (pt)
PT (1) PT956294E (pt)
RU (1) RU2175328C2 (pt)
SK (1) SK284915B6 (pt)
TR (1) TR199900310T2 (pt)
WO (1) WO1998006741A1 (pt)
ZA (1) ZA977239B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
IL136139A0 (en) * 1998-01-26 2001-05-20 Basf Ag Thrombin inhibitors
JP2002501044A (ja) * 1998-01-26 2002-01-15 ビーエーエスエフ アクチェンゲゼルシャフト カリクレインプロテアーゼ阻害剤としての複素環アミジン
AU765072B2 (en) * 1998-02-09 2003-09-11 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines as protease inhibitors, in particular as urokinase inhibitors
EP1150979A1 (en) * 1999-02-09 2001-11-07 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines as protease inhibitors
TR200102912T2 (tr) * 1999-04-09 2002-03-21 Basf Ag. Trombin ihtibit”rlerinin ”n ila‡larì.
WO2000061574A2 (de) * 1999-04-09 2000-10-19 Basf Aktiengesellschaft Verfahren zur herstellung von thiophenyl-amidinen
MXPA01010114A (es) 1999-04-09 2002-07-30 Basf Ag Inhibidores de peso molecular bajo de las proteasas complemento.
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
KR20010002891A (ko) * 1999-06-18 2001-01-15 성재갑 아릴 또는 헤테로아릴 그룹을 갖는 트롬빈 억제제 및 그 제조 방법
DE19933861A1 (de) * 1999-07-23 2001-01-25 Basf Ag Verfahren zur Herstellung von 2-Aminomethyl-4-cyano-thiazol
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
FI122575B (fi) 2006-12-04 2012-03-30 Dieffenbacher Panelboard Oy Laitteisto kuitujen, kuten lastujen sirottelemiseksi
CN104940200B (zh) 2010-03-30 2019-06-28 维颂公司 多取代芳族化合物作为凝血酶的抑制剂
CN110423221A (zh) 2013-03-15 2019-11-08 维颂公司 作为凝血酶抑制剂的卤代吡唑
MX2015012867A (es) * 2013-03-15 2016-06-10 Verseon Corp Compuestos aromaticos multisustituidos como inhibidores de serina proteasa.
CN103520160B (zh) * 2013-10-17 2015-04-22 广东药学院 三棱中肽类化合物的应用
CN106687445A (zh) 2014-09-17 2017-05-17 维颂公司 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物
CN107405333A (zh) 2015-02-27 2017-11-28 维颂公司 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) * 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
BR9607582A (pt) * 1995-02-17 1998-07-07 Basf Ag Composto e peptídeo ou substância peptidomimética
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
DE19632772A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine

Also Published As

Publication number Publication date
DE19632773A1 (de) 1998-02-19
KR20000030002A (ko) 2000-05-25
IL127751A0 (en) 1999-10-28
SK899A3 (en) 1999-06-11
NO990662D0 (no) 1999-02-12
PL188411B1 (pl) 2005-01-31
BG103096A (en) 1999-09-30
CZ48699A3 (cs) 1999-05-12
HRP970441B1 (en) 2005-04-30
RU2175328C2 (ru) 2001-10-27
PL331540A1 (en) 1999-07-19
TR199900310T2 (xx) 1999-04-21
WO1998006741A1 (de) 1998-02-19
JP4089981B2 (ja) 2008-05-28
EP0956294A1 (de) 1999-11-17
MY132820A (en) 2007-10-31
ES2221062T3 (es) 2004-12-16
JP2000516598A (ja) 2000-12-12
AU735364B2 (en) 2001-07-05
ATE268781T1 (de) 2004-06-15
DK0956294T3 (da) 2004-10-11
BR9711191A (pt) 1999-08-17
CZ299634B6 (cs) 2008-10-01
CO4900030A1 (es) 2000-03-27
HRP970441A2 (en) 1998-06-30
NZ333679A (en) 1999-09-29
ID17873A (id) 1998-02-05
HUP0001826A2 (hu) 2000-09-28
SK284915B6 (sk) 2006-02-02
CA2263220A1 (en) 1998-02-19
AR009070A1 (es) 2000-03-08
HUP0001826A3 (en) 2002-01-28
ZA977239B (en) 1999-02-15
EP0956294B1 (de) 2004-06-09
CN1228783A (zh) 1999-09-15
DE59711714D1 (de) 2004-07-15
NO990662L (no) 1999-02-12
AU3941797A (en) 1998-03-06
US6114358A (en) 2000-09-05

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