TR200102912T2 - Trombin ihtibitrlerinin n ilalarì. - Google Patents
Trombin ihtibitrlerinin n ilalarì.Info
- Publication number
- TR200102912T2 TR200102912T2 TR2001/02912T TR200102912T TR200102912T2 TR 200102912 T2 TR200102912 T2 TR 200102912T2 TR 2001/02912 T TR2001/02912 T TR 2001/02912T TR 200102912 T TR200102912 T TR 200102912T TR 200102912 T2 TR200102912 T2 TR 200102912T2
- Authority
- TR
- Turkey
- Prior art keywords
- thrombin
- compounds
- vigilants
- relates
- inflammatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Mevcut buluç farmakolojik olarak aktif olan 5 üyeli heterosiklik amidinlerin ön ilaçlar , ki bunlardan tripsin benzeri serin proteazlar n, özellikle trombin'in rekabet edebilir önleyicileri olan in vivo bileçikleri üretilebilmektedir, bunlar n haz rlanmas ve ilaç olarak kullan lmalar ile ilgilidir. Buluç ayr ca bileçenler olarak aktif bileçiklerin ön ilaçlar n içeren farmasötik bileçimler ve bu bileçiklerin trombin önleyicileri, p ht laçma ve iltihaplanmaya karç maddeler olarak kullan lmalar ile de ilgilidir.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19915930 | 1999-04-09 | ||
DE19934123 | 1999-07-23 | ||
DE19947920 | 1999-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200102912T2 true TR200102912T2 (tr) | 2002-03-21 |
Family
ID=27219075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/02912T TR200102912T2 (tr) | 1999-04-09 | 2000-04-05 | Trombin ihtibitrlerinin n ilalarì. |
Country Status (18)
Country | Link |
---|---|
US (1) | US7144902B1 (tr) |
EP (1) | EP1165601A2 (tr) |
JP (1) | JP2002542165A (tr) |
KR (1) | KR20010108481A (tr) |
CN (1) | CN1355810A (tr) |
AU (1) | AU765244B2 (tr) |
BG (1) | BG105986A (tr) |
BR (1) | BR0009674A (tr) |
CA (1) | CA2370267A1 (tr) |
HK (1) | HK1046289A1 (tr) |
HU (1) | HUP0202401A3 (tr) |
IL (1) | IL145772A0 (tr) |
NO (1) | NO20014875L (tr) |
NZ (1) | NZ515026A (tr) |
PL (1) | PL352824A1 (tr) |
SK (1) | SK14222001A3 (tr) |
TR (1) | TR200102912T2 (tr) |
WO (1) | WO2000061609A2 (tr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
WO2004002985A1 (en) * | 2002-06-27 | 2004-01-08 | Lg Life Sciences Ltd. | Peptidic thrombin inhibitor compound |
CA2525940A1 (en) | 2003-05-16 | 2004-11-25 | National Institute For Biological Standards And Control (Nibsc) | Mixture |
USRE46830E1 (en) | 2004-10-19 | 2018-05-08 | Polypeptide Laboratories Holding (Ppl) Ab | Method for solid phase peptide synthesis |
EP1964578A3 (en) * | 2005-05-05 | 2008-11-05 | Chroma Therapeutics Limited | Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase |
SI1879573T1 (sl) | 2005-05-10 | 2013-04-30 | Incyte Corporation Experimental Station | Modulatorji indolamin 2,3-dioksigenaze in postopki za uporabo le-te |
ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
JP5319532B2 (ja) | 2006-09-19 | 2013-10-16 | インサイト・コーポレイション | インドールアミン2,3−ジオキシゲナーゼのモジュレーターとしてのn−ヒドロキシアミジノヘテロサイクル |
NO2824100T3 (tr) | 2008-07-08 | 2018-07-21 | ||
WO2011075684A1 (en) | 2009-12-18 | 2011-06-23 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
US9206123B2 (en) | 2009-12-18 | 2015-12-08 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
EP2697196A1 (en) | 2011-04-13 | 2014-02-19 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
ME03792B (me) | 2013-11-08 | 2021-04-20 | Incyte Holdings Corp | Postupak sinteze inhibitora indolamin 2,3-dioksigenaze |
JP6556146B2 (ja) * | 2014-08-26 | 2019-08-07 | 武田薬品工業株式会社 | 複素環化合物 |
CN106674190B (zh) * | 2016-12-13 | 2019-05-10 | 台州市创源工业技术有限公司 | 一种2-噻吩甲胺的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
AR005245A1 (es) * | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
TW523513B (en) | 1996-03-01 | 2003-03-11 | Akzo Nobel Nv | Serine protease inhibitors |
DE19632773A1 (de) * | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
EP1049673A1 (de) * | 1998-01-26 | 2000-11-08 | Basf Aktiengesellschaft | Heterocyclische amidine als kallikrein protease inhibitoren |
EP1051431A1 (de) * | 1998-01-26 | 2000-11-15 | Basf Aktiengesellschaft | Thrombininhibitoren |
KR20000047461A (ko) * | 1998-12-29 | 2000-07-25 | 성재갑 | 트롬빈 억제제 |
JP4489976B2 (ja) * | 1999-04-09 | 2010-06-23 | ビーエーエスエフ ソシエタス・ヨーロピア | 補体プロテアーゼの低分子インヒビター |
-
2000
- 2000-04-05 EP EP00920661A patent/EP1165601A2/de not_active Withdrawn
- 2000-04-05 JP JP2000611551A patent/JP2002542165A/ja active Pending
- 2000-04-05 CN CN00807958A patent/CN1355810A/zh active Pending
- 2000-04-05 KR KR1020017012870A patent/KR20010108481A/ko not_active Application Discontinuation
- 2000-04-05 WO PCT/EP2000/003009 patent/WO2000061609A2/de not_active Application Discontinuation
- 2000-04-05 CA CA002370267A patent/CA2370267A1/en not_active Abandoned
- 2000-04-05 IL IL14577200A patent/IL145772A0/xx unknown
- 2000-04-05 NZ NZ515026A patent/NZ515026A/en unknown
- 2000-04-05 AU AU41156/00A patent/AU765244B2/en not_active Ceased
- 2000-04-05 TR TR2001/02912T patent/TR200102912T2/tr unknown
- 2000-04-05 BR BR0009674-1A patent/BR0009674A/pt not_active IP Right Cessation
- 2000-04-05 SK SK1422-2001A patent/SK14222001A3/sk not_active Application Discontinuation
- 2000-04-05 PL PL00352824A patent/PL352824A1/xx unknown
- 2000-04-05 HU HU0202401A patent/HUP0202401A3/hu unknown
- 2000-04-05 US US09/958,349 patent/US7144902B1/en not_active Expired - Fee Related
-
2001
- 2001-10-05 BG BG105986A patent/BG105986A/bg unknown
- 2001-10-08 NO NO20014875A patent/NO20014875L/no not_active Application Discontinuation
-
2002
- 2002-10-30 HK HK02107849.6A patent/HK1046289A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
BR0009674A (pt) | 2002-01-15 |
SK14222001A3 (sk) | 2002-07-02 |
NO20014875L (no) | 2001-11-13 |
HUP0202401A2 (en) | 2002-10-28 |
WO2000061609A3 (de) | 2001-03-15 |
HK1046289A1 (zh) | 2003-01-03 |
EP1165601A2 (de) | 2002-01-02 |
AU765244B2 (en) | 2003-09-11 |
AU4115600A (en) | 2000-11-14 |
CA2370267A1 (en) | 2000-10-19 |
PL352824A1 (en) | 2003-09-08 |
JP2002542165A (ja) | 2002-12-10 |
WO2000061609B1 (de) | 2001-04-26 |
BG105986A (bg) | 2002-06-28 |
WO2000061609A2 (de) | 2000-10-19 |
HUP0202401A3 (en) | 2003-11-28 |
NZ515026A (en) | 2003-10-31 |
KR20010108481A (ko) | 2001-12-07 |
US7144902B1 (en) | 2006-12-05 |
IL145772A0 (en) | 2002-07-25 |
NO20014875D0 (no) | 2001-10-08 |
CN1355810A (zh) | 2002-06-26 |
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