TR200102524T2 - Dihetero sübstitüe edilmiş metaloproteaz inhibitörleri. - Google Patents
Dihetero sübstitüe edilmiş metaloproteaz inhibitörleri.Info
- Publication number
- TR200102524T2 TR200102524T2 TR2001/02524T TR200102524T TR200102524T2 TR 200102524 T2 TR200102524 T2 TR 200102524T2 TR 2001/02524 T TR2001/02524 T TR 2001/02524T TR 200102524 T TR200102524 T TR 200102524T TR 200102524 T2 TR200102524 T2 TR 200102524T2
- Authority
- TR
- Turkey
- Prior art keywords
- compounds
- dihetero
- metalloprotease inhibitors
- pharmaceutical compositions
- metalloprotease
- Prior art date
Links
- 239000003475 metalloproteinase inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010013082 Discomfort Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
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- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
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- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
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- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
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- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
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- Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Thiazole And Isothizaole Compounds (AREA)
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Abstract
Metaloproteaz inhibitörleri olan ve bu enzimlerin asiri aktifligi ile ayirt edilen rahatsizliklarin tedavisinde etkili olan bilesikler tarif edilmektedir. Özellikle, bilesikler Formül (1) yapisina sahiptir, burada M, Q, T, W, Z, R1, R2, R3, R4, R4', R5, R6, R6',R7, m ve n tarifnamede verilen anlamlara sahiptir. Bu bulus ayrica bahsedilen förmülün optik izomerlerini, diastereomerlerini ve enantiomerlerini, ve farmasötik olarak uygun tuzlarini, biyo-hidroliz edilebilir amdilerini, esterlerini ve imidlerini de içerir. Ayrica, bu bilesikleri içeren farmasötik bilesimler ve bu bilesiklr ve farmasötik bilesimler kullanilarak metaloproteaz ile ilgili hastaliklari tedavi ve önlenmesi yöntemleri tarif edilmektedir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12271899P | 1999-03-03 | 1999-03-03 |
Publications (1)
Publication Number | Publication Date |
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TR200102524T2 true TR200102524T2 (tr) | 2002-02-21 |
Family
ID=22404346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/02524T TR200102524T2 (tr) | 1999-03-03 | 2000-03-01 | Dihetero sübstitüe edilmiş metaloproteaz inhibitörleri. |
Country Status (25)
Country | Link |
---|---|
US (2) | US6566381B1 (tr) |
EP (1) | EP1165530A2 (tr) |
JP (1) | JP2002538146A (tr) |
KR (1) | KR20010102485A (tr) |
CN (1) | CN1362951A (tr) |
AR (1) | AR022824A1 (tr) |
AU (1) | AU767344B2 (tr) |
BR (1) | BR0009244A (tr) |
CA (1) | CA2366954A1 (tr) |
CO (1) | CO5180578A1 (tr) |
CZ (1) | CZ20013155A3 (tr) |
HK (1) | HK1044935A1 (tr) |
HU (1) | HUP0201714A3 (tr) |
IL (1) | IL145085A0 (tr) |
MA (1) | MA26775A1 (tr) |
MX (1) | MXPA01008857A (tr) |
NO (1) | NO20014243L (tr) |
NZ (1) | NZ513830A (tr) |
PE (1) | PE20001640A1 (tr) |
PL (1) | PL350452A1 (tr) |
RU (1) | RU2001126719A (tr) |
SK (1) | SK12462001A3 (tr) |
TR (1) | TR200102524T2 (tr) |
WO (1) | WO2000051993A2 (tr) |
ZA (1) | ZA200106966B (tr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL145085A0 (en) * | 1999-03-03 | 2002-06-30 | Procter & Gamble | Dihetero-substituted metalloprotease inhibitors |
PL355764A1 (en) * | 1999-10-14 | 2004-05-17 | The Procter & Gamble Company | Beta disubstituted metalloprotease inhibitors |
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-
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- 2000-03-01 IL IL14508500A patent/IL145085A0/xx unknown
- 2000-03-01 US US09/516,743 patent/US6566381B1/en not_active Expired - Fee Related
- 2000-03-01 NZ NZ513830A patent/NZ513830A/en unknown
- 2000-03-01 AU AU37118/00A patent/AU767344B2/en not_active Ceased
- 2000-03-01 MX MXPA01008857A patent/MXPA01008857A/es unknown
- 2000-03-01 CZ CZ20013155A patent/CZ20013155A3/cs unknown
- 2000-03-01 HU HU0201714A patent/HUP0201714A3/hu unknown
- 2000-03-01 EP EP00915936A patent/EP1165530A2/en not_active Withdrawn
- 2000-03-01 SK SK1246-2001A patent/SK12462001A3/sk unknown
- 2000-03-01 KR KR1020017011235A patent/KR20010102485A/ko not_active Application Discontinuation
- 2000-03-01 JP JP2000602220A patent/JP2002538146A/ja not_active Withdrawn
- 2000-03-01 BR BR0009244-4A patent/BR0009244A/pt not_active IP Right Cessation
- 2000-03-01 WO PCT/US2000/005195 patent/WO2000051993A2/en not_active Application Discontinuation
- 2000-03-01 CA CA002366954A patent/CA2366954A1/en not_active Abandoned
- 2000-03-01 CN CN00806920A patent/CN1362951A/zh active Pending
- 2000-03-01 PL PL00350452A patent/PL350452A1/xx not_active Application Discontinuation
- 2000-03-01 RU RU2001126719/04A patent/RU2001126719A/ru unknown
- 2000-03-01 TR TR2001/02524T patent/TR200102524T2/tr unknown
- 2000-03-03 AR ARP000100950A patent/AR022824A1/es unknown
- 2000-03-03 CO CO00015569A patent/CO5180578A1/es not_active Application Discontinuation
- 2000-03-22 PE PE2000000247A patent/PE20001640A1/es not_active Application Discontinuation
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2001
- 2001-08-23 ZA ZA200106966A patent/ZA200106966B/en unknown
- 2001-08-31 NO NO20014243A patent/NO20014243L/no not_active Application Discontinuation
- 2001-09-03 MA MA26311A patent/MA26775A1/fr unknown
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2002
- 2002-06-24 HK HK02104690.3A patent/HK1044935A1/zh unknown
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2003
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Also Published As
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WO2000051993A3 (en) | 2000-12-21 |
CN1362951A (zh) | 2002-08-07 |
NO20014243L (no) | 2001-10-17 |
CO5180578A1 (es) | 2002-07-30 |
US6762198B2 (en) | 2004-07-13 |
PL350452A1 (en) | 2002-12-16 |
CZ20013155A3 (cs) | 2002-01-16 |
IL145085A0 (en) | 2002-06-30 |
HUP0201714A3 (en) | 2003-05-28 |
HK1044935A1 (zh) | 2002-11-08 |
MXPA01008857A (es) | 2002-07-02 |
US20030225074A1 (en) | 2003-12-04 |
KR20010102485A (ko) | 2001-11-15 |
CA2366954A1 (en) | 2000-09-08 |
AU767344B2 (en) | 2003-11-06 |
HUP0201714A2 (en) | 2002-10-28 |
SK12462001A3 (sk) | 2002-04-04 |
NZ513830A (en) | 2001-09-28 |
EP1165530A2 (en) | 2002-01-02 |
AU3711800A (en) | 2000-09-21 |
ZA200106966B (en) | 2002-03-13 |
AR022824A1 (es) | 2002-09-04 |
NO20014243D0 (no) | 2001-08-31 |
BR0009244A (pt) | 2002-04-16 |
MA26775A1 (fr) | 2004-12-20 |
RU2001126719A (ru) | 2004-02-20 |
JP2002538146A (ja) | 2002-11-12 |
WO2000051993A2 (en) | 2000-09-08 |
US6566381B1 (en) | 2003-05-20 |
PE20001640A1 (es) | 2001-02-01 |
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