TR200102914T2 - Trombin önleyicilerinin önilaçları - Google Patents

Trombin önleyicilerinin önilaçları

Info

Publication number
TR200102914T2
TR200102914T2 TR2001/02914T TR200102914T TR200102914T2 TR 200102914 T2 TR200102914 T2 TR 200102914T2 TR 2001/02914 T TR2001/02914 T TR 2001/02914T TR 200102914 T TR200102914 T TR 200102914T TR 200102914 T2 TR200102914 T2 TR 200102914T2
Authority
TR
Turkey
Prior art keywords
prodrugs
thrombin inhibitors
formula
amidines
trypsin
Prior art date
Application number
TR2001/02914T
Other languages
English (en)
Inventor
Baucke Dorit
Mack Helmut
Seitz Werner
Hornberger Wilfried
Backfisch Gisela
Delzer J�Rgen
Original Assignee
Basf Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26004346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200102914(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Basf Ag. filed Critical Basf Ag.
Publication of TR200102914T2 publication Critical patent/TR200102914T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Mevcut bulus formül (I)'in önilaçlari ile ilgilidir. Söz konusu formülün anlami tarifname içerisinde verilmektedir. Farmasötik olarak aktif olan önilaçlar, heterosiklik amidinler açiklanmaktadir. Tripsin benzeri serin proteazlarin, özellikle trombinin, rekabet edebilir önleyicileri olan in vivo bilesikler amidinlerden üretilmektedir. Bulus önilaçlarin üretilmeleri ve ilaç olarak kullanilmalari ile de ilgilidir.
TR2001/02914T 1999-04-09 2000-04-05 Trombin önleyicilerinin önilaçları TR200102914T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19915930 1999-04-09
DE10006799 2000-02-15

Publications (1)

Publication Number Publication Date
TR200102914T2 true TR200102914T2 (tr) 2002-01-21

Family

ID=26004346

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02914T TR200102914T2 (tr) 1999-04-09 2000-04-05 Trombin önleyicilerinin önilaçları

Country Status (16)

Country Link
EP (1) EP1169318A1 (tr)
JP (1) JP2002541254A (tr)
KR (1) KR20020004995A (tr)
CN (1) CN1349526A (tr)
AU (1) AU3659200A (tr)
BG (1) BG105985A (tr)
BR (1) BR0009653A (tr)
CA (1) CA2368830A1 (tr)
HK (1) HK1045516A1 (tr)
HU (1) HUP0202431A3 (tr)
IL (1) IL145670A0 (tr)
NO (1) NO20014807L (tr)
PL (1) PL352834A1 (tr)
SK (1) SK14092001A3 (tr)
TR (1) TR200102914T2 (tr)
WO (1) WO2000061577A1 (tr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
MXPA04012396A (es) * 2002-06-14 2005-06-17 Sato Fumihiko Compuestos de imidazol, metodos y uso para la produccion de los mismos.
JP5140428B2 (ja) 2004-08-23 2013-02-06 ロッコ・システムズ・プライベイト・リミテッド 集積回路ダイシング装置のチャック用供給機構

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
NZ302649A (en) * 1995-02-17 2000-01-28 Basf Ag Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof
DE19631084A1 (de) * 1996-08-01 1998-02-05 Basf Ag Verwendung von (Meth)acrylsäure-Copolymeren zur Erhöhung der Permeabilität der Schleimhaut
DE19635674A1 (de) * 1996-09-03 1998-03-05 Basf Ag Verfahren zur Herstellung von Amidinen

Also Published As

Publication number Publication date
WO2000061577A1 (de) 2000-10-19
PL352834A1 (en) 2003-09-08
CN1349526A (zh) 2002-05-15
HUP0202431A2 (hu) 2002-11-28
CA2368830A1 (en) 2000-10-19
HUP0202431A3 (en) 2003-03-28
SK14092001A3 (sk) 2002-05-09
BR0009653A (pt) 2002-01-08
JP2002541254A (ja) 2002-12-03
AU3659200A (en) 2000-11-14
NO20014807D0 (no) 2001-10-03
HK1045516A1 (zh) 2002-11-29
IL145670A0 (en) 2002-06-30
EP1169318A1 (de) 2002-01-09
BG105985A (en) 2002-06-28
NO20014807L (no) 2001-12-04
KR20020004995A (ko) 2002-01-16

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