ATE303989T1 - Inhibitoren von serin proteasen - Google Patents
Inhibitoren von serin proteasenInfo
- Publication number
- ATE303989T1 ATE303989T1 AT01938403T AT01938403T ATE303989T1 AT E303989 T1 ATE303989 T1 AT E303989T1 AT 01938403 T AT01938403 T AT 01938403T AT 01938403 T AT01938403 T AT 01938403T AT E303989 T1 ATE303989 T1 AT E303989T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- serine proteases
- factor
- compounds
- useful
- Prior art date
Links
- 108010022999 Serine Proteases Proteins 0.000 title abstract 2
- 102000012479 Serine Proteases Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2000/002302 WO2000076971A2 (en) | 1999-06-14 | 2000-06-13 | Serine protease inhibitors |
| GBGB0030306.5A GB0030306D0 (en) | 2000-12-13 | 2000-12-13 | Compounds |
| PCT/GB2001/002572 WO2001096304A1 (en) | 2000-06-13 | 2001-06-12 | Serine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE303989T1 true ATE303989T1 (de) | 2005-09-15 |
Family
ID=9904939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01938403T ATE303989T1 (de) | 2000-06-13 | 2001-06-12 | Inhibitoren von serin proteasen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6784182B2 (de) |
| EP (1) | EP1289953B1 (de) |
| AT (1) | ATE303989T1 (de) |
| AU (1) | AU2001264081A1 (de) |
| DE (1) | DE60113252T2 (de) |
| ES (1) | ES2247120T3 (de) |
| GB (1) | GB0030306D0 (de) |
| WO (1) | WO2001096304A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0030303D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| WO2003010160A2 (en) * | 2001-07-26 | 2003-02-06 | Eli Lilly And Company | 1-glycinyl-4 (methylpiperidin-4-yl) piperazines and -piperridines as factor xa antagonists |
| EP1455788A1 (de) * | 2001-12-12 | 2004-09-15 | Eli Lilly And Company | 1-glycinyl-4-aminomethyl-piperidin-derivate als faktor-xa-hemmer |
| DE60336986D1 (de) | 2002-03-05 | 2011-06-16 | Sumitomo Chemical Co | Verfahren zur herstellung von biarylverbindungen |
| PL373066A1 (en) | 2002-04-01 | 2005-08-08 | Eli Lilly And Company | Certain 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazine compounds as inhibitors of the serine protease factor xa |
| PE20040804A1 (es) | 2002-12-19 | 2004-12-31 | Boehringer Ingelheim Pharma | DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa |
| JP2006526633A (ja) * | 2003-06-02 | 2006-11-24 | サマリタン，ファーマスーティカルス，インク． | 抗ｈｉｖ性ベンズアミド化合物 |
| JP2006526635A (ja) * | 2003-06-02 | 2006-11-24 | サマリタン，ファーマスーティカルス，インク． | 血清中コルチゾール量を調節する方法および組成物 |
| US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| EP2285783B1 (de) | 2008-04-29 | 2014-05-21 | Boehringer Ingelheim International GmbH | Indazolverbindungen als ccr1-rezeptorantagonisten |
| EP2297112B1 (de) * | 2008-05-06 | 2013-04-03 | Boehringer Ingelheim International GmbH | Pyrazolverbindungen als ccr1-antagonisten |
| MX2011002951A (es) * | 2008-09-26 | 2011-04-26 | Boehringer Ingelheim Int | Compuestos de azaindazol como antagonistas del receptor de ccr1. |
| KR20120093754A (ko) | 2009-03-10 | 2012-08-23 | 메드 디스커버리 에스에이 | 세린 프로테아제 저해제의 호중구감소증 치료에서의 용도 |
| EA021015B1 (ru) | 2009-10-21 | 2015-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Индазолы и пиразолопиридины в качестве антагонистов рецептора ccr1 |
| JP5542214B2 (ja) | 2009-10-27 | 2014-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体アンタゴニストとしての複素環化合物 |
| JP2013512954A (ja) * | 2009-12-08 | 2013-04-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換インダゾール及びアザインダゾール化合物の生成に有効な中間体の合成方法 |
| JP5793182B2 (ja) | 2010-04-30 | 2015-10-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体アンタゴニストとしてのアザインダゾールアミド化合物 |
| JP5684406B2 (ja) | 2010-12-23 | 2015-03-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体アンタゴニストとしてのピラゾロピペリジン化合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5346907A (en) | 1988-04-05 | 1994-09-13 | Abbott Laboratories | Amino acid analog CCK antagonists |
| IE902295A1 (en) | 1989-07-07 | 1991-01-16 | Abbott Lab | Amino acid analog cck antagonists |
| CA2200163A1 (en) | 1996-03-22 | 1997-09-22 | Michael Robert Wiley | Antithrombotic diamides |
| CA2258915A1 (en) | 1996-06-25 | 1997-12-31 | Michael Robert Wiley | Anticoagulant agents |
| IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| WO1999000126A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
| IL133621A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| WO1999000127A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
| ES2241151T3 (es) | 1997-06-26 | 2005-10-16 | Eli Lilly And Company | Agentes antitromboticos. |
| WO1999011657A1 (en) | 1997-08-29 | 1999-03-11 | Proteus Molecular Design Ltd. | 1-amino-7-isoquinoline derivatives as serine protease inhibitors |
| AU2054700A (en) | 1998-12-23 | 2000-07-31 | Eli Lilly And Company | Antithrombotic amides |
| ES2226485T3 (es) | 1998-12-23 | 2005-03-16 | Eli Lilly And Company | Amidas aromaticas. |
| JP2002533453A (ja) | 1998-12-23 | 2002-10-08 | イーライ・リリー・アンド・カンパニー | Ｘａ因子のインヒビターとしてのヘテロ芳香族アミド |
| ATE261941T1 (de) | 1998-12-24 | 2004-04-15 | Lilly Co Eli | Heterocyclische amide als inhibitoren von faktor xa |
| JP2003500385A (ja) | 1999-05-24 | 2003-01-07 | コア・セラピューティクス，インコーポレイテッド | Ｘａ因子阻害剤 |
| CA2374646A1 (en) | 1999-05-24 | 2000-11-30 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
| JP2003502314A (ja) * | 1999-06-14 | 2003-01-21 | イーライ・リリー・アンド・カンパニー | 化合物 |
| AU5413600A (en) | 1999-06-14 | 2001-01-02 | Eli Lilly And Company | Compounds |
-
2000
- 2000-12-13 GB GBGB0030306.5A patent/GB0030306D0/en not_active Ceased
-
2001
- 2001-06-12 EP EP01938403A patent/EP1289953B1/de not_active Expired - Lifetime
- 2001-06-12 AT AT01938403T patent/ATE303989T1/de not_active IP Right Cessation
- 2001-06-12 WO PCT/GB2001/002572 patent/WO2001096304A1/en active IP Right Grant
- 2001-06-12 DE DE60113252T patent/DE60113252T2/de not_active Expired - Fee Related
- 2001-06-12 ES ES01938403T patent/ES2247120T3/es not_active Expired - Lifetime
- 2001-06-12 AU AU2001264081A patent/AU2001264081A1/en not_active Abandoned
- 2001-06-12 US US10/030,186 patent/US6784182B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60113252T2 (de) | 2006-06-08 |
| US6784182B2 (en) | 2004-08-31 |
| US20020151724A1 (en) | 2002-10-17 |
| WO2001096304A1 (en) | 2001-12-20 |
| AU2001264081A1 (en) | 2001-12-24 |
| DE60113252D1 (de) | 2005-10-13 |
| GB0030306D0 (en) | 2001-01-24 |
| ES2247120T3 (es) | 2006-03-01 |
| EP1289953A1 (de) | 2003-03-12 |
| EP1289953B1 (de) | 2005-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |