DE60113252D1 - Inhibitoren von serin proteasen - Google Patents
Inhibitoren von serin proteasenInfo
- Publication number
- DE60113252D1 DE60113252D1 DE60113252T DE60113252T DE60113252D1 DE 60113252 D1 DE60113252 D1 DE 60113252D1 DE 60113252 T DE60113252 T DE 60113252T DE 60113252 T DE60113252 T DE 60113252T DE 60113252 D1 DE60113252 D1 DE 60113252D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- serin proteases
- serin
- proteases
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/GB00/02302 | 2000-06-13 | ||
| PCT/GB2000/002302 WO2000076971A2 (en) | 1999-06-14 | 2000-06-13 | Serine protease inhibitors |
| GBGB0030306.5A GB0030306D0 (en) | 2000-12-13 | 2000-12-13 | Compounds |
| GB0030306 | 2000-12-13 | ||
| PCT/GB2001/002572 WO2001096304A1 (en) | 2000-06-13 | 2001-06-12 | Serine protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60113252D1 true DE60113252D1 (de) | 2005-10-13 |
| DE60113252T2 DE60113252T2 (de) | 2006-06-08 |
Family
ID=9904939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60113252T Expired - Fee Related DE60113252T2 (de) | 2000-06-13 | 2001-06-12 | Inhibitoren von serin proteasen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6784182B2 (de) |
| EP (1) | EP1289953B1 (de) |
| AT (1) | ATE303989T1 (de) |
| AU (1) | AU2001264081A1 (de) |
| DE (1) | DE60113252T2 (de) |
| ES (1) | ES2247120T3 (de) |
| GB (1) | GB0030306D0 (de) |
| WO (1) | WO2001096304A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0030303D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| ES2298386T3 (es) * | 2001-07-26 | 2008-05-16 | Eli Lilly And Company | 1-glicinil-4-(1-metilpiperidin-4-il)piperazinas y -piperidinas como antagonistas del factor xa. |
| AU2002359379A1 (en) | 2001-12-12 | 2003-06-23 | Eli Lilly And Company | Chemical compounds |
| EP1481967B1 (de) * | 2002-03-05 | 2011-05-04 | Sumitomo Chemical Company, Limited | Verfahren zur herstellung von biarylverbindungen |
| EP1492767B1 (de) | 2002-04-01 | 2005-09-07 | Eli Lilly And Company | Bestimmte 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazin verbindungen als inhibitoren der serin protease factor xa |
| PE20040804A1 (es) | 2002-12-19 | 2004-12-31 | Boehringer Ingelheim Pharma | DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa |
| WO2005000205A2 (en) * | 2003-06-02 | 2005-01-06 | Samaritan Pharmaceuticals, Inc. | Methods and compositions for modulating serum cortisol levels |
| CA2527211A1 (en) * | 2003-06-02 | 2004-12-16 | Samaritan Pharmaceuticals, Inc. | Anti-hiv benzamide compounds |
| US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| US8008327B2 (en) * | 2008-04-29 | 2011-08-30 | Boehringer Ingelheim International Gmbh | Indazole compounds as CCR1 receptor antagonists |
| CA2722811C (en) * | 2008-05-06 | 2016-07-05 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as ccr1 antagonists |
| CN102227425A (zh) | 2008-09-26 | 2011-10-26 | 贝林格尔·英格海姆国际有限公司 | 作为ccr1受体拮抗剂的氮杂吲唑化合物 |
| EP2405925B1 (de) | 2009-03-10 | 2015-01-14 | Med Discovery Sa | Kallikrein-inhibitoren zur behandlung von neutropenie |
| RS53130B (en) | 2009-10-21 | 2014-06-30 | Boehringer Ingelheim International Gmbh | INDASOL AND PYRAZOLOPYRIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS |
| EP2493875B1 (de) | 2009-10-27 | 2014-08-06 | Boehringer Ingelheim International GmbH | Iheterozyklische verbindungen als ccr1-rezeptorantagonisten |
| EA201200820A1 (ru) * | 2009-12-08 | 2013-01-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов |
| US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
| WO2012087782A1 (en) | 2010-12-23 | 2012-06-28 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5346907A (en) * | 1988-04-05 | 1994-09-13 | Abbott Laboratories | Amino acid analog CCK antagonists |
| IE902295A1 (en) | 1989-07-07 | 1991-01-16 | Abbott Lab | Amino acid analog cck antagonists |
| CA2200163A1 (en) | 1996-03-22 | 1997-09-22 | Michael Robert Wiley | Antithrombotic diamides |
| US5863929A (en) | 1996-06-25 | 1999-01-26 | Eli Lilly And Company | Anticoagulant agents |
| IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| WO1999000121A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
| EP1007037A4 (de) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | Antithrombose mittel |
| WO1999000128A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
| CA2295153A1 (en) | 1997-06-26 | 1999-01-07 | Gerald Floyd Smith | Antithrombotic agents |
| DE69830410T2 (de) | 1997-08-29 | 2006-01-26 | Tularik Ltd. | Meta-benzamidinderivate als serinprotease-inhibitoren |
| WO2000039111A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | Antithrombotic amides |
| WO2000039117A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa |
| US6635657B1 (en) | 1998-12-23 | 2003-10-21 | Eli Lilly And Company | Aromatic amides |
| US6660739B1 (en) | 1998-12-24 | 2003-12-09 | Eli Lilly And Company | Heterocyclic amides as inhibitors of factor Xa |
| JP2003500382A (ja) * | 1999-05-24 | 2003-01-07 | シーオーアール セラピューティクス インコーポレイテッド | Ｘａ因子の阻害剤 |
| WO2000071508A2 (en) | 1999-05-24 | 2000-11-30 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
| JP2003502314A (ja) | 1999-06-14 | 2003-01-21 | イーライ・リリー・アンド・カンパニー | 化合物 |
| EP1192135A2 (de) | 1999-06-14 | 2002-04-03 | Eli Lilly And Company | Inhibitoren von serin proteasen |
-
2000
- 2000-12-13 GB GBGB0030306.5A patent/GB0030306D0/en not_active Ceased
-
2001
- 2001-06-12 AT AT01938403T patent/ATE303989T1/de not_active IP Right Cessation
- 2001-06-12 ES ES01938403T patent/ES2247120T3/es not_active Expired - Lifetime
- 2001-06-12 AU AU2001264081A patent/AU2001264081A1/en not_active Abandoned
- 2001-06-12 WO PCT/GB2001/002572 patent/WO2001096304A1/en active IP Right Grant
- 2001-06-12 EP EP01938403A patent/EP1289953B1/de not_active Expired - Lifetime
- 2001-06-12 DE DE60113252T patent/DE60113252T2/de not_active Expired - Fee Related
- 2001-06-12 US US10/030,186 patent/US6784182B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB0030306D0 (en) | 2001-01-24 |
| US6784182B2 (en) | 2004-08-31 |
| ES2247120T3 (es) | 2006-03-01 |
| AU2001264081A1 (en) | 2001-12-24 |
| EP1289953B1 (de) | 2005-09-07 |
| WO2001096304A1 (en) | 2001-12-20 |
| EP1289953A1 (de) | 2003-03-12 |
| US20020151724A1 (en) | 2002-10-17 |
| ATE303989T1 (de) | 2005-09-15 |
| DE60113252T2 (de) | 2006-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE304532T1 (de) | Inhibitoren von serin proteasen | |
| TR200402535T4 (tr) | Serin proteaz inhibitörleri. | |
| DE60022508D1 (de) | Inhibitoren von serin proteasen | |
| ATE275544T1 (de) | Serinprotease-inhibitoren | |
| DE60113252D1 (de) | Inhibitoren von serin proteasen | |
| ATE355101T1 (de) | Inhibitoren von serin proteasen | |
| DE60033689D1 (de) | Inhibitoren von serinproteasen | |
| WO2000076970A3 (en) | Serine protease inhibitors | |
| MXPA03006224A (es) | Inhibidores de cruzipaina y otras proteasas de cisteina. | |
| NO20002848L (no) | Nye forbindelser | |
| SE0001803D0 (sv) | New compounds i | |
| ATE287403T1 (de) | 6-phenylbenzonaphthyidine | |
| DE60124397D1 (de) | Inhibitoren von serinproteasen | |
| ATE344795T1 (de) | Inhibitoren von serinproteasen | |
| ATE364037T1 (de) | Tryptasehemmer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |