HUP0202431A3 - Prodrugs of thrombin inhibitors - Google Patents

Prodrugs of thrombin inhibitors

Info

Publication number
HUP0202431A3
HUP0202431A3 HU0202431A HUP0202431A HUP0202431A3 HU P0202431 A3 HUP0202431 A3 HU P0202431A3 HU 0202431 A HU0202431 A HU 0202431A HU P0202431 A HUP0202431 A HU P0202431A HU P0202431 A3 HUP0202431 A3 HU P0202431A3
Authority
HU
Hungary
Prior art keywords
prodrugs
thrombin inhibitors
thrombin
inhibitors
Prior art date
Application number
HU0202431A
Other languages
English (en)
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26004346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0202431(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Basf Ag filed Critical Basf Ag
Publication of HUP0202431A2 publication Critical patent/HUP0202431A2/hu
Publication of HUP0202431A3 publication Critical patent/HUP0202431A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
HU0202431A 1999-04-09 2000-04-05 Prodrugs of thrombin inhibitors HUP0202431A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19915930 1999-04-09
DE10006799 2000-02-15

Publications (2)

Publication Number Publication Date
HUP0202431A2 HUP0202431A2 (hu) 2002-11-28
HUP0202431A3 true HUP0202431A3 (en) 2003-03-28

Family

ID=26004346

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202431A HUP0202431A3 (en) 1999-04-09 2000-04-05 Prodrugs of thrombin inhibitors

Country Status (16)

Country Link
EP (1) EP1169318A1 (hu)
JP (1) JP2002541254A (hu)
KR (1) KR20020004995A (hu)
CN (1) CN1349526A (hu)
AU (1) AU3659200A (hu)
BG (1) BG105985A (hu)
BR (1) BR0009653A (hu)
CA (1) CA2368830A1 (hu)
HK (1) HK1045516A1 (hu)
HU (1) HUP0202431A3 (hu)
IL (1) IL145670A0 (hu)
NO (1) NO20014807L (hu)
PL (1) PL352834A1 (hu)
SK (1) SK14092001A3 (hu)
TR (1) TR200102914T2 (hu)
WO (1) WO2000061577A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
MXPA04012396A (es) * 2002-06-14 2005-06-17 Sato Fumihiko Compuestos de imidazol, metodos y uso para la produccion de los mismos.
JP5140428B2 (ja) 2004-08-23 2013-02-06 ロッコ・システムズ・プライベイト・リミテッド 集積回路ダイシング装置のチャック用供給機構

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
NZ302649A (en) * 1995-02-17 2000-01-28 Basf Ag Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof
DE19631084A1 (de) * 1996-08-01 1998-02-05 Basf Ag Verwendung von (Meth)acrylsäure-Copolymeren zur Erhöhung der Permeabilität der Schleimhaut
DE19635674A1 (de) * 1996-09-03 1998-03-05 Basf Ag Verfahren zur Herstellung von Amidinen

Also Published As

Publication number Publication date
WO2000061577A1 (de) 2000-10-19
PL352834A1 (en) 2003-09-08
TR200102914T2 (tr) 2002-01-21
CN1349526A (zh) 2002-05-15
HUP0202431A2 (hu) 2002-11-28
CA2368830A1 (en) 2000-10-19
SK14092001A3 (sk) 2002-05-09
BR0009653A (pt) 2002-01-08
JP2002541254A (ja) 2002-12-03
AU3659200A (en) 2000-11-14
NO20014807D0 (no) 2001-10-03
HK1045516A1 (zh) 2002-11-29
IL145670A0 (en) 2002-06-30
EP1169318A1 (de) 2002-01-09
BG105985A (en) 2002-06-28
NO20014807L (no) 2001-12-04
KR20020004995A (ko) 2002-01-16

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