HUP0202401A3 - Five-membered heterocyclic amidinec as prodrugs of thrombin inhibitors, pharmaceutical compositions comprising thereof and their use - Google Patents
Five-membered heterocyclic amidinec as prodrugs of thrombin inhibitors, pharmaceutical compositions comprising thereof and their useInfo
- Publication number
- HUP0202401A3 HUP0202401A3 HU0202401A HUP0202401A HUP0202401A3 HU P0202401 A3 HUP0202401 A3 HU P0202401A3 HU 0202401 A HU0202401 A HU 0202401A HU P0202401 A HUP0202401 A HU P0202401A HU P0202401 A3 HUP0202401 A3 HU P0202401A3
- Authority
- HU
- Hungary
- Prior art keywords
- amidinec
- prodrugs
- pharmaceutical compositions
- membered heterocyclic
- thrombin inhibitors
- Prior art date
Links
- 229940122388 Thrombin inhibitor Drugs 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000003868 thrombin inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19915930 | 1999-04-09 | ||
| DE19934123 | 1999-07-23 | ||
| DE19947920 | 1999-10-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0202401A2 HUP0202401A2 (en) | 2002-10-28 |
| HUP0202401A3 true HUP0202401A3 (en) | 2003-11-28 |
Family
ID=27219075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202401A HUP0202401A3 (en) | 1999-04-09 | 2000-04-05 | Five-membered heterocyclic amidinec as prodrugs of thrombin inhibitors, pharmaceutical compositions comprising thereof and their use |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7144902B1 (hu) |
| EP (1) | EP1165601A2 (hu) |
| JP (1) | JP2002542165A (hu) |
| KR (1) | KR20010108481A (hu) |
| CN (1) | CN1355810A (hu) |
| AU (1) | AU765244B2 (hu) |
| BG (1) | BG105986A (hu) |
| BR (1) | BR0009674A (hu) |
| CA (1) | CA2370267A1 (hu) |
| HK (1) | HK1046289A1 (hu) |
| HU (1) | HUP0202401A3 (hu) |
| IL (1) | IL145772A0 (hu) |
| NO (1) | NO20014875L (hu) |
| NZ (1) | NZ515026A (hu) |
| PL (1) | PL352824A1 (hu) |
| SK (1) | SK14222001A3 (hu) |
| TR (1) | TR200102912T2 (hu) |
| WO (1) | WO2000061609A2 (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
| WO2004002985A1 (en) * | 2002-06-27 | 2004-01-08 | Lg Life Sciences Ltd. | Peptidic thrombin inhibitor compound |
| CA2525940A1 (en) | 2003-05-16 | 2004-11-25 | National Institute For Biological Standards And Control (Nibsc) | Mixture |
| USRE46830E1 (en) | 2004-10-19 | 2018-05-08 | Polypeptide Laboratories Holding (Ppl) Ab | Method for solid phase peptide synthesis |
| EP1964578A3 (en) * | 2005-05-05 | 2008-11-05 | Chroma Therapeutics Limited | Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase |
| SI1879573T1 (sl) | 2005-05-10 | 2013-04-30 | Incyte Corporation Experimental Station | Modulatorji indolamin 2,3-dioksigenaze in postopki za uporabo le-te |
| ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| JP5319532B2 (ja) | 2006-09-19 | 2013-10-16 | インサイト・コーポレイション | インドールアミン２，３−ジオキシゲナーゼのモジュレーターとしてのｎ−ヒドロキシアミジノヘテロサイクル |
| NO2824100T3 (hu) | 2008-07-08 | 2018-07-21 | ||
| WO2011075684A1 (en) | 2009-12-18 | 2011-06-23 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| US9206123B2 (en) | 2009-12-18 | 2015-12-08 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| EP2697196A1 (en) | 2011-04-13 | 2014-02-19 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| ME03792B (me) | 2013-11-08 | 2021-04-20 | Incyte Holdings Corp | Postupak sinteze inhibitora indolamin 2,3-dioksigenaze |
| JP6556146B2 (ja) * | 2014-08-26 | 2019-08-07 | 武田薬品工業株式会社 | 複素環化合物 |
| CN106674190B (zh) * | 2016-12-13 | 2019-05-10 | 台州市创源工业技术有限公司 | 一种2-噻吩甲胺的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| AR005245A1 (es) * | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
| TW523513B (en) | 1996-03-01 | 2003-03-11 | Akzo Nobel Nv | Serine protease inhibitors |
| DE19632773A1 (de) * | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
| EP1049673A1 (de) * | 1998-01-26 | 2000-11-08 | Basf Aktiengesellschaft | Heterocyclische amidine als kallikrein protease inhibitoren |
| EP1051431A1 (de) * | 1998-01-26 | 2000-11-15 | Basf Aktiengesellschaft | Thrombininhibitoren |
| KR20000047461A (ko) * | 1998-12-29 | 2000-07-25 | 성재갑 | 트롬빈 억제제 |
| JP4489976B2 (ja) * | 1999-04-09 | 2010-06-23 | ビーエーエスエフ ソシエタス・ヨーロピア | 補体プロテアーゼの低分子インヒビター |
-
2000
- 2000-04-05 EP EP00920661A patent/EP1165601A2/de not_active Withdrawn
- 2000-04-05 JP JP2000611551A patent/JP2002542165A/ja active Pending
- 2000-04-05 CN CN00807958A patent/CN1355810A/zh active Pending
- 2000-04-05 KR KR1020017012870A patent/KR20010108481A/ko not_active Application Discontinuation
- 2000-04-05 WO PCT/EP2000/003009 patent/WO2000061609A2/de not_active Application Discontinuation
- 2000-04-05 CA CA002370267A patent/CA2370267A1/en not_active Abandoned
- 2000-04-05 IL IL14577200A patent/IL145772A0/xx unknown
- 2000-04-05 NZ NZ515026A patent/NZ515026A/en unknown
- 2000-04-05 AU AU41156/00A patent/AU765244B2/en not_active Ceased
- 2000-04-05 TR TR2001/02912T patent/TR200102912T2/xx unknown
- 2000-04-05 BR BR0009674-1A patent/BR0009674A/pt not_active IP Right Cessation
- 2000-04-05 SK SK1422-2001A patent/SK14222001A3/sk not_active Application Discontinuation
- 2000-04-05 PL PL00352824A patent/PL352824A1/xx unknown
- 2000-04-05 HU HU0202401A patent/HUP0202401A3/hu unknown
- 2000-04-05 US US09/958,349 patent/US7144902B1/en not_active Expired - Fee Related
-
2001
- 2001-10-05 BG BG105986A patent/BG105986A/bg unknown
- 2001-10-08 NO NO20014875A patent/NO20014875L/no not_active Application Discontinuation
-
2002
- 2002-10-30 HK HK02107849.6A patent/HK1046289A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0009674A (pt) | 2002-01-15 |
| SK14222001A3 (sk) | 2002-07-02 |
| NO20014875L (no) | 2001-11-13 |
| TR200102912T2 (tr) | 2002-03-21 |
| HUP0202401A2 (en) | 2002-10-28 |
| WO2000061609A3 (de) | 2001-03-15 |
| HK1046289A1 (zh) | 2003-01-03 |
| EP1165601A2 (de) | 2002-01-02 |
| AU765244B2 (en) | 2003-09-11 |
| AU4115600A (en) | 2000-11-14 |
| CA2370267A1 (en) | 2000-10-19 |
| PL352824A1 (en) | 2003-09-08 |
| JP2002542165A (ja) | 2002-12-10 |
| WO2000061609B1 (de) | 2001-04-26 |
| BG105986A (bg) | 2002-06-28 |
| WO2000061609A2 (de) | 2000-10-19 |
| NZ515026A (en) | 2003-10-31 |
| KR20010108481A (ko) | 2001-12-07 |
| US7144902B1 (en) | 2006-12-05 |
| IL145772A0 (en) | 2002-07-25 |
| NO20014875D0 (no) | 2001-10-08 |
| CN1355810A (zh) | 2002-06-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0302412A3 (en) | Betha-carboline derivatives useful as inhibitors of phosphodiesterase and pharmaceutical compositions containing the same | |
| HUP0200347A2 (en) | N-cyanomethylamides as protease inhibitors, pharmaceutical compositions containing them and their use | |
| HUP0201214A2 (en) | Inhibitors of impdh enzyme, pharmaceutical compositions containing them and their use | |
| HUP0200804A3 (en) | The use of pharmaceutical compositions containing 4-h-1-benzopyran-4-one derivatives as inhibitors of smooth muscle cell proliferation | |
| HUP0302485A3 (en) | Arylmethylamine derivatives for use as tryptase inhibitors and pharmaceutical compositions containing them | |
| HUP0302991A3 (en) | Isoxazoles and their use as inhibitors of erk and pharmaceutical compositions containing the compounds | |
| HUP0302922A3 (en) | Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation and pharmaceutical compositions containing them | |
| HUP0300318A3 (en) | Pyrazolobenzodiazepines as cdk2 inhibitors and pharmaceutical compositions containing them and their use | |
| HUP0400194A3 (en) | Imidazolidindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them | |
| HUP0200391A3 (en) | Use of pharmaceutical compositions comprising dipeptidy peptidase iv inhibitors for the promotion of growth | |
| HK1057214A1 (en) | New mandelic acid derivatives and their use as throbin inhibitors | |
| HUP0500173A3 (en) | Alpha-sulphonamido-acetamide derivatives as beta-amyloid inhibitors and pharmaceutical compositions containing them | |
| HUP0301113A3 (en) | Pyrrolidine derivatives as cyclic amp-specific phosphodiesterase inhibitors, pharmaceutical compositions containing them and their use | |
| AU2001240542A1 (en) | Heterocyclic compounds and their use as parp inhibitors | |
| HUP0201011A2 (en) | Aminopyrimidines as sorbitol dehydrogenase inhibitors and pharmaceutical compositions containing them | |
| HUP0303653A3 (en) | Tricyclic and heterocyclic derivative and pharmaceutical compositions containing them as the active ingredient | |
| HUP0400193A3 (en) | Imidazolindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them | |
| HK1053107A1 (zh) | 作為jnk抗化劑的pyrazoloanthrone及其衍生物和它們的成份 | |
| HUP0203813A3 (en) | Aminobenzophenones as inhibitors of il-1betha and tnf-alpha, pharmaceutical compositions containing them and their use | |
| HUP0202401A2 (en) | Five-membered heterocyclic amidinec as prodrugs of thrombin inhibitors, pharmaceutical compositions comprising thereof and their use | |
| HUP0203288A3 (en) | Pyrrole derivatives as phosphodiesterase vii inhibitors, pharmaceutical compositions containing them and their use | |
| HUP0303149A3 (en) | Aminopyridinyl-, aminoguanidinyl- and alkoxyguanidinyl- substituted phenyl acetamides as protease inhibitors, their use and pharmaceutical compositions containing them | |
| IL164022A0 (en) | Phosphate derivatives of fluoroxindole and pharmaceutical compositions containing the same | |
| HUP0203311A3 (en) | New pharmaceutical compositions of prolonged effect | |
| HUP0203245A3 (en) | Imidazopyridine derivatives as phosphodiesterase vii inhibitors and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |