TR200102912T2 - Trombin ihtibit”rlerinin ”n ila‡larì. - Google Patents

Trombin ihtibit”rlerinin ”n ila‡larì.

Info

Publication number
TR200102912T2
TR200102912T2 TR2001/02912T TR200102912T TR200102912T2 TR 200102912 T2 TR200102912 T2 TR 200102912T2 TR 2001/02912 T TR2001/02912 T TR 2001/02912T TR 200102912 T TR200102912 T TR 200102912T TR 200102912 T2 TR200102912 T2 TR 200102912T2
Authority
TR
Turkey
Prior art keywords
thrombin
compounds
vigilants
relates
inflammatory
Prior art date
Application number
TR2001/02912T
Other languages
English (en)
Turkish (tr)
Inventor
Bauke Dorit
Mack Helmut
Seitz Werner
Backfisch Gisela
Delzer J�Rgen
Hornberger Wilfried
Original Assignee
Basf Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag. filed Critical Basf Ag.
Publication of TR200102912T2 publication Critical patent/TR200102912T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TR2001/02912T 1999-04-09 2000-04-05 Trombin ihtibit”rlerinin ”n ila‡larì. TR200102912T2 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19915930 1999-04-09
DE19934123 1999-07-23
DE19947920 1999-10-06

Publications (1)

Publication Number Publication Date
TR200102912T2 true TR200102912T2 (tr) 2002-03-21

Family

ID=27219075

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02912T TR200102912T2 (tr) 1999-04-09 2000-04-05 Trombin ihtibit”rlerinin ”n ila‡larì.

Country Status (18)

Country Link
US (1) US7144902B1 (xx)
EP (1) EP1165601A2 (xx)
JP (1) JP2002542165A (xx)
KR (1) KR20010108481A (xx)
CN (1) CN1355810A (xx)
AU (1) AU765244B2 (xx)
BG (1) BG105986A (xx)
BR (1) BR0009674A (xx)
CA (1) CA2370267A1 (xx)
HK (1) HK1046289A1 (xx)
HU (1) HUP0202401A3 (xx)
IL (1) IL145772A0 (xx)
NO (1) NO20014875L (xx)
NZ (1) NZ515026A (xx)
PL (1) PL352824A1 (xx)
SK (1) SK14222001A3 (xx)
TR (1) TR200102912T2 (xx)
WO (1) WO2000061609A2 (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
WO2004002985A1 (en) * 2002-06-27 2004-01-08 Lg Life Sciences Ltd. Peptidic thrombin inhibitor compound
EP1625405A1 (en) * 2003-05-16 2006-02-15 National Institute for Biological Standards and Control (NIBSC) Activation mixture
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
US20090215800A1 (en) * 2005-05-05 2009-08-27 Chroma Therapeutics Ltd Enzyme and Receptor Modulation
DK2559690T3 (en) 2005-05-10 2016-04-25 Incyte Holdings Corp Modulators of indoleamine 2,3-dioxygenase and methods of use thereof
EP1971583B1 (en) 2005-12-20 2015-03-25 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
WO2008036642A2 (en) * 2006-09-19 2008-03-27 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) * 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
BRPI0915692B8 (pt) 2008-07-08 2021-05-25 Incyte Corp compostos derivados de 1,2,5-oxadiazóis, sua forma sólida, sua composição, bem como seus usos
US9206123B2 (en) 2009-12-18 2015-12-08 Activesite Pharmaceuticals, Inc. Prodrugs of inhibitors of plasma kallikrein
EP2512466A4 (en) 2009-12-18 2013-07-03 Activesite Pharmaceuticals Inc PRODRUGS OF INHIBITORS OF PLASMATIC KALLICREIN
WO2012142308A1 (en) 2011-04-13 2012-10-18 Activesite Pharmaceuticals, Inc. Prodrugs of inhibitors of plasma kallikrein
SG10201803874PA (en) 2013-11-08 2018-07-30 Incyte Holdings Corp Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
WO2016031815A1 (ja) * 2014-08-26 2016-03-03 武田薬品工業株式会社 複素環化合物
CN106674190B (zh) * 2016-12-13 2019-05-10 台州市创源工业技术有限公司 一种2-噻吩甲胺的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
AR005245A1 (es) * 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
TW523513B (en) 1996-03-01 2003-03-11 Akzo Nobel Nv Serine protease inhibitors
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
EP1049673A1 (de) 1998-01-26 2000-11-08 Basf Aktiengesellschaft Heterocyclische amidine als kallikrein protease inhibitoren
CN1289341A (zh) 1998-01-26 2001-03-28 Basf公司 凝血酶抑制剂
KR20000047461A (ko) * 1998-12-29 2000-07-25 성재갑 트롬빈 억제제
HUP0203167A3 (en) * 1999-04-09 2003-09-29 Basf Ag Peptidic substances, their preparations and their use as complement protease inhibitors

Also Published As

Publication number Publication date
SK14222001A3 (sk) 2002-07-02
AU765244B2 (en) 2003-09-11
AU4115600A (en) 2000-11-14
HUP0202401A2 (en) 2002-10-28
KR20010108481A (ko) 2001-12-07
CN1355810A (zh) 2002-06-26
BG105986A (bg) 2002-06-28
BR0009674A (pt) 2002-01-15
PL352824A1 (en) 2003-09-08
WO2000061609A3 (de) 2001-03-15
NO20014875L (no) 2001-11-13
WO2000061609B1 (de) 2001-04-26
NO20014875D0 (no) 2001-10-08
NZ515026A (en) 2003-10-31
EP1165601A2 (de) 2002-01-02
HK1046289A1 (zh) 2003-01-03
WO2000061609A2 (de) 2000-10-19
JP2002542165A (ja) 2002-12-10
US7144902B1 (en) 2006-12-05
IL145772A0 (en) 2002-07-25
HUP0202401A3 (en) 2003-11-28
CA2370267A1 (en) 2000-10-19

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