DE69607443T2 - Zwischenprodukte und ihre Anwendung für die Herstellung von N,N'-überbrückten Bisindolylmaleimiden - Google Patents

Zwischenprodukte und ihre Anwendung für die Herstellung von N,N'-überbrückten Bisindolylmaleimiden

Info

Publication number
DE69607443T2
DE69607443T2 DE69607443T DE69607443T DE69607443T2 DE 69607443 T2 DE69607443 T2 DE 69607443T2 DE 69607443 T DE69607443 T DE 69607443T DE 69607443 T DE69607443 T DE 69607443T DE 69607443 T2 DE69607443 T2 DE 69607443T2
Authority
DE
Germany
Prior art keywords
intermediates
production
application
bridged bisindolylmaleimides
bisindolylmaleimides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69607443T
Other languages
English (en)
Other versions
DE69607443D1 (de
Inventor
Margaret Mary Faul
Christine Ann Krumrich
Winneroski, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21725638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69607443(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69607443D1 publication Critical patent/DE69607443D1/de
Application granted granted Critical
Publication of DE69607443T2 publication Critical patent/DE69607443T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69607443T 1995-11-20 1996-11-18 Zwischenprodukte und ihre Anwendung für die Herstellung von N,N'-überbrückten Bisindolylmaleimiden Expired - Fee Related DE69607443T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US734595P 1995-11-20 1995-11-20

Publications (2)

Publication Number Publication Date
DE69607443D1 DE69607443D1 (de) 2000-05-04
DE69607443T2 true DE69607443T2 (de) 2000-08-10

Family

ID=21725638

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69607443T Expired - Fee Related DE69607443T2 (de) 1995-11-20 1996-11-18 Zwischenprodukte und ihre Anwendung für die Herstellung von N,N'-überbrückten Bisindolylmaleimiden

Country Status (31)

Country Link
EP (1) EP0776899B1 (de)
JP (2) JP4100708B2 (de)
KR (1) KR100342142B1 (de)
CN (1) CN1066734C (de)
AR (2) AR004718A1 (de)
AT (1) ATE191219T1 (de)
AU (1) AU701659B2 (de)
BR (1) BR9611709A (de)
CA (1) CA2237401C (de)
CO (1) CO4750824A1 (de)
CZ (1) CZ150398A3 (de)
DE (1) DE69607443T2 (de)
DK (1) DK0776899T3 (de)
EA (1) EA000639B1 (de)
ES (1) ES2145978T3 (de)
GR (1) GR3033729T3 (de)
HU (1) HU225716B1 (de)
IL (1) IL124415A (de)
MX (1) MX9803791A (de)
MY (1) MY118946A (de)
NO (1) NO310195B1 (de)
NZ (1) NZ323282A (de)
PE (1) PE17998A1 (de)
PL (1) PL184728B1 (de)
PT (1) PT776899E (de)
TR (1) TR199800876T2 (de)
TW (1) TW371661B (de)
UA (1) UA56145C2 (de)
WO (1) WO1997019080A1 (de)
YU (1) YU49316B (de)
ZA (1) ZA969645B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
DE69911935T3 (de) * 1998-03-13 2008-02-07 The University Of British Columbia, Vancouver Granulatimide-derivate zur behandlung von krebs
US6127401A (en) * 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US6300106B1 (en) 2000-11-22 2001-10-09 Ppg Industries Ohio, Inc. Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate
EP2181999A1 (de) 2008-11-03 2010-05-05 Zentiva, A.S. Verfahren zur Herstellung von Ruboxistaurin
WO2023192984A1 (en) * 2022-03-31 2023-10-05 4M Therapeutics Inc. N-desmethyl ruboxistaurin as kinase inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
CN1050844C (zh) 1993-12-07 2000-03-29 伊莱利利公司 蛋白激酶ｃ抑制剂
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides

Also Published As

Publication number Publication date
CZ150398A3 (cs) 1998-12-16
GR3033729T3 (en) 2000-10-31
ATE191219T1 (de) 2000-04-15
DE69607443D1 (de) 2000-05-04
JP2000500496A (ja) 2000-01-18
ES2145978T3 (es) 2000-07-16
DK0776899T3 (da) 2000-07-10
HU225716B1 (en) 2007-07-30
ZA969645B (en) 1998-05-18
WO1997019080A1 (en) 1997-05-29
PL184728B1 (pl) 2002-12-31
KR19990067600A (ko) 1999-08-25
YU49316B (sh) 2005-06-10
CA2237401C (en) 2003-10-21
AU7738896A (en) 1997-06-11
EA000639B1 (ru) 1999-12-29
PT776899E (pt) 2000-08-31
TR199800876T2 (xx) 1998-08-21
NO982105D0 (no) 1998-05-08
AU701659B2 (en) 1999-02-04
YU61096A (sh) 1999-03-04
BR9611709A (pt) 1999-02-23
IL124415A0 (en) 1998-12-06
EP0776899B1 (de) 2000-03-29
MX9803791A (es) 1998-09-30
KR100342142B1 (ko) 2002-08-22
HUP9901975A3 (en) 2000-01-28
CN1066734C (zh) 2001-06-06
AR004719A1 (es) 1999-03-10
IL124415A (en) 2003-11-23
PE17998A1 (es) 1998-04-20
EA199800368A1 (ru) 1998-12-24
JP4100708B2 (ja) 2008-06-11
UA56145C2 (uk) 2003-05-15
CO4750824A1 (es) 1999-03-31
EP0776899A1 (de) 1997-06-04
CN1207740A (zh) 1999-02-10
AR004718A1 (es) 1999-03-10
MY118946A (en) 2005-02-28
JP2008138006A (ja) 2008-06-19
TW371661B (en) 1999-10-11
HUP9901975A2 (hu) 1999-11-29
PL326753A1 (en) 1998-10-26
CA2237401A1 (en) 1997-05-29
NO310195B1 (no) 2001-06-05
NO982105L (no) 1998-05-08
NZ323282A (en) 1999-01-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee