AR004718A1 - Procedimiento para preparar bisindolilmaleimidas con un puente n,n', utiles como inhibidores de la proteina c quinasa y procedimiento para preparar compuestos intermediarios de aplicacion en dicho procedimiento - Google Patents
Procedimiento para preparar bisindolilmaleimidas con un puente n,n', utiles como inhibidores de la proteina c quinasa y procedimiento para preparar compuestos intermediarios de aplicacion en dicho procedimientoInfo
- Publication number
- AR004718A1 AR004718A1 ARP960105256A ARP960105256A AR004718A1 AR 004718 A1 AR004718 A1 AR 004718A1 AR P960105256 A ARP960105256 A AR P960105256A AR P960105256 A ARP960105256 A AR P960105256A AR 004718 A1 AR004718 A1 AR 004718A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- preparing
- bridge
- protein
- bisindolylmaleimides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Se trata de la preparación de bis-indolilmaleimidas con un puente N,N de fórmula (II), útiles como inhibidores de la proteína C quinasa. La invenciónproporciona además el uso de estos compuestos para preparar otros bisindolilmaleimida s con unpuente N,N de fórmula (IV), en los que en laposición 13 hay un grupo -CH2-NH(CF3)(CH3),-CH2-NH(CF3) ó -CH2- NR3R4 donde R3 y R4 son hidrógeno, alquilo (C1-C4) fenilo o bencilo indistintamente, tambiéncon propiedades inhibidoras de la prot eína Cquinasa. Se describe también la preparación de dichos inhibidores y de los enantiómeros bioactivos de losmismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US734595P | 1995-11-20 | 1995-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004718A1 true AR004718A1 (es) | 1999-03-10 |
Family
ID=21725638
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960105256A AR004718A1 (es) | 1995-11-20 | 1996-11-20 | Procedimiento para preparar bisindolilmaleimidas con un puente n,n', utiles como inhibidores de la proteina c quinasa y procedimiento para preparar compuestos intermediarios de aplicacion en dicho procedimiento |
| ARP960105257A AR004719A1 (es) | 1995-11-20 | 1996-11-20 | Compuestos debisindolilmaleimidas con un punte n, n' y formulaciones farmaceuticas que los contienen, dichos compuestos son utiles comointermediarios para preparar otras bisindolilmaleimidas que poseen dicho puente n, n' |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960105257A AR004719A1 (es) | 1995-11-20 | 1996-11-20 | Compuestos debisindolilmaleimidas con un punte n, n' y formulaciones farmaceuticas que los contienen, dichos compuestos son utiles comointermediarios para preparar otras bisindolilmaleimidas que poseen dicho puente n, n' |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0776899B1 (es) |
| JP (2) | JP4100708B2 (es) |
| KR (1) | KR100342142B1 (es) |
| CN (1) | CN1066734C (es) |
| AR (2) | AR004718A1 (es) |
| AT (1) | ATE191219T1 (es) |
| AU (1) | AU701659B2 (es) |
| BR (1) | BR9611709A (es) |
| CA (1) | CA2237401C (es) |
| CO (1) | CO4750824A1 (es) |
| CZ (1) | CZ150398A3 (es) |
| DE (1) | DE69607443T2 (es) |
| DK (1) | DK0776899T3 (es) |
| EA (1) | EA000639B1 (es) |
| ES (1) | ES2145978T3 (es) |
| GR (1) | GR3033729T3 (es) |
| HU (1) | HU225716B1 (es) |
| IL (1) | IL124415A (es) |
| MX (1) | MX9803791A (es) |
| MY (1) | MY118946A (es) |
| NO (1) | NO310195B1 (es) |
| NZ (1) | NZ323282A (es) |
| PE (1) | PE17998A1 (es) |
| PL (1) | PL184728B1 (es) |
| PT (1) | PT776899E (es) |
| TR (1) | TR199800876T2 (es) |
| TW (1) | TW371661B (es) |
| UA (1) | UA56145C2 (es) |
| WO (1) | WO1997019080A1 (es) |
| YU (1) | YU49316B (es) |
| ZA (1) | ZA969645B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2245029A1 (en) | 1998-03-13 | 1999-09-13 | University Of British Columbia | Granulatimide compounds as g2 checkpoint inhibitors |
| EP1070068B2 (en) * | 1998-03-13 | 2007-01-17 | The University Of British Columbia | Granulatimide derivatives for use in cancer treatment |
| US6127401A (en) * | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
| US6300106B1 (en) | 2000-11-22 | 2001-10-09 | Ppg Industries Ohio, Inc. | Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate |
| EP2181999A1 (en) | 2008-11-03 | 2010-05-05 | Zentiva, A.S. | Method of manufacturing ruboxistarin |
| WO2023192984A1 (en) * | 2022-03-31 | 2023-10-05 | 4M Therapeutics Inc. | N-desmethyl ruboxistaurin as kinase inhibitor |
| WO2024159211A1 (en) * | 2023-01-27 | 2024-08-02 | Mellicell, Inc. | Methods and compositions for treatment of obesity and diseases associated with fat cell enlargement |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| HU219709B (hu) | 1993-12-07 | 2001-06-28 | Eli Lilly And Co. | Proteinkináz C gátló hatású kondenzált indolszármazékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények |
| US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
-
1996
- 1996-11-18 EA EA199800368A patent/EA000639B1/ru not_active IP Right Cessation
- 1996-11-18 DK DK96308317T patent/DK0776899T3/da active
- 1996-11-18 EP EP96308317A patent/EP0776899B1/en not_active Expired - Lifetime
- 1996-11-18 CZ CZ981503A patent/CZ150398A3/cs unknown
- 1996-11-18 ZA ZA9609645A patent/ZA969645B/xx unknown
- 1996-11-18 TW TW085114104A patent/TW371661B/zh active
- 1996-11-18 DE DE69607443T patent/DE69607443T2/de not_active Expired - Fee Related
- 1996-11-18 PT PT96308317T patent/PT776899E/pt unknown
- 1996-11-18 TR TR1998/00876T patent/TR199800876T2/xx unknown
- 1996-11-18 AU AU77388/96A patent/AU701659B2/en not_active Ceased
- 1996-11-18 WO PCT/US1996/018518 patent/WO1997019080A1/en not_active Application Discontinuation
- 1996-11-18 BR BR9611709A patent/BR9611709A/pt not_active IP Right Cessation
- 1996-11-18 PE PE1996000828A patent/PE17998A1/es not_active Application Discontinuation
- 1996-11-18 KR KR1019980703626A patent/KR100342142B1/ko not_active IP Right Cessation
- 1996-11-18 NZ NZ323282A patent/NZ323282A/xx unknown
- 1996-11-18 AT AT96308317T patent/ATE191219T1/de not_active IP Right Cessation
- 1996-11-18 UA UA98052516A patent/UA56145C2/uk unknown
- 1996-11-18 JP JP51983897A patent/JP4100708B2/ja not_active Expired - Fee Related
- 1996-11-18 IL IL12441596A patent/IL124415A/xx not_active IP Right Cessation
- 1996-11-18 HU HU9901975A patent/HU225716B1/hu not_active IP Right Cessation
- 1996-11-18 CN CN96199575A patent/CN1066734C/zh not_active Expired - Fee Related
- 1996-11-18 PL PL96326753A patent/PL184728B1/pl not_active IP Right Cessation
- 1996-11-18 YU YU61096A patent/YU49316B/sh unknown
- 1996-11-18 CA CA002237401A patent/CA2237401C/en not_active Expired - Fee Related
- 1996-11-18 ES ES96308317T patent/ES2145978T3/es not_active Expired - Lifetime
- 1996-11-19 MY MYPI96004798A patent/MY118946A/en unknown
- 1996-11-19 CO CO96060836A patent/CO4750824A1/es unknown
- 1996-11-20 AR ARP960105256A patent/AR004718A1/es unknown
- 1996-11-20 AR ARP960105257A patent/AR004719A1/es unknown
-
1998
- 1998-05-08 NO NO19982105A patent/NO310195B1/no not_active IP Right Cessation
- 1998-05-13 MX MX9803791A patent/MX9803791A/es unknown
-
2000
- 2000-06-20 GR GR20000401423T patent/GR3033729T3/el not_active IP Right Cessation
-
2007
- 2007-12-28 JP JP2007338808A patent/JP2008138006A/ja not_active Ceased
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