BRPI0409374A - composto, composição farmacêutica, uso de pelo menos um composto, e, método para o tratamento de um distúrbio médico - Google Patents

composto, composição farmacêutica, uso de pelo menos um composto, e, método para o tratamento de um distúrbio médico

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Publication number
BRPI0409374A
BRPI0409374A BRPI0409374-7A BRPI0409374A BRPI0409374A BR PI0409374 A BRPI0409374 A BR PI0409374A BR PI0409374 A BRPI0409374 A BR PI0409374A BR PI0409374 A BRPI0409374 A BR PI0409374A
Authority
BR
Brazil
Prior art keywords
alkyl
cycloalkyl
compound
haloalkyl
atoms
Prior art date
Application number
BRPI0409374-7A
Other languages
English (en)
Inventor
Wilfried Braje
Andreas Haupt
Wilfried Lubisch
Roland Grandel
Karla Drescher
Herve Geneste
Liliane Unger
Daryl R Sauer
Sean C Turner
Original Assignee
Abbott Gmbh & Co Kg
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Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of BRPI0409374A publication Critical patent/BRPI0409374A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DE PELO MENOS UM COMPOSTO, E, MéTODO PARA O TRATAMENTO DE UM DISTúRBIO MéDICO" A invenção refere-se aos compostos N-¢(piperazinil) hetaril! arilsulfonamida de fórmula geral (I) em que Q é um radical heteroaromático de 6 membros bivalente que possui 1 ou 2 átomos de N como membros de anel e que opcionalmente transporta um ou dois substituintes R aque é/são selecionado(s), independentemente um de cada outro, dentre halogênio, CN, NO~ 2~, CO~ 2~R¬ 4¬, COR¬ 5¬, alquila C~ 1~-C~ 4~ e haloalquila C~ 1~-C~ 4~-; Ar é fenila ou um radical heteroaromático de 6 membros que possui 1 ou 2 átomos N como membros de anel e que opcionalmente transporta um ou dois substituintes R¬ b¬, que é/são selecionado(s) dentre halogênio, NO~ 2~, CN, CO~ 2~R¬ 4¬, COR¬ 5¬, C~ 1~-C~ 6~-alquila, alquenila C~ 2~-C~ 6~, alquinila C~ 2~-C~ 6~, cicloalquila C~ 3~-C~ 6~, cicloalquil- C~ 3~-C~ 6~- alquila C~ 1~-C~ 4~ e -haloalquila C~ 1~C~ 4~, sendo também possível que dois radicais R¬ b¬ que são ligados aos átomos C adjacentes de Ar estarem juntos com alquileno C~ 3~-C~ 4~-; R¬ 1¬ é hidrogênio, alquila C~ 1~-C~ 4~, haloalquila C~ 1~-C~ 4~, cicloalquila C~ 3~-C~ 6~, cicloalquil C~ 3~-C~ 6~- alquila C~ 1~-C~ 4~, hidroxialquila C~ 1~-C~ 4~, alcóxi C~ 1~-C~ 4~- alquila C~ 1~-C~ 4~, alquenila C~ 3~-C~ 4~-ou alquinila C~ 3~-C~ 4~-; com os radicais n, R¬ 1¬, R¬ 2¬, R¬ 3¬, e R¬ 4¬ tendo os significados dados nas reivindicações da patente, os N-óxidos e os sais de adição de ácido fisiologicamente tolerados destes compostos e às composições farmacêuticas que compreendem pelo menos um composto N-¢(piperazinil) hetaril! arilsulfonamida como reivindicado em uma das reivindicações 1 a 10 e/ou pelo menos um sal de adição de ácido fisiologicamente tolerado de 1 e/ou um N-óxido de 1, onde apropriado junto com veículos fisiologicamente aceitáveis e/ou substâncias auxiliares para tratar doenças que respondem à influência de antagonistas ou agonistas de receptor de dopamina D~ 3~, em particular para tratar doenças do sistema nervoso central e distúrbios da função renal.
BRPI0409374-7A 2003-04-14 2004-04-13 composto, composição farmacêutica, uso de pelo menos um composto, e, método para o tratamento de um distúrbio médico BRPI0409374A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/413,233 US20040204422A1 (en) 2003-04-14 2003-04-14 N-[(Piperazinyl)hetaryl]arylsulfonamide compounds
PCT/EP2004/003872 WO2004089905A1 (en) 2003-04-14 2004-04-13 N-[(piperazinyl)hetaryl]arylsulfonamide compounds with affinity for the dopamine d3 receptor

Publications (1)

Publication Number Publication Date
BRPI0409374A true BRPI0409374A (pt) 2006-04-25

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ID=33131380

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409374-7A BRPI0409374A (pt) 2003-04-14 2004-04-13 composto, composição farmacêutica, uso de pelo menos um composto, e, método para o tratamento de um distúrbio médico

Country Status (17)

Country Link
US (3) US20040204422A1 (pt)
EP (1) EP1613596B1 (pt)
JP (1) JP4864694B2 (pt)
KR (1) KR101124911B1 (pt)
CN (1) CN1805937B (pt)
AT (1) ATE388939T1 (pt)
AU (1) AU2004228354B2 (pt)
BR (1) BRPI0409374A (pt)
CA (1) CA2522319C (pt)
DE (1) DE602004012400T2 (pt)
ES (1) ES2303065T3 (pt)
IL (1) IL171421A (pt)
MX (1) MXPA05010986A (pt)
NZ (1) NZ543101A (pt)
PL (1) PL1613596T3 (pt)
WO (1) WO2004089905A1 (pt)
ZA (1) ZA200509122B (pt)

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DE602004012400T2 (de) 2009-04-02
NZ543101A (en) 2009-02-28
ZA200509122B (en) 2007-04-25
CN1805937A (zh) 2006-07-19
US20110294817A1 (en) 2011-12-01
PL1613596T3 (pl) 2008-09-30
KR20060005367A (ko) 2006-01-17
US8476275B2 (en) 2013-07-02
CA2522319C (en) 2013-10-15
US20070054918A1 (en) 2007-03-08
JP2006522769A (ja) 2006-10-05
WO2004089905A1 (en) 2004-10-21
JP4864694B2 (ja) 2012-02-01
ATE388939T1 (de) 2008-03-15
MXPA05010986A (es) 2005-12-15
EP1613596B1 (en) 2008-03-12
CN1805937B (zh) 2012-07-11
CA2522319A1 (en) 2004-10-21
IL171421A (en) 2012-03-29
US20040204422A1 (en) 2004-10-14
EP1613596A1 (en) 2006-01-11
AU2004228354A1 (en) 2004-10-21
ES2303065T3 (es) 2008-08-01
DE602004012400D1 (de) 2008-04-24
KR101124911B1 (ko) 2012-03-27
AU2004228354B2 (en) 2010-04-22

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