MA34591B1 - Dérivés de benzimidazole utilisés comme inhibiteurs de pi3 kinase - Google Patents

Dérivés de benzimidazole utilisés comme inhibiteurs de pi3 kinase

Info

Publication number
MA34591B1
MA34591B1 MA35789A MA35789A MA34591B1 MA 34591 B1 MA34591 B1 MA 34591B1 MA 35789 A MA35789 A MA 35789A MA 35789 A MA35789 A MA 35789A MA 34591 B1 MA34591 B1 MA 34591B1
Authority
MA
Morocco
Prior art keywords
relates
benzimidazole derivatives
pi3k2
transplant rejection
pi3k
Prior art date
Application number
MA35789A
Other languages
English (en)
Inventor
Junya Qu
Ralph Rivero
Robert Sanchez
Rosanna Tedesco
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of MA34591B1 publication Critical patent/MA34591B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne l'utilisation de dérivés de benzimidazole pour la modulation, notamment l'inhibition de l'activité ou de la fonction de la famille des phosphoinositide-3-OH kinases (désignées ci-après PI3 kinases), en particulier la PI3K±, la PI3K´, la PI3K², et/ou la PI3K³. La présente invention concerne plus particulièrement l'utilisation de benzimidazoles dans le traitement d'un ou plusieurs états maladifs choisis parmi les troubles auto-immuns, les maladies inflammatoires, les maladies cardio-vasculaires, les maladies neurodégénératives, l'allergie, l'asthme, la pancréatite, la défaillance de plusieurs organes, les néphropathies, l'agrégation plaquettaire, le cancer, la motilité du sperme, le rejet d'une transplantation, le rejet de greffe et les lésions pulmonaires. Mieux, la présente invention concerne des composés de benzimidazole sélectifs envers la PI3K² pour traiter le cancer.
MA35789A 2010-10-06 2011-09-23 Dérivés de benzimidazole utilisés comme inhibiteurs de pi3 kinase MA34591B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39031410P 2010-10-06 2010-10-06
US201161528397P 2011-08-29 2011-08-29
PCT/US2011/052857 WO2012047538A1 (fr) 2010-10-06 2011-09-23 Dérivés de benzimidazole utilisés comme inhibiteurs de pi3 kinase

Publications (1)

Publication Number Publication Date
MA34591B1 true MA34591B1 (fr) 2013-10-02

Family

ID=45925614

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35789A MA34591B1 (fr) 2010-10-06 2011-09-23 Dérivés de benzimidazole utilisés comme inhibiteurs de pi3 kinase

Country Status (39)

Country Link
US (10) US20130196990A1 (fr)
EP (2) EP3170813B1 (fr)
JP (1) JP5719028B2 (fr)
KR (1) KR101594002B1 (fr)
CN (1) CN103124496B (fr)
AR (1) AR083296A1 (fr)
AU (1) AU2011312594B2 (fr)
BR (1) BR112013008259A2 (fr)
CA (1) CA2812608C (fr)
CL (1) CL2013000935A1 (fr)
CO (1) CO6700852A2 (fr)
CR (1) CR20130192A (fr)
CY (1) CY1118792T1 (fr)
DK (1) DK2624696T3 (fr)
DO (1) DOP2013000059A (fr)
EA (1) EA022623B1 (fr)
ES (2) ES2616238T3 (fr)
HR (1) HRP20170279T1 (fr)
HU (1) HUE033209T2 (fr)
IL (1) IL225140A (fr)
JO (1) JO3194B1 (fr)
LT (1) LT2624696T (fr)
MA (1) MA34591B1 (fr)
ME (1) ME02663B (fr)
MX (1) MX337662B (fr)
MY (1) MY170236A (fr)
NZ (1) NZ608069A (fr)
PE (1) PE20140192A1 (fr)
PH (1) PH12013500646A1 (fr)
PL (1) PL2624696T3 (fr)
PT (1) PT2624696T (fr)
RS (1) RS55662B1 (fr)
SG (1) SG188974A1 (fr)
SI (1) SI2624696T1 (fr)
SM (1) SMT201700158T1 (fr)
TW (1) TWI513690B (fr)
UY (1) UY33648A (fr)
WO (1) WO2012047538A1 (fr)
ZA (1) ZA201301951B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3170813B1 (fr) 2010-10-06 2018-12-12 GlaxoSmithKline LLC Dérivés de benzimidazole comme inhibiteurs de pi3 kinase
US8778937B2 (en) * 2011-12-20 2014-07-15 Glaxosmithkline Llc Benzimidazole boronic acid derivatives as PI3 kinase inhibitors
KR20150103735A (ko) * 2013-01-09 2015-09-11 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 조합물
WO2015042027A1 (fr) * 2013-09-19 2015-03-26 Glaxosmithkline Llc Polythérapie
CA2921156A1 (fr) * 2013-09-19 2015-03-26 Glaxosmithkline Llc Polytherapie medicamenteuse
CA2926596C (fr) 2013-10-16 2020-07-14 Shanghai Yingli Pharmaceutical Co., Ltd Compose heterocyclique condense, son procede de preparation, composition pharmaceutique et leurs utilisations
CN103910682B (zh) * 2013-11-28 2016-03-02 大连理工大学 一种基于邻苯二胺环化的苯并咪唑类化合物制备方法
EP3082422A4 (fr) * 2013-12-20 2017-07-05 Biomed Valley Discoveries, Inc. Traitements du cancer faisant appel à des associations d'inhibiteurs de l'erk et de la mek de type 1
US9499523B2 (en) 2014-06-13 2016-11-22 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
CA2952037A1 (fr) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Inhibiteurs de phosphatidylinositol-3-kinase
CA2952018A1 (fr) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Derives de quinazolinone utilises comme inhibiteurs de la phosphatidylinositol 3-kinase
JP6455995B2 (ja) 2014-06-13 2019-01-23 ギリアード サイエンシーズ， インコーポレイテッド ホスファチジルイノシトール３−キナーゼ阻害剤
CA2952025A1 (fr) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Inhibiteur de la phosphatidylinositol 3-kinase
EA029789B1 (ru) 2014-12-19 2018-05-31 Янссен Фармацевтика Нв ПРОИЗВОДНЫЕ ИМИДАЗОПИРИДАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ
JP6586463B2 (ja) 2014-12-19 2019-10-02 ヤンセン ファーマシューティカ エヌ．ベー． ＰＩ３Ｋβ阻害剤としての複素環連結イミダゾピリダジン誘導体
GB201504689D0 (en) 2015-03-19 2015-05-06 Glaxosmithkline Ip Dev Ltd Chemical compounds
MX382601B (es) 2015-10-09 2025-03-13 Janssen Pharmaceutica Nv DERIVADOS DE QUINOXALINA Y PIRIDOPRAZINA COMO INHIBIDORES DE PI3Kß.
WO2017121684A1 (fr) * 2016-01-14 2017-07-20 Bayer Pharma Aktiengesellschaft 2-(morpholin-4-yl)-1,7-naphthyridines substituées en 5
EA037871B1 (ru) 2016-06-16 2021-05-28 Янссен Фармацевтика Нв Производные азабензимидазола в качестве ингибиторов pi3k beta
HRP20210508T1 (hr) 2016-06-16 2021-05-28 Janssen Pharmaceutica Nv Biciklički derivati piridina, pirazina i pirimidina kao inhibitori pi3k beta
WO2018013534A1 (fr) * 2016-07-11 2018-01-18 Dana-Farber Cancer Institute, Inc. Méthodes de traitement de cancers épithéliaux déficients en pten au moyen d'une combinaison d'agents anti-pi3kbêta et anti-point de contrôle immunitaire
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
WO2018057808A1 (fr) 2016-09-23 2018-03-29 Gilead Sciences, Inc. Dérivés de benzimidazole et leur utilisation en tant qu'inhibiteurs de phosphatidylinositol 3-kinase
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
WO2018106667A1 (fr) 2016-12-05 2018-06-14 Microbiotix, Inc. Inhibiteurs à large spectre de filovirus
EA201992296A1 (ru) 2017-03-29 2020-02-12 Янссен Фармацевтика Нв Производные хиноксалина и пиридопиразина в качестве ингибиторов pi3k-бета
MX393995B (es) 2017-07-28 2025-03-24 Yuhan Corp Proceso mejorado para preparar derivados de aminopirimidina
WO2019106605A1 (fr) 2017-12-01 2019-06-06 Board Of Regents, The University Of Texas System Polythérapie pour le traitement du cancer
US11253189B2 (en) 2018-01-24 2022-02-22 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and methods for evaluating neuromodulation therapy via detection of magnetic fields
CN111000847B (zh) * 2020-01-02 2021-03-19 黑龙江中医药大学 一种治疗肺纤维化的药物制剂及其用途
CN111346095B (zh) * 2020-03-14 2021-06-08 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 用于治疗神经外科术后头痛的药物制剂

Family Cites Families (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2016710A1 (fr) 1989-05-15 1990-11-15 Prasun K. Chakravarty Benzimidazoles substitues comme antagonistes de l'antiotensine ii
IL95975A (en) 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
US5559235A (en) 1991-10-29 1996-09-24 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
TW284688B (fr) 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
US5502187A (en) 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
JPH08502721A (ja) 1992-04-03 1996-03-26 ジ・アップジョン・カンパニー 医薬的に活性な二環式‐複素環アミン
GB9210400D0 (en) 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
US5342947A (en) 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
JPH0867674A (ja) 1993-07-02 1996-03-12 Senju Pharmaceut Co Ltd 眼圧降下剤
CZ154994A3 (en) 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
CZ104795A3 (en) 1994-04-29 1996-02-14 Lilly Co Eli Benzimidazole derivative, process of its preparation, its use for preparing a pharmaceutical preparation and the pharmaceutical composition containing thereof
US5491237A (en) 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
US5563143A (en) 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
DE19514579A1 (de) 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
CA2242579A1 (fr) 1996-01-09 1997-07-17 Eli Lilly And Company Antagonistes benzimidazolyles du recepteur du neuropeptide y
AU2139097A (en) 1996-03-01 1997-09-16 Eli Lilly And Company Methods of treating or preventing sleep apnea
CA2248013A1 (fr) 1996-03-11 1997-09-18 Eli Lilly And Company Therapie de traitement ou de prevention de la cystite interstitielle
DE69819311T2 (de) 1997-03-07 2004-07-29 Metabasis Therapeutics Inc., San Diego Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
ES2226812T3 (es) 1999-04-02 2005-04-01 Neurogen Corporation Derivados de aminoalquilimidazol condensados con arilo y heteroarilo:moduladores selesctivos de los preseptores gabaa.
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
JP2000323278A (ja) 1999-05-14 2000-11-24 Toray Ind Inc 発光素子
JP2003505369A (ja) 1999-07-15 2003-02-12 エヌピーエス アレリックス コーポレーション 偏頭痛を治療するための複素環式化合物
AU6762400A (en) 1999-08-12 2001-03-13 Cor Therapeutics, Inc. Inhibitors of factor xa
WO2001021634A1 (fr) 1999-09-21 2001-03-29 Lion Bioscience Ag Derives de benzimidazole et bibliotheques combinatoires contenant ces derives
PT1236726E (pt) 1999-12-03 2005-04-29 Ono Pharmaceutical Co Derivados de triazaespiro[5.5]undecano e farmacos que os contem como ingrediente activo
US20020072530A1 (en) 2000-02-01 2002-06-13 Bing-Yan Zhu Indole and benzimidazole inhibitors of factor Xa
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
US6472095B2 (en) 2000-12-29 2002-10-29 Utc Fuel Cells, Llc Hybrid fuel cell reactant flow fields
TW593278B (en) 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
EP1377549A1 (fr) 2001-03-12 2004-01-07 Millennium Pharmaceuticals, Inc. Heterocycles fonctionnalises en tant que modulateurs de la fonction du recepteur de chimiokines et procedes de mise en oeuvre
NZ528270A (en) 2001-03-19 2005-10-28 Ono Pharmaceutical Co Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient
FR2822463B1 (fr) 2001-03-21 2004-07-30 Lipha Derives bicycliques de guanidines et leurs applications en therapeutique
WO2002076960A1 (fr) 2001-03-22 2002-10-03 Abbott Gmbh & Co. Kg Procede faisant intervenir un metal de transition
US7081454B2 (en) * 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors
CN1514833A (zh) * 2001-03-28 2004-07-21 ����˹�ж�-����˹˹������˾ 新型酪氨酸激酶抑制剂
US6677365B2 (en) 2001-04-03 2004-01-13 Telik, Inc. Antagonists of MCP-1 function and methods of use thereof
CN1293072C (zh) 2001-04-20 2007-01-03 惠氏公司 作为5－羟色胺－6配体的杂环基氧基－、－硫代－和－氨基吲哚衍生物
AU2002309585B2 (en) 2001-04-20 2008-01-31 Wyeth Heterocyclylalkoxy-, -alkylthio- and -alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
JP2005500303A (ja) 2001-06-15 2005-01-06 ジェネンテック・インコーポレーテッド ヒト成長ホルモンアンタゴニスト
CA2448737C (fr) 2001-07-20 2010-06-01 Boehringer Ingelheim (Canada) Ltd. Inhibiteurs de polymerase virale
FR2827862A1 (fr) 2001-07-27 2003-01-31 Lipha Derives imidazolylalkylarylalcanoiques et leurs applications en therapeutique
DE10139416A1 (de) 2001-08-17 2003-03-06 Aventis Pharma Gmbh Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
FR2829765A1 (fr) 2001-09-14 2003-03-21 Lipha Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique
CA2457647A1 (fr) 2001-10-02 2003-04-10 Acadia Pharmaceuticals, Inc. Derives de benzimidazolidinone utilises comme agents muscariniques
WO2004089942A2 (fr) 2001-10-02 2004-10-21 Acadia Pharmaceuticals Inc. Derives de benzimidazolidinone utilises en tant qu'agents muscariniques
ES2367422T3 (es) 2001-10-09 2011-11-03 Amgen Inc. Derivados de imidazol como agentes antiinflamatorios.
EP1442028A4 (fr) 2001-11-06 2009-11-04 Bristol Myers Squibb Co Derives d'acides substitues en tant qu'agents de lutte contre le diabete et contre l'obesite, et procede associe
EP1460067A4 (fr) 2001-11-26 2005-12-07 Takeda Pharmaceutical Derive bicyclique, procede de production de ce derive et utilisation correspondante
JP2005519915A (ja) 2002-01-18 2005-07-07 セレテック・リミテッド・ライアビリティ・カンパニー Ｅｄｇ受容体に関連する症状の処置方法
US20050176858A1 (en) 2002-02-15 2005-08-11 Bridgestone Corporation Rubber composition and pneumatic tire made therefrom
BR0306016A (pt) 2002-03-13 2005-01-04 Array Biopharma Inc Derivados de benzimidazol n3 alquilado como inibidores da mek
DE60330227D1 (de) 2002-03-13 2010-01-07 Array Biopharma Inc N3-alkylierte benzimidazol-derivate als mek-hemmer
RU2300528C2 (ru) 2002-03-13 2007-06-10 Эррэй Биофарма, Инк. N3-алкилированные бензимидазольные производные в качестве ингибиторов мек
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
SE0200843D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
US7205412B2 (en) 2002-07-03 2007-04-17 Samsung Electronics Co., Ltd. Antibiotic additive and ink composition comprising the same
DE10229777A1 (de) 2002-07-03 2004-01-29 Bayer Ag Indolin-Phenylsulfonamid-Derivate
US7138420B2 (en) 2002-08-08 2006-11-21 Boehringer Ingelheim Pharmaceuticals Inc. Substituted benzimidazole compounds
US20040063938A1 (en) 2002-09-30 2004-04-01 Pfizer Inc Process for preparing haloalkyl pyrimidines
AU2003294249A1 (en) 2002-11-08 2004-06-03 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
EP1571146A4 (fr) 2002-12-10 2010-09-01 Ono Pharmaceutical Co Composes heterocycliques contenant de l'azote et leur utilisation medicale
TW200418806A (en) 2003-01-13 2004-10-01 Fujisawa Pharmaceutical Co HDAC inhibitor
US20050020654A1 (en) 2003-03-15 2005-01-27 Pershadsingh Harrihar A. Novel PPAR agonists, pharmaceutical compositions and uses thereof
WO2004089918A1 (fr) * 2003-04-09 2004-10-21 Japan Tobacco Inc. Compose pentacyclique heteroaromatique et son usage medical
JPWO2004093912A1 (ja) 2003-04-23 2006-07-13 協和醗酵工業株式会社 好中球性炎症疾患の予防および／または治療剤
WO2004098494A2 (fr) 2003-04-30 2004-11-18 Cytokinetics, Inc. Composés, compositions et procédés
SE0301699D0 (sv) * 2003-06-10 2003-06-10 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
US7250417B2 (en) 2003-07-02 2007-07-31 Sugen Inc. Arylmethyl triazolo- and imidazopyrazines as c-Met inhibitors
US7312215B2 (en) * 2003-07-29 2007-12-25 Bristol-Myers Squibb Company Benzimidazole C-2 heterocycles as kinase inhibitors
DE10342503A1 (de) 2003-09-12 2005-04-14 Merck Patent Gmbh Benzyl-Benzimidazolylderivate
NZ545864A (en) 2003-09-22 2009-12-24 S Bio Pte Ltd Benzimidazole derivates: preparation and pharmaceutical applications
WO2005051929A1 (fr) 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Conversion de nitriles aromatiques en tetrazoles
WO2005051928A1 (fr) 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Procede de preparation de composes de tetrazolyle
WO2005066151A2 (fr) 2003-12-19 2005-07-21 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
US20050209284A1 (en) 2004-02-12 2005-09-22 Boehringer Ingelheim Pharmaceuticals, Inc. Tec kinase inhibitors
JP4866723B2 (ja) 2004-02-26 2012-02-01 協和発酵キリン株式会社 好中球性炎症疾患の予防及び／または治療剤
CA2558389C (fr) 2004-03-15 2013-10-08 Anormed, Inc. Procede de synthese d'un antagoniste de cxcr4
CA2558030A1 (fr) 2004-03-15 2005-09-29 Eli Lilly And Company Derives de 4-(5-(aminomethyl)-indole-1-ylmethyl)-benzamide et composes associes, utiles comme antagonistes des recepteurs opioides pour traiter l'obesite
AU2005244736B2 (en) 2004-05-07 2012-06-28 Exelixis Patent Company Llc Raf modulators and methods of use
US7687638B2 (en) 2004-06-04 2010-03-30 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
CA2577100A1 (fr) 2004-08-16 2006-03-02 Smithkline Beecham Corporation Composes chimiques
NZ554545A (en) 2004-09-17 2010-10-29 Whitehead Inst Of Biomedical R Compounds, compositions and methods of inhibiting alpha-synuclein toxicity
WO2006050053A2 (fr) 2004-11-01 2006-05-11 Nuada, Llc Composes et methodes d'utilisation de ces composes
US20090264384A1 (en) 2004-11-01 2009-10-22 Nuada, Inc. Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
WO2007134169A2 (fr) 2006-05-10 2007-11-22 Nuada, Llc Composés d'acide indole, benzimidazole et benzolactame boronique, analogues de ces composés et méthodes d'utilisation correspondantes
US8003806B2 (en) 2004-11-12 2011-08-23 OSI Pharmaceuticals, LLC Integrin antagonists useful as anticancer agents
WO2006060737A2 (fr) 2004-12-03 2006-06-08 Takeda San Diego, Inc. Inhibiteurs de kinesine mitotique
EP1856096B1 (fr) 2005-01-10 2010-09-01 Bristol-Myers Squibb Company Derives de phenylglycinamide utilises comme anticoagulants
US7429608B2 (en) 2005-01-20 2008-09-30 Amgen Inc. Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments
CN1834090B (zh) 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途
WO2007024294A2 (fr) 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certains urees substitues, modulateurs de l'activite des kinases
WO2006132625A1 (fr) 2005-06-03 2006-12-14 Ppg Industries Ohio, Inc. Preparation pour la deshydrohalogenation en phase vapeur de 1,1,2-trihalogenoethane en 1,1-dihalogenoethylene et procedes d'elaboration et d'emploi de telles preparations
KR101280096B1 (ko) 2005-06-29 2013-06-28 컴퓨메딕스 리미티드 전도성 브리지를 포함하는 센서 어셈블리
JP2009500451A (ja) 2005-07-11 2009-01-08 スミスクライン ビーチャム コーポレーション ピラノピリジン化合物
JP2007063261A (ja) 2005-08-01 2007-03-15 Kyowa Hakko Kogyo Co Ltd Ｘ線照射による肺障害の予防及び／または治療剤
WO2007023880A1 (fr) 2005-08-24 2007-03-01 Kyowa Hakko Kogyo Co., Ltd. Inhibiteur de la production de chimiokines
ATE548363T1 (de) 2005-08-29 2012-03-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen
TW200720261A (en) 2005-08-31 2007-06-01 Sankyo Co Phenylene derivatives
ATE512953T1 (de) 2005-09-08 2011-07-15 S Heterocyclische verbindungen
WO2007054965A2 (fr) 2005-09-23 2007-05-18 Alembic Limited Procede de preparation de tetrazoles a partir de derives cyano aromatiques
GB0520164D0 (en) 2005-10-04 2005-11-09 Novartis Ag Organic compounds
AU2006327300A1 (en) 2005-12-20 2007-06-28 Astrazeneca Ab Substituted Cinnoline derivatives as GABAa-receptor modulators and method for their synthesis
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
EP1991545A2 (fr) 2005-12-23 2008-11-19 AstraZeneca AB Pyrrolopyridines, pyrrolopyrimidines et pyrroloazepines antibactériennes
AU2006336504C9 (en) 2005-12-28 2015-05-14 Vertex Pharmaceuticals Incorporated 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
EP1976835A2 (fr) 2006-01-13 2008-10-08 Takeda San Diego, Inc. Inhibiteurs des histone desacetylases
EP1976839A4 (fr) 2006-01-26 2011-06-15 Foldrx Pharmaceuticals Inc Composés et procédés de modulation du trafic de protéines
WO2007091950A1 (fr) 2006-02-07 2007-08-16 Astrazeneca Ab Benzimidazoles et imidazopyridines utiles dans le traitement de maladies ou de troubles associés au récepteur cannabinoïde 2 (cb2) tels que la douleur
WO2007101347A1 (fr) 2006-03-07 2007-09-13 Aegera Therapeutics Inc. Composés de liaison au domaine bir
BRPI0711040A2 (pt) 2006-03-31 2011-08-23 Astrazeneca Ab uso de um composto, método para o tratamento ou prevenção de distúrbios, composto, e, composição farmacêutica
DE102006025777A1 (de) 2006-05-31 2007-12-06 Merck Patent Gmbh Neue Materialien für organische Elektrolumineszenzvorrichtungen
EP1873157A1 (fr) 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines et sels de ceux-ci, compositions pharmaceutiques contenant ces composes, procedes de preparation associes, et leur utilisation
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
EP1878724A1 (fr) 2006-07-15 2008-01-16 sanofi-aventis Synthèse régiosélective des benzimidazoles et azabenzimidazoles catalysée par le palladium
WO2008012623A1 (fr) 2006-07-25 2008-01-31 Pfizer Products Inc. Composés de benzimidazolyle constituant des potentialisateurs du sous-type de récepteur de glutamate mglur2
WO2008019309A1 (fr) 2006-08-04 2008-02-14 Metabasis Therapeutics, Inc. Nouveaux inhibiteurs du fructose 1,6-bisphosphatase
US8236783B2 (en) 2006-08-15 2012-08-07 Duke University ROS-sensitive iron chelators and methods of using the same
WO2008032086A1 (fr) * 2006-09-14 2008-03-20 Astrazeneca Ab Dérivés de 2-benzimidazolyl-6-morpholino-4-phénylpyrimidine convenant comme inhibiteurs de pi3k et de mtor pour le traitement de troubles proliférants
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
MX2009004019A (es) 2006-10-19 2009-06-19 Signal Pharm Llc Compuestos heteroarilo, composiciones de los mismos, y uso de los mismos como inhibidores de proteina cinasa.
WO2008052072A2 (fr) 2006-10-24 2008-05-02 Acadia Pharmaceuticals Inc. Composés destinés au traitement de la douleur et procédés de dépistage à cet effet
US20100204187A1 (en) 2007-01-23 2010-08-12 Jorge Salas Solana Purine Derivatives
EP1988091B1 (fr) 2007-02-07 2015-06-10 Kyowa Hakko Kirin Co., Ltd. Composés tricycliques
EP2131840B1 (fr) 2007-03-07 2018-10-17 MEI Pharma, Inc. Combinaison d'un agent anticancéreux à base de benzimidazole et d'un second agent anticancéreux
SI2134691T1 (sl) 2007-03-08 2012-06-29 Janssen Pharmaceutica Nv Derivati kvinolina kot PARP in TANK inhibitorji
KR20100020487A (ko) 2007-05-24 2010-02-22 와이어쓰 엘엘씨 히스타민-3 길항제로서 아자시클릴벤즈아미드 유도체
TW200906825A (en) 2007-05-30 2009-02-16 Scripps Research Inst Inhibitors of protein kinases
KR20100023907A (ko) 2007-06-26 2010-03-04 사노피-아벤티스 벤즈이미다졸 및 아자벤즈이미다졸의 위치선택적 구리 촉매화 합성
EP2014662A1 (fr) 2007-07-12 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Indolylalkylthienopyrimidylamine en tant que modulateurs du récepteur EP2
EP2014663A1 (fr) 2007-07-12 2009-01-14 Bayer Schering Pharma AG Thienopyrimidylamine en tant que modulateurs du récepteur EP2
RU2522456C2 (ru) 2007-08-21 2014-07-10 Синомикс, Инк. Соединения, ингибирующие (блокирующие) горький вкус, способы их применения и получения
WO2009027736A2 (fr) 2007-08-27 2009-03-05 Astrazeneca Ab Composés chimiques 000-1
WO2009039140A1 (fr) 2007-09-17 2009-03-26 Smithkline Beecham Corporation Dérivés de pyridopyrimidine en tant qu'inhibiteurs de kinase p13
US20090118301A1 (en) 2007-11-02 2009-05-07 Arbor Vita Corporation Compositions and Methods for Treating Cancer
SG186040A1 (en) 2007-11-27 2012-12-28 Cellzome Ltd Amino triazoles as pi3k inhibitors
WO2009079011A1 (fr) 2007-12-19 2009-06-25 The Scripps Research Institute Benzimidazoles et analogues comme inhibiteurs de la rho-kinase
KR20100113557A (ko) 2008-01-11 2010-10-21 노파르티스 아게 키나제 억제제로서의 피리미딘
AR070127A1 (es) 2008-01-11 2010-03-17 Novartis Ag Pirrolo - pirimidinas y pirrolo -piridinas
CN102014914A (zh) 2008-01-15 2011-04-13 惠氏有限责任公司 3h-[1,2,3]三唑并[4,5-d]嘧啶化合物、其作为mtor激酶和pi3激酶抑制剂的用途、以及它们的合成
CL2009000119A1 (es) 2008-01-22 2010-03-05 Boehringer Ingelheim Int Compuestos derivados de amino-bencimidazoles sustituidos; composicion farmaceutica; y su uso en el tratamiento del alzheimer.
FR2928924B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
AU2009228945B2 (en) 2008-03-27 2013-05-02 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
RU2490260C2 (ru) 2008-03-27 2013-08-20 Янссен Фармацевтика Нв Тетрагидрофенантридиноны и тетрагидроциклопентахинолиноны в качестве ингибиторов parp и ингибиторов полимеризации тубулина
US20090253161A1 (en) 2008-04-03 2009-10-08 Duke University Fluorescent prochelators for cellular iron detection
CN102046179B (zh) 2008-04-09 2015-01-14 英菲尼提制药公司 脂肪酸酰胺水解酶抑制剂
CA2725689A1 (fr) 2008-06-04 2009-12-10 Astrazeneca Ab Derives de thiazolo [5,4-b] pyridine et d'oxazolo [5,4-b] comme agents antibacteriens
JP2010031250A (ja) 2008-06-23 2010-02-12 Sumitomo Chemical Co Ltd 組成物及び該組成物を用いてなる発光素子
WO2010000020A1 (fr) 2008-06-30 2010-01-07 Cathrx Ltd Cathéter
AU2009266889B2 (en) 2008-07-03 2013-05-02 Glaxosmithkline Llc Benzimidazoles and related analogs as sirtuin modulators
CA2730271A1 (fr) * 2008-07-07 2010-01-14 Xcovery Holding Company Llc Inhibiteurs selectifs des isoformes de la pi3 kinase
WO2010006096A1 (fr) 2008-07-11 2010-01-14 Smithkline Beecham Corporation Procédés de préparation de composés antiviraux et compositions les contenant
US8501957B2 (en) 2008-12-10 2013-08-06 China Medical University Benzimidazole compounds and their use as anticancer agents
EP2565193B1 (fr) 2009-01-23 2014-03-19 Rigel Pharmaceuticals, Inc. Compositions et procédés d'inhibition de la voie JAK
CN102427731B (zh) 2009-02-27 2015-05-13 英安塔制药有限公司 丙型肝炎病毒抑制剂
US8975247B2 (en) 2009-03-18 2015-03-10 The Board Of Trustees Of The Leland Stanford Junion University Methods and compositions of treating a flaviviridae family viral infection
EP2419551A2 (fr) 2009-03-18 2012-02-22 Basf Se Électrolyte et additifs tensio-actifs pour le dépôt galvanique de couches d'aluminium lisses et compactes à partir de liquides ioniques
WO2010108187A2 (fr) 2009-03-20 2010-09-23 Brandeis University Composés et procédés pour traiter les infections microbiennes gastro-intestinales mammaliennes
WO2010114726A1 (fr) 2009-03-31 2010-10-07 Merck Sharp & Dohme Corp. Dérivés d'aminobenzotriazole
SI2414369T1 (sl) 2009-04-02 2015-12-31 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Derivati imidazo(2,1-b)(1,3,4)tiadiazola
WO2010118208A1 (fr) 2009-04-09 2010-10-14 Exelixis, Inc. Dérivés benzoxazepin-4-(5h)-yle et leur utilisation pour traiter le cancer
AU2010241929A1 (en) 2009-04-27 2011-10-06 High Point Pharmaceuticals, Llc Substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors
WO2010126922A1 (fr) 2009-04-30 2010-11-04 Glaxosmithkline Llc Benzimidazolecarboxamides constituant des inhibiteurs de la kinase d'adhérence focale
CN102459249A (zh) 2009-05-22 2012-05-16 埃克塞里艾克西斯公司 作为PI3K/mTOR抑制剂的苯并氧氮杂环庚三烯以及它们使用与制造方法
BRPI1010896A2 (pt) 2009-05-26 2019-09-24 Exelixis Inc benzoxazepinas como inibidores de pi3k/mtor e métodos de seus usos e fabricação
WO2010141360A1 (fr) 2009-06-05 2010-12-09 Merck Sharp & Dohme Corp. Derives de benzotriazole biaryle
WO2010144686A1 (fr) 2009-06-10 2010-12-16 North Carolina State University Inhibition et dispersion de bio-films bactériens avec dérivés de benzimidazole
WO2011000020A1 (fr) 2009-06-12 2011-01-06 Sbc Research Pty Ltd Procédé amélioré de détection
JP2011003793A (ja) 2009-06-19 2011-01-06 Idemitsu Kosan Co Ltd 有機ｅｌ素子
WO2011009010A1 (fr) 2009-07-15 2011-01-20 University Of Medicine And Dentistry Of New Jersey Nouveaux composés pour inhiber l'activité eef2 kinase
MX2012004560A (es) 2009-10-29 2012-05-08 Bristol Myers Squibb Co Compuestos de quinuclidina como ligandos del receptor de acetilcolina nicotinico alfa-7.
US8754113B2 (en) 2009-12-15 2014-06-17 Shionogi & Co., Ltd. Oxadiazole derivative having endothelial lipase inhibitory activity
ES2362337B1 (es) 2009-12-17 2012-05-16 Consejo Superior De Investigaciones Cient�?Ficas (Csic) Derivados de aminociclitoles, procedimiento de obtencion y usos.
EP3170813B1 (fr) * 2010-10-06 2018-12-12 GlaxoSmithKline LLC Dérivés de benzimidazole comme inhibiteurs de pi3 kinase
JP6588336B2 (ja) 2013-10-11 2019-10-09 ユニ・チャーム株式会社 ペットフード

Also Published As

Publication number Publication date
EP3170813A1 (fr) 2017-05-24
HRP20170279T1 (hr) 2017-04-07
US20140142321A1 (en) 2014-05-22
WO2012047538A1 (fr) 2012-04-12
MX2013003918A (es) 2013-06-05
US20180263994A1 (en) 2018-09-20
SG188974A1 (en) 2013-06-28
CR20130192A (es) 2013-10-03
US8541411B2 (en) 2013-09-24
ES2616238T3 (es) 2017-06-12
JP2013539753A (ja) 2013-10-28
US9156797B2 (en) 2015-10-13
TWI513690B (zh) 2015-12-21
CN103124496B (zh) 2016-03-30
AU2011312594A1 (en) 2013-04-11
US8674090B2 (en) 2014-03-18
PL2624696T3 (pl) 2017-07-31
SI2624696T1 (sl) 2017-04-26
US20190255064A1 (en) 2019-08-22
CA2812608C (fr) 2020-07-14
MX337662B (es) 2016-03-14
CN103124496A (zh) 2013-05-29
US20120088767A1 (en) 2012-04-12
DK2624696T3 (en) 2017-03-13
CY1118792T1 (el) 2017-07-12
EA201390302A1 (ru) 2013-09-30
US20170112844A1 (en) 2017-04-27
LT2624696T (lt) 2017-03-10
EP2624696A1 (fr) 2013-08-14
JP5719028B2 (ja) 2015-05-13
CA2812608A1 (fr) 2012-04-12
EP2624696A4 (fr) 2014-03-26
UY33648A (es) 2012-04-30
US10314845B2 (en) 2019-06-11
BR112013008259A2 (pt) 2017-12-12
US8865912B2 (en) 2014-10-21
AR083296A1 (es) 2013-02-13
TW201307297A (zh) 2013-02-16
US20150246889A1 (en) 2015-09-03
MY170236A (en) 2019-07-11
EP2624696B1 (fr) 2016-12-21
KR20130099142A (ko) 2013-09-05
ME02663B (fr) 2017-06-20
ES2714384T3 (es) 2019-05-28
JO3194B1 (ar) 2018-03-08
PH12013500646A1 (en) 2015-11-13
US20140018534A1 (en) 2014-01-16
NZ608069A (en) 2014-06-27
US20130196990A1 (en) 2013-08-01
US20130197221A1 (en) 2013-08-01
US10660898B2 (en) 2020-05-26
SMT201700158T1 (it) 2017-05-08
AU2011312594B2 (en) 2014-10-02
US9062003B2 (en) 2015-06-23
RS55662B1 (sr) 2017-06-30
EA022623B1 (ru) 2016-02-29
ZA201301951B (en) 2014-08-27
PE20140192A1 (es) 2014-02-24
CO6700852A2 (es) 2013-06-28
DOP2013000059A (es) 2013-05-31
CL2013000935A1 (es) 2013-07-05
US8435988B2 (en) 2013-05-07
KR101594002B1 (ko) 2016-02-15
EP3170813B1 (fr) 2018-12-12
IL225140A (en) 2016-09-29
US20140378456A1 (en) 2014-12-25
HUE033209T2 (hu) 2017-11-28
PT2624696T (pt) 2017-03-21
US9872860B2 (en) 2018-01-23

Similar Documents

Publication Publication Date Title
MA34591B1 (fr) Dérivés de benzimidazole utilisés comme inhibiteurs de pi3 kinase
MA31443B1 (fr) Derives de quinoline en tant qu'inhibiteurs de pi3 kinase
MA38327A2 (fr) Dihydropyrimidinones bicycliques substituées et leur utilisation à titre d'inhibiteurs de l'activité élastase neutrophile
MA30395B1 (fr) Dérivés de thiazolidinedione utilisés comme inhibiteurs des kinases PI3
MA34650B1 (fr) Antagonistes du récepteur cgrp de pipéridinone carboxamide azaindane
EA200870292A1 (ru) Соединения на основе имидазола, композиции, содержащие их, и способы их применения
NZ598985A (en) Bruton's tyrosine kinase inhibitors
TW200612951A (en) New pyridazin-3(2h)-one derivatives
MY161416A (en) 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4yl)-1h-pyrazol-1-yl]octane-or heptane-nitrile as jak inhibitors
EA201171306A1 (ru) ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-α]ПИРИДИНА, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ β-СЕКРЕТАЗЫ
MX346336B (es) Derivados de quinazolin-4 (3h)-ona utilizados como inhibidores de pi3 cinasa.
EA200970818A1 (ru) Гетероциклические соединения, содержащие их композиции и способы их применения
UA109131C2 (ru) 5,7-ЗАМЕЩЕННЫЕ ИМИДАЗО[1,2-c]ПИРИМИДИНЫ КАК ИНГИБИТОРЫ JAK-КИНАЗ
MA40123A1 (fr) Pyrimidines utilisées en tant qu'inhibiteurs du facteur xia
MA37450B1 (fr) Inhibiteurs d'indazole du trajet de signal de wnt et leurs utilisations thérapeutiques
EA201300556A1 (ru) Аминоспиртзамещенные производные 2,3-дигидроимидазо[1,2-с] хиназолина, пригодные для лечения гиперпролиферативных нарушений и заболеваний, связанных с ангиогенезом
MA31336B1 (fr) Inhibiteurs de pi3k alpha a base de pyridopyrimidinone
EA200870396A1 (ru) Лечение аллергических заболеваний глаз
EA201291055A1 (ru) Ингибиторы протеинтирозинкиназной активности и их применение для лечения глазных заболеваний
MA38346A3 (fr) 2,3-benzodiazépines bicyclo- et spirocyclosubstituées
EA201491449A1 (ru) 1h-индазол-3-карбоксамидные соединения в качестве ингибиторов гликогенсинтазы киназы 3-бета
EA201790282A1 (ru) Замещенные бициклические дигидропиримидиноны и их применение в качестве ингибиторов активности нейтрофил-эластазы
MX2010006331A (es) Hidantoinas sustituidas como inhibidores de cinasa mek.
WO2023107714A3 (fr) Méthodes de traitement de troubles neurologiques
EA201171030A1 (ru) 2-МОРФОЛИНОПИРИДО[3,2-d]ПИРИМИДИНЫ