EA201992296A1 - Производные хиноксалина и пиридопиразина в качестве ингибиторов pi3k-бета - Google Patents

Производные хиноксалина и пиридопиразина в качестве ингибиторов pi3k-бета

Info

Publication number
EA201992296A1
EA201992296A1 EA201992296A EA201992296A EA201992296A1 EA 201992296 A1 EA201992296 A1 EA 201992296A1 EA 201992296 A EA201992296 A EA 201992296A EA 201992296 A EA201992296 A EA 201992296A EA 201992296 A1 EA201992296 A1 EA 201992296A1
Authority
EA
Eurasian Patent Office
Prior art keywords
quinoxaline
pi3k
beta inhibitors
pyridopyrazine derivatives
compounds
Prior art date
Application number
EA201992296A
Other languages
English (en)
Inventor
Патрик Рене Анжибо
Оливье Алексис Жорж Керолль
Дидье Жан-Клод Бертело
Кристоф Мейер
Мэттью Филипп Виктор Виллот
Ливен Мерпул
Тьерри Франсуа Ален Жан Жуссом
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201992296A1 publication Critical patent/EA201992296A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Abstract

Настоящее изобретение относится к замещенным производным хиноксалина и пиридопиразина формулы (I)где переменные имеют значения, определенные в формуле изобретения. Соединения согласно настоящему изобретению являются пригодными в качестве ингибиторов pI3Kβ. Кроме того, настоящее изобретение относится к фармацевтическим композициям, содержащим указанные соединения в качестве активного ингредиента, а также к применению указанных соединений в качестве лекарственного препарата.
EA201992296A 2017-03-29 2018-03-29 Производные хиноксалина и пиридопиразина в качестве ингибиторов pi3k-бета EA201992296A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17163625 2017-03-29
PCT/EP2018/058175 WO2018178280A1 (en) 2017-03-29 2018-03-29 Quinoxaline and pyridopyrazine derivatives as pi3k-beta inhibitors

Publications (1)

Publication Number Publication Date
EA201992296A1 true EA201992296A1 (ru) 2020-02-12

Family

ID=58454972

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992296A EA201992296A1 (ru) 2017-03-29 2018-03-29 Производные хиноксалина и пиридопиразина в качестве ингибиторов pi3k-бета

Country Status (13)

Country Link
US (1) US11130751B2 (ru)
EP (1) EP3601254B1 (ru)
JP (1) JP7053654B2 (ru)
KR (1) KR20190133729A (ru)
CN (1) CN110461827A (ru)
AU (1) AU2018246321B2 (ru)
BR (1) BR112019020309A2 (ru)
CA (1) CA3054107A1 (ru)
EA (1) EA201992296A1 (ru)
ES (1) ES2925176T3 (ru)
IL (1) IL269598B (ru)
MX (1) MX2019011610A (ru)
WO (1) WO2018178280A1 (ru)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170848A1 (en) 2006-03-02 2009-07-02 Smithkline Beecham Corporation Thiazolones for use as pi3 kinase inhibitors
EP2046333A4 (en) 2006-07-24 2010-09-15 Glaxosmithkline Llc THIOZOLIDINEDIONE DERIVATIVES AS INHIBITORS OF P13-KINASE
EP2173354A4 (en) * 2007-08-09 2011-10-05 Glaxosmithkline Llc CHINOXALIN DERIVATIVES AS PI3 KINASE INHIBITORS
KR101897881B1 (ko) 2008-01-04 2018-09-12 인텔리카인, 엘엘씨 특정 화학 물질, 조성물 및 방법
AU2010213192A1 (en) 2009-02-13 2011-08-04 Bayer Intellectual Property Gmbh Fused pyrimidines
WO2010108074A2 (en) 2009-03-20 2010-09-23 Amgen Inc. Inhibitors of pi3 kinase
EA026693B1 (ru) 2009-08-17 2017-05-31 Интелликайн ЭлЭлСи Производные бензоксазола и бензотиазола в качестве ингибиторов pi3-киназы
US8569296B2 (en) 2009-09-29 2013-10-29 Xcovery Holding Company, Llc PI3K (delta) selective inhibitors
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
UY33304A (es) 2010-04-02 2011-10-31 Amgen Inc Compuestos heterocíclicos y sus usos
PL2624696T3 (pl) 2010-10-06 2017-07-31 Glaxosmithkline Llc Pochodne benzimidazolu jako inhibitory kinazy PI3
WO2012116237A2 (en) 2011-02-23 2012-08-30 Intellikine, Llc Heterocyclic compounds and uses thereof
WO2013028263A1 (en) 2011-08-24 2013-02-28 Glaxosmithkline Llc Pyrazolopyrimidine derivatives as pi3 kinase inhibitors
US8778937B2 (en) 2011-12-20 2014-07-15 Glaxosmithkline Llc Benzimidazole boronic acid derivatives as PI3 kinase inhibitors
US8906910B2 (en) 2011-12-20 2014-12-09 Glaxosmithkline Llc Imidazopyridine derivatives as PI3 kinase
GB201212513D0 (en) 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
US9309243B2 (en) 2012-07-13 2016-04-12 Ucb Biopharma Sprl Imidazopyridine derivatives as modulators of TNF activity
RU2663999C2 (ru) 2013-10-16 2018-08-14 Шанхай Инли Фармасьютикал Ко., Лтд Конденсированное гетероциклическое соединение, способ его получения, его фармацевтическая композиция и применения
ES2760507T3 (es) 2014-12-19 2020-05-14 Janssen Pharmaceutica Nv Derivados de imidazopiridazina enlazados a heterociclilo como inhibidores de PI3Kß
ES2761051T3 (es) 2014-12-19 2020-05-18 Janssen Pharmaceutica Nv Derivados de imidazopiridazina como inhibidores de PI3Kbeta
US9637488B2 (en) * 2015-01-29 2017-05-02 Fuqiang Ruan Heterocyclic compounds as inhibitors of class I PI3KS
BR112018007068B1 (pt) * 2015-10-09 2024-01-02 Janssen Pharmaceutica N.V. Derivados de quinoxalina e piridopirazina como inibidores de pi3kbeta, seu uso e composição farmacêutica que os compreende

Also Published As

Publication number Publication date
WO2018178280A1 (en) 2018-10-04
US20200181132A1 (en) 2020-06-11
JP2020512352A (ja) 2020-04-23
AU2018246321B2 (en) 2021-07-29
IL269598A (en) 2019-11-28
JP7053654B2 (ja) 2022-04-12
EP3601254B1 (en) 2022-05-25
EP3601254A1 (en) 2020-02-05
CA3054107A1 (en) 2018-10-04
BR112019020309A2 (pt) 2020-04-28
KR20190133729A (ko) 2019-12-03
AU2018246321A1 (en) 2019-11-14
US11130751B2 (en) 2021-09-28
ES2925176T3 (es) 2022-10-14
CN110461827A (zh) 2019-11-15
MX2019011610A (es) 2019-11-08
IL269598B (en) 2022-08-01

Similar Documents

Publication Publication Date Title
MY196909A (en) Boronic acid derivatives and therapeutic uses thereof
EA201990851A1 (ru) Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5
EA201892734A1 (ru) ПРОИЗВОДНЫЕ АЗАБЕНЗИМИДАЗОЛА В КАЧЕСТВЕ ИНГИБИТОРОВ pI3K BETA
EA201890573A1 (ru) Новые замещенные 6-6-бициклическим ароматическим кольцом аналоги нуклеозидов для применения в качестве ингибиторов prmt5
EA201891103A1 (ru) Композиции для лечения спинальной мышечной атрофии
EA201890906A1 (ru) ПРОИЗВОДНЫЕ ХИНОКСАЛИНА И ПИРИДОПИРАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ
EA201792421A1 (ru) Амидозамещенные производные циклогексана
MX2022013612A (es) Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas.
EA202090486A2 (ru) Соединения для лечения спинальной мышечной атрофии
EA201691803A1 (ru) Ингибиторы калликреина плазмы человека
EA201690598A1 (ru) Аминогетероарил бензамиды в качестве ингибиторов киназы
EA201591003A1 (ru) Производные бороновой кислоты и их терапевтическое применение
EA201891063A1 (ru) Производные дигидроимидазопиразинона, применимые в лечении рака
EA202190960A1 (ru) Конденсированные пирролины, которые действуют как ингибиторы убиквитин-специфической протеазы 30 (usp30)
EA201390198A1 (ru) Гетероциклическое соединение
EA201692003A1 (ru) Макроциклические производные пиримидина
EA201891179A1 (ru) N-замещенные индольные производные в качестве модуляторов pge2 рецепторов
GEP20227353B (en) Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
EA201692000A1 (ru) Макроциклические производные пиридина
MX2020005944A (es) Analogos espirobiciclicos novedosos.
EA201591541A1 (ru) Ингибиторы бета-секретазы 1 (bace 1)
EA201992679A1 (ru) N-замещенные индольные производные
PH12019500731A1 (en) Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors
EA201691962A1 (ru) Амидозамещенные азольные соединения в качестве ингибиторов tnks1 и/или tnks2
EA202091400A1 (ru) Производные пиррола в качестве ингибиторов асс