EA201291055A1 - Ингибиторы протеинтирозинкиназной активности и их применение для лечения глазных заболеваний - Google Patents

Ингибиторы протеинтирозинкиназной активности и их применение для лечения глазных заболеваний

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Publication number
EA201291055A1
EA201291055A1 EA201291055A EA201291055A EA201291055A1 EA 201291055 A1 EA201291055 A1 EA 201291055A1 EA 201291055 A EA201291055 A EA 201291055A EA 201291055 A EA201291055 A EA 201291055A EA 201291055 A1 EA201291055 A1 EA 201291055A1
Authority
EA
Eurasian Patent Office
Prior art keywords
eye diseases
proteintirozinkinase
treatment
application
activity inhibitors
Prior art date
Application number
EA201291055A
Other languages
English (en)
Inventor
Стефан Раппель
Лицзе Чжань
Стефен Уилльям Кларидж
Фрэнк Раппель
Фредерик Годетт
Аркадий Вайсбург
Original Assignee
Метилджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Метилджен Инк. filed Critical Метилджен Инк.
Publication of EA201291055A1 publication Critical patent/EA201291055A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к соединениям и их композициям, которые являются ингибиторами протеинтирозинкиназ. Соединения применяют для лечения глазных заболеваний, расстройств и состояний. Указанные соединения имеют формулы (I), (II) или (III), где R=(IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) или (XII).
EA201291055A 2010-04-16 2011-04-08 Ингибиторы протеинтирозинкиназной активности и их применение для лечения глазных заболеваний EA201291055A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32480310P 2010-04-16 2010-04-16
PCT/CA2011/000390 WO2011127565A1 (en) 2010-04-16 2011-04-08 Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders

Publications (1)

Publication Number Publication Date
EA201291055A1 true EA201291055A1 (ru) 2013-09-30

Family

ID=44788641

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201291055A EA201291055A1 (ru) 2010-04-16 2011-04-08 Ингибиторы протеинтирозинкиназной активности и их применение для лечения глазных заболеваний
EA201291052A EA201291052A1 (ru) 2010-04-16 2011-04-08 Ингибиторы протеинтирозинкиназной активности

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201291052A EA201291052A1 (ru) 2010-04-16 2011-04-08 Ингибиторы протеинтирозинкиназной активности

Country Status (18)

Country Link
US (3) US8906852B2 (ru)
EP (2) EP2563794A4 (ru)
JP (2) JP2013525286A (ru)
KR (2) KR20130100234A (ru)
CN (2) CN103025740B (ru)
AR (2) AR080875A1 (ru)
AU (2) AU2011241420B2 (ru)
CA (2) CA2796008A1 (ru)
CO (2) CO6640224A2 (ru)
EA (2) EA201291055A1 (ru)
MX (2) MX2012012031A (ru)
MY (1) MY157319A (ru)
NZ (2) NZ602954A (ru)
SG (2) SG184883A1 (ru)
TW (2) TW201204734A (ru)
UA (1) UA108878C2 (ru)
WO (2) WO2011127567A1 (ru)
ZA (2) ZA201207482B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009026717A1 (en) * 2007-08-29 2009-03-05 Methylgene Inc. Inhibitors of protein tyrosine kinase activity
BRPI0923670A2 (pt) * 2008-03-05 2013-07-30 Methylgene Inc inibidores da atividade de proteÍna tirosina quinase e seu uso, bem como composiÇço compreendendo os mesmos
KR20130100234A (ko) * 2010-04-16 2013-09-10 메틸진 인코포레이티드 단백질 티로신 키나아제 활성의 억제 및 안구 질환을 치료하는 이의 용도
US20130096135A1 (en) * 2011-09-30 2013-04-18 Methylgene Inc. Selected Inhibitors of Protein Tyrosine Kinase Activity
WO2013044360A1 (en) * 2011-09-30 2013-04-04 Methylgene Inc. Inhibitors of protein tyrosine kinase activity
WO2013044361A1 (en) * 2011-09-30 2013-04-04 Methylgene Inc. Inhibitors of protein tyrosine kinase activity
CA2857603C (en) 2011-12-15 2016-08-02 Pfizer Limited Sulfonamide derivatives
EP3200589A4 (en) 2014-09-10 2018-07-25 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
WO2016183150A1 (en) * 2015-05-12 2016-11-17 Temple University-Of The Commonwealth System Of Higher Education Novel sigma-2 receptor binders and their method of use
CN108530464B (zh) * 2017-03-02 2020-10-27 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020619A1 (en) * 2003-07-24 2005-01-27 Patrick Betschmann Thienopyridine kinase inhibitors
KR101257343B1 (ko) * 2004-07-30 2013-04-23 메틸진 인코포레이티드 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달 억제제
AU2006229343A1 (en) * 2005-03-28 2006-10-05 Kirin Pharma Kabushiki Kaisha Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
ES2473341T3 (es) * 2005-05-20 2014-07-04 Methylgene Inc Inhibidores de la se�alizaci�n del receptor del VEGF y del receptor del HGF
BRPI0610322B8 (pt) * 2005-05-20 2021-05-25 Methylgene Inc inibidores de sinalização de receptor de vegf e de receptor de hgf e composição farmacêutica
ES2593279T3 (es) * 2007-08-29 2016-12-07 Methylgene Inc. Procesos e intermedios para preparar inhibidores de cinasa heterocíclicos condensados
WO2009026717A1 (en) * 2007-08-29 2009-03-05 Methylgene Inc. Inhibitors of protein tyrosine kinase activity
BRPI0923670A2 (pt) * 2008-03-05 2013-07-30 Methylgene Inc inibidores da atividade de proteÍna tirosina quinase e seu uso, bem como composiÇço compreendendo os mesmos
KR20130100234A (ko) * 2010-04-16 2013-09-10 메틸진 인코포레이티드 단백질 티로신 키나아제 활성의 억제 및 안구 질환을 치료하는 이의 용도
WO2013044361A1 (en) * 2011-09-30 2013-04-04 Methylgene Inc. Inhibitors of protein tyrosine kinase activity

Also Published As

Publication number Publication date
AR080871A1 (es) 2012-05-16
KR20130100234A (ko) 2013-09-10
CN103025740B (zh) 2015-07-01
JP2013523846A (ja) 2013-06-17
US20110257175A1 (en) 2011-10-20
NZ602954A (en) 2014-11-28
AU2011241420B2 (en) 2015-04-16
EP2563795A1 (en) 2013-03-06
CA2796054A1 (en) 2011-10-20
CO6640224A2 (es) 2013-03-22
NZ602948A (en) 2014-09-26
WO2011127565A1 (en) 2011-10-20
SG184883A1 (en) 2012-11-29
AR080875A1 (es) 2012-05-16
CN103025740A (zh) 2013-04-03
KR20130058006A (ko) 2013-06-03
EP2563795A4 (en) 2013-10-23
US20140315801A1 (en) 2014-10-23
ZA201207557B (en) 2013-06-26
CN102947315A (zh) 2013-02-27
CO6630193A2 (es) 2013-03-01
US20110257100A1 (en) 2011-10-20
SG184882A1 (en) 2012-11-29
MX2012012032A (es) 2012-12-17
MX2012012031A (es) 2012-12-17
CA2796008A1 (en) 2011-10-20
TW201204734A (en) 2012-02-01
US8455484B2 (en) 2013-06-04
UA108878C2 (ru) 2015-06-25
AU2011241422A1 (en) 2012-11-01
JP2013525286A (ja) 2013-06-20
EA201291052A1 (ru) 2013-04-30
WO2011127567A1 (en) 2011-10-20
ZA201207482B (en) 2013-09-25
MY157319A (en) 2016-05-31
US8906852B2 (en) 2014-12-09
AU2011241422B2 (en) 2015-05-07
EP2563794A1 (en) 2013-03-06
EP2563794A4 (en) 2013-12-04
TW201204735A (en) 2012-02-01

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