CO6640224A2 - Inhibidores de la actividad de la proteína tirosina quinasa - Google Patents
Inhibidores de la actividad de la proteína tirosina quinasaInfo
- Publication number
- CO6640224A2 CO6640224A2 CO12207317A CO12207317A CO6640224A2 CO 6640224 A2 CO6640224 A2 CO 6640224A2 CO 12207317 A CO12207317 A CO 12207317A CO 12207317 A CO12207317 A CO 12207317A CO 6640224 A2 CO6640224 A2 CO 6640224A2
- Authority
- CO
- Colombia
- Prior art keywords
- tyrosine kinase
- inhibitors
- kinase protein
- protein activity
- compounds
- Prior art date
Links
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title abstract 3
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 230000004952 protein activity Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 abstract 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 230000011664 signaling Effects 0.000 abstract 2
- 102000009465 Growth Factor Receptors Human genes 0.000 abstract 1
- 108010009202 Growth Factor Receptors Proteins 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Esta invención se refiere a compuestos que inhiben la actividad de la proteína tirosina quinasa. En particular, la invención se refiere a compuestos que inhiben la actividad de la proteína tirosina quinasa de los receptores de los factores de crecimiento, lo que da como resultado la inhibición de la señalización del receptor, por ejemplo, la inhibición de la señalización del receptor del VEGF (factor de crecimiento endotelial vascular). La invención también proporciona compuestos, composiciones y métodos para el tratamiento de enfermedades y condiciones de proliferación de células y enfermedades, desordenes o condiciones oftálmicas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32480310P | 2010-04-16 | 2010-04-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6640224A2 true CO6640224A2 (es) | 2013-03-22 |
Family
ID=44788641
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12207310A CO6630193A2 (es) | 2010-04-16 | 2012-11-15 | Inhibidores de la actividad de la proteína tirosina quinasa seleccionada |
CO12207317A CO6640224A2 (es) | 2010-04-16 | 2012-11-15 | Inhibidores de la actividad de la proteína tirosina quinasa |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12207310A CO6630193A2 (es) | 2010-04-16 | 2012-11-15 | Inhibidores de la actividad de la proteína tirosina quinasa seleccionada |
Country Status (18)
Country | Link |
---|---|
US (3) | US8455484B2 (es) |
EP (2) | EP2563795A4 (es) |
JP (2) | JP2013523846A (es) |
KR (2) | KR20130058006A (es) |
CN (2) | CN103025740B (es) |
AR (2) | AR080871A1 (es) |
AU (2) | AU2011241420B2 (es) |
CA (2) | CA2796008A1 (es) |
CO (2) | CO6630193A2 (es) |
EA (2) | EA201291052A1 (es) |
MX (2) | MX2012012032A (es) |
MY (1) | MY157319A (es) |
NZ (2) | NZ602954A (es) |
SG (2) | SG184882A1 (es) |
TW (2) | TW201204735A (es) |
UA (1) | UA108878C2 (es) |
WO (2) | WO2011127565A1 (es) |
ZA (2) | ZA201207482B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0816064B8 (pt) * | 2007-08-29 | 2021-05-25 | Methylgene Inc | composto inibidor da atividade de proteína tirosina quinase, seu uso, e composição farmacêutica |
AU2009221583B2 (en) * | 2008-03-05 | 2013-06-20 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
CN103025740B (zh) * | 2010-04-16 | 2015-07-01 | 梅特希尔基因公司 | 蛋白酪氨酸激酶活性的抑制剂及其治疗眼科疾病的用途 |
WO2013044361A1 (en) * | 2011-09-30 | 2013-04-04 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
WO2013044362A1 (en) * | 2011-09-30 | 2013-04-04 | Methylgene Inc. | Selected inhibitors of protein tyrosine kinase activity |
WO2013044360A1 (en) * | 2011-09-30 | 2013-04-04 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
CA2857603C (en) | 2011-12-15 | 2016-08-02 | Pfizer Limited | Sulfonamide derivatives |
WO2016040554A1 (en) | 2014-09-10 | 2016-03-17 | Temple University-Of The Commonwealth System Of Higher Education | Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use |
WO2016183150A1 (en) * | 2015-05-12 | 2016-11-17 | Temple University-Of The Commonwealth System Of Higher Education | Novel sigma-2 receptor binders and their method of use |
CN108530464B (zh) * | 2017-03-02 | 2020-10-27 | 深圳海王医药科技研究院有限公司 | 一种多靶点激酶抑制剂 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050020619A1 (en) * | 2003-07-24 | 2005-01-27 | Patrick Betschmann | Thienopyridine kinase inhibitors |
AU2005266803B2 (en) * | 2004-07-30 | 2011-10-27 | Methylgene Inc. | Inhibitors of VEGF receptor and HGF receptor signaling |
AU2006229343A1 (en) * | 2005-03-28 | 2006-10-05 | Kirin Pharma Kabushiki Kaisha | Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency |
JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
WO2008041053A2 (en) | 2005-05-20 | 2008-04-10 | Methylgene, Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
BRPI0610382A2 (pt) * | 2005-05-20 | 2010-06-15 | Methylgene Inc | inibidores de sinalização de receptor de vegf e receptor de hgf |
EP2183255A4 (en) * | 2007-08-29 | 2011-06-15 | Methylgene Inc | METHOD AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF CONDENSED HETEROCYCLIC KINASE INHIBITORS |
BRPI0816064B8 (pt) * | 2007-08-29 | 2021-05-25 | Methylgene Inc | composto inibidor da atividade de proteína tirosina quinase, seu uso, e composição farmacêutica |
AU2009221583B2 (en) | 2008-03-05 | 2013-06-20 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
CN103025740B (zh) * | 2010-04-16 | 2015-07-01 | 梅特希尔基因公司 | 蛋白酪氨酸激酶活性的抑制剂及其治疗眼科疾病的用途 |
WO2013044361A1 (en) * | 2011-09-30 | 2013-04-04 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
-
2011
- 2011-04-08 CN CN201180029735.1A patent/CN103025740B/zh not_active Expired - Fee Related
- 2011-04-08 US US13/082,944 patent/US8455484B2/en not_active Expired - Fee Related
- 2011-04-08 JP JP2013504075A patent/JP2013523846A/ja not_active Ceased
- 2011-04-08 WO PCT/CA2011/000390 patent/WO2011127565A1/en active Application Filing
- 2011-04-08 SG SG2012076725A patent/SG184882A1/en unknown
- 2011-04-08 MX MX2012012032A patent/MX2012012032A/es not_active Application Discontinuation
- 2011-04-08 EA EA201291052A patent/EA201291052A1/ru unknown
- 2011-04-08 AR ARP110101191A patent/AR080871A1/es unknown
- 2011-04-08 AR ARP110101195A patent/AR080875A1/es unknown
- 2011-04-08 CN CN2011800297313A patent/CN102947315A/zh active Pending
- 2011-04-08 EP EP11768307.8A patent/EP2563795A4/en not_active Withdrawn
- 2011-04-08 TW TW100112308A patent/TW201204735A/zh unknown
- 2011-04-08 SG SG2012076733A patent/SG184883A1/en unknown
- 2011-04-08 EA EA201291055A patent/EA201291055A1/ru unknown
- 2011-04-08 MX MX2012012031A patent/MX2012012031A/es active IP Right Grant
- 2011-04-08 AU AU2011241420A patent/AU2011241420B2/en not_active Ceased
- 2011-04-08 TW TW100112307A patent/TW201204734A/zh unknown
- 2011-04-08 CA CA2796008A patent/CA2796008A1/en not_active Abandoned
- 2011-04-08 NZ NZ602954A patent/NZ602954A/en not_active IP Right Cessation
- 2011-04-08 EP EP20110768305 patent/EP2563794A4/en not_active Withdrawn
- 2011-04-08 KR KR1020127030161A patent/KR20130058006A/ko not_active Application Discontinuation
- 2011-04-08 KR KR1020127029841A patent/KR20130100234A/ko not_active Application Discontinuation
- 2011-04-08 NZ NZ602948A patent/NZ602948A/en not_active IP Right Cessation
- 2011-04-08 MY MYPI2012004621A patent/MY157319A/en unknown
- 2011-04-08 JP JP2013504076A patent/JP2013525286A/ja not_active Ceased
- 2011-04-08 US US13/082,923 patent/US8906852B2/en not_active Expired - Fee Related
- 2011-04-08 WO PCT/CA2011/000394 patent/WO2011127567A1/en active Application Filing
- 2011-04-08 UA UAA201211687A patent/UA108878C2/ru unknown
- 2011-04-08 AU AU2011241422A patent/AU2011241422B2/en not_active Ceased
- 2011-04-08 CA CA2796054A patent/CA2796054A1/en not_active Abandoned
-
2012
- 2012-10-05 ZA ZA2012/07482A patent/ZA201207482B/en unknown
- 2012-10-09 ZA ZA2012/07557A patent/ZA201207557B/en unknown
- 2012-11-15 CO CO12207310A patent/CO6630193A2/es active IP Right Grant
- 2012-11-15 CO CO12207317A patent/CO6640224A2/es active IP Right Grant
-
2014
- 2014-06-18 US US14/308,408 patent/US20140315801A1/en not_active Abandoned
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Application granted |