EA201491449A1 - 1h-индазол-3-карбоксамидные соединения в качестве ингибиторов гликогенсинтазы киназы 3-бета - Google Patents

1h-индазол-3-карбоксамидные соединения в качестве ингибиторов гликогенсинтазы киназы 3-бета

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Publication number
EA201491449A1
EA201491449A1 EA201491449A EA201491449A EA201491449A1 EA 201491449 A1 EA201491449 A1 EA 201491449A1 EA 201491449 A EA201491449 A EA 201491449A EA 201491449 A EA201491449 A EA 201491449A EA 201491449 A1 EA201491449 A1 EA 201491449A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitors
disorders
kinase
carboxamide compounds
glycogensyntase
Prior art date
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EA201491449A
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English (en)
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EA024939B1 (ru
Inventor
Мария Алессандра Ализи
Никола Каццолла
Патриция Драгоне
Гвидо Фурлотти
Катерина Мауджери
Розелла Омбрато
Франческа Манчини
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
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Application filed by Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Publication of EA201491449A1 publication Critical patent/EA201491449A1/ru
Publication of EA024939B1 publication Critical patent/EA024939B1/ru

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Abstract

Изобретение относится к 1Н-индазол-3-карбоксамидным соединениям, имеющим общую формулу (I), в качестве ингибиторов гликогенсинтазы киназы 3-бета (GSK-3β) и к их применению при лечении связанных с GSK-3β заболеваний, таких как, например, (i) инсулинрезистентные нарушения; (ii) нейродегенеративные заболевания; (iii) расстройства настроения; (iv) шизофренические расстройства; (v) злокачественные расстройства; (vi) воспаление, (vii) расстройства вследствие токсикомании; (viii) эпилепсии; (ix) невропатическая боль.
EA201491449A 2012-02-21 2013-02-07 1h-индазол-3-карбоксамидные соединения в качестве ингибиторов гликогенсинтазы киназы 3-бета EA024939B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12156292 2012-02-21
PCT/EP2013/052400 WO2013124158A1 (en) 2012-02-21 2013-02-07 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Publications (2)

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EA201491449A1 true EA201491449A1 (ru) 2014-11-28
EA024939B1 EA024939B1 (ru) 2016-11-30

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US (3) US9611249B2 (ru)
EP (1) EP2817302B1 (ru)
JP (1) JP6141331B2 (ru)
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HRP20220664T1 (hr) 2018-05-07 2022-06-24 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1h-indazol-3-karboksamid spojevi kao inhibitori glikogen sintaza kinaze 3 beta
AU2019280693B2 (en) 2018-06-05 2024-10-10 Actuate Therapeutics Inc. Methods of treating malignant lymphoproliferative disorders
JP7434294B2 (ja) 2018-09-13 2024-02-20 ブリストル－マイヤーズ スクイブ カンパニー キナーゼ阻害剤としてのインダゾールカルボキサミド

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HRP20160125T1 (hr) 2016-03-11
DK2817302T3 (en) 2016-03-21
MX351287B (es) 2017-10-09
EA024939B1 (ru) 2016-11-30
CA2860250A1 (en) 2013-08-29
EP2817302B1 (en) 2015-12-30
SI2817302T1 (sl) 2016-03-31
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US10160746B2 (en) 2018-12-25
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UA112564C2 (uk) 2016-09-26
KR20140130124A (ko) 2014-11-07
BR112014018655B1 (pt) 2022-02-08
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CN104093712B (zh) 2016-11-09
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ES2564961T3 (es) 2016-03-30
JP6141331B2 (ja) 2017-06-07
SG11201403602WA (en) 2014-07-30

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