MA30663B1 - Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif - Google Patents
Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actifInfo
- Publication number
- MA30663B1 MA30663B1 MA31663A MA31663A MA30663B1 MA 30663 B1 MA30663 B1 MA 30663B1 MA 31663 A MA31663 A MA 31663A MA 31663 A MA31663 A MA 31663A MA 30663 B1 MA30663 B1 MA 30663B1
- Authority
- MA
- Morocco
- Prior art keywords
- derivative
- active ingredient
- acid ester
- receptor modulator
- ester derivatives
- Prior art date
Links
- -1 AMINOPHOSPHORIC ACID ESTER Chemical class 0.000 title 1
- 239000004480 active ingredient Substances 0.000 title 1
- 229940075993 receptor modulator Drugs 0.000 title 1
- DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 abstract 3
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
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- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
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Abstract
Fournir un dérivé aminophosphorique ayant une excellente activité modulatoire dU récepteur de sphingosine-1-phosphate (S1P). Suite aux recherches intensives continues pour créer un composé fortement sûr qui a une activité modulatoire sur le récepteur de S1P, il a été découvert que le dérivé aminophosphorique représenté par la formule générale (1) suivante, a une forte action activité modulatoire sur le récepteur de S1P.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006215280 | 2006-08-08 |
Publications (1)
Publication Number | Publication Date |
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MA30663B1 true MA30663B1 (fr) | 2009-08-03 |
Family
ID=39032957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31663A MA30663B1 (fr) | 2006-08-08 | 2009-02-26 | Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif |
Country Status (27)
Country | Link |
---|---|
US (1) | US8232319B2 (fr) |
EP (1) | EP2058317B1 (fr) |
JP (1) | JP5188972B2 (fr) |
KR (1) | KR101339976B1 (fr) |
CN (1) | CN101501049B (fr) |
CA (1) | CA2659598A1 (fr) |
CY (1) | CY1114681T1 (fr) |
DK (1) | DK2058317T3 (fr) |
ES (1) | ES2438265T3 (fr) |
HK (1) | HK1131154A1 (fr) |
HR (1) | HRP20131172T1 (fr) |
IL (1) | IL196275A (fr) |
MA (1) | MA30663B1 (fr) |
ME (1) | ME02095B (fr) |
MX (1) | MX2009001456A (fr) |
MY (1) | MY152176A (fr) |
NO (1) | NO20090606L (fr) |
NZ (1) | NZ574011A (fr) |
PL (1) | PL2058317T3 (fr) |
PT (1) | PT2058317E (fr) |
RS (1) | RS53080B (fr) |
RU (1) | RU2430925C2 (fr) |
SG (1) | SG174028A1 (fr) |
SI (1) | SI2058317T1 (fr) |
TN (1) | TNSN08545A1 (fr) |
WO (1) | WO2008018427A1 (fr) |
ZA (1) | ZA200900206B (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5452237B2 (ja) | 2008-02-07 | 2014-03-26 | 杏林製薬株式会社 | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
CA2724450A1 (fr) * | 2008-05-19 | 2009-11-26 | Takeshi Tsubuki | Procede de production d'un derive d'aminoalcool optiquement actif |
NZ589412A (en) * | 2008-05-20 | 2012-11-30 | Kyorin Seiyaku Kk | Use of a sphingosine-1-phosphate (S1P) agonist for maintance of induced remission of autoimmune or inflammatory diseases after inital treatment |
KR20190004843A (ko) | 2008-07-23 | 2019-01-14 | 아레나 파마슈티칼스, 인크. | 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[b]인돌-3-일)아세트산 유도체 |
NZ591001A (en) | 2008-08-27 | 2012-11-30 | Arena Pharm Inc | Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
PT2452944E (pt) | 2009-07-09 | 2014-10-13 | Kyorin Seiyaku Kk | Derivados de sulfureto de difenilo e medicamentos que os contêm como ingredientes activos |
WO2011094008A1 (fr) | 2010-01-27 | 2011-08-04 | Arena Pharmaceuticals, Inc. | Procédés de préparation d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclopenta]indol-3-yl) acétique et de ses sels |
CA2789480A1 (fr) | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Procedes de synthese de modulateurs des recepteurs s1p1 et leurs formes cristallines |
TWI519539B (zh) * | 2010-12-21 | 2016-02-01 | Kyorin Seiyaku Kk | Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof |
US8513418B2 (en) * | 2011-04-18 | 2013-08-20 | Allergan, Inc. | Substituted bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators |
CN102863345A (zh) * | 2011-07-06 | 2013-01-09 | 中国医学科学院药物研究所 | 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途 |
JPWO2015194157A1 (ja) * | 2014-06-16 | 2017-04-20 | 杏林製薬株式会社 | ジフェニルスルフィド誘導体の製造方法及び製造中間体 |
CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
KR102603199B1 (ko) | 2015-06-22 | 2023-11-16 | 아레나 파마슈티칼스, 인크. | S1p1 수용체-관련 장애에서의 사용을 위한 (r)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[b]인돌-3-일)아세트산 (화합물 1)의 결정성 l-아르기닌 염 |
JP6885971B2 (ja) | 2016-06-07 | 2021-06-16 | テスラ,インコーポレイテッド | 電動機冷却システム |
JP2020507611A (ja) | 2017-02-16 | 2020-03-12 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 原発性胆汁性胆管炎の治療のための化合物および方法 |
JP2020507610A (ja) | 2017-02-16 | 2020-03-12 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法 |
US10967702B2 (en) | 2017-09-07 | 2021-04-06 | Tesla, Inc. | Optimal source electric vehicle heat pump with extreme temperature heating capability and efficient thermal preconditioning |
KR20210074291A (ko) | 2018-09-06 | 2021-06-21 | 아레나 파마슈티칼스, 인크. | 자가면역 및 염증성 장애의 치료에 유용한 화합물 |
BR112021010400A2 (pt) | 2019-02-26 | 2021-08-24 | Bayer Aktiengesellschaft | Derivados heterocíclicos bicíclicos condensados como agentes de controle de praga |
US20230398099A1 (en) * | 2020-11-09 | 2023-12-14 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
US11932078B2 (en) | 2021-03-31 | 2024-03-19 | Tesla, Inc. | Electric vehicle heat pump using enhanced valve unit |
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CN1290819C (zh) * | 1997-04-04 | 2006-12-20 | 三菱制药株式会社 | 2-氨基丙烷-1,3-二醇化合物、其作为医药的用途及其合成中间体 |
JPH1180026A (ja) * | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
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2007
- 2007-08-07 KR KR1020097004756A patent/KR101339976B1/ko not_active IP Right Cessation
- 2007-08-07 SI SI200731372T patent/SI2058317T1/sl unknown
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- 2007-08-07 MY MYPI20085394 patent/MY152176A/en unknown
- 2007-08-07 ME MEP-2013-551A patent/ME02095B/fr unknown
- 2007-08-07 CA CA002659598A patent/CA2659598A1/fr not_active Abandoned
- 2007-08-07 WO PCT/JP2007/065397 patent/WO2008018427A1/fr active Application Filing
- 2007-08-07 DK DK07792066.8T patent/DK2058317T3/da active
- 2007-08-07 JP JP2008528818A patent/JP5188972B2/ja not_active Expired - Fee Related
- 2007-08-07 RS RS20130551A patent/RS53080B/en unknown
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- 2007-08-07 CN CN2007800295082A patent/CN101501049B/zh not_active Expired - Fee Related
- 2007-08-07 SG SG2011055589A patent/SG174028A1/en unknown
- 2007-08-07 US US12/310,007 patent/US8232319B2/en not_active Expired - Fee Related
- 2007-08-07 PL PL07792066T patent/PL2058317T3/pl unknown
- 2007-08-07 EP EP07792066.8A patent/EP2058317B1/fr active Active
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- 2009-02-10 NO NO20090606A patent/NO20090606L/no not_active Application Discontinuation
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