MA30663B1 - Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif - Google Patents

Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif

Info

Publication number
MA30663B1
MA30663B1 MA31663A MA31663A MA30663B1 MA 30663 B1 MA30663 B1 MA 30663B1 MA 31663 A MA31663 A MA 31663A MA 31663 A MA31663 A MA 31663A MA 30663 B1 MA30663 B1 MA 30663B1
Authority
MA
Morocco
Prior art keywords
derivative
active ingredient
acid ester
receptor modulator
ester derivatives
Prior art date
Application number
MA31663A
Other languages
English (en)
Inventor
Yasushi Kohno
Kiyoshi Fujii
Tatsuhiro Saito
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of MA30663B1 publication Critical patent/MA30663B1/fr

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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Abstract

Fournir un dérivé aminophosphorique ayant une excellente activité modulatoire dU récepteur de sphingosine-1-phosphate (S1P). Suite aux recherches intensives continues pour créer un composé fortement sûr qui a une activité modulatoire sur le récepteur de S1P, il a été découvert que le dérivé aminophosphorique représenté par la formule générale (1) suivante, a une forte action activité modulatoire sur le récepteur de S1P.
MA31663A 2006-08-08 2009-02-26 Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif MA30663B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006215280 2006-08-08

Publications (1)

Publication Number Publication Date
MA30663B1 true MA30663B1 (fr) 2009-08-03

Family

ID=39032957

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31663A MA30663B1 (fr) 2006-08-08 2009-02-26 Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif

Country Status (27)

Country Link
US (1) US8232319B2 (fr)
EP (1) EP2058317B1 (fr)
JP (1) JP5188972B2 (fr)
KR (1) KR101339976B1 (fr)
CN (1) CN101501049B (fr)
CA (1) CA2659598A1 (fr)
CY (1) CY1114681T1 (fr)
DK (1) DK2058317T3 (fr)
ES (1) ES2438265T3 (fr)
HK (1) HK1131154A1 (fr)
HR (1) HRP20131172T1 (fr)
IL (1) IL196275A (fr)
MA (1) MA30663B1 (fr)
ME (1) ME02095B (fr)
MX (1) MX2009001456A (fr)
MY (1) MY152176A (fr)
NO (1) NO20090606L (fr)
NZ (1) NZ574011A (fr)
PL (1) PL2058317T3 (fr)
PT (1) PT2058317E (fr)
RS (1) RS53080B (fr)
RU (1) RU2430925C2 (fr)
SG (1) SG174028A1 (fr)
SI (1) SI2058317T1 (fr)
TN (1) TNSN08545A1 (fr)
WO (1) WO2008018427A1 (fr)
ZA (1) ZA200900206B (fr)

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TWI519539B (zh) * 2010-12-21 2016-02-01 Kyorin Seiyaku Kk Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof
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CN107405332A (zh) 2015-01-06 2017-11-28 艾尼纳制药公司 治疗与s1p1受体有关的病症的方法
KR102603199B1 (ko) 2015-06-22 2023-11-16 아레나 파마슈티칼스, 인크. Ｓ1ｐ1 수용체-관련 장애에서의 사용을 위한 (ｒ)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[ｂ]인돌-3-일)아세트산 (화합물 1)의 결정성 ｌ-아르기닌 염
JP6885971B2 (ja) 2016-06-07 2021-06-16 テスラ，インコーポレイテッド 電動機冷却システム
JP2020507611A (ja) 2017-02-16 2020-03-12 アリーナ ファーマシューティカルズ， インコーポレイテッド 原発性胆汁性胆管炎の治療のための化合物および方法
JP2020507610A (ja) 2017-02-16 2020-03-12 アリーナ ファーマシューティカルズ， インコーポレイテッド 腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法
US10967702B2 (en) 2017-09-07 2021-04-06 Tesla, Inc. Optimal source electric vehicle heat pump with extreme temperature heating capability and efficient thermal preconditioning
KR20210074291A (ko) 2018-09-06 2021-06-21 아레나 파마슈티칼스, 인크. 자가면역 및 염증성 장애의 치료에 유용한 화합물
BR112021010400A2 (pt) 2019-02-26 2021-08-24 Bayer Aktiengesellschaft Derivados heterocíclicos bicíclicos condensados como agentes de controle de praga
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CA2659598A1 (fr) 2008-02-14
RU2430925C2 (ru) 2011-10-10
TNSN08545A1 (en) 2010-04-14
ZA200900206B (en) 2009-12-30
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MY152176A (en) 2014-08-15
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ME02095B (fr) 2014-06-30
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JP5188972B2 (ja) 2013-04-24
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