MA26961A1 - Agonistes selectifs des recepteurs ep4 pour le traitement de l'osteoporose - Google Patents

Agonistes selectifs des recepteurs ep4 pour le traitement de l'osteoporose

Info

Publication number
MA26961A1
MA26961A1 MA27159A MA27159A MA26961A1 MA 26961 A1 MA26961 A1 MA 26961A1 MA 27159 A MA27159 A MA 27159A MA 27159 A MA27159 A MA 27159A MA 26961 A1 MA26961 A1 MA 26961A1
Authority
MA
Morocco
Prior art keywords
bone
loss
receptors
osteoporosis
relates
Prior art date
Application number
MA27159A
Other languages
English (en)
Inventor
Kimberly O'keefe Cameron
Bruce Allen Lefker
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA26961A1 publication Critical patent/MA26961A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DEPOSANT Société dite: PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 27 Novembre 2000 60/253,275 Voir en annexe le titre de l'invention et le texte de l'abrégé Agonistes sélectifs des récepteurs EP4 pour le traitement de 1'ostéoporose L'invention concerne des agonistes de prostaglandines sélectives des récepteurs EP4, de formule (I), dans laquelle R2, X, Z et Q répondent aux définitions figurant dans le présent mémoire. La présente invention concerne également des compositions pharmaceutiques contenant ces composés. La présente invention concerne également des méthodes de traitement d'affections qui comportent une faible masse osseuse, en particulier 1'ostéoporose, la fragilité, une fracture ostéoporotique, un défaut osseux, la perte de tissu osseux idiopathique de l'enfant, une perte d'os alvéolaire, une perte d'os mandibulaire, une fracture d'un os, une ostéotomie, une perte de tissu osseux associée à la périodontite ou une incarnation prostétique, chez un mammifère, comprenant l'administration de ces composés.
MA27159A 2000-11-27 2003-05-13 Agonistes selectifs des recepteurs ep4 pour le traitement de l'osteoporose MA26961A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25327500P 2000-11-27 2000-11-27

Publications (1)

Publication Number Publication Date
MA26961A1 true MA26961A1 (fr) 2004-12-20

Family

ID=22959588

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27159A MA26961A1 (fr) 2000-11-27 2003-05-13 Agonistes selectifs des recepteurs ep4 pour le traitement de l'osteoporose

Country Status (41)

Country Link
US (3) US6552067B2 (fr)
EP (1) EP1339678B1 (fr)
JP (2) JP3984164B2 (fr)
KR (1) KR20030053063A (fr)
CN (1) CN1476429A (fr)
AR (1) AR035074A1 (fr)
AT (1) ATE374182T1 (fr)
AU (1) AU2002210848A1 (fr)
BG (1) BG107697A (fr)
BR (1) BR0115687A (fr)
CA (1) CA2429850C (fr)
CY (1) CY1106976T1 (fr)
CZ (1) CZ20031257A3 (fr)
DE (1) DE60130675T2 (fr)
DK (1) DK1339678T3 (fr)
EA (1) EA200300379A1 (fr)
EC (1) ECSP034623A (fr)
EE (1) EE200300246A (fr)
ES (1) ES2291361T3 (fr)
GT (2) GT200100238A (fr)
HN (1) HN2001000266A (fr)
HU (1) HUP0400807A2 (fr)
IL (1) IL155368A0 (fr)
IS (1) IS6775A (fr)
MA (1) MA26961A1 (fr)
MX (1) MXPA03004623A (fr)
NO (1) NO20032360L (fr)
NZ (1) NZ525164A (fr)
OA (1) OA12533A (fr)
PA (1) PA8533901A1 (fr)
PE (1) PE20020637A1 (fr)
PL (1) PL362030A1 (fr)
PT (1) PT1339678E (fr)
SI (1) SI1339678T1 (fr)
SK (1) SK5562003A3 (fr)
SV (1) SV2003000746A (fr)
TN (1) TNSN01166A1 (fr)
TW (1) TW200424170A (fr)
UY (1) UY27038A1 (fr)
WO (1) WO2002042268A2 (fr)
ZA (1) ZA200302803B (fr)

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US6552067B2 (en) 2003-04-22
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