MA27017A1 - Procede pour la production d'une composition pharmaceutique a faible dose ayant une distribution et activite medicamenteuses uniformes - Google Patents

Procede pour la production d'une composition pharmaceutique a faible dose ayant une distribution et activite medicamenteuses uniformes

Info

Publication number
MA27017A1
MA27017A1 MA27375A MA27375A MA27017A1 MA 27017 A1 MA27017 A1 MA 27017A1 MA 27375 A MA27375 A MA 27375A MA 27375 A MA27375 A MA 27375A MA 27017 A1 MA27017 A1 MA 27017A1
Authority
MA
Morocco
Prior art keywords
production
activity
pharmaceutical composition
distribution
low
Prior art date
Application number
MA27375A
Other languages
English (en)
Inventor
Daniel Scott Gierer
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA27017A1 publication Critical patent/MA27017A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DEPOSANT Société dite : PFIZER PRODUCTS INC REVENDICATION DE PRIORITES US 1er Mai 2001 60/287,841 Voir en annexe le titre de l'invention et le texte de l'abrégé Procédé pour la production d'une composition pharmaceutique à faible dose ayant une distribution et activité médicamenteuses uniformes Procédé pour la production d'une composition pharmaceutique ayant une distribution et une activité médicamenteuses uniformes, qui utilise du dioxyde de silicium pour réduire la perte d'ingrédient actif au cours du procédé de production. Le procédé est particulièrement utile pour la production de compositions sous forme de comprimés faiblement dosés.
MA27375A 2001-05-01 2003-10-28 Procede pour la production d'une composition pharmaceutique a faible dose ayant une distribution et activite medicamenteuses uniformes MA27017A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28784101P 2001-05-01 2001-05-01

Publications (1)

Publication Number Publication Date
MA27017A1 true MA27017A1 (fr) 2004-12-20

Family

ID=23104578

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27375A MA27017A1 (fr) 2001-05-01 2003-10-28 Procede pour la production d'une composition pharmaceutique a faible dose ayant une distribution et activite medicamenteuses uniformes

Country Status (44)

Country Link
US (2) US7037530B2 (fr)
EP (1) EP1383482B1 (fr)
JP (1) JP2004531537A (fr)
KR (1) KR100568380B1 (fr)
CN (1) CN1240375C (fr)
AP (1) AP2003002900A0 (fr)
AR (1) AR033288A1 (fr)
AT (1) ATE367152T1 (fr)
AU (1) AU2002236166B2 (fr)
BG (1) BG108297A (fr)
BR (1) BR0209283A (fr)
CA (1) CA2445519C (fr)
CZ (1) CZ20032959A3 (fr)
DE (1) DE60221238T2 (fr)
DK (1) DK1383482T3 (fr)
DO (1) DOP2002000389A (fr)
EA (1) EA005949B1 (fr)
EC (1) ECSP034826A (fr)
EE (1) EE200300537A (fr)
ES (1) ES2286226T3 (fr)
GE (1) GEP20053654B (fr)
GT (1) GT200200078A (fr)
HK (1) HK1065705A1 (fr)
HR (1) HRP20030858A2 (fr)
HU (1) HUP0401391A3 (fr)
IL (1) IL158390A0 (fr)
IS (1) IS6985A (fr)
MA (1) MA27017A1 (fr)
MX (1) MXPA03009391A (fr)
NO (1) NO20034709L (fr)
NZ (1) NZ528886A (fr)
OA (1) OA12596A (fr)
PA (1) PA8544401A1 (fr)
PE (1) PE20021137A1 (fr)
PL (1) PL366453A1 (fr)
PT (1) PT1383482E (fr)
SK (1) SK286536B6 (fr)
TN (1) TNSN03106A1 (fr)
TW (1) TWI264311B (fr)
UA (1) UA75135C2 (fr)
UY (1) UY27277A1 (fr)
WO (1) WO2002087546A2 (fr)
YU (1) YU81503A (fr)
ZA (1) ZA200307819B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2479924C (fr) 2002-03-28 2008-07-15 Pfizer Products Inc. Lasofoxifene purifie et procede de purification du lasofoxifene racemique
PA8576201A1 (es) * 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco
US7799273B2 (en) 2004-05-06 2010-09-21 Smp Logic Systems Llc Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes
US7444197B2 (en) 2004-05-06 2008-10-28 Smp Logic Systems Llc Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes
WO2008143607A1 (fr) * 2006-05-17 2008-11-27 Wm. Wrigley Jr. Company Procédé de préparation d'un produit alimentaire
FI20070521L (fi) 2006-11-10 2008-05-11 Atacama Labs Oy Rakeita, tabletteja ja rakeistusmenetelmä
FI20080351A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi matalan lääkepitoisuuden tabletin valmistamiseksi
US8951562B2 (en) 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
WO2008074144A1 (fr) * 2006-12-20 2008-06-26 Genpharm Ulc Composition contenant un acide bisphosphonique combiné à de la vitamine d
US20080181972A1 (en) * 2007-01-29 2008-07-31 Valentina Amico Compositions and Methods for Maintaining, Strengthening, Improving, or Promoting Eye Health
PL2487161T3 (pl) 2007-02-23 2017-03-31 Gilead Sciences, Inc. Modulatory farmakokinetycznych właściwości środków terapeutycznych
SG190618A1 (en) 2008-05-02 2013-06-28 Gilead Sciences Inc The use of solid carrier particles to improve the processability of a pharmaceutical agent
EP2291233B1 (fr) * 2008-05-09 2019-09-04 Atacama Labs Oy Procédé de granulation par voie sèche
UA104590C2 (ru) 2008-06-06 2014-02-25 Берингер Ингельхайм Интернациональ Гмбх Капсулированная лекарственная форма, содержащая суспензионную композицию производной индолинона
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
EP2391349B1 (fr) * 2009-01-29 2014-07-23 UCB Pharma, S.A. Compositions pharmaceutiques comprenant des dérivés de 2-oxo-1-pyrrolidine
EP2391351B1 (fr) * 2009-01-29 2014-08-20 UCB Pharma, S.A. Compositions pharmaceutiques comprenant des dérivés de 2-oxo-1-pyrrolidine
US20140350945A1 (en) * 2013-05-22 2014-11-27 Professional Compounding Centers Of America System and Method for Validation of Pharmaceutical Composition Formulations
CN103830196A (zh) * 2014-03-14 2014-06-04 王志刚 一种酒石酸拉索昔芬分散片及其制备方法
CN106176649B (zh) * 2016-08-31 2020-04-17 北京斯利安药业有限公司 叶酸vb12片及其制备方法
KR102558187B1 (ko) * 2017-02-17 2023-07-24 메사추세츠 인스티튜트 오브 테크놀로지 제약 정제를 비롯한 정제의 제작을 위한 시스템 및 방법
CZ309820B6 (cs) * 2021-04-23 2023-11-08 Pro.Med.Cs Praha A.S. Způsob přípravy pevné lékové formy obsahující kompozici s nízkým obsahem účinné látky

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725555A (en) * 1967-08-01 1973-04-03 Ciba Geigy Corp Bactericidal compositions and method of killing bacteria using bis-(phenoxyphenyl) carbonates
US3725556A (en) 1970-11-12 1973-04-03 D Hanssen Method of manufacturing rapidly disintegrating pharmaceutical tablets
US4013785A (en) 1975-03-21 1977-03-22 Bristol-Myers Company Apap tablet containing fumed silica and process for manufacturing same
GB1570993A (en) * 1976-05-21 1980-07-09 Fisons Ltd Pharmaceutical tablet formulation
DE2845326C2 (de) 1978-10-18 1985-05-23 Beiersdorf Ag, 2000 Hamburg Verwendung einer spezifischen mikrodispersen, amorphen, porösen Kieselsäure zur Herstellung von Digoxin enthaltenden Tabletten mit stark beschleunigter Wirkstoff-Freisetzung
US4489026A (en) 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
US5004613A (en) 1987-07-27 1991-04-02 Mcneil-Ppc, Inc. Oral sustained release pharmaceutical formulation and process
US5047246A (en) 1988-09-09 1991-09-10 Bristol-Myers Company Direct compression cyclophosphamide tablet
US5107331A (en) * 1989-03-07 1992-04-21 The Color Group Method and apparatus for producing half-tone separations at the same screen angle
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
IE67345B1 (en) * 1991-03-12 1996-03-20 Akzo Nv Low dose dry pharmaceutical preparations
US5464632C1 (en) 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
US5358941A (en) 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
US5928668A (en) 1993-12-21 1999-07-27 Applied Analytical Industries, Inc. Method for dry blend compression of medicaments
US5976570A (en) 1993-12-21 1999-11-02 Applied Analytical Industries, Inc. Method for preparing low dose pharmaceutical products
ES2082723B1 (es) 1994-07-20 1996-10-01 Lilly Sa Formulacion farmaceutica de fluoxetina en forma dispersable.
US5478572A (en) * 1994-09-06 1995-12-26 Bristol-Myers Squibb Co. Gepirone dosage form
ES2079327B1 (es) 1994-12-13 1996-08-01 Lilly Sa Formulaciones farmaceuticas de cefaclor.
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
GB9501127D0 (en) 1995-01-20 1995-03-08 Wellcome Found Tablet
US5726168A (en) * 1995-10-12 1998-03-10 Eli Lilly And Company Lipophilic benzothiophenes
UA51676C2 (uk) * 1995-11-02 2002-12-16 Пфайзер Інк. (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція
US5733578A (en) 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
IL120266A (en) 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
CA2218756A1 (fr) * 1996-10-25 1998-04-25 Kristin Sue Marron Derives de substitution de benzo¢b!thiophene actifs comme modulateurs selectifs des recepteurs d'oestrogene
US6080427A (en) 1997-04-17 2000-06-27 Bristol-Myers Squibb Company Cefadroxil monohydrate tablet formulation
DE69834154T2 (de) 1997-07-01 2007-01-25 Pfizer Products Inc., Groton Verfahren zur Herstellung von einem Cyclodextrin
US6300367B1 (en) * 1999-04-20 2001-10-09 Protein Technologies International, Inc. Composition for and method of preventing or treating breast cancer
US6555551B1 (en) * 1999-08-31 2003-04-29 Mutual Pharmaceutical Co., Inc. Stable formulations of ACE inhibitors, and methods for preparation thereof
AR029538A1 (es) * 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos

Also Published As

Publication number Publication date
AU2002236166B2 (en) 2006-12-07
BG108297A (bg) 2005-07-29
IS6985A (is) 2003-10-09
WO2002087546A2 (fr) 2002-11-07
EP1383482A2 (fr) 2004-01-28
HK1065705A1 (en) 2005-03-04
PA8544401A1 (es) 2003-07-28
DE60221238T2 (de) 2007-10-31
UY27277A1 (es) 2002-11-29
US7176221B2 (en) 2007-02-13
AR033288A1 (es) 2003-12-10
NO20034709L (no) 2003-10-31
DK1383482T3 (da) 2007-10-29
KR100568380B1 (ko) 2006-04-05
HRP20030858A2 (en) 2005-08-31
HUP0401391A2 (hu) 2004-12-28
US7037530B2 (en) 2006-05-02
US20030004182A1 (en) 2003-01-02
JP2004531537A (ja) 2004-10-14
ES2286226T3 (es) 2007-12-01
CN1240375C (zh) 2006-02-08
NO20034709D0 (no) 2003-10-21
MXPA03009391A (es) 2004-01-29
CZ20032959A3 (cs) 2004-01-14
ECSP034826A (es) 2004-02-26
BR0209283A (pt) 2004-07-13
ZA200307819B (en) 2004-10-07
EP1383482B1 (fr) 2007-07-18
GEP20053654B (en) 2005-11-10
YU81503A (sh) 2006-08-17
ATE367152T1 (de) 2007-08-15
GT200200078A (es) 2003-01-31
KR20040015226A (ko) 2004-02-18
PT1383482E (pt) 2007-09-20
SK286536B6 (sk) 2008-12-05
PE20021137A1 (es) 2002-12-14
CN1531423A (zh) 2004-09-22
AP2003002900A0 (en) 2003-12-31
PL366453A1 (en) 2005-02-07
EA200301040A1 (ru) 2004-04-29
EA005949B1 (ru) 2005-08-25
DOP2002000389A (es) 2002-11-30
NZ528886A (en) 2005-04-29
IL158390A0 (en) 2004-05-12
HUP0401391A3 (en) 2009-06-29
SK13552003A3 (sk) 2004-09-08
UA75135C2 (en) 2006-03-15
TWI264311B (en) 2006-10-21
CA2445519A1 (fr) 2002-11-07
EE200300537A (et) 2004-04-15
CA2445519C (fr) 2009-01-20
DE60221238D1 (de) 2007-08-30
WO2002087546A3 (fr) 2003-02-13
OA12596A (en) 2006-06-08
TNSN03106A1 (fr) 2005-12-23
US20060093667A1 (en) 2006-05-04

Similar Documents

Publication Publication Date Title
MA27017A1 (fr) Procede pour la production d'une composition pharmaceutique a faible dose ayant une distribution et activite medicamenteuses uniformes
MA27318A1 (fr) Comprime de lasofoxifene et son enrobage
HUP0102337A2 (hu) Eljárás gyulladásgátló, különösen fertőtlenítő hatású és/vagy sebgyógyulást elősegítő szerek felső légutakba és/vagy fülbe történő beadására szolgáló készítmények előállítására
WO2001090091A8 (fr) Inhibiteurs de 11-beta-hydroxy-steroide-deshydrogenase de type 1
EP2322146A3 (fr) Formules multi-particules comprenant deux principes actives
GEP20033131B (en) Azabicycloalkanes as CCR5 Modulators, Pharmaceutical Compositions Containing the Same and Their Use for Treatment and Prevention of Diseases Caused by CCR5 Activity
WO2001001973A8 (fr) Inhibiteurs de recaptage de noradrenaline hautement selectifs et leurs methodes d'utilisation
CA2214026A1 (fr) Compositions pharmaceutiques comprenant des inhibiteurs de la monoamine oxydase b
CA2385890A1 (fr) Compositions a liberation regulee contenant de la nimesulide
WO2003037337A8 (fr) Preparations de depot d'iloperidone et de polymere en etoile
PL367447A1 (en) Novel 2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient
WO2003045306A3 (fr) Composes phenoxy amine et compositions pour administrer des principes actifs
HUP0303454A2 (hu) 4-Ciano-trifluor-3-(4-fluor-fenil-szulfonil)-2-hidroxi-2-metil-propiono-m-toluididet és pvp-t tartalmazó szilárd gyógyászati készítmény
WO2002030467A3 (fr) Composition destinee a soigner des plaies, renfermant un compose actif du point de vue therapeutique, du miel notamment
HUP0105481A2 (hu) Klaritromicint vagy származékait tartalmazó gyógyászati készítmények és eljárás előállításukra, valamint alkalmazásuk
HK1079688A1 (en) Statin product for enhancing cognitive maintenance
EP1262197A3 (fr) Combinaison thérapeutique pour traiter les troubles du sommeil, y compris l'apnée du sommeil
CA2340734A1 (fr) Derive de pyridyl-4h-1,2,4-oxadiazine optiquement actif et son utilisation dans le traitement des maladies vasculaires
BR0008739A (pt) Composições de liberação controlada debeta-histina
BR0114395A (pt) Composição farmacêutica para administração por suprimento via oral
BR0014440A (pt) Formulações de liberação controlada oral
EP1247533A3 (fr) Traitement combiné de la sclérose en plaques, d'autres maladies démyélinisantes et de la neuropathie périphérique, en particulier des neuropathies douloureuses et de la neuropathie diabétique
HK1046637A1 (en) Use of racemic alpha-lipoic acid in preparation pharmaceutical for treatment of migraine.
JP2010001228A (ja) 歯周病予防又は治療剤、及び口腔用組成物
DZ3103A1 (fr) Nouvelles pyrazolo Ä4,3-EÜdiazépines substituées, compositions pharmaceutiques les contenant, utili sation à titre de médicament et procédés pour leurs préparation.