EA200301040A1 - Способ производства фармацевтической композиции низкой дозы - Google Patents

Способ производства фармацевтической композиции низкой дозы

Info

Publication number
EA200301040A1
EA200301040A1 EA200301040A EA200301040A EA200301040A1 EA 200301040 A1 EA200301040 A1 EA 200301040A1 EA 200301040 A EA200301040 A EA 200301040A EA 200301040 A EA200301040 A EA 200301040A EA 200301040 A1 EA200301040 A1 EA 200301040A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
manufacture
low dose
manufacturing
effectiveness
Prior art date
Application number
EA200301040A
Other languages
English (en)
Other versions
EA005949B1 (ru
Inventor
Дэниел Скотт Гайерер
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200301040A1 publication Critical patent/EA200301040A1/ru
Publication of EA005949B1 publication Critical patent/EA005949B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описан способ производства фармацевтической композиции, имеющей равномерные распределение лекарства и эффективность, в котором используют диоксид кремния для уменьшения потерь активного ингредиента в ходе процесса производства. Способ особенно полезен для производства таблеточных композиций низкой дозировки.Отчет о международном поиске был опубликован 2003.02.13.
EA200301040A 2001-05-01 2002-03-13 Способ производства фармацевтической композиции низкой дозы EA005949B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28784101P 2001-05-01 2001-05-01
PCT/IB2002/000766 WO2002087546A2 (en) 2001-05-01 2002-03-13 Method for manufacturing a low dose pharmaceutical composition

Publications (2)

Publication Number Publication Date
EA200301040A1 true EA200301040A1 (ru) 2004-04-29
EA005949B1 EA005949B1 (ru) 2005-08-25

Family

ID=23104578

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200301040A EA005949B1 (ru) 2001-05-01 2002-03-13 Способ производства фармацевтической композиции низкой дозы

Country Status (44)

Country Link
US (2) US7037530B2 (ru)
EP (1) EP1383482B1 (ru)
JP (1) JP2004531537A (ru)
KR (1) KR100568380B1 (ru)
CN (1) CN1240375C (ru)
AP (1) AP2003002900A0 (ru)
AR (1) AR033288A1 (ru)
AT (1) ATE367152T1 (ru)
AU (1) AU2002236166B2 (ru)
BG (1) BG108297A (ru)
BR (1) BR0209283A (ru)
CA (1) CA2445519C (ru)
CZ (1) CZ20032959A3 (ru)
DE (1) DE60221238T2 (ru)
DK (1) DK1383482T3 (ru)
DO (1) DOP2002000389A (ru)
EA (1) EA005949B1 (ru)
EC (1) ECSP034826A (ru)
EE (1) EE200300537A (ru)
ES (1) ES2286226T3 (ru)
GE (1) GEP20053654B (ru)
GT (1) GT200200078A (ru)
HK (1) HK1065705A1 (ru)
HR (1) HRP20030858A2 (ru)
HU (1) HUP0401391A3 (ru)
IL (1) IL158390A0 (ru)
IS (1) IS6985A (ru)
MA (1) MA27017A1 (ru)
MX (1) MXPA03009391A (ru)
NO (1) NO20034709L (ru)
NZ (1) NZ528886A (ru)
OA (1) OA12596A (ru)
PA (1) PA8544401A1 (ru)
PE (1) PE20021137A1 (ru)
PL (1) PL366453A1 (ru)
PT (1) PT1383482E (ru)
SK (1) SK286536B6 (ru)
TN (1) TNSN03106A1 (ru)
TW (1) TWI264311B (ru)
UA (1) UA75135C2 (ru)
UY (1) UY27277A1 (ru)
WO (1) WO2002087546A2 (ru)
YU (1) YU81503A (ru)
ZA (1) ZA200307819B (ru)

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US7799273B2 (en) 2004-05-06 2010-09-21 Smp Logic Systems Llc Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes
US7444197B2 (en) 2004-05-06 2008-10-28 Smp Logic Systems Llc Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes
EP2023745A1 (en) * 2006-05-17 2009-02-18 WM. Wrigley Jr., Company Method of preparing a food product
US8951562B2 (en) 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
FI20080351A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi matalan lääkepitoisuuden tabletin valmistamiseksi
FI20070521L (fi) 2006-11-10 2008-05-11 Atacama Labs Oy Rakeita, tabletteja ja rakeistusmenetelmä
US20100179110A1 (en) * 2006-12-20 2010-07-15 Mostafa Akbarieh Composition Containing a Bisphosphonic Acid in Combination with Vitamin D
US20080181972A1 (en) * 2007-01-29 2008-07-31 Valentina Amico Compositions and Methods for Maintaining, Strengthening, Improving, or Promoting Eye Health
HUE029866T2 (en) 2007-02-23 2017-03-28 Gilead Sciences Inc Modulation of pharmacokinetic parameters of therapeutic agents
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WO2009135946A1 (en) * 2008-05-09 2009-11-12 Atacama Labs Oy Method and apparatus for dry granulation
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
EA029996B1 (ru) * 2008-06-06 2018-06-29 Бёрингер Ингельхайм Интернациональ Гмбх Капсулярная лекарственная форма, содержащая суспензионную композицию производного индолинона
CA2747395C (en) * 2009-01-29 2015-01-13 Ucb Pharma, S.A. Pharmaceutical compositions comprising 2-oxo-1-pyrrolidine derivatives
DK2391351T3 (da) * 2009-01-29 2014-12-01 Ucb Pharma Sa Farmaceutisk sammensætning omfattende 2-oxo-1-pyrrolidinderivater
US20140350945A1 (en) * 2013-05-22 2014-11-27 Professional Compounding Centers Of America System and Method for Validation of Pharmaceutical Composition Formulations
CN103830196A (zh) * 2014-03-14 2014-06-04 王志刚 一种酒石酸拉索昔芬分散片及其制备方法
CN106176649B (zh) * 2016-08-31 2020-04-17 北京斯利安药业有限公司 叶酸vb12片及其制备方法
WO2018152320A1 (en) * 2017-02-17 2018-08-23 Massachusetts Institute Of Technology Systems and methods for the fabrication of tablets, including pharmaceutical tablets

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Also Published As

Publication number Publication date
DOP2002000389A (es) 2002-11-30
US7037530B2 (en) 2006-05-02
BG108297A (bg) 2005-07-29
EP1383482A2 (en) 2004-01-28
WO2002087546A2 (en) 2002-11-07
US7176221B2 (en) 2007-02-13
CA2445519A1 (en) 2002-11-07
SK13552003A3 (sk) 2004-09-08
NZ528886A (en) 2005-04-29
DE60221238T2 (de) 2007-10-31
CN1240375C (zh) 2006-02-08
KR100568380B1 (ko) 2006-04-05
IS6985A (is) 2003-10-09
NO20034709L (no) 2003-10-31
JP2004531537A (ja) 2004-10-14
ATE367152T1 (de) 2007-08-15
AR033288A1 (es) 2003-12-10
ES2286226T3 (es) 2007-12-01
NO20034709D0 (no) 2003-10-21
CZ20032959A3 (cs) 2004-01-14
HUP0401391A2 (hu) 2004-12-28
HRP20030858A2 (en) 2005-08-31
PT1383482E (pt) 2007-09-20
DE60221238D1 (de) 2007-08-30
EE200300537A (et) 2004-04-15
KR20040015226A (ko) 2004-02-18
WO2002087546A3 (en) 2003-02-13
US20030004182A1 (en) 2003-01-02
ECSP034826A (es) 2004-02-26
PA8544401A1 (es) 2003-07-28
PL366453A1 (en) 2005-02-07
AU2002236166B2 (en) 2006-12-07
SK286536B6 (sk) 2008-12-05
TWI264311B (en) 2006-10-21
US20060093667A1 (en) 2006-05-04
PE20021137A1 (es) 2002-12-14
GEP20053654B (en) 2005-11-10
HK1065705A1 (en) 2005-03-04
BR0209283A (pt) 2004-07-13
IL158390A0 (en) 2004-05-12
CN1531423A (zh) 2004-09-22
MXPA03009391A (es) 2004-01-29
GT200200078A (es) 2003-01-31
ZA200307819B (en) 2004-10-07
EA005949B1 (ru) 2005-08-25
AP2003002900A0 (en) 2003-12-31
MA27017A1 (fr) 2004-12-20
YU81503A (sh) 2006-08-17
UA75135C2 (en) 2006-03-15
OA12596A (en) 2006-06-08
DK1383482T3 (da) 2007-10-29
TNSN03106A1 (fr) 2005-12-23
EP1383482B1 (en) 2007-07-18
HUP0401391A3 (en) 2009-06-29
UY27277A1 (es) 2002-11-29
CA2445519C (en) 2009-01-20

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