HUP0401391A2 - Eljárás kisdózisú, egyenletes hatóanyag-eloszlású és hatáserősségű gyógyszerkészítmény előállítására és a gyógyszerkészítmény - Google Patents

Eljárás kisdózisú, egyenletes hatóanyag-eloszlású és hatáserősségű gyógyszerkészítmény előállítására és a gyógyszerkészítmény

Info

Publication number
HUP0401391A2
HUP0401391A2 HU0401391A HUP0401391A HUP0401391A2 HU P0401391 A2 HUP0401391 A2 HU P0401391A2 HU 0401391 A HU0401391 A HU 0401391A HU P0401391 A HUP0401391 A HU P0401391A HU P0401391 A2 HUP0401391 A2 HU P0401391A2
Authority
HU
Hungary
Prior art keywords
potency
active ingredient
active
mixture
minutes
Prior art date
Application number
HU0401391A
Other languages
English (en)
Inventor
Daniel Scott Gierer
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0401391A2 publication Critical patent/HUP0401391A2/hu
Publication of HUP0401391A3 publication Critical patent/HUP0401391A3/hu

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgyát egy, kisdózisú, egyenletes hatóanyag-eloszlású éshatáserősségű gyógyszerkészítmények előállítására szolgáló eljárásképezi, amely szerint a következő sorrendben az alábbi lépésekethajtják végre: (1) szilícium-dioxidot és legalább egy gyógyászatilagelfogadható segédanyagot, vivőanyagot vagy töltőanyagot nagy nyírásisebességű granulátorban kevernek megfelelő időtartamig (példáulkörülbelül 5 percig) keverék előállításához; (2) egy hatóanyagotgranulátorba adagolnak és keverik további időtartamig (például kb. 5-10 percig) aktív keverék előállításához; (3) az aktív keveréketátviszik a granulátorból egy keverőbe; (4) adott esetben egy vagy többtovábbi gyógyászatilag elfogadható se gédanyagot, vivőanyagot vagytöltőanyagot hozzáadnak az aktív keverékhez, és (5) keverik megfelelőidőtartamig (például kb. 10-15 percig) egyenletes hatóanyag-eloszlásúés egyforma hatáserősségű gyógyszerkészítmény előállítása céljából. Atalálmány további tárgya kis dózisú gyógyszerkészítmény, amely áll egyhatóanyagból (például a cisz-[6-fenil-5-[4-(2-pirrolidin-1-iletoxi)fenil]-5,6,7,8 tetrahidronaftalin-2-ol D-tartarátsójából), szilícium-dioxidból és legalább egy gyógyászatilag elfogadható segédanyagból,vivőanyagból vagy töltőanyagból, ahol a hatóanyag kevesebb mint 4,0tömeg% mennyiségben, a szilícium dioxid pedig körülbelül 0,1-2 tömeg%mennyiségben van jelen. Ó
HU0401391A 2001-05-01 2002-03-13 Method for manufacturing a low dose pharmaceutical composition having uniform drug distribution and potency and the pharmaceutical compositin HUP0401391A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28784101P 2001-05-01 2001-05-01
PCT/IB2002/000766 WO2002087546A2 (en) 2001-05-01 2002-03-13 Method for manufacturing a low dose pharmaceutical composition

Publications (2)

Publication Number Publication Date
HUP0401391A2 true HUP0401391A2 (hu) 2004-12-28
HUP0401391A3 HUP0401391A3 (en) 2009-06-29

Family

ID=23104578

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401391A HUP0401391A3 (en) 2001-05-01 2002-03-13 Method for manufacturing a low dose pharmaceutical composition having uniform drug distribution and potency and the pharmaceutical compositin

Country Status (44)

Country Link
US (2) US7037530B2 (hu)
EP (1) EP1383482B1 (hu)
JP (1) JP2004531537A (hu)
KR (1) KR100568380B1 (hu)
CN (1) CN1240375C (hu)
AP (1) AP2003002900A0 (hu)
AR (1) AR033288A1 (hu)
AT (1) ATE367152T1 (hu)
AU (1) AU2002236166B2 (hu)
BG (1) BG108297A (hu)
BR (1) BR0209283A (hu)
CA (1) CA2445519C (hu)
CZ (1) CZ20032959A3 (hu)
DE (1) DE60221238T2 (hu)
DK (1) DK1383482T3 (hu)
DO (1) DOP2002000389A (hu)
EA (1) EA005949B1 (hu)
EC (1) ECSP034826A (hu)
EE (1) EE200300537A (hu)
ES (1) ES2286226T3 (hu)
GE (1) GEP20053654B (hu)
GT (1) GT200200078A (hu)
HK (1) HK1065705A1 (hu)
HR (1) HRP20030858A2 (hu)
HU (1) HUP0401391A3 (hu)
IL (1) IL158390A0 (hu)
IS (1) IS6985A (hu)
MA (1) MA27017A1 (hu)
MX (1) MXPA03009391A (hu)
NO (1) NO20034709L (hu)
NZ (1) NZ528886A (hu)
OA (1) OA12596A (hu)
PA (1) PA8544401A1 (hu)
PE (1) PE20021137A1 (hu)
PL (1) PL366453A1 (hu)
PT (1) PT1383482E (hu)
SK (1) SK286536B6 (hu)
TN (1) TNSN03106A1 (hu)
TW (1) TWI264311B (hu)
UA (1) UA75135C2 (hu)
UY (1) UY27277A1 (hu)
WO (1) WO2002087546A2 (hu)
YU (1) YU81503A (hu)
ZA (1) ZA200307819B (hu)

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Also Published As

Publication number Publication date
AR033288A1 (es) 2003-12-10
US20060093667A1 (en) 2006-05-04
ECSP034826A (es) 2004-02-26
GT200200078A (es) 2003-01-31
YU81503A (sh) 2006-08-17
HUP0401391A3 (en) 2009-06-29
WO2002087546A2 (en) 2002-11-07
WO2002087546A3 (en) 2003-02-13
SK13552003A3 (sk) 2004-09-08
US7037530B2 (en) 2006-05-02
NO20034709L (no) 2003-10-31
DE60221238D1 (de) 2007-08-30
KR20040015226A (ko) 2004-02-18
AP2003002900A0 (en) 2003-12-31
TNSN03106A1 (fr) 2005-12-23
ATE367152T1 (de) 2007-08-15
US20030004182A1 (en) 2003-01-02
KR100568380B1 (ko) 2006-04-05
EA005949B1 (ru) 2005-08-25
ZA200307819B (en) 2004-10-07
JP2004531537A (ja) 2004-10-14
ES2286226T3 (es) 2007-12-01
GEP20053654B (en) 2005-11-10
DOP2002000389A (es) 2002-11-30
IS6985A (is) 2003-10-09
EA200301040A1 (ru) 2004-04-29
CA2445519A1 (en) 2002-11-07
EP1383482A2 (en) 2004-01-28
DK1383482T3 (da) 2007-10-29
PA8544401A1 (es) 2003-07-28
SK286536B6 (sk) 2008-12-05
OA12596A (en) 2006-06-08
CZ20032959A3 (cs) 2004-01-14
HK1065705A1 (en) 2005-03-04
MA27017A1 (fr) 2004-12-20
BR0209283A (pt) 2004-07-13
EP1383482B1 (en) 2007-07-18
MXPA03009391A (es) 2004-01-29
PE20021137A1 (es) 2002-12-14
EE200300537A (et) 2004-04-15
US7176221B2 (en) 2007-02-13
PT1383482E (pt) 2007-09-20
CN1531423A (zh) 2004-09-22
NO20034709D0 (no) 2003-10-21
PL366453A1 (en) 2005-02-07
CA2445519C (en) 2009-01-20
DE60221238T2 (de) 2007-10-31
UY27277A1 (es) 2002-11-29
TWI264311B (en) 2006-10-21
BG108297A (bg) 2005-07-29
AU2002236166B2 (en) 2006-12-07
HRP20030858A2 (en) 2005-08-31
NZ528886A (en) 2005-04-29
CN1240375C (zh) 2006-02-08
IL158390A0 (en) 2004-05-12
UA75135C2 (en) 2006-03-15

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